All Stories

  1. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

    Article • Nature, August 2015, Nature

    Dr Marcos Malumbres

  2. An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress

    Article • Cell Death and Differentiation, August 2015, Nature

    Dr Marcos Malumbres

  3. Aurora B in cancer

    Article • Molecular and Cellular Biology, August 2015, ASM Journals

    Dr Marcos Malumbres

  4. PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

    Article • Nature Communications, July 2015, Nature

    Dr Marcos Malumbres

  5. Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice

    Article • Blood, July 2015, American Society of Hematology

    Dr Marcos Malumbres

  6. An Atypical Oncogene Within the Atypical E2Fs

    Article • JNCI Journal of the National Cancer Institute, June 2015, Oxford University Press (OUP)

    Dr Marcos Malumbres

  7. A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain

    Article • Neuron, May 2015, Elsevier

    Dr Marcos Malumbres

  8. Casein Kinase 1δ Is an APC/CCdh1 Substrate that Regulates Cerebellar Granule Cell Neurogenesis

    Article • Cell Reports, April 2015, Elsevier

    Dr Marcos Malumbres

  9. Functional Reprogramming of Polyploidization in Megakaryocytes

    Article • Developmental Cell, January 2015, Elsevier

    Dr Marcos Malumbres

  10. Cyclin C surprises in tumour suppression

    Article • Nature, October 2014, Nature

    Dr Marcos Malumbres

  11. Splicing together sister chromatids

    Article • The EMBO Journal, September 2014, EMBO

    Dr Marcos Malumbres

  12. Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia

    Article • Nature Communications, June 2014, Nature

    Dr Marcos Malumbres

  13. A centrosomal route for cancer genome instability

    Article • Nature, May 2014, Nature

    Dr Marcos Malumbres

  14. Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry

    Article • BioEssays, May 2014, Wiley

    Dr Marcos Malumbres

  15. APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction

    Article • Developmental Cell, May 2014, Elsevier

    Dr Marcos Malumbres

  16. Dependency of the Spindle Assembly Checkpoint on Cdk1 Renders the Anaphase Transition Irreversible

    Article • Current Biology, March 2014, Elsevier

    Dr Marcos Malumbres

  17. A Synthetic Lethal Interaction between APC/C and Topoisomerase Poisons Uncovered by Proteomic Screens

    Article • Cell Reports, February 2014, Elsevier

    Dr Marcos Malumbres

  18. Cyclin-dependent kinases

    Article • Genome Biology, January 2014, Springer Science + Business Media

    Dr Marcos Malumbres

  19. The Greatwall–PP2A Axis in Cell Cycle Control

    Article • January 2014, Springer Science + Business Media

    Dr Marcos Malumbres

  20. The functional relevance of polyploidization in the skin

    Article • Experimental Dermatology, December 2013, Wiley

    Dr Marcos Malumbres

  21. The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors

    Article • Nature Communications, December 2013, Nature

    Dr Marcos Malumbres

  22. Correction to Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest

    Article • ACS Nano, November 2013, American Chemical Society (ACS)

    Dr Marcos Malumbres

  23. Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest

    Article • ACS Nano, September 2013, American Chemical Society (ACS)

    Dr Marcos Malumbres

  24. microRNA-203: Tumor Suppression and Beyond

    Article • MicroRNA, September 2013, Bentham Science Publishers

    Dr Marcos Malumbres

  25. The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes

    Article • Molecular Cell, September 2013, Elsevier

    Dr Marcos Malumbres

  26. Mitosis-targeting therapies: a troubleshooting guide

    Article • Current Opinion in Pharmacology, August 2013, Elsevier

    Dr Marcos Malumbres

  27. A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

    Article • Cancer Cell, August 2013, Elsevier

    Dr Marcos Malumbres, Dr Christoph Bock

  28. Robust mitotic entry is ensured by a latching switch

    Article • Biology Open, July 2013, The Company of Biologists

    Dr Marcos Malumbres

  29. miRNAs and cancer: An epigenetics view

    Article • Molecular Aspects of Medicine, July 2013, Elsevier

    Dr Marcos Malumbres

  30. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1

    Article • Cell Cycle, April 2013, Taylor & Francis

    Dr Marcos Malumbres

  31. Mitotic Kinases

    Article • January 2013, Springer Science + Business Media

    Dr Marcos Malumbres

  32. Cyclins and Cyclin-dependent Kinases

    Article • January 2013, Springer Science + Business Media

    Dr Marcos Malumbres

  33. The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice

    Article • Learning & Memory, December 2012, Cold Spring Harbor Laboratory Press

    Dr Marcos Malumbres

  34. HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

    Article • Molecular Cell, December 2012, Elsevier

    Dr Marcos Malumbres

  35. Inhibiting Cell Cycle Kinases in Cancer Therapy

    Article • November 2012, Bentham Science Publishers

    Dr Marcos Malumbres

  36. Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2

    Article • Genes & Cancer, November 2012, SAGE Publications

    Dr Marcos Malumbres

  37. Cell Cycle-Based Therapies Move Forward

    Article • Cancer Cell, October 2012, Elsevier

    Dr Marcos Malumbres

  38. Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells

    Article • Cellular and Molecular Life Sciences, September 2012, Springer Science + Business Media

    Dr Marcos Malumbres

  39. miRNAs versus oncogenes: the power of social networking

    Article • Molecular Systems Biology, February 2012, EMBO

    Dr Marcos Malumbres

  40. Tpx2 Controls Spindle Integrity, Genome Stability, and Tumor Development

    Article • Cancer Research, January 2012, American Association for Cancer Research (AACR)

    Dr Marcos Malumbres

  41. Killing cells by targeting mitosis

    Article • Cell Death and Differentiation, January 2012, Nature

    Dr Marcos Malumbres

  42. Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

    Article • Scientific Reports, December 2011, Nature

    Dr Marcos Malumbres

  43. Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1

    Article • Molecular Cell, December 2011, Elsevier

    Dr Marcos Malumbres

  44. Tumor suppression by Spinophilin

    Article • Cell Cycle, September 2011, Taylor & Francis

    Dr Marcos Malumbres

  45. Non-mitotic functions of the Anaphase-Promoting Complex

    Article • Seminars in Cell and Developmental Biology, August 2011, Elsevier

    Dr Marcos Malumbres

  46. From Plk1 to Plk5

    Article • Cell Cycle, July 2011, Taylor & Francis

    Dr Marcos Malumbres

  47. Physiological Relevance of Cell Cycle Kinases

    Article • Physiological Reviews, July 2011, American Physiological Society

    Dr Marcos Malumbres

  48. Oncogene-Induced Mitotic Stress: p53 and pRb Get Mad Too

    Article • Cancer Cell, June 2011, Elsevier

    Dr Marcos Malumbres

  49. The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway

    Article • Cell Cycle, May 2011, Taylor & Francis

    Dr Marcos Malumbres

  50. MicroRNAs and the cell cycle

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, May 2011, Elsevier

    Dr Marcos Malumbres

  51. Targeting Aneuploidy for Cancer Therapy

    Article • Cell, February 2011, Elsevier

    Dr Marcos Malumbres

  52. Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

    Article • Cell, January 2011, Elsevier

    Dr Marcos Malumbres

  53. Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin

    Article • Nature Structural & Molecular Biology, December 2010, Springer Science + Business Media

    Professor Guillermo Montoya, Dr Marcos Malumbres

  54. Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase

    Article • Cancer Cell, December 2010, Elsevier

    Dr Marcos Malumbres

  55. RINGO C is required to sustain the spindle-assembly checkpoint

    Article • Journal of Cell Science, August 2010, The Company of Biologists

    Dr Marcos Malumbres

  56. RINGO C is required to sustain the spindle-assembly checkpoint

    Article • Journal of Cell Science, July 2010, The Company of Biologists

    Dr Marcos Malumbres

  57. The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions

    Article • Biochemical Society Transactions, February 2010, Portland Press Ltd.

    Dr Marcos Malumbres

  58. Cyclin-dependent kinases: a family portrait

    Article • Nature, November 2009, Nature

    Dr Marcos Malumbres

  59. A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary

    Article • PLoS ONE, March 2009, PLOS

    Dr Marcos Malumbres

  60. Cell cycle, CDKs and cancer: a changing paradigm

    Article • Nature Reviews Drug Discovery, March 2009, Nature

    Dr Marcos Malumbres

  61. E2F2 represses cell cycle regulators to maintain quiescence

    Article • Cell Cycle, December 2008, Taylor & Francis

    Dr Marcos Malumbres

  62. Cell cycle control of pituitary development and disease

    Article • November 2008, Bioscientifica

    Dr Marcos Malumbres

  63. Control of cell proliferation pathways by microRNAs

    Article • Cell Cycle, October 2008, Taylor & Francis

    Dr Marcos Malumbres

  64. Emerging cancer therapeutic opportunities by inhibiting mitotic kinases

    Article • Current Opinion in Pharmacology, August 2008, Elsevier

    Professor Guillermo Montoya, Dr Marcos Malumbres

  65. Genomic stability and tumour suppression by the APC/C cofactor Cdh1

    Article • Nature, June 2008, Nature

    Dr Marcos Malumbres

  66. Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression

    Article • Cancer Cell, June 2008, Elsevier

    Dr Marcos Malumbres

  67. Cyclin-Dependent Kinases and Their Regulators as Potential Targets for Anticancer Therapeutics

    Article • January 2008, Springer Science + Business Media

    Dr Marcos Malumbres

  68. CDK inhibitors in cancer therapy: what is next?

    Article • Trends in Pharmacological Sciences, January 2008, Elsevier

    Dr Marcos Malumbres

  69. Cdk1 is sufficient to drive the mammalian cell cycle

    Article • Nature, August 2007, Nature

    Dr Marcos Malumbres

  70. Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression

    Article • Oncogene, June 2007, Nature

    Dr Marcos Malumbres

  71. Targeting Cell Cycle Kinases for Cancer Therapy

    Article • Current Medicinal Chemistry, April 2007, Bentham Science Publishers

    Dr Marcos Malumbres

  72. Mice thrive without Cdk4 and Cdk2

    Article • Molecular Oncology, March 2007, Wiley

    Dr Marcos Malumbres

  73. Cell cycle kinases in cancer

    Article • Current Opinion in Genetics & Development, February 2007, Elsevier

    Dr Marcos Malumbres

  74. Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients

    Article • Human Mutation, January 2007, Wiley

    Dr Marcos Malumbres

  75. Cannabinoid receptors as novel targets for the treatment of melanoma

    Article • The FASEB Journal, December 2006, Federation of American Societies For Experimental Biology (FASEB)

    Dr Marcos Malumbres

  76. A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

    Article • Carcinogenesis, November 2006, Oxford University Press (OUP)

    Dr Marcos Malumbres

  77. Mouse Models to Study the In Vivo Function of Cyclin-Dependent Kinases in Normal Homeostasis and Tumor Development

    Article • October 2006, Taylor & Francis

    Dr Marcos Malumbres

  78. Involvement of the pRb pathway in UVR-induced melanoma

    Article • Melanoma Research, September 2006, Wolters Kluwer Health

    Dr Marcos Malumbres

  79. Rapid Growth of Invasive Metastatic Melanoma in Carcinogen-Treated Hepatocyte Growth Factor/Scatter Factor-Transgenic Mice Carrying an Oncogenic CDK4 Mutation

    Article • American Journal Of Pathology, August 2006, Elsevier

    Dr Marcos Malumbres

  80. Therapeutic opportunities to control tumor cell cycles

    Article • Clinical & Translational Oncology, June 2006, Springer Science + Business Media

    Dr Marcos Malumbres

  81. Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin

    Article • International Journal of Cancer, January 2006, Wiley

    Dr Marcos Malumbres

  82. Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

    Article • Oncogene, January 2006, Nature

    Dr Marcos Malumbres

  83. Is Cyclin D1-CDK4 kinase a bona fide cancer target?

    Article • Cancer Cell, January 2006, Elsevier

    Dr Marcos Malumbres

  84. Preclinical Models for Cell Cycle-Targeted Therapies

    Article • January 2006, Springer Science + Business Media

    Dr Marcos Malumbres

  85. Mammalian cyclin-dependent kinases

    Article • Trends in Biochemical Sciences, November 2005, Elsevier

    Dr Marcos Malumbres

  86. Cdk4 promotes adipogenesis through PPARγ activation

    Article • Cell Metabolism, October 2005, Elsevier

    Dr Marcos Malumbres

  87. Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1

    Article • Cancer Cell, June 2005, Elsevier

    Dr Marcos Malumbres

  88. Revisiting the “Cdk-Centric” View of the Mammalian Cell Cycle

    Article • Cell Cycle, November 2004, Taylor & Francis

    Dr Marcos Malumbres

  89. The European dimension for the mouse genome mutagenesis program

    Article • Nature Genetics, September 2004, Nature

    Dr Marcos Malumbres, Professor Werner Muller

  90. Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6

    Article • Cell, August 2004, Elsevier

    Dr Marcos Malumbres

  91. Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15Ink4b-deficient mice

    Article • Oncogene, December 2003, Nature

    Dr Marcos Malumbres

  92. RAS oncogenes: The first 30 years

    Article • Nature Reviews Drug Discovery, September 2003, Nature

    Dr Marcos Malumbres

  93. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

    Article • Nature Genetics, August 2003, Nature

    Dr Marcos Malumbres

  94. Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number

    Article • Oncogene, August 2003, Nature

    Dr Marcos Malumbres

  95. Timeline: RAS oncogenes: the first 30 years

    Article • Nature Reviews Drug Discovery, June 2003, Nature

    Dr Marcos Malumbres

  96. Driving the Cell Cycle to Cancer

    Article • January 2003, Springer Science + Business Media

    Dr Marcos Malumbres

  97. Cell Cycle and Cancer: The G1 Restriction Point and the G1 / S Transition

    Article • Current Genomics, August 2002, Bentham Science Publishers

    Dr Marcos Malumbres

  98. Cyclin D-dependent kinases, INK4 inhibitors and cancer

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, March 2002, Elsevier

    Dr Marcos Malumbres

  99. MILESTONES IN CELL DIVISION TO CYCLE OR NOT TO CYCLE: A CRITICAL DECISION IN CANCER

    Article • Nature Reviews Drug Discovery, December 2001, Nature

    Dr Marcos Malumbres

  100. Invasive melanoma in Cdk4-targeted mice

    Article • Proceedings of the National Academy of Sciences, October 2001, Proceedings of the National Academy of Sciences

    Dr Marcos Malumbres

  101. The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways

    Article • Oncogene, May 2000, Nature

    Dr Marcos Malumbres

  102. Characterization of the murine p19ARF promoter CpG island and its methylation pattern in primary lymphomas

    Article • Carcinogenesis, April 2000, Oxford University Press (OUP)

    Dr Marcos Malumbres

  103. Genetic Analysis of Mammalian Cyclin-Dependent Kinases and Their Inhibitors

    Article • Biological Chemistry, January 2000, De Gruyter

    Dr Marcos Malumbres

  104. Targeted Gene Transfer System Using a Streptavidin-Transforming Growth Factor-alpha Chimeric Protein

    Article • DNA and Cell Biology, October 1999, Mary Ann Liebert Inc

    Dr Marcos Malumbres

  105. Cooperative alterations of Rb pathway regulators in mouse primary T cell lymphomas

    Article • Carcinogenesis, September 1999, Oxford University Press (OUP)

    Dr Marcos Malumbres

  106. Hypermethylation of the cell cycle inhibitor p15INK4b 3′-untranslated region interferes with its transcriptional regulation in primary lymphomas

    Article • Oncogene, January 1999, Nature

    Dr Marcos Malumbres

  107. An AC-repeat adjacent to mouse Cdkn2B allows the detection of specific allelic losses in the p15 INK4b and p16 INK4a tumor suppressor genes

    Article • Mammalian Genome, March 1998, Springer Science + Business Media

    Dr Marcos Malumbres

  108. Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas

    Article • Oncogene, December 1997, Nature

    Dr Marcos Malumbres

  109. Molecular control mechanisms of lysine and threonine biosynthesis in amino acid-producing corynebacteria: Redirecting carbon flow

    Article • FEMS Microbiology Letters, October 1996, Oxford University Press (OUP)

    Dr Marcos Malumbres

  110. Molecular control mechanisms of lysine and threonine biosynthesis in amino acid-producing corynebacteria: Redirecting carbon flow

    Article • FEMS Microbiology Letters, October 1996, Oxford University Press (OUP)

    Dr Marcos Malumbres

  111. The galE gene encoding the UDP-galactose 4-epimerase of Brevibacterium lactofermentum is coupled transcriptionally to the dmdR gene

    Article • Gene, January 1996, Elsevier

    Dr Marcos Malumbres

  112. Directed mutagenesis of a regulatory palindromic sequence upstream from the Brevibacterium lactofermentum tryptophan operon

    Article • Gene, January 1994, Elsevier

    Dr Marcos Malumbres

  113. Codon preference in Corynebacteria

    Article • Gene, November 1993, Elsevier

    Dr Marcos Malumbres

  114. Analysis of the codon usage of the cephamycin C producer Nocardia lactamdurans

    Article • FEMS Microbiology Letters, June 1993, Oxford University Press (OUP)

    Dr Marcos Malumbres, Dr Juan Jose R Coque

  115. The bleomycin resistance gene of transposon Tn5 is an excellent marker for transformation of corynebacteria

    Article • Applied Microbiology and Biotechnology, March 1992, Springer Science + Business Media

    Dr Marcos Malumbres

  116. Nucleotide sequence of the threonine synthase ( thrC ) gene of Brevibacterium lactofermentum

    Article • Nucleic Acids Research, January 1988, Oxford University Press (OUP)

    Dr Marcos Malumbres