All Stories

  1. RAF1 kinase contributes to autophagic lysosome reformation

    Article • Cell Reports, April 2025, Elsevier

    Professor Manuela Baccarini

  2. Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision

    Article • Molecular Cell, February 2025, Elsevier

    Professor Manuela Baccarini

  3. Signaling proteins in HSC fate determination are unequally segregated during asymmetric cell division

    Article • Journal of Cell Biology, June 2024, Rockefeller University Press

    Professor Manuela Baccarini

  4. Sequestration of translation initiation factors in p62 condensates

    Article • Cell Reports, December 2023, Elsevier

    Professor Manuela Baccarini

  5. RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status

    Article • Oncogene, April 2023, Springer Science + Business Media

    Professor Manuela Baccarini

  6. Interplay between PLEKHG3-regulated actin dynamics and lysosomal trafficking in cell motility

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Professor Manuela Baccarini

  7. amica: an interactive and user-friendly web-platform for the analysis of proteomics data

    Article • BMC Genomics, December 2022, Springer Science + Business Media

    Professor Manuela Baccarini

  8. BRAF increases endothelial cell stiffness through reorganization of the actin cytoskeleton

    Article • The FASEB Journal, August 2022, Wiley

    Professor Manuela Baccarini

  9. Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells

    Article • Autophagy, April 2022, Taylor & Francis

    Professor Manuela Baccarini

  10. amica: an interactive and user-friendly web-platform for the analysis of proteomics data

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Professor Manuela Baccarini

  11. Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons

    Article • PLoS Pathogens, July 2021, PLOS

    Professor Manuela Baccarini

  12. ERK phosphorylation is RAF independent in naïve and activated B cells but RAF dependent in plasma cell differentiation

    Article • Science Signaling, May 2021, American Association for the Advancement of Science

    Professor Manuela Baccarini

  13. Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

    Article • Cancer Cell, May 2019, Elsevier

    Professor Manuela Baccarini

  14. RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell‐cell junctions

    Article • European Journal of Biochemistry, March 2019, Wiley

    Professor Manuela Baccarini

  15. Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

    Article • Science Signaling, October 2018, American Association for the Advancement of Science

    Professor Manuela Baccarini

  16. The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants

    Article • Oncogene, June 2018, Springer Science + Business Media

    Professor Manuela Baccarini

  17. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion

    Article • Cell Stem Cell, June 2018, Elsevier

    Dr Christoph Bock, Professor Manuela Baccarini

  18. RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Professor Manuela Baccarini

  19. RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα

    Article • Science Signaling, March 2017, American Association for the Advancement of Science

    Professor Manuela Baccarini

  20. Deciphering the RAS/ERK pathway in vivo

    Article • Biochemical Society Transactions, February 2017, Portland Press Ltd.

    Professor Manuela Baccarini

  21. Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development

    Article • Journal of Biological Chemistry, February 2017, Elsevier

    Professor Manuela Baccarini

  22. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

    Article • Nature Communications, December 2016, Springer Science + Business Media

    Professor Manuela Baccarini

  23. MEK1 is required for the development of NRAS-driven leukemia

    Article • Oncotarget, October 2016, Impact Journals, LLC

    Professor Manuela Baccarini

  24. Epidermal RAF prevents allergic skin disease

    Article • eLife, July 2016, eLife

    Professor Manuela Baccarini

  25. Editorial overview: Cell regulation

    Article • Current Opinion in Cell Biology, April 2016, Elsevier

    Professor Manuela Baccarini

  26. Knock‐in(g) RAF for a loop

    Article • The EMBO Journal, December 2015, Springer Science + Business Media

    Professor Manuela Baccarini

  27. Alike but Different: RAF Paralogs and Their Signaling Outputs

    Article • Cell, May 2015, Elsevier

    Professor Manuela Baccarini

  28. C-Raf promotes Angiogenesis during Normal Growth Plate Maturation

    Article • Development, January 2015, The Company of Biologists

    Professor Manuela Baccarini

  29. p38 links RAS to GATA2

    Article • EMBO Reports, August 2014, EMBO

    Professor Manuela Baccarini

  30. “RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway

    Article • FEBS Letters, June 2014, Wiley

    Professor Manuela Baccarini

  31. Sorafenib Suppresses JNK-Dependent Apoptosis through Inhibition of ZAK

    Article • Molecular Cancer Therapeutics, January 2014, American Association for Cancer Research (AACR)

    Professor Manuela Baccarini

  32. BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

    Article • eLife, November 2013, eLife

    Professor Manuela Baccarini, Dr Rosamaria Ruggieri, Dr Sandra S Ojeda

  33. Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK

    Article • Cancer Research, October 2013, American Association for Cancer Research (AACR)

    Professor Manuela Baccarini

  34. EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers

    Article • International Journal of Molecular Sciences, September 2013, MDPI AG

    Professor Manuela Baccarini

  35. RKIP regulates MAP kinase signaling in cells with defective B-Raf activity

    Article • Cellular Signalling, May 2013, Elsevier

    Professor Manuela Baccarini

  36. MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance

    Article • Molecular Cell, April 2013, Elsevier

    Professor Manuela Baccarini

  37. Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

    Article • Cancer Cell, March 2013, Elsevier

    Professor Manuela Baccarini

  38. B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance

    Article • Cell Reports, October 2012, Elsevier

    Professor Manuela Baccarini

  39. Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis

    Article • Oncogene, June 2012, Springer Science + Business Media

    Professor Manuela Baccarini

  40. ERK Signaling, But Not c-Raf, Is Required for Gonadotropin-Releasing Hormone (GnRH)-Induced Regulation of Nur77 in Pituitary Gonadotropes

    Article • Endocrinology, February 2012, Endocrine Society

    Professor Manuela Baccarini

  41. Angiogenic Sprouting Requires the Fine Tuning of Endothelial Cell Cohesion by the Raf-1/Rok-α Complex

    Article • Developmental Cell, January 2012, Elsevier

    Professor Manuela Baccarini

  42. Conservation of Salmonella Infection Mechanisms in Plants and Animals

    Article • PLOS One, September 2011, PLOS

    Professor Manuela Baccarini, Dr Adam Schikora

  43. Pancreatic β‐cell Raf‐1 is required for glucose tolerance, insulin secretion, andinsulin 2transcription

    Article • The FASEB Journal, August 2011, Wiley

    Professor Manuela Baccarini

  44. Raf kinases in cancer–roles and therapeutic opportunities

    Article • Oncogene, May 2011, Springer Science + Business Media

    Professor Manuela Baccarini

  45. C-Raf Is Required for the Initiation of Lung Cancer by K-RasG12D

    Article • Cancer Discovery, May 2011, American Association for Cancer Research (AACR)

    Professor Manuela Baccarini

  46. c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma

    Article • Cancer Cell, May 2011, Elsevier

    Professor Manuela Baccarini

  47. Partner exchange: protein–protein interactions in the Raf pathway

    Article • Trends in Biochemical Sciences, December 2010, Elsevier

    Professor Manuela Baccarini

  48. Ras and Raf pathways in epidermis development and carcinogenesis

    Article • British Journal of Cancer, November 2010, Springer Science + Business Media

    Professor Manuela Baccarini

  49. Keratinocyte-Specific Stat3 Heterozygosity Impairs Development of Skin Tumors in Human Papillomavirus 8 Transgenic Mice

    Article • Cancer Research, September 2010, American Association for Cancer Research (AACR)

    Professor Marco De Andrea, Professor Manuela Baccarini

  50. Targets of Raf in tumorigenesis

    Article • Carcinogenesis, January 2010, Oxford University Press (OUP)

    Professor Manuela Baccarini

  51. Deciphering Signaling Pathways In Vivo: The Ras/Raf/Mek/Erk Cascade

    Article • January 2010, Springer Science + Business Media

    Professor Manuela Baccarini

  52. From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity

    Article • Journal of Cell Biology, November 2009, Rockefeller University Press

    Professor Manuela Baccarini

  53. Disruption of epidermal specific Stat3 expression and delayed skin tumor development in HPV8 transgenic mice

    Article • Cytokine, October 2009, Elsevier

    Professor Manuela Baccarini, Professor Marco De Andrea

  54. Raf-1 Addiction in Ras-Induced Skin Carcinogenesis

    Article • Cancer Cell, August 2009, Elsevier

    Professor Manuela Baccarini

  55. A Mek1–Mek2 heterodimer determines the strength and duration of the Erk signal

    Article • Nature Structural & Molecular Biology, February 2009, Springer Science + Business Media

    Professor Manuela Baccarini

  56. Raf Protects Against Colitis by Promoting Mouse Colon Epithelial Cell Survival Through NF-κB

    Article • Gastroenterology, August 2008, Elsevier

    Professor Manuela Baccarini

  57. Fibronectin-Tissue Transglutaminase Matrix Rescues RGD-impaired Cell Adhesion through Syndecan-4 and β1 Integrin Co-signaling

    Article • Journal of Biological Chemistry, July 2008, Elsevier

    Professor Manuela Baccarini

  58. B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic β-cell carcinogenesis

    Article • Oncogene, May 2008, Springer Science + Business Media

    Professor Manuela Baccarini

  59. Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development

    Article • Journal of Cell Biology, March 2008, Rockefeller University Press

    Professor Manuela Baccarini

  60. RASSF1A Elicits Apoptosis through an MST2 Pathway Directing Proapoptotic Transcription by the p73 Tumor Suppressor Protein

    Article • Molecular Cell, September 2007, Elsevier

    Professor Manuela Baccarini, Dr David Matallanas

  61. Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo

    Article • Nature Neuroscience, March 2007, Springer Science + Business Media

    Professor Manuela Baccarini, Dr Jian Zhong

  62. ERK and Beyond: Insights from B-Raf and Raf-1 Conditional Knockouts

    Article • Cell Cycle, July 2006, Taylor & Francis

    Professor Manuela Baccarini

  63. A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation

    Article • Blood, July 2006, American Society of Hematology

    Professor Manuela Baccarini

  64. Essential role of B-Raf in ERK activation during extraembryonic development

    Article • Proceedings of the National Academy of Sciences, January 2006, Proceedings of the National Academy of Sciences

    Professor Manuela Baccarini

  65. Raf-1 sets the threshold of Fas sensitivity by modulating Rok-α signaling

    Article • Journal of Cell Biology, December 2005, Rockefeller University Press

    Professor Manuela Baccarini

  66. Second nature: Biological functions of the Raf‐1 “kinase”

    Article • FEBS Letters, March 2005, Wiley

    Professor Manuela Baccarini

  67. Raf-1 regulates Rho signaling and cell migration

    Article • Journal of Cell Biology, March 2005, Rockefeller University Press

    Professor Manuela Baccarini

  68. Role of the Kinase MST2 in Suppression of Apoptosis by the Proto-Oncogene Product Raf-1

    Article • Science, December 2004, American Association for the Advancement of Science

    Professor Manuela Baccarini

  69. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

    Article • Journal of Clinical Investigation, October 2004, American Society for Clinical Investigation

    Professor Manuela Baccarini

  70. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

    Article • Journal of Clinical Investigation, October 2004, American Society for Clinical Investigation

    Professor Manuela Baccarini

  71. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

    Article • Nature Immunology, April 2003, Springer Science + Business Media

    Professor Manuela Baccarini, David Levy

  72. Raf-1 Antagonizes Erythroid Differentiation by Restraining Caspase Activation

    Article • Journal of Experimental Medicine, November 2002, Rockefeller University Press

    Professor Manuela Baccarini

  73. An old kinase on a new path: Raf and apoptosis

    Article • Cell Death and Differentiation, July 2002, Springer Science + Business Media

    Professor Manuela Baccarini

  74. Opposite effects of different doses of MCSF on ERK phosphorylation and cell proliferation in macrophages

    Article • Oncogene, May 2002, Springer Science + Business Media

    Professor Manuela Baccarini, Elisabetta Rovida

  75. Dephosphorylation of Ser-259 Regulates Raf-1 Membrane Association

    Article • Journal of Biological Chemistry, March 2002, Elsevier

    Professor Manuela Baccarini

  76. Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

    Article • The EMBO Journal, April 2001, Springer Science + Business Media

    Professor Manuela Baccarini

  77. Protective Role of Raf-1 in Salmonella-Induced Macrophage Apoptosis

    Article • Journal of Experimental Medicine, February 2001, Rockefeller University Press

    Professor Manuela Baccarini

  78. Salmonella-Induced Caspase-2 Activation in Macrophages

    Article • Journal of Experimental Medicine, October 2000, Rockefeller University Press

    Professor Manuela Baccarini

  79. The Raf‐1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments

    Article • The FASEB Journal, October 2000, Wiley

    Professor Manuela Baccarini

  80. Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

    Article • Journal of Biological Chemistry, July 2000, Elsevier

    Professor Manuela Baccarini

  81. Raf‐1 and B‐Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain

    Article • European Journal of Neuroscience, June 1999, Wiley

    Professor Manuela Baccarini

  82. Host factor I, Hfq, binds to Escherichia coli ompA mRNA in a growth rate-dependent fashion and regulates its stability

    Article • Proceedings of the National Academy of Sciences, November 1998, Proceedings of the National Academy of Sciences

    Professor Manuela Baccarini

  83. Activation of bcl‐2 suppressible 40 and 44 kDa p38‐like kinases during apoptosis of early and late B lymphocytic cell lines

    Article • FEBS Letters, May 1998, Wiley

    Professor Manuela Baccarini

  84. Altered Growth Factor Response in Myeloid Progenitor Cell Mutants Derived after Retroviral Insertlonal Mutagenesis

    Article • January 1996, Springer Science + Business Media

    Professor Manuela Baccarini

  85. Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo.

    Article • Molecular and Cellular Biology, September 1994, ASM Journals

    Professor Manuela Baccarini

  86. Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors.

    Article • Genes & Development, August 1994, Cold Spring Harbor Laboratory Press

    Professor Manuela Baccarini

  87. Bacterially Expressed Murine CSF-1 Possesses Agonistic Activity in Its Monomeric Form

    Article • Biochemical and Biophysical Research Communications, April 1993, Elsevier

    Professor Manuela Baccarini

  88. Upregulation of Lineage Specific Receptors and Ligands in Multipotential Progenitor Cells is Part of an Endogenous Program of Differentiation

    Article • Growth Factors, January 1993, Taylor & Francis

    Professor Manuela Baccarini

  89. Colony Stimulating Factor-1

    Article • January 1990, Springer Science + Business Media

    Professor Manuela Baccarini

  90. Cooperative effects of colony-stimulating factor 1 and recombinant interleukin 2 on proliferation and induction of cytotoxicity of macrophage precursors generated from mouse bone marrow cell cultures.

    Article • Journal of Experimental Medicine, March 1989, Rockefeller University Press

    Professor Manuela Baccarini

  91. Liver‐associated macrophage precursor cells proliferate under impairment of regular hemopoiesis

    Article • European Journal of Immunology, May 1988, Wiley

    Professor Manuela Baccarini

  92. Extracellular killing of Leishmania promastigotes and amastigotes by macrophage precursors derived from bone marrow cultures

    Article • Journal of Experimental Medicine, April 1988, Rockefeller University Press

    Professor Manuela Baccarini

  93. Organ-Associated Macrophage Precursor Cells as Effector Cells Against Tumor Targets and Microorganisms

    Article • January 1987, Springer Science + Business Media

    Professor Manuela Baccarini

  94. Functional heterogeneity of murine macrophage precursor cells from spleen and bone marrow

    Article • Cellular Immunology, September 1986, Elsevier

    Professor Manuela Baccarini

  95. A fast and objective assay for cell mediated intra- and extracellular killing of Leishmania promastigotes

    Article • Journal of Immunological Methods, February 1986, Elsevier

    Professor Manuela Baccarini

  96. Liver‐associated macrophage precursors as natural cytotoxic effectors against Candida albicans and Yac‐1 cells

    Article • European Journal of Immunology, January 1986, Wiley

    Professor Manuela Baccarini

  97. Killing of Yeast, Germ-tube and Mycelial Forms of Candida albicans by Murine Effectors as Measured by a Radiolabel Release Microassay

    Article • Microbiology, March 1985, Society for General Microbiology

    Professor Manuela Baccarini

  98. Enhancement of natural killer cell activity in mice by treatment with a thymic factor

    Article • Medical Oncology, June 1984, Springer Science + Business Media

    Professor Manuela Baccarini

  99. Modulating Effects of Thymic Factors on Natural Cell-Mediated Reactivities of Natural and Cyclophosphamide-Treated Mice

    Article • January 1984, Springer Science + Business Media

    Professor Manuela Baccarini

  100. Phagocytic killing of Candida albicans by different murine effector cells

    Article • Medical Mycology, January 1983, Oxford University Press (OUP)

    Professor Manuela Baccarini

  101. A radiolabel release microassay for phagocytic killing of Candida albicans

    Article • Journal of Immunological Methods, August 1982, Elsevier

    Professor Manuela Baccarini

  102. The role of the peritoneal cavity in successful treatment of a murine lymphoma with chemotherapy and non-specific immunostimulation

    Article • Medical Oncology, August 1982, Springer Science + Business Media

    Professor Manuela Baccarini

  103. Cellular mechanisms underlying the adjuvant activity of Candida albicans in a mouse lymphoma model

    Article • International Journal of Cancer, April 1982, Wiley

    Professor Manuela Baccarini

  104. Influence of thymosin α1 on natural resistance and cytotoxicity against (CA)

    Article • International Journal of Immunopharmacology, January 1982, Elsevier

    Professor Manuela Baccarini