All Stories

  1. Small Molecule-facilitated Degradation of ANO1 Protein: A NEW TARGETING APPROACH FOR ANTICANCER THERAPEUTICS

    Article • Journal of Biological Chemistry, March 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lewis Whitehead

  2. Automated Ligand- and Structure-Based Protocol for in Silico Prediction of Human Serum Albumin Binding

    Article • Journal of Chemical Information and Modeling, April 2013, American Chemical Society (ACS)

    Dr Lewis Whitehead

  3. Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B

    Article • PLoS ONE, September 2012, PLOS

    Dr Lewis Whitehead

  4. Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

    Article • Bioorganic & Medicinal Chemistry Letters, September 2012, Elsevier

    Dr Lewis Whitehead

  5. The Chemical Tuning of a Weak Zinc Binding Motif for Histone Deacetylase Using Electronic Effects

    Article • Chemical Biology & Drug Design, May 2012, Wiley

    Dr Lewis Whitehead

  6. Discovery of LFF571: An Investigational Agent for Clostridium difficile Infection

    Article • Journal of Medicinal Chemistry, March 2012, American Chemical Society (ACS)

    Dr Lewis Whitehead

  7. Antibacterial Optimization of 4-Aminothiazolyl Analogues of the Natural Product GE2270 A: Identification of the Cycloalkylcarboxylic Acids

    Article • Journal of Medicinal Chemistry, December 2011, American Chemical Society (ACS)

    Dr Lewis Whitehead

  8. An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential

    Article • Journal of Cheminformatics, November 2011, Springer Science + Business Media

    Dr Lewis Whitehead

  9. Atomic-scale characterization of conformational changes in the preQ1 riboswitch aptamer upon ligand binding

    Article • Journal of Molecular Graphics and Modelling, September 2011, Elsevier

    Dr Lewis Whitehead

  10. In VitroandIn VivoActivities of Novel, Semisynthetic Thiopeptide Inhibitors of Bacterial Elongation Factor Tu

    Article • Antimicrobial Agents and Chemotherapy, August 2011, ASM Journals

    Dr Lewis Whitehead

  11. The design, synthesis and structure–activity relationships of novel isoindoline-based histone deacetylase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, August 2011, Elsevier

    Dr Lewis Whitehead

  12. Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

    Article • Bioorganic & Medicinal Chemistry, August 2011, Elsevier

    Dr Lewis Whitehead

  13. Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors

    Article • Journal of Medicinal Chemistry, July 2011, American Chemical Society (ACS)

    Dr Lewis Whitehead

  14. Avoidance of the Ames test liability for aryl–amines via computation

    Article • Bioorganic & Medicinal Chemistry, May 2011, Elsevier

    Dr Lewis Whitehead

  15. Conformational Refinement of Hydroxamate-Based Histone Deacetylase Inhibitors and Exploration of 3-Piperidin-3-ylindole Analogues of Dacinostat (LAQ824)

    Article • Journal of Medicinal Chemistry, April 2010, American Chemical Society (ACS)

    Dr Lewis Whitehead

  16. A Collaborative Hit-to-Lead Investigation Leveraging Medicinal Chemistry Expertise with High Throughput Library Design, Synthesis and Purification Capabilities

    Article • Combinatorial Chemistry & High Throughput Screening, February 2006, Bentham Science Publishers

    Dr Lewis Whitehead

  17. Application of Non-Parametric Regression to Quantitative Structure–Activity Relationships

    Article • Bioorganic & Medicinal Chemistry, April 2002, Elsevier

    Dr Lewis Whitehead

  18. Molecular dynamics simulation of the hydrocarbon region of a biomembrane using a reduced representation model

    Article • Journal of Computational Chemistry, January 2001, Wiley

    Dr Lewis Whitehead

  19. γ-Dissociations of 3-alkylbicyclo[1.1.1]pent-1-yl radicals into [1.1.1]propellane and alkyl radicals: verification of a theoretical prediction

    Article • Physical Chemistry Chemical Physics, January 1999, Royal Society of Chemistry

    Dr Lewis Whitehead, Dr John C. Walton