All Stories

  1. The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

    Article • Cartilage, April 2019, SAGE Publications

    Professor Marcel Karperien

  2. Glucose Gradients Influence Zonal Matrix Deposition in 3D Cartilage Constructs

    Article • Tissue Engineering Part A, December 2014, Mary Ann Liebert Inc

    Professor Marcel Karperien

  3. Mesenchymal Stromal/Stem Cell–or Chondrocyte-Seeded Microcarriers as Building Blocks for Cartilage Tissue Engineering

    Article • Tissue Engineering Part A, September 2014, Mary Ann Liebert Inc

    Professor Marcel Karperien

  4. A Supramolecular Host–Guest Carrier System for Growth Factors Employing VHH Fragments

    Article • Journal of the American Chemical Society, August 2014, American Chemical Society (ACS)

    Professor Marcel Karperien

  5. Locked-in Biomimetic Surface Gradients that are Tunable in Size, Density and Functionalization

    Article • ChemPhysChem, August 2014, Wiley

    Professor Marcel Karperien

  6. Identification of Novel SHOX Target Genes in the Developing Limb Using a Transgenic Mouse Model

    Article • PLoS ONE, June 2014, PLOS

    Professor Marcel Karperien

  7. Modeling Biological Pathway Dynamics With Timed Automata

    Article • IEEE Journal of Biomedical and Health Informatics, May 2014, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Marcel Karperien

  8. DKK1, FRZB, GREM1 prevent IL1B induced articular cartilage degradation

    Article • Osteoarthritis and Cartilage, April 2014, Elsevier

    Professor Marcel Karperien

  9. Producing artificial chondrons for improved cartilage repair

    Article • Osteoarthritis and Cartilage, April 2014, Elsevier

    Professor Marcel Karperien

  10. Injectable hydrogels for cartilage repair

    Article • Osteoarthritis and Cartilage, April 2014, Elsevier

    Professor Marcel Karperien

  11. Setting Parameters for Biological Models With ANIMO

    Article • Electronic Proceedings in Theoretical Computer Science, March 2014, Open Publishing Association

    Professor Marcel Karperien

  12. Extracellular Matrix Domain Formation as an Indicator of Chondrocyte Dedifferentiation and Hypertrophy

    Article • Tissue Engineering Part C Methods, February 2014, Mary Ann Liebert Inc

    Professor Marcel Karperien

  13. Hydrogels by supramolecular crosslinking of terpyridine end group functionalized 8-arm poly(ethylene glycol)

    Article • Soft Matter, January 2014, Royal Society of Chemistry

    Professor Marcel Karperien

  14. Biological networks 101: Computational modeling for molecular biologists

    Article • Gene, January 2014, Elsevier

    Professor Marcel Karperien

  15. On-Chip Electrophoresis in Supported Lipid Bilayer Membranes Achieved Using Low Potentials

    Article • Journal of the American Chemical Society, December 2013, American Chemical Society (ACS)

    Professor Marcel Karperien

  16. Boosting Angiogenesis and Functional Vascularization in Injectable Dextran–Hyaluronic Acid Hydrogels by Endothelial-Like Mesenchymal Stromal Cells

    Article • Tissue Engineering Part A, November 2013, Mary Ann Liebert Inc

    Professor Marcel Karperien

  17. Label-Free Detection of Insulin and Glucagon within Human Islets of Langerhans Using Raman Spectroscopy

    Article • PLoS ONE, October 2013, PLOS

    Professor Marcel Karperien

  18. A Dual Flow Bioreactor with Controlled Mechanical Stimulation for Cartilage Tissue Engineering

    Article • Tissue Engineering Part C Methods, October 2013, Mary Ann Liebert Inc

    Professor Marcel Karperien

  19. Copy number variants in patients with short stature

    Article • European Journal of Human Genetics, September 2013, Springer Science + Business Media

    Professor Marcel Karperien

  20. Fibroblast Growth Factor-1 Is a Mesenchymal Stromal Cell-Secreted Factor Stimulating Proliferation of Osteoarthritic Chondrocytes in Co-Culture

    Article • Stem Cells and Development, September 2013, Mary Ann Liebert Inc

    Professor Marcel Karperien

  21. Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans

    Article • PLoS ONE, May 2013, PLOS

    Professor Marcel Karperien

  22. In vivo screening of extracellular matrix components produced under multiple experimental conditions implanted in one animal

    Article • Integrative Biology, May 2013, Oxford University Press (OUP)

    Professor Marcel Karperien

  23. Nanostructured 3D Constructs Based on Chitosan and Chondroitin Sulphate Multilayers for Cartilage Tissue Engineering

    Article • PLoS ONE, February 2013, PLOS

    Professor Marcel Karperien, Professor Rui L. Reis

  24. Cell Sources for Articular Cartilage Repair Strategies: Shifting from Monocultures to Cocultures

    Article • Tissue Engineering Part B Reviews, February 2013, Mary Ann Liebert Inc

    Professor Marcel Karperien

  25. Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: Perspectives from stem cell biology and molecular medicine

    Article • Journal of Cellular Physiology, January 2013, Wiley

    Professor Marcel Karperien

  26. Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation

    Article • Arthritis Research & Therapy, January 2013, Springer Science + Business Media

    Professor Marcel Karperien

  27. A fluorogenic monolayer to detect the co-immobilization of peptides that combine cartilage targeting and regeneration

    Article • Journal of Materials Chemistry B, January 2013, Royal Society of Chemistry

    Professor Marcel Karperien

  28. GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors

    Article • Arthritis Research & Therapy, January 2013, Springer Science + Business Media

    Professor Marcel Karperien

  29. WNT Signaling and Cartilage: Of Mice and Men

    Article • Calcified Tissue International, December 2012, Springer Science + Business Media

    Professor Marcel Karperien

  30. Hypoxia Inhibits Hypertrophic Differentiation and Endochondral Ossification in Explanted Tibiae

    Article • PLoS ONE, November 2012, PLOS

    Professor Marcel Karperien

  31. Sotos Syndrome Is Associated with Deregulation of the MAPK/ERK-Signaling Pathway

    Article • PLoS ONE, November 2012, PLOS

    Professor Marcel Karperien

  32. Fetal Mesenchymal Stromal Cells Differentiating towards Chondrocytes Acquire a Gene Expression Profile Resembling Human Growth Plate Cartilage

    Article • PLoS ONE, November 2012, PLOS

    Professor Marcel Karperien

  33. Modelling biological pathway dynamics with Timed Automata

    Article • November 2012, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Marcel Karperien

  34. Recognizing different tissues in human fetal femur cartilage by label-free Raman microspectroscopy

    Article • Journal of Biomedical Optics, November 2012, SPIE

    Professor Marcel Karperien

  35. Trophic Effects of Mesenchymal Stem Cells in Chondrocyte Co-Cultures are Independent of Culture Conditions and Cell Sources

    Article • Tissue Engineering Part A, August 2012, Mary Ann Liebert Inc

    Professor Marcel Karperien

  36. A Wnt/β-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes

    Article • Arthritis & Rheumatism, July 2012, Wiley

    Professor Marcel Karperien

  37. Wettability Influences Cell Behavior on Superhydrophobic Surfaces with Different Topographies

    Article • Biointerphases, July 2012, American Vacuum Society

    Professor Marcel Karperien

  38. The effect of platelet lysate supplementation of a dextran-based hydrogel on cartilage formation

    Article • Biomaterials, May 2012, Elsevier

    Professor Marcel Karperien

  39. Self-attaching and cell-attracting in-situ forming dextran-tyramine conjugates hydrogels for arthroscopic cartilage repair

    Article • Biomaterials, April 2012, Elsevier

    Professor Marcel Karperien

  40. Patterns of Amino Acid Metabolism by Proliferating Human Mesenchymal Stem Cells

    Article • Tissue Engineering Part A, March 2012, Mary Ann Liebert Inc

    Professor Marcel Karperien

  41. Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering

    Article • Biomaterials, February 2012, Elsevier

    Professor Marcel Karperien

  42. Nanomaterials for the Local and Targeted Delivery of Osteoarthritis Drugs

    Article • Journal of Nanomaterials, January 2012, Wiley

    Professor Marcel Karperien

  43. Injectable Hydrogels by Enzymatic Co-Crosslinking of Dextran and Hyaluronic Acid Tyramine Conjugates

    Article • Macromolecular Symposia, December 2011, Wiley

    Professor Marcel Karperien

  44. Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo

    Article • Clinical Sarcoma Research, July 2011, Springer Science + Business Media

    Professor Marcel Karperien

  45. Chitosan Scaffolds Containing Hyaluronic Acid for Cartilage Tissue Engineering

    Article • Tissue Engineering Part C Methods, July 2011, Mary Ann Liebert Inc

    Professor Marcel Karperien, Professor Rui L. Reis

  46. Raman Microspectroscopy: A Noninvasive Analysis Tool for Monitoring of Collagen-Containing Extracellular Matrix Formation in a Medium-Throughput Culture System

    Article • Tissue Engineering Part C Methods, July 2011, Mary Ann Liebert Inc

    Professor Marcel Karperien

  47. Apc bridges Wnt/β-catenin and BMP signaling during osteoblast differentiation of KS483 cells

    Article • Experimental Cell Research, June 2011, Elsevier

    Professor Marcel Karperien

  48. Trophic Effects of Mesenchymal Stem Cells Increase Chondrocyte Proliferation and Matrix Formation

    Article • Tissue Engineering Part A, May 2011, Mary Ann Liebert Inc

    Professor Marcel Karperien

  49. Chitosan Scaffolds Containing Hyaluronic Acid for Cartilage Tissue Engineering

    Article • Tissue Engineering Part C Methods, March 2011, Mary Ann Liebert Inc

    Professor Marcel Karperien, Professor Rui L. Reis

  50. Chitosan/Poly(ɛ-caprolactone) blend scaffolds for cartilage repair

    Article • Biomaterials, February 2011, Elsevier

    Professor Marcel Karperien, Professor Rui L. Reis

  51. Cartilage Tissue Engineering

    Article • January 2011, Karger Publishers

    Professor Marcel Karperien

  52. Mechanisms of Growth Plate Maturation and Epiphyseal Fusion

    Article • Hormone Research in Paediatrics, January 2011, Karger Publishers

    Professor Marcel Karperien, Professor Lars Sävendahl

  53. No Haploinsufficiency but Loss of Heterozygosity for EXT in Multiple Osteochondromas

    Article • American Journal Of Pathology, October 2010, Elsevier

    Professor Marcel Karperien, Professor Pancras C.W. Hogendoorn

  54. 108 AN EX VIVO MODEL FOR DEGENERATIVE CARTILAGE DISEASE

    Article • Osteoarthritis and Cartilage, October 2010, Elsevier

    Professor Marcel Karperien

  55. The majority of the genetic risk for Paget’s disease of bone is explained by genetic variants close to the CSF1, OPTN, TM7SF4, and TNFRSF11A genes

    Article • Human Genetics, September 2010, Springer Science + Business Media

    Professor Marcel Karperien

  56. Enzymatically Crosslinked Dextran-Tyramine Hydrogels as Injectable Scaffolds for Cartilage Tissue Engineering

    Article • Tissue Engineering Part A, August 2010, Mary Ann Liebert Inc

    Professor Marcel Karperien

  57. APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis

    Article • Journal of Bone and Mineral Research, June 2010, Wiley

    Professor Marcel Karperien

  58. Genetic variation in the TNFRSF11A gene encoding RANK is associated with susceptibility to Paget's disease of bone

    Article • Journal of Bone and Mineral Research, June 2010, Wiley

    Professor Marcel Karperien

  59. Measuring Hormones, Molecular Tests and their Clinical Application

    Article • April 2010, Wiley

    Professor Marcel Karperien

  60. Primary chondrocytes enhance cartilage tissue formation upon co-culture with a range of cell types

    Article • Soft Matter, January 2010, Royal Society of Chemistry

    Professor Marcel Karperien

  61. Genome-Wide SNP Array Analysis in Patients with Features of Sotos Syndrome

    Article • Hormone Research in Paediatrics, January 2010, Karger Publishers

    Professor Marcel Karperien

  62. Marginal Growth Increase, Altered Bone Quality and Polycystic Ovaries in Female Prepubertal Rats after Treatment with the Aromatase Inhibitor Exemestane

    Article • Hormone Research in Paediatrics, January 2010, Karger Publishers

    Professor Marcel Karperien

  63. Impaired Body Weight and Tail Length Gain and Altered Bone Quality after Treatment with the Aromatase Inhibitor Exemestane in Male Rats

    Article • Hormone Research in Paediatrics, January 2010, Karger Publishers

    Professor Marcel Karperien

  64. Epiphyseal Fusion in the Human Growth Plate Does not Involve Classical Apoptosis

    Article • Pediatric Research, December 2009, Springer Science + Business Media

    Professor Marcel Karperien, Professor Lars Sävendahl

  65. Glucocorticoid-Induced Osteoporosis in Growing Mice Is Not Prevented by Simultaneous Intermittent PTH Treatment

    Article • Calcified Tissue International, October 2009, Springer Science + Business Media

    Professor Marcel Karperien

  66. Tissue assembly and organization: Developmental mechanisms in microfabricated tissues

    Article • Biomaterials, October 2009, Elsevier

    Professor Marcel Karperien

  67. Inactive Wnt/β-catenin pathway in conventional high-grade osteosarcoma

    Article • The Journal of Pathology, September 2009, Wiley

    Professor Marcel Karperien, Professor Pancras C.W. Hogendoorn

  68. Adenomatous polyposis coli-mediated control of β-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

    Article • BMC Developmental Biology, April 2009, Springer Science + Business Media

    Professor Marcel Karperien

  69. Founder Effect in Different European Countries for the Recurrent P392L SQSTM1 Mutation in Paget’s Disease of Bone

    Article • Calcified Tissue International, June 2008, Springer Science + Business Media

    Professor Marcel Karperien

  70. Successful Long-Term Growth Hormone Therapy in a Girl with Haploinsufficiency of the Insulin-Like Growth Factor-I Receptor due to a Terminal 15q26.2->qter Deletion Detected by Multiplex Ligation Probe Amplification

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2008, Endocrine Society

    Professor Marcel Karperien

  71. Stem cells

    Article • January 2008, Elsevier

    Professor Marcel Karperien

  72. Cellular signaling

    Article • January 2008, Elsevier

    Professor Marcel Karperien

  73. Morphogenesis, generation of tissue in the embryo

    Article • January 2008, Elsevier

    Professor Marcel Karperien

  74. Induction of stimulating thyrotropin receptor antibodies after radioiodine therapy for toxic multinodular goitre and Graves' disease measured with a novel bioassay

    Article • Nuclear Medicine Communications, February 2007, Wolters Kluwer Health

    Professor Marcel Karperien

  75. Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP‐Stimulated Bone Formation

    Article • Journal of Bone and Mineral Research, January 2007, Oxford University Press (OUP)

    Professor Paul HA Quax, Professor Marcel Karperien

  76. Novel Late Response Genes of PTHrP in Chondrocytes

    Article • Hormone Research in Paediatrics, October 2006, Karger Publishers

    Professor Marcel Karperien

  77. The Role of p27Kip1 in the Regulation of Growth Plate Chondrocyte Proliferation in Mice

    Article • Pediatric Research, September 2006, Springer Science + Business Media

    Professor Marcel Karperien

  78. Clinical and Biochemical Characteristics of a Male Patient with a Novel Homozygous STAT5b Mutation

    Article • The Journal of Clinical Endocrinology & Metabolism, September 2006, Endocrine Society

    Professor Marcel Karperien

  79. Novel Early Target Genes of Parathyroid Hormone-Related Peptide in Chondrocytes

    Article • Endocrinology, June 2006, Endocrine Society

    Professor Marcel Karperien

  80. Full Length or Fragments in Hormone Studies?

    Article • Journal of Bone and Mineral Research, February 2006, Wiley

    Professor Marcel Karperien

  81. Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: The role of the retinoic acid receptor

    Article • Bone, February 2006, Elsevier

    Professor Marcel Karperien

  82. Skeletogenesis: Genetics

    Article • January 2006, Wiley

    Professor Marcel Karperien

  83. Multiple Mechanisms Are Involved in Inhibition of Osteoblast Differentiation by PTHrP and PTH in KS483 Cells

    Article • Journal of Bone and Mineral Research, August 2005, Wiley

    Professor Marcel Karperien

  84. Downregulation of Wnt Signaling by Increased Expression of Dickkopf-1 and -2 is a Prerequisite for Late-Stage Osteoblast Differentiation of KS483 Cells

    Article • Journal of Bone and Mineral Research, June 2005, Wiley

    Professor Marcel Karperien

  85. Structural and Functional Characteristics of the Val44Met Insulin-Like Growth Factor I Missense Mutation: Correlation with Effects on Growth and Development

    Article • Molecular Endocrinology, March 2005, Endocrine Society

    Professor Marcel Karperien

  86. Genomic and non-genomic actions of sex steroids in the growth plate

    Article • Pediatric Nephrology, February 2005, Springer Science + Business Media

    Professor Marcel Karperien

  87. Thyroid hormone, but not parathyroid hormone, partially restores glucocorticoid-induced growth retardation

    Article • Pediatric Nephrology, February 2005, Springer Science + Business Media

    Professor Marcel Karperien

  88. Genotype-Phenotype Correlation in Patients Suspected of Having Sotos Syndrome

    Article • Hormone Research in Paediatrics, January 2004, Karger Publishers

    Professor Marcel Karperien

  89. Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma

    Article • The Journal of Pathology, December 2003, Wiley

    Professor Marcel Karperien

  90. Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells

    Article • Bone, December 2003, Elsevier

    Professor Marcel Karperien

  91. Localization and Regulation of the Growth Hormone Receptor and Growth Hormone-Binding Protein in the Rat Growth Plate

    Article • Journal of Bone and Mineral Research, August 2002, Wiley

    Professor Marcel Karperien

  92. Erratum

    Article • Bone, August 2002, Elsevier

    Professor Marcel Karperien

  93. Iodide Kinetics and Experimental131I Therapy in a Xenotransplanted Human Sodium-Iodide Symporter-Transfected Human Follicular Thyroid Carcinoma Cell Line

    Article • The Journal of Clinical Endocrinology & Metabolism, March 2002, Endocrine Society

    Professor Marcel Karperien

  94. Optical Imaging of Cancer Metastasis to Bone Marrow

    Article • American Journal Of Pathology, March 2002, Elsevier

    Professor Marcel Karperien

  95. Urokinase-Receptor/Integrin Complexes Are Functionally Involved in Adhesion and Progression of Human Breast Cancer in Vivo

    Article • American Journal Of Pathology, September 2001, Elsevier

    Professor Paul HA Quax, Professor Marcel Karperien

  96. Reestablishment of In Vitro and In Vivo Iodide Uptake by Transfection of the Human Sodium Iodide Symporter (hNIS) in a hNIS Defective Human Thyroid Carcinoma Cell Line

    Article • Thyroid, November 2000, Mary Ann Liebert Inc

    Professor Marcel Karperien

  97. The Monoclonal Antibodies 18d7/91f2 Recognize a Receptor Regulatory Protein on Mouse Bone Marrow Stromal Cells

    Article • Journal of Bone and Mineral Research, July 2000, Wiley

    Professor Marcel Karperien

  98. Expression of Indian Hedgehog, Parathyroid Hormone-Related Protein, and Their Receptors in the Postnatal Growth Plate of the Rat: Evidence for a Locally Acting Growth Restraining Feedback Loop After Birth

    Article • Journal of Bone and Mineral Research, June 2000, Wiley

    Professor Marcel Karperien

  99. Expression of Vascular Endothelial Growth Factors and Their Receptors during Osteoblast Differentiation

    Article • Endocrinology, May 2000, Endocrine Society

    Professor Marcel Karperien

  100. Differentiation-Dependent Alternative Splicing and Expression of the Extracellular Matrix Protein 1 Gene in Human Keratinocytes

    Article • Journal of Investigative Dermatology, April 2000, Elsevier

    Professor Marcel Karperien

  101. A Frame-Shift Mutation in the Type I Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Causing Blomstrand Lethal Osteochondrodysplasia

    Article • The Journal of Clinical Endocrinology & Metabolism, October 1999, Endocrine Society

    Professor Marcel Karperien

  102. Identification of a Retinoic Acid-Inducible Element in the Murine PTH/PTHrP (Parathyroid Hormone/Parathyroid Hormone-Related Peptide) Receptor Gene

    Article • Molecular Endocrinology, July 1999, Endocrine Society

    Professor Marcel Karperien

  103. Parathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the Type I PTH/PTHrP receptor

    Article • Mechanisms of Development, March 1999, Elsevier

    Professor Marcel Karperien

  104. Expression of the Parathyroid Hormone-Related Peptide Gene in Retinoic Acid-Induced Differentiation: Involvement of ETS and Sp1

    Article • Molecular Endocrinology, September 1997, Endocrine Society

    Professor Marcel Karperien

  105. Tissue-Specific Transcription Start Sites and Alternative Splicing of the Parathyroid Hormone (PTH)/PTH-Related Peptide (PTHrP) Receptor Gene: A New PTH/PTHrP Receptor Splice Variant that Lacks the Signal Peptide1

    Article • Endocrinology, April 1997, Endocrine Society

    Professor Marcel Karperien

  106. Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes

    Article • Mechanisms of Development, July 1994, Elsevier

    Professor Marcel Karperien

  107. Activation of junB by PKC and PKA signal transduction through a novel cis -acting element

    Article • Nucleic Acids Research, January 1991, Oxford University Press (OUP)

    Professor Marcel Karperien

  108. Outer-membrane PhoE protein of Escherichia coli K-12 as an exposure vector: possibilities and limitations

    Article • Gene, March 1990, Elsevier

    Professor Marcel Karperien

  109. Measuring Hormones, Molecular Tests, and Their Clinical Application

    Article • Wiley

    Professor Marcel Karperien

  110. Chapter 2. Signal Transduction Cascades Controlling Osteoblast Differentiation

    Article • Wiley

    Professor Marcel Karperien