All Stories

  1. Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort

    Article • Scientific Reports, January 2026, Springer Science + Business Media

    Manuel Portero-Otin

  2. Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs

    Article • Scientific Reports, December 2025, Springer Science + Business Media

    Manuel Portero-Otin

  3. Mission cholesterol: Uncovering its hidden role in ALS neurodegeneration

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, November 2025, Elsevier

    Manuel Portero-Otin

  4. Exploring platelet metabolomics and fatty acid profiles for ALS prognosis and diagnosis

    Article • Scientific Reports, October 2025, Springer Science + Business Media

    Manuel Portero-Otin

  5. Mitochondrial lipidome's fatty acid profile and peroxidation index are programmed tissue-specific traits

    Article • Redox Biology, October 2025, Elsevier

    Manuel Portero-Otin

  6. Nuclear pore complex dysfunction drives TDP-43 pathology in ALS

    Article • Redox Biology, October 2025, Elsevier

    Manuel Portero-Otin

  7. Ether lipids and sphingolipids drive sex-specific human aging dynamics

    Article • Redox Biology, September 2025, Elsevier

    Manuel Portero-Otin

  8. TDP-43 loss-of-function triggers mitochondrial dysfunction and metabolic imbalance

    Article • Neural Regeneration Research, July 2025, Wolters Kluwer Health

    Manuel Portero-Otin

  9. Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation

    Article • Sclerosis, March 2025, MDPI AG

    Manuel Portero-Otin

  10. Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut-Brain Axis and Therapeutic Potential of Microbiota Modulation

    Article • December 2024, MDPI AG

    Manuel Portero-Otin

  11. Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease

    Article • Scientific Reports, October 2024, Springer Science + Business Media

    Manuel Portero-Otin

  12. TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

    Article • Acta Neuropathologica, September 2024, Springer Science + Business Media

    Manuel Portero-Otin

  13. TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells

    Article • Redox Biology, September 2024, Elsevier

    Manuel Portero-Otin

  14. High-Fat Diet-Induced Obesity Increases Brain Mitochondrial Complex I and Lipoxidation-Derived Protein Damage

    Article • Antioxidants, January 2024, MDPI AG

    Manuel Portero-Otin

  15. A functional interaction between TDP-43 and USP10 reveals USP10 dysfunction in TDP-43 proteinopathies

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Manuel Portero-Otin

  16. Human lifespan and sex-specific patterns of resilience to disease: a retrospective population-wide cohort study

    Article • BMC Medicine, January 2024, Springer Science + Business Media

    Manuel Portero-Otin

  17. Phenotypic molecular features of long-lived animal species

    Article • Free Radical Biology and Medicine, November 2023, Elsevier

    Manuel Portero-Otin

  18. Low adherence to the Mediterranean diet is associated with increased prevalence and number of atherosclerotic plaques in the ILERVAS cohort

    Article • Atherosclerosis, September 2023, Elsevier

    Manuel Portero-Otin

  19. Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial

    Article • Nutrients, August 2023, MDPI AG

    Manuel Portero-Otin

  20. Hakuna MAM-Tata: Investigating the role of mitochondrial-associated membranes in ALS

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, August 2023, Elsevier

    Manuel Portero-Otin

  21. Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis

    Article • Journal of Neurochemistry, July 2023, Wiley

    Manuel Portero-Otin

  22. Dietary Advanced Glycation End Products: Their Role in the Insulin Resistance of Aging

    Article • Cells, June 2023, MDPI AG

    jaime uribarri, Manuel Portero-Otin

  23. Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity

    Article • Journal of Clinical Investigation, May 2023, American Society for Clinical Investigation

    Manuel Portero-Otin

  24. Plasma acylcarnitines and gut‐derived aromatic amino acids as sex‐specific hub metabolites of the human aging metabolome

    Article • Aging Cell, March 2023, Wiley

    Manuel Portero-Otin

  25. Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2

    Article • Proceedings of the National Academy of Sciences, February 2023, Proceedings of the National Academy of Sciences

    Manuel Portero-Otin

  26. Ether Lipid-Mediated Antioxidant Defense in Alzheimer’s Disease

    Article • Antioxidants, January 2023, MDPI AG

    Manuel Portero-Otin

  27. Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain

    Article • Antioxidants, January 2023, MDPI AG

    Manuel Portero-Otin

  28. Lipidomic Alterations in the Cerebral Cortex and White Matter in Sporadic Alzheimer’s Disease

    Article • Aging and Disease, January 2023, Aging and Disease

    Manuel Portero-Otin

  29. Lipidomic alterations in the cerebral cortex and white matter in sporadic Alzheimer’s disease

    Article • November 2022, Cold Spring Harbor Laboratory Press

    Manuel Portero-Otin

  30. DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection

    Article • Antioxidants, November 2022, MDPI AG

    Jose Fernandez-Real, Manuel Portero-Otin

  31. A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers

    Article • Disease Models & Mechanisms, August 2022, The Company of Biologists

    Manuel Portero-Otin

  32. Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients

    Article • Journal of Cerebral Blood Flow & Metabolism, July 2022, SAGE Publications

    Manuel Portero-Otin

  33. Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy

    Article • Acta Neuropathologica, July 2022, Springer Science + Business Media

    Manuel Portero-Otin

  34. Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function

    Article • The ISME Journal, June 2022, Oxford University Press (OUP)

    Manuel Portero-Otin

  35. Metabolomics reveals that fittest trail runners show a better adaptation of bioenergetic pathways

    Article • Journal of Science and Medicine in Sport, May 2022, Elsevier

    Manuel Portero-Otin

  36. Microbiota alterations in proline metabolism impact depression

    Article • Cell Metabolism, May 2022, Elsevier

    Manuel Portero-Otin

  37. Human Atheromatous Plaques Expressed Sensing Adaptor STING, a Potential Role in Vascular Inflammation Pathogenesis

    Article • Thrombosis and Haemostasis, February 2022, Thieme Publishing Group

    Manuel Portero-Otin

  38. Selective brain regional changes in lipid profile with human aging

    Article • GeroScience, February 2022, Springer Science + Business Media

    Manuel Portero-Otin

  39. Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia

    Article • Nutrients, January 2022, MDPI AG

    Manuel Portero-Otin

  40. Cell senescence, loss of splicing, and lipid metabolism in TDP-43-related neurodegenerative processes

    Article • Neural Regeneration Research, January 2022, Medknow

    Manuel Portero-Otin

  41. Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway

    Article • European Journal of Biochemistry, November 2021, Wiley

    PhD. Guillermo Lopez-Lluch, Manuel Portero-Otin

  42. Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age

    Article • International Journal of Molecular Sciences, November 2021, MDPI AG

    Manuel Portero-Otin

  43. Restriction of Dietary Advanced Glycation End Products Induces a Differential Plasma Metabolome and Lipidome Profile

    Article • Molecular Nutrition & Food Research, October 2021, Wiley

    jaime uribarri, Manuel Portero-Otin

  44. Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment

    Article • International Journal of Molecular Sciences, August 2021, MDPI AG

    Manuel Portero-Otin

  45. Dietary AGEs as Exogenous Boosters of Inflammation

    Article • Nutrients, August 2021, MDPI AG

    jaime uribarri, Manuel Portero-Otin

  46. Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype

    Article • Scientific Reports, August 2021, Springer Science + Business Media

    Manuel Portero-Otin

  47. Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model

    Article • Neuropathology and Applied Neurobiology, July 2021, Wiley

    Manuel Portero-Otin

  48. Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment

    Article • July 2021, MDPI AG

    Manuel Portero-Otin

  49. Subjects with detectable Saccharomyces cerevisiae in the gut microbiota show deficits in attention and executive function

    Article • Journal of Internal Medicine, May 2021, Wiley

    Manuel Portero-Otin

  50. Nuclear lipidome is altered in amyotrophic lateral sclerosis: A pilot study

    Article • Journal of Neurochemistry, May 2021, Wiley

    Manuel Portero-Otin

  51. New insights into human prefrontal cortex aging with a lipidomics approach

    Article • Expert Review of Proteomics, May 2021, Taylor & Francis

    Manuel Portero-Otin

  52. The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer’s Disease Pathology

    Article • Life, April 2021, MDPI AG

    Manuel Portero-Otin

  53. The motor neuron disease mouse model hSOD1-G93A presents a non-canonical profile of senescence biomarkers in the spinal cord

    Article • February 2021, Springer Science + Business Media

    Manuel Portero-Otin

  54. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

    Article • Gut, January 2021, BMJ

    Manuel Portero-Otin

  55. Lipid alterations in human frontal cortex in ALS‐FTLD‐TDP43 proteinopathy spectrum are partly related to peroxisome impairment

    Article • Neuropathology and Applied Neurobiology, January 2021, Wiley

    Manuel Portero-Otin

  56. Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression

    Article • Brain Communications, January 2021, Oxford University Press (OUP)

    Manuel Portero-Otin

  57. The Motor Neuron Disease Mouse Model hSOD1-G93A Presents a Non-canonical Profile of Senescence Biomarkers in the Spinal Cord

    Article • December 2020, Springer Science + Business Media

    Manuel Portero-Otin

  58. The Motor Neuron Disease Mouse Model hSOD1-G93A Presents a Non-canonical Profile of Senescence Biomarkers in the Spinal Cord

    Article • December 2020, Springer Science + Business Media

    Manuel Portero-Otin

  59. The Motor Neuron Disease Mouse Model hSOD1-G93A Presents a Non-canonical Profile of Senescence Biomarkers in The Spinal Cord

    Article • November 2020, Springer Science + Business Media

    Manuel Portero-Otin

  60. Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids

    Article • Cell Metabolism, October 2020, Elsevier

    Manuel Portero-Otin

  61. REMOTE Ischemic Perconditioning Among Acute Ischemic Stroke Patients in Catalonia: REMOTE-CAT PROJECT

    Article • Frontiers in Neurology, September 2020, Frontiers

    Manuel Portero-Otin

  62. In Vivo Anti-Inflammatory Effects and Related Mechanisms of Processed Egg Yolk, a Potential Anti-Inflammaging Dietary Supplement

    Article • Nutrients, September 2020, MDPI AG

    Manuel Portero-Otin

  63. Molecular phenomics of a high-calorie diet-induced porcine model of prepubertal obesity

    Article • The Journal of Nutritional Biochemistry, September 2020, Elsevier

    Manuel Portero-Otin

  64. The Aging Imageomics Study: rationale, design and baseline characteristics of the study population

    Article • Mechanisms of Ageing and Development, July 2020, Elsevier

    Manuel Portero-Otin

  65. Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile

    Article • Microbiome, April 2020, Springer Science + Business Media

    Manuel Portero-Otin

  66. Dietary intake of bioactive ingredients impacts liver and adipose tissue transcriptomes in a porcine model of prepubertal early obesity

    Article • Scientific Reports, March 2020, Springer Science + Business Media

    Manuel Portero-Otin

  67. Selected cryptic exons accumulate in hippocampal cell nuclei in Alzheimer’s disease with and without associated TDP-43 proteinopathy

    Article • Brain, February 2020, Oxford University Press (OUP)

    Manuel Portero-Otin

  68. Poultry diets containing (keto)carotenoid-enriched maize improve egg yolk color and maintain quality

    Article • Animal Feed Science and Technology, February 2020, Elsevier

    Manuel Portero-Otin

  69. Lipidomic profiling identifies signatures of metabolic risk

    Article • EBioMedicine, January 2020, Elsevier

    Manuel Portero-Otin

  70. Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential

    Article • Redox Biology, January 2020, Elsevier

    Manuel Portero-Otin

  71. Subcutaneous advanced glycation end-products and lung function according to glucose abnormalities: The ILERVAS Project

    Article • Diabetes & Metabolism, December 2019, Elsevier

    Manuel Portero-Otin

  72. Adipose Tissue Mitochondrial Factors Profile after Dietary Bioactive Compound Weight Reduction Treatments in a Mice Obesity Model

    Article • International Journal of Molecular Sciences, November 2019, MDPI AG

    Manuel Portero-Otin

  73. Gender-Specific Beneficial Effects of Docosahexaenoic Acid Dietary Supplementation in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

    Article • Neurotherapeutics, November 2019, Springer Science + Business Media

    Manuel Portero-Otin

  74. Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project

    Article • Cardiovascular Diabetology, November 2019, Springer Science + Business Media

    Manuel Portero-Otin

  75. Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project

    Article • Journal of Atherosclerosis and Thrombosis, October 2019, Japan Atherosclerosis Society

    Manuel Portero-Otin

  76. Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness

    Article • Journal of Translational Medicine, September 2019, Springer Science + Business Media

    Manuel Portero-Otin

  77. Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients

    Article • Frontiers in Neuroscience, September 2019, Frontiers

    Manuel Portero-Otin

  78. Nuclear lipidome is altered in amyotrophic lateral sclerosis: a preliminary study

    Article • June 2019, Cold Spring Harbor Laboratory Press

    Manuel Portero-Otin

  79. A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma

    Article • Scandinavian Journal of Trauma Resuscitation and Emergency Medicine, May 2019, Springer Science + Business Media

    Manuel Portero-Otin

  80. Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential

    Article • Obesity, May 2019, Wiley

    Manuel Portero-Otin

  81. Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study

    Article • Neurotherapeutics, May 2019, Springer Science + Business Media

    Manuel Portero-Otin

  82. Lung function measurements in the prediabetes stage: data from the ILERVAS Project

    Article • Acta Diabetologica, April 2019, Springer Science + Business Media

    Manuel Portero-Otin

  83. Altered Dynein Axonemal Assembly Factor 1 Expression in C-Boutons in Bulbar and Spinal Cord Motor-Neurons in Sporadic Amyotrophic Lateral Sclerosis

    Article • Journal of Neuropathology & Experimental Neurology, April 2019, Oxford University Press (OUP)

    Manuel Portero-Otin

  84. Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Manuel Portero-Otin

  85. Prevalencia de enfermedad pulmonar obstructiva crónica no diagnosticada en una población con factores de riesgo cardiovascular

    Article • Medicina Clínica, November 2018, Elsevier

    Manuel Portero-Otin

  86. Location-dependent effects of trauma on oxidative stress in humans

    Article • PLOS One, October 2018, PLOS

    Manuel Portero-Otin

  87. Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging

    Article • Experimental Gerontology, October 2018, Elsevier

    Manuel Portero-Otin

  88. Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue

    Article • Autophagy, July 2018, Taylor & Francis

    Manuel Portero-Otin

  89. Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study

    Article • Journal of the European Academy of Dermatology and Venereology, July 2018, Wiley

    Manuel Portero-Otin

  90. Aberrant regulation of the GSK‐3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy

    Article • EMBO Molecular Medicine, July 2018, EMBO

    Manuel Portero-Otin

  91. Essential Physiological Differences Characterize Short- and Long-Lived Strains of Drosophila melanogaster

    Article • The Journals of Gerontology Series A, June 2018, Oxford University Press (OUP)

    Manuel Portero-Otin

  92. Manipulation of gut intestinal fungy for the treatment of cardiovascular diseases

    Article • Beneficial Microbes, February 2018, Wageningen Academic Publishers

    Jose Fernandez-Real, Manuel Portero-Otin, Dr Josep Puig, Gerard Blasco, MATILDE RODRIGUEZ CHACON, Wifredo Ricart

  93. Altered Expression of miR-181a-5p and miR-23a-3p Is Associated With Obesity and TNFα-Induced Insulin Resistance

    Article • The Journal of Clinical Endocrinology & Metabolism, February 2018, Endocrine Society

    Manuel Portero-Otin

  94. Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence

    Article • Cellular Physiology and Biochemistry, January 2018, Karger Publishers

    Jose Fernandez-Real, Manuel Portero-Otin

  95. Metabolomic Estimation of the Diagnosis and Onset Time of Permanent and Transient Cerebral Ischemia

    Article • Molecular Neurobiology, December 2017, Springer Science + Business Media

    Manuel Portero-Otin

  96. Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome

    Article • Oncotarget, December 2017, Impact Journals, LLC

    Manuel Portero-Otin

  97. Tumour-microenvironmental blood flow determines a metabolomic signature identifying lysophospholipids and resolvin D as biomarkers in endometrial cancer patients

    Article • Oncotarget, November 2017, Impact Journals, LLC

    Manuel Portero-Otin

  98. Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

    Article • Aging Cell, October 2017, Wiley

    Manuel Portero-Otin, Isidro Ferrer

  99. Pulque for your health?

    Article • September 2017, Cold Spring Harbor Laboratory Press

    Manuel Portero-Otin

  100. Lipid Profile in Human Frontal Cortex is Sustained Throughout Healthy Adult Lifespan to Decay at Advanced Ages

    Article • The Journals of Gerontology Series A, August 2017, Oxford University Press (OUP)

    Manuel Portero-Otin

  101. Characterization of the post-prandial insulinemic response and low glycaemic index of a soy beverage

    Article • PLOS One, August 2017, PLOS

    Manuel Portero-Otin

  102. Differential metabolic profiles associated to movement behaviour of stream-resident brown trout (Salmo trutta)

    Article • PLOS One, July 2017, PLOS

    Manuel Portero-Otin, Dr Enric Aparicio

  103. Adipose tissue: a new pituitary gland?

    Article • The FASEB Journal, June 2017, Federation of American Societies For Experimental Biology (FASEB)

    Manuel Portero-Otin, Jose Fernandez-Real, Wifredo Ricart

  104. The Gut Metagenome Changes in Parallel to Waist Circumference, Brain Iron Deposition, and Cognitive Function

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2017, Endocrine Society

    Dr Josep Puig, Dr Josep Garre-Olmo, Gerard Blasco, Manuel Portero-Otin, Jose Fernandez-Real, Wifredo Ricart, Fernando Fernandez-Aranda

  105. High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition

    Article • Phytochemistry Reviews, June 2017, Springer Science + Business Media

    Manuel Portero-Otin

  106. Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, May 2017, Elsevier

    Manuel Portero-Otin

  107. Biofortification of crops with nutrients: factors affecting utilization and storage

    Article • Current Opinion in Biotechnology, April 2017, Elsevier

    Manuel Portero-Otin

  108. Sixty years old is the breakpoint of human frontal cortex aging

    Article • Free Radical Biology and Medicine, February 2017, Elsevier

    Manuel Portero-Otin

  109. Adipocyte lipopolysaccharide binding protein (LBP) is linked to a specific lipidomic signature

    Article • Obesity, December 2016, Wiley

    Manuel Portero-Otin, Jose Fernandez-Real

  110. Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex

    Article • Frontiers in Molecular Neuroscience, December 2016, Frontiers

    Manuel Portero-Otin

  111. Metabolomics Predicts Neuroimaging Characteristics of Transient Ischemic Attack Patients

    Article • EBioMedicine, December 2016, Elsevier

    Manuel Portero-Otin

  112. The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage

    Article • Scientific Reports, October 2016, Springer Science + Business Media

    Manuel Portero-Otin

  113. Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism

    Article • Oncotarget, July 2016, Impact Journals, LLC

    Manuel Portero-Otin

  114. Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

    Article • Neurobiology of Disease, April 2016, Elsevier

    Manuel Portero-Otin

  115. Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, April 2016, Elsevier

    Manuel Portero-Otin

  116. A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans

    Article • The Journals of Gerontology Series A, March 2016, Oxford University Press (OUP)

    Manuel Portero-Otin

  117. Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury

    Article • Glia, February 2016, Wiley

    Manuel Portero-Otin

  118. Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity

    Article • Diabetologia, February 2016, Springer Science + Business Media

    Manuel Portero-Otin, Jose Fernandez-Real

  119. Erratum: Obesity changes the human gut mycobiome

    Article • Scientific Reports, February 2016, Springer Science + Business Media

    Manuel Portero-Otin, Jose Fernandez-Real

  120. Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS

    Article • Acta Neuropathologica Communications, January 2016, Springer Science + Business Media

    Manuel Portero-Otin

  121. Gut Microbiota Interacts With Brain Microstructure and Function

    Article • The Journal of Clinical Endocrinology & Metabolism, December 2015, Endocrine Society

    Manuel Portero-Otin, Fernando Fernandez-Aranda, Jose Fernandez-Real

  122. Obesity changes the human gut mycobiome

    Article • Scientific Reports, October 2015, Springer Science + Business Media

    Manuel Portero-Otin, Jose Fernandez-Real

  123. Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy

    Article • Human Molecular Genetics, September 2015, Oxford University Press (OUP)

    Manuel Portero-Otin

  124. Dietary Advanced Glycation End Products and Their Role in Health and Disease

    Article • Advances in Nutrition, July 2015, Oxford University Press (OUP)

    Jaime Uribarri, Manuel Portero-Otin, jaime uribarri

  125. Human Aging Is a Metabolome-related Matter of Gender

    Article • The Journals of Gerontology Series A, May 2015, Oxford University Press (OUP)

    Manuel Portero-Otin

  126. Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis

    Article • Plant Biotechnology Journal, April 2015, Wiley

    Manuel Portero-Otin

  127. Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice

    Article • Journal of Neuropathology & Experimental Neurology, April 2015, Oxford University Press (OUP)

    Manuel Portero-Otin

  128. Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy

    Article • Cell Death and Differentiation, March 2015, Springer Science + Business Media

    Manuel Portero-Otin

  129. Nutridynamics: mechanism(s) of action of bioactive compounds and their effects

    Article • International Journal of Food Sciences and Nutrition, January 2015, Taylor & Francis

    Manuel Portero-Otin

  130. Deregulation of purine metabolism in Alzheimer's disease

    Article • Neurobiology of Aging, January 2015, Elsevier

    Manuel Portero-Otin

  131. Lipidomics of Human Brain Aging and Alzheimer's Disease Pathology

    Article • January 2015, Elsevier

    Manuel Portero-Otin

  132. The Antioxidant Effect of LMN Diet, Rich in Polyphenols and Polyunsaturated Fatty Acids, in Alzheimer’s Disease

    Article • January 2015, Elsevier

    Manuel Portero-Otin

  133. Muscle metabolic reprogramming by mitochondrial stress

    Article • The FASEB Journal, December 2014, Federation of American Societies For Experimental Biology (FASEB)

    Professor Susanne Klaus, Manuel Portero-Otin

  134. Metabolomics predicts stroke recurrence after transient ischemic attack

    Article • Neurology, December 2014, Wolters Kluwer Health

    Manuel Portero-Otin

  135. Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype

    Article • The FASEB Journal, August 2014, Federation of American Societies For Experimental Biology (FASEB)

    Manuel Portero-Otin

  136. Brain Iron Overload, Insulin Resistance, and Cognitive Performance in Obese Subjects: A Preliminary MRI Case-Control Study

    Article • Diabetes Care, August 2014, American Diabetes Association

    Manuel Portero-Otin, Fernando Fernandez-Aranda, Jose Fernandez-Real

  137. Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

    Article • Aging Cell, July 2014, Wiley

    Manuel Portero-Otin

  138. Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model

    Article • Molecular and Cellular Neuroscience, July 2014, Elsevier

    Manuel Portero-Otin

  139. Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner

    Article • NeuroMolecular Medicine, July 2014, Springer Science + Business Media

    Manuel Portero-Otin

  140. Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer

    Article • Biochemical Pharmacology, July 2014, Elsevier

    Manuel Portero-Otin

  141. Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

    Article • Journal of Neuropathology & Experimental Neurology, July 2014, Oxford University Press (OUP)

    Manuel Portero-Otin

  142. Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

    Article • Aging Cell, February 2014, Wiley

    Manuel Portero-Otin

  143. Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

    Article • Human Molecular Genetics, February 2014, Oxford University Press (OUP)

    Manuel Portero-Otin

  144. Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

    Article • Neurotherapeutics, January 2014, Springer Science + Business Media

    Manuel Portero-Otin

  145. Plasma antioxidant capacity in critical polytraumatized patients?: methods, severity, and anatomic location

    Article • Critical Care, January 2014, Springer Science + Business Media

    Manuel Portero-Otin

  146. Plasma long-chain free fatty acids predict mammalian longevity

    Article • Scientific Reports, November 2013, Springer Science + Business Media

    Manuel Portero-Otin

  147. Human omental and subcutaneous adipose tissue exhibit specific lipidomic signatures

    Article • The FASEB Journal, November 2013, Federation of American Societies For Experimental Biology (FASEB)

    Manuel Portero-Otin, Jose Fernandez-Real

  148. Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile

    Article • Genes & Nutrition, September 2013, Springer Science + Business Media

    Manuel Portero-Otin

  149. T‐type calcium channel blockers inhibit autophagy and promote apoptosis of malignant melanoma cells

    Article • Pigment Cell & Melanoma Research, September 2013, Wiley

    Manuel Portero-Otin

  150. Estudio de la vulnerabilidad neuronal selectiva en el sistema nervioso central humano

    Article • Revista Española de Geriatría y Gerontología, September 2013, Elsevier

    Manuel Portero-Otin

  151. Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

    Article • Brain, June 2013, Oxford University Press (OUP)

    Manuel Portero-Otin

  152. Specific Lipidome Signatures in Central Nervous System from Methionine-Restricted Mice

    Article • Journal of Proteome Research, April 2013, American Chemical Society (ACS)

    Manuel Portero-Otin

  153. Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

    Article • Human Molecular Genetics, April 2013, Oxford University Press (OUP)

    Manuel Portero-Otin

  154. Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system

    Article • AJP Endocrinology and Metabolism, March 2013, American Physiological Society

    Manuel Portero-Otin

  155. Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats

    Article • Transgenic Research, February 2013, Springer Science + Business Media

    Manuel Portero-Otin

  156. Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions

    Article • International Journal of Molecular Sciences, February 2013, MDPI AG

    Manuel Portero-Otin

  157. Atherosclerosis prevention by nutritional factors: A meta-analysis in small animal models

    Article • Nutrition Metabolism and Cardiovascular Diseases, February 2013, Elsevier

    Manuel Portero-Otin

  158. Membrane lipid unsaturation as physiological adaptation to animal longevity

    Article • Frontiers in Physiology, January 2013, Frontiers

    Manuel Portero-Otin

  159. Dietary intake of green tea polyphenols regulates insulin sensitivity with an increase in AMP-activated protein kinase α content and changes in mitochondrial respiratory complexes

    Article • Molecular Nutrition & Food Research, December 2012, Wiley

    Manuel Portero-Otin

  160. Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters

    Article • Cardiovascular Research, December 2012, European Society of Cardiology

    Manuel Portero-Otin

  161. Fish oil and 3-thia fatty acid have additive effects on lipid metabolism but antagonistic effects on oxidative damage when fed to rats for 50 weeks

    Article • The Journal of Nutritional Biochemistry, November 2012, Elsevier

    Manuel Portero-Otin

  162. Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism

    Article • Journal of Neurochemistry, September 2012, Wiley

    Manuel Portero-Otin

  163. Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, September 2012, Elsevier

    Manuel Portero-Otin

  164. Plant-Derived Phenolics Inhibit the Accrual of Structurally Characterised Protein and Lipid Oxidative Modifications

    Article • PLOS One, August 2012, PLOS

    Manuel Portero-Otin

  165. Region Specific Vulnerability to Lipid Peroxidation in the Human Central Nervous System

    Article • August 2012, IntechOpen

    Manuel Portero-Otin

  166. Tetradecylthioacetic Acid Attenuates Inflammation and Has Antioxidative Potential During Experimental Colitis in Rats

    Article • Digestive Diseases and Sciences, August 2012, Springer Science + Business Media

    Manuel Portero-Otin

  167. Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction

    Article • Amino Acids, June 2012, Springer Science + Business Media

    Manuel Portero-Otin

  168. Amyloid Generation and Dysfunctional Immunoproteasome Activation with Disease Progression in Animal Model of Familial Alzheimer's Disease

    Article • Brain Pathology, January 2012, Wiley

    Manuel Portero-Otin

  169. Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

    Article • Experimental Diabetes Research, January 2012, Hindawi Publishing Corporation

    Manuel Portero-Otin

  170. Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats

    Article • Scandinavian Journal of Gastroenterology, November 2011, Taylor & Francis

    Manuel Portero-Otin

  171. Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

    Article • Journal of Bioenergetics and Biomembranes, October 2011, Springer Science + Business Media

    Manuel Portero-Otin

  172. Oxidative Damage Compromises Energy Metabolism in the Axonal Degeneration Mouse Model of X-Adrenoleukodystrophy

    Article • Antioxidants & Redox Signaling, October 2011, Mary Ann Liebert Inc

    Manuel Portero-Otin

  173. Antioxidants halt axonal degeneration in a mouse model of X‐adrenoleukodystrophy

    Article • Annals of Neurology, July 2011, Wiley

    Manuel Portero-Otin

  174. Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS

    Article • Acta Neuropathologica, June 2011, Springer Science + Business Media

    Manuel Portero-Otin

  175. Multicompartmental LC-Q-TOF-Based Metabonomics as an Exploratory Tool to Identify Novel Pathways Affected by Polyphenol-Rich Diets in Mice

    Article • Journal of Proteome Research, June 2011, American Chemical Society (ACS)

    Manuel Portero-Otin

  176. Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q10

    Article • Free Radical Biology and Medicine, May 2011, Elsevier

    Manuel Portero-Otin

  177. Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease

    Article • Journal of Neuropathology & Experimental Neurology, April 2011, Oxford University Press (OUP)

    Manuel Portero-Otin

  178. Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle

    Article • Journal of Applied Physiology, March 2011, American Physiological Society

    Manuel Portero-Otin

  179. The β-Blocker Atenolol Lowers the Longevity-Related Degree of Fatty Acid Unsaturation, Decreases Protein Oxidative Damage, and Increases Extracellular Signal-Regulated Kinase Signaling in the Heart of C57BL/6 Mice

    Article • Rejuvenation Research, December 2010, SAGE Publications

    Manuel Portero-Otin

  180. Pathological aspects of lipid peroxidation

    Article • Free Radical Research, September 2010, Taylor & Francis

    Professor Shlomo Sasson, guy cohen, Manuel Portero-Otin

  181. Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

    Article • PLOS One, July 2010, PLOS

    Professor Masaru Tanokura, Manuel Portero-Otin

  182. When cholesterol is not cholesterol: a note on the enzymatic determination of its concentration in model systems containing vegetable extracts

    Article • Lipids in Health and Disease, June 2010, Springer Science + Business Media

    Manuel Portero-Otin

  183. A fish oil-rich diet reduces vascular oxidative stress in apoE–/–mice

    Article • Free Radical Research, June 2010, Taylor & Francis

    Manuel Portero-Otin

  184. Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease

    Article • Free Radical Biology and Medicine, May 2010, Elsevier

    Manuel Portero-Otin

  185. Glicación de proteínas mitocondriales, estrés oxidativo y envejecimiento

    Article • Revista Española de Geriatría y Gerontología, May 2010, Elsevier

    Manuel Portero-Otin

  186. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction

    Article • Proceedings of the National Academy of Sciences, April 2010, Proceedings of the National Academy of Sciences

    Manuel Portero-Otin

  187. Biomarkers of aging in Drosophila

    Article • Aging Cell, March 2010, Wiley

    Manuel Portero-Otin

  188. Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy

    Article • Human Molecular Genetics, February 2010, Oxford University Press (OUP)

    Manuel Portero-Otin

  189. Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates

    Article • Brain Pathology, February 2010, Wiley

    Manuel Portero-Otin

  190. Effects of Increased Iron Intake During the Neonatal Period on the Brain of Adult AβPP/PS1 Transgenic Mice

    Article • Journal of Alzheimer’s Disease, January 2010, SAGE Publications

    Manuel Portero-Otin

  191. Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart

    Article • Mechanisms of Ageing and Development, January 2010, Elsevier

    Manuel Portero-Otin

  192. Modification of brain lipids but not phenotype in α-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids

    Article • Neurochemistry International, January 2010, Elsevier

    Manuel Portero-Otin

  193. Mitochondrial ATP‐Synthase in the Entorhinal Cortex Is a Target of Oxidative Stress at Stages I/II of Alzheimer's Disease Pathology

    Article • Brain Pathology, December 2009, Wiley

    Manuel Portero-Otin

  194. Cell Death and Learning Impairment in Mice Caused by in Vitro Modified Pro-NGF Can Be Related to Its Increased Oxidative Modifications in Alzheimer Disease

    Article • American Journal Of Pathology, December 2009, Elsevier

    Manuel Portero-Otin

  195. Hyperglycemia and Glycation in Diabetic Complications

    Article • Antioxidants & Redox Signaling, December 2009, Mary Ann Liebert Inc

    Manuel Portero-Otin

  196. Dietary antioxidants interfere with Amplex Red-coupled-fluorescence assays

    Article • Biochemical and Biophysical Research Communications, October 2009, Elsevier

    Manuel Portero-Otin

  197. Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart

    Article • Journal of Bioenergetics and Biomembranes, June 2009, Springer Science + Business Media

    Manuel Portero-Otin

  198. Erratum

    Article • Journal of Neuropathology & Experimental Neurology, January 2009, Oxford University Press (OUP)

    Manuel Portero-Otin

  199. Type-Dependent Oxidative Damage in Frontotemporal Lobar Degeneration: Cortical Astrocytes Are Targets of Oxidative Damage

    Article • Journal of Neuropathology & Experimental Neurology, December 2008, Oxford University Press (OUP)

    Manuel Portero-Otin

  200. Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver

    Article • Biogerontology, November 2008, Springer Science + Business Media

    Manuel Portero-Otin

  201. Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease

    Article • Free Radical Biology and Medicine, October 2008, Elsevier

    Manuel Portero-Otin

  202. Effect of Every Other Day Feeding on Mitochondrial Free Radical Production and Oxidative Stress in Mouse Liver

    Article • Rejuvenation Research, June 2008, SAGE Publications

    Manuel Portero-Otin

  203. Maillard Reaction versus Other Nonenzymatic Modifications in Neurodegenerative Processes

    Article • Annals of the New York Academy of Sciences, April 2008, Wiley

    Manuel Portero-Otin

  204. Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats

    Article • Biochemical and Biophysical Research Communications, April 2008, Elsevier

    Manuel Portero-Otin

  205. Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

    Article • Human Molecular Genetics, March 2008, Oxford University Press (OUP)

    Manuel Portero-Otin

  206. Methionine Restriction Decreases Endogenous Oxidative Molecular Damage and Increases Mitochondrial Biogenesis and Uncoupling Protein 4 in Rat Brain

    Article • Rejuvenation Research, December 2007, SAGE Publications

    Manuel Portero-Otin

  207. Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor‐β: implications for diabetic atherosclerosis

    Article • The FASEB Journal, May 2007, Wiley

    Manuel Portero-Otin

  208. Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver

    Article • Biogerontology, May 2007, Springer Science + Business Media

    Manuel Portero-Otin

  209. Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis

    Article • Brain, May 2007, Oxford University Press (OUP)

    Manuel Portero-Otin

  210. Survival and death of mature avian motoneurons in organotypic slice culture: Trophic requirements for survival and different types of degeneration

    Article • The Journal of Comparative Neurology, February 2007, Wiley

    Manuel Portero-Otin

  211. Fiebre reumática: entidad subyacente en un caso de amigdalitis

    Article • Medicina de Familia SEMERGEN, December 2006, Elsevier

    Manuel Portero-Otin

  212. Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease

    Article • Journal of Neurochemistry, July 2006, Wiley

    Manuel Portero-Otin

  213. Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria

    Article • Biogerontology, July 2006, Springer Science + Business Media

    Manuel Portero-Otin

  214. Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

    Article • The FASEB Journal, June 2006, Wiley

    Manuel Portero-Otin

  215. Effect of experimental and cold exposure induced hyperthyroidism on H2O2 production and susceptibility to oxidative stress of rat liver mitochondria

    Article • Archives of Biochemistry and Biophysics, March 2006, Elsevier

    Manuel Portero-Otin

  216. Effects of fasting on oxidative stress in rat liver mitochondria

    Article • Free Radical Research, January 2006, Taylor & Francis

    Manuel Portero-Otin

  217. Lesión oxidativa de proteínas de hígado y corazón de rata durante el proceso de envejecimiento

    Article • Revista Española de Geriatría y Gerontología, January 2006, Elsevier

    Manuel Portero-Otin

  218. Stimulation of Suicidal Erythrocyte Death by Methylglyoxal

    Article • Cellular Physiology and Biochemistry, January 2006, Karger Publishers

    Manuel Portero-Otin

  219. Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate

    Article • AGE, December 2005, Springer Science + Business Media

    Manuel Portero-Otin

  220. Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals

    Article • Mechanisms of Ageing and Development, October 2005, Elsevier

    Manuel Portero-Otin

  221. Proteins in Human Brain Cortex Are Modified by Oxidation, Glycoxidation, and Lipoxidation

    Article • Journal of Biological Chemistry, June 2005, Elsevier

    Manuel Portero-Otin

  222. Fluorescent Products from Aminophospholipids and Glucose

    Article • January 2005, Elsevier

    Manuel Portero-Otin

  223. Mitochondrial Aminophospholipid Modification by Advanced Maillard Reaction is Related to the Longevity of Mammalian Species

    Article • January 2005, Elsevier

    Manuel Portero-Otin

  224. Presence of Pyrraline in Human Urine and its Relationship with Glycaemic Control

    Article • January 2005, Elsevier

    Manuel Portero-Otin

  225. Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals

    Article • Biogerontology, January 2005, Springer Science + Business Media

    Manuel Portero-Otin

  226. Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon

    Article • Experimental Gerontology, October 2004, Elsevier

    Manuel Portero-Otin

  227. Advanced glycation end products in urine: Are some sugar-derived products better than others?

    Article • Journal of Laboratory and Clinical Medicine, August 2004, Elsevier

    Manuel Portero-Otin

  228. Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria

    Article • Mechanisms of Ageing and Development, August 2004, Elsevier

    Manuel Portero-Otin

  229. Cold-induced hyperthyroidism produces oxidative damage in rat tissues and increases susceptibility to oxidants

    Article • The International Journal of Biochemistry & Cell Biology, July 2004, Elsevier

    Manuel Portero-Otin

  230. Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain

    Article • Experimental Gerontology, May 2004, Elsevier

    Manuel Portero-Otin

  231. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling

    Article • The EMBO Journal, August 2003, Springer Science + Business Media

    Manuel Portero-Otin

  232. Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3

    Article • Biochemical Journal, December 2002, Portland Press Ltd.

    Manuel Portero-Otin

  233. Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls

    Article • Mechanisms of Ageing and Development, September 2002, Elsevier

    Manuel Portero-Otin

  234. Influence of hyper‐ and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle

    Article • Molecular and Cellular Biochemistry, May 2001, Springer Science + Business Media

    Manuel Portero-Otin

  235. Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage

    Article • Mechanisms of Ageing and Development, April 2001, Elsevier

    Manuel Portero-Otin

  236. Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals

    Article • Mechanisms of Ageing and Development, January 2000, Elsevier

    Manuel Portero-Otin

  237. Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.

    Article • Diabetes, November 1999, American Diabetes Association

    Manuel Portero-Otin

  238. Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins

    Article • Free Radical Biology and Medicine, October 1999, Elsevier

    Manuel Portero-Otin

  239. A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat

    Article • Mechanisms of Ageing and Development, January 1999, Elsevier

    Manuel Portero-Otin

  240. Effect of thyroid status on lipid composition and peroxidation in the mouse liver

    Article • Free Radical Biology and Medicine, January 1999, Elsevier

    Manuel Portero-Otin

  241. Carboxymethylated phosphatidylethanolamine in mitochondrial membranes of mammals

    Article • European Journal of Biochemistry, August 1998, Wiley

    Manuel Portero-Otin

  242. Urinary pyrraline as a biochemical marker of non-oxidative maillard reactions in vivo

    Article • Life Sciences, December 1996, Elsevier

    Manuel Portero-Otin

  243. Pyrraline Ether Crosslinks as a Basis for Protein Crosslinking by the Advanced Maillard Reaction in Aging and Diabetes

    Article • Archives of Biochemistry and Biophysics, January 1996, Elsevier

    Manuel Portero-Otin

  244. Structure of advanced Maillard reaction products and their pathological role

    Article • Nephrology Dialysis Transplantation, January 1996, Oxford University Press (OUP)

    Manuel Portero-Otin

  245. Evidence for the Maillard reaction in rat lung collagen and its relationship with solubility and age

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, August 1995, Elsevier

    Manuel Portero-Otin

  246. Chromatographic evidence for amadori product formation in rat liver aminophospholipids

    Article • Life Sciences, July 1995, Elsevier

    Manuel Portero-Otin

  247. Chromatographic evidence for pyrraline formation during protein glycation in vitro and in vivo

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, February 1995, Elsevier

    Manuel Portero-Otin

  248. Relationship between solubility and fluorescence due to glycoxidation products in rat lung collagen

    Article • Free Radical Biology and Medicine, November 1993, Elsevier

    Manuel Portero-Otin

  249. Mechanisms of glycation in atherogenesis

    Article • Medical Hypotheses, March 1993, Elsevier

    Manuel Portero-Otin