All Stories

  1. Red-Light-Photosensitized Tyrosine 10 Nitration of β-Amyloid1–42 Diverts the Protein from Forming Toxic Aggregates

    Article • ACS Chemical Neuroscience, July 2024, American Chemical Society (ACS)

    Maria Laura Giuffrida

  2. Exploring the therapeutic potential of Aloin: unraveling neuroprotective and anticancer mechanisms, and strategies for enhanced stability and delivery

    Article • Scientific Reports, July 2024, Springer Science + Business Media

    Maria Laura Giuffrida

  3. A zinc–porphyrin–peptide conjugate via “click-chemistry”: synthesis and amyloid-β interaction

    Article • New Journal of Chemistry, January 2024, Royal Society of Chemistry

    Maria Laura Giuffrida

  4. Molecular Connections between DNA Replication and Cell Death in β-Amyloid-Treated Neurons

    Article • Current Neuropharmacology, September 2023, Bentham Science Publishers

    Maria Laura Giuffrida

  5. Exploring the Role of Hsp60 in Alzheimer’s Disease and Type 2 Diabetes: Suggestion for Common Drug Targeting

    Article • International Journal of Molecular Sciences, August 2023, MDPI AG

    Maria Laura Giuffrida

  6. Amyloid β and Alzheimer’s Disease: Molecular Updates from Physiology to Pathology

    Article • International Journal of Molecular Sciences, April 2023, MDPI AG

    Maria Laura Giuffrida

  7. Aβ8-20 Fragment as an Anti-Fibrillogenic and Neuroprotective Agent: Advancing toward Efficient Alzheimer’s Disease Treatment

    Article • ACS Chemical Neuroscience, March 2023, American Chemical Society (ACS)

    Maria Laura Giuffrida

  8. Green Light-Triggerable Chemo-Photothermal Activity of Cytarabine-Loaded Polymer Carbon Dots: Mechanism and Preliminary In Vitro Evaluation

    Article • ACS Applied Materials & Interfaces, January 2023, American Chemical Society (ACS)

    Maria Laura Giuffrida

  9. A novel material based on an antibacterial choline-calixarene nanoassembly embedded in thin films

    Article • Journal of Materials Science, November 2022, Springer Science + Business Media

    Maria Laura Giuffrida

  10. KLVFF oligopeptide-decorated amphiphilic cyclodextrin nanomagnets for selective amyloid beta recognition and fishing

    Article • Journal of Colloid and Interface Science, May 2022, Elsevier

    Professor Placido Giuseppe Mineo, Maria Laura Giuffrida

  11. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models

    Article • ACS Chemical Neuroscience, January 2022, American Chemical Society (ACS)

    Maria Laura Giuffrida

  12. A novel facile one-pot synthesis of photothermally responsive carbon polymer dots as promising drug nanocarriers

    Article • Chemical Communications, January 2022, Royal Society of Chemistry

    Maria Laura Giuffrida

  13. Investigation on the solid-phase synthesis of silybin prodrugs and their timed-release

    Article • Bioorganic & Medicinal Chemistry, November 2021, Elsevier

    Maria Laura Giuffrida

  14. β-amyloid monomers drive up neuronal aerobic glycolysis in response to energy stressors

    Article • Aging, July 2021, Impact Journals, LLC

    Maria Laura Giuffrida

  15. Novel Peptide-Calix[4]arene Conjugate Inhibits Aβ Aggregation and Rescues Neurons from Aβ’s Oligomers Cytotoxicity In Vitro

    Article • ACS Chemical Neuroscience, April 2021, American Chemical Society (ACS)

    Maria Laura Giuffrida

  16. Synthesis and biological evaluation of novel β-cyclodextrin-fluvastatin conjugates

    Article • Results in Chemistry, January 2021, Elsevier

    Maria Laura Giuffrida

  17. Trehalose Conjugates of Silybin as Prodrugs for Targeting Toxic Aβ Aggregates

    Article • ACS Chemical Neuroscience, July 2020, American Chemical Society (ACS)

    Maria Laura Giuffrida

  18. A promising connection between BDNF and Alzheimer’s disease

    Article • Aging, August 2018, Impact Journals, LLC

    Maria Laura Giuffrida

  19. Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity

    Article • Chemistry - A European Journal, April 2018, Wiley

    Maria Laura Giuffrida

  20. A New Ratiometric Lysosomal Copper(II) Fluorescent Probe To Map a Dynamic Metallome in Live Cells

    Article • Inorganic Chemistry, February 2018, American Chemical Society (ACS)

    Maria Laura Giuffrida

  21. Neurotrophic effect of Abeta monomer

    Article • Aging Cell, November 2017, Wiley

    Enrico Rizzarelli, Maria Laura Giuffrida, Fiorenza Gianì, Agata Copani

  22. Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease

    Article • ACS Medicinal Chemistry Letters, October 2016, American Chemical Society (ACS)

    Maria Laura Giuffrida

  23. Corrigendum: Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity

    Article • ChemBioChem, September 2016, Wiley

    Dr Giuseppe Pappalardo, Maria Laura Giuffrida

  24. Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity

    Article • ChemBioChem, July 2016, Wiley

    Dr Giuseppe Pappalardo, Maria Laura Giuffrida

  25. Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity

    Article • Journal of Natural Products, October 2015, American Chemical Society (ACS)

    Maria Laura Giuffrida

  26. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1–42)-induced toxicity

    Article • European Journal of Pharmacology, October 2015, Elsevier

    Maria Laura Giuffrida

  27. Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

    Article • Frontiers in Cellular Neuroscience, August 2015, Frontiers

    Dr Giuseppe Pappalardo, Maria Laura Giuffrida

  28. Molecular and cytotoxic properties of hIAPP17–29 and rIAPP17–29 fragments: A comparative study with the respective full-length parent polypeptides

    Article • European Journal of Medicinal Chemistry, June 2014, Elsevier

    Dr Giuseppe Pappalardo, Maria Laura Giuffrida

  29. Synthesis of a new monovalent copper probe, and relative complexation studies are reported

    Article • Chemical Communications, May 2014, Royal Society of Chemistry

    Dr Giuseppe Trusso Sfrazzetto, Professor Cristina Satriano, Maria Laura Giuffrida

  30. The first ratiometric fluorescent probe for neuronal Cu(I) is reported

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Dr Giuseppe Trusso Sfrazzetto, Professor Cristina Satriano, Maria Laura Giuffrida

  31. Ratiometric fluorescence sensing and cellular imaging of Cu2+ by a new water soluble trehalose-naphthalimide based chemosensor

    Article • RSC Advances, January 2013, Royal Society of Chemistry

    Luca Prodi, Professor Cristina Satriano, Maria Laura Giuffrida

  32. Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide

    Article • Soft Matter, January 2013, Royal Society of Chemistry

    Professor Cristina Satriano, Luca Prodi, Maria Laura Giuffrida

  33. Beta-Amyloid Monomer and Insulin/IGF-1 Signaling in Alzheimer's Disease

    Article • Molecular Neurobiology, August 2012, Springer Science + Business Media

    Maria Laura Giuffrida

  34. Gluconjugates of 8-hydroxyquinolines as potential anti-cancer prodrugs

    Article • Dalton Transactions, January 2012, Royal Society of Chemistry

    Maria Laura Giuffrida

  35. Metallostasis and amyloid β-degrading enzymes

    Article • Metallomics, January 2012, Oxford University Press (OUP)

    Maria Laura Giuffrida

  36. Neurotoxic properties of the anabolic androgenic steroids nandrolone and methandrostenolone in primary neuronal cultures

    Article • Journal of Neuroscience Research, February 2011, Wiley

    Maria Laura Giuffrida

  37. Targeting Group II Metabotropic Glutamate (mGlu) Receptors for the Treatment of Psychosis Associated with Alzheimer's Disease: Selective Activation of mGlu2 Receptors Amplifies β-Amyloid Toxicity in Cultured Neurons, Whereas Dual Activation of mGlu2 an...

    Article • Molecular Pharmacology, December 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Maria Laura Giuffrida

  38. The Monomer State of Beta-Amyloid: Where the Alzheimer's Disease Protein Meets Physiology

    Article • Reviews in the Neurosciences, January 2010, De Gruyter

    Maria Laura Giuffrida

  39. TGF-β1 Pathway as a New Target for Neuroprotection in Alzheimer's Disease

    Article • CNS Neuroscience & Therapeutics, November 2009, Wiley

    Maria Laura Giuffrida

  40. β-Amyloid Monomers Are Neuroprotective

    Article • Journal of Neuroscience, August 2009, Society for Neuroscience

    Maria Laura Giuffrida

  41. Enhanced expression of ERα in astrocytes modifies the response of cortical neurons to β-amyloid toxicity

    Article • Neurobiology of Disease, March 2009, Elsevier

    Maria Laura Giuffrida

  42. Design and synthesis of new trehalose‐conjugated pentapeptides as inhibitors of Aβ(1–42) fibrillogenesis and toxicity

    Article • Journal of Peptide Science, January 2009, Wiley

    Maria Laura Giuffrida

  43. Carnosine interaction with nitric oxide and astroglial cell protection

    Article • Journal of Neuroscience Research, January 2007, Wiley

    Maria Laura Giuffrida

  44. Aβ(25–35) and its C‐ and/or N‐blocked derivatives: Copper driven structural features and neurotoxicity

    Article • Journal of Neuroscience Research, November 2006, Wiley

    Maria Laura Giuffrida

  45. C/EBP ? and ? mimic retinoic acid activation of IGFBP-5 in neuroblastoma cells by a mechanism independent from binding to their site

    Article • Experimental Cell Research, April 2005, Elsevier

    Maria Laura Giuffrida

  46. Silencing of endogenous IGFBP-5 by micro RNA interference affects proliferation, apoptosis and differentiation of neuroblastoma cells

    Article • Cell Death and Differentiation, December 2004, Springer Science + Business Media

    Maria Laura Giuffrida

  47. Insulin‐like Growth Factor Binding Protein 5: Contribution to Growth and Differentiation of Neuroblastoma Cells

    Article • Annals of the New York Academy of Sciences, December 2004, Wiley

    Maria Laura Giuffrida

  48. Cyclin D1-dependent regulation of B-myb activity in early stages of neuroblastoma differentiation

    Article • Cell Death and Differentiation, October 2002, Springer Science + Business Media

    Maria Laura Giuffrida