All Stories

  1. Interfering with HuR–RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

    Article • Journal of Medicinal Chemistry, January 2018, American Chemical Society (ACS)

    Dr Leonardo Manzoni

  2. Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ6 Integrin by Biochemical and Molecular Docking Studies

    Article • Cancers, September 2017, MDPI AG

    Dr Leonardo Manzoni

  3. Regulation of HuR structure and function by dihydrotanshinone-I

    Article • Nucleic Acids Research, July 2017, Oxford University Press (OUP)

    Dr Leonardo Manzoni

  4. 4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn 2+ chelators as dual action antitumoral agents

    Article • Bioorganic & Medicinal Chemistry Letters, April 2017, Elsevier

    Dr Leonardo Manzoni

  5. Integrin-targeted peptide- and peptidomimetic-drug conjugates for the treatment of tumors

    Article • Recent Patents on Anti-Cancer Drug Discovery, February 2017, Bentham Science Publishers

    Dr Leonardo Manzoni, Dr. Paola Perego

  6. Dual action Smac mimetics–zinc chelators as pro-apoptotic antitumoral agents

    Article • Bioorganic & Medicinal Chemistry Letters, August 2016, Elsevier

    Dr Leonardo Manzoni

  7. New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Dr Leonardo Manzoni

  8. Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Dr Leonardo Manzoni

  9. Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD–paclitaxel conjugates for integrin-assisted drug delivery

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Dr Leonardo Manzoni, Dr. Paola Perego

  10. Enhancement of the Uptake and Cytotoxic Activity of Doxorubicin in Cancer Cells by Novel cRGD-Semipeptide-Anchoring Liposomes

    Article • Molecular Pharmaceutics, July 2014, American Chemical Society (ACS)

    Dr Leonardo Manzoni

  11. Synthesis and biological evaluation of dual actioncyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5integrins and IAP proteins

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Dr Leonardo Manzoni

  12. Iron Oxide-Gold Core-Shell Nanoparticles as Multimodal Imaging Contrast Agent

    Article • IEEE Sensors Journal, June 2013, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Leonardo Manzoni

  13. MicroPET/CT imaging of αvβ3 integrin via a novel 68Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction

    Article • European Journal of Nuclear Medicine and Molecular Imaging, May 2013, Springer Science + Business Media

    Dr Leonardo Manzoni

  14. Molecular Targeting of Imaging and Drug Delivery Probes in Atherosclerosis

    Article • January 2013, Elsevier

    Dr Leonardo Manzoni

  15. Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

    Article • Bioorganic & Medicinal Chemistry, November 2012, Elsevier

    Dr Leonardo Manzoni, Dr. Paola Perego

  16. Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

    Article • Bioorganic & Medicinal Chemistry, November 2012, Elsevier

    Dr Leonardo Manzoni, Professor Martino Bolognesi, Dr. Paola Perego

  17. Design, Synthesis, and Biological Evaluation of Novel cRGD–Paclitaxel Conjugates for Integrin-Assisted Drug Delivery

    Article • Bioconjugate Chemistry, August 2012, American Chemical Society (ACS)

    Dr Leonardo Manzoni, Dr. Paola Perego

  18. Synthesis of Gd and68Ga Complexes in Conjugation with a Conformationally Optimized RGD Sequence as Potential MRI and PET Tumor-Imaging Probes

    Article • ChemMedChem, April 2012, Wiley

    Dr Leonardo Manzoni

  19. A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts

    Article • Contrast Media & Molecular Imaging, November 2011, Wiley

    Dr Leonardo Manzoni

  20. Characterization of iron oxide-gold core-shell multifunctional nanoparticles in biomedical imaging

    Article • October 2011, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Leonardo Manzoni

  21. Cyclic RGD Functionalized Gold Nanoparticles for Tumor Targeting

    Article • Bioconjugate Chemistry, April 2011, American Chemical Society (ACS)

    Dr Leonardo Manzoni

  22. Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis

    Article • Investigational New Drugs, July 2010, Springer Science + Business Media

    Dr Leonardo Manzoni

  23. Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

    Article • British Journal of Cancer, May 2010, Nature

    Dr Leonardo Manzoni, Professor Martino Bolognesi

  24. Cyclic RGD-Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

    Article • Chemistry - A European Journal, October 2009, Wiley

    Dr Leonardo Manzoni

  25. Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP Protein Family

    Article • Journal of Molecular Biology, September 2009, Elsevier

    Dr Leonardo Manzoni, Professor Martino Bolognesi

  26. Functionalized Cyclic RGD Peptidomimetics: Conjugable ligands for α v β 3 Receptor Imaging

    Article • Bioconjugate Chemistry, August 2009, American Chemical Society (ACS)

    Dr Leonardo Manzoni

  27. Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy

    Article • Bioorganic & Medicinal Chemistry, August 2009, Elsevier

    Dr Leonardo Manzoni, Professor Martino Bolognesi

  28. Cyclic RGD-Containing Functionalized Azabicycloalkane Peptides as Potent Integrin Antagonists for Tumor Targeting

    Article • ChemMedChem, April 2009, Wiley

    Dr Leonardo Manzoni

  29. 4-Aminoproline-based arginine-glycine-aspartate integrin binders with exposed ligation points: practical in-solution synthesis, conjugation and binding affinity evaluation

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Dr Leonardo Manzoni

  30. Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

    Article • Biochemical and Biophysical Research Communications, January 2009, Elsevier

    Dr Leonardo Manzoni, Professor Martino Bolognesi

  31. Targeting the X-Linked Inhibitor of Apoptosis Protein through 4-Substituted Azabicyclo[5.3.0]alkane Smac Mimetics. Structure, Activity, and Recognition Principles

    Article • Journal of Molecular Biology, December 2008, Elsevier

    Dr Leonardo Manzoni, Professor Martino Bolognesi

  32. A Potent Integrin Antagonist from a Small Library of Cyclic RGD Pentapeptide Mimics Including Benzyl-Substituted Azabicycloalkane Amino Acids

    Article • ChemMedChem, October 2008, Wiley

    Dr Leonardo Manzoni

  33. Nonpeptide Integrin Antagonists: RGD Mimetics Incorporating Substituted Azabicycloalkanes as Amino Acid Replacements

    Article • European Journal of Organic Chemistry, March 2007, Wiley

    Dr Leonardo Manzoni

  34. Click chemistry to functionalise peptidomimetics

    Article • Tetrahedron Letters, May 2006, Elsevier

    Dr Leonardo Manzoni

  35. Froc: A New Fluorous Protective Group for Peptide and Oligosaccharide Synthesis †

    Article • Organic Letters, March 2006, American Chemical Society (ACS)

    Dr Leonardo Manzoni

  36. Targeting integrins: Insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

    Article • Bioorganic & Medicinal Chemistry, January 2006, Elsevier

    Professor Anna Bernardi, Dr Leonardo Manzoni

  37. Synthesis of Functionalized Azabicycloalkane Amino Acids as Dipeptide Mimics

    Article • Synthesis, January 2006, Thieme Publishing Group

    Dr Leonardo Manzoni

  38. Biological and molecular properties of a new  v 3/ v 5 integrin antagonist

    Article • Molecular Cancer Therapeutics, November 2005, American Association for Cancer Research (AACR)

    Dr Leonardo Manzoni

  39. Synthesis of some oligopyridine–galactose conjugates and their metal complexes: a simple entry to multivalent sugar ligands

    Article • Tetrahedron, October 2005, Elsevier

    Dr Leonardo Manzoni

  40. Functionalized Azabicycloalkane Amino Acids by Nitrone 1,3-Dipolar Intramolecular Cycloaddition

    Article • The Journal of Organic Chemistry, May 2005, American Chemical Society (ACS)

    Dr Leonardo Manzoni

  41. Synthesis of the Lewis a Trisaccharide Based on an Anomeric Silyl Fluorous Tag.

    Article • ChemInform, February 2005, Wiley

    Dr Leonardo Manzoni

  42. Synthesis of the Lewis a Trisaccharide Based on an Anomeric Silyl Fluorous Tag

    Article • Organic Letters, November 2004, American Chemical Society (ACS)

    Dr Leonardo Manzoni

  43. Stereoselective synthesis of Cα-tetrasubstituted azabicyclo[X.3.0]alkane amino acids

    Article • Tetrahedron Letters, August 2004, Elsevier

    Dr Leonardo Manzoni

  44. The first example of ring-closing olefin metathesis of dehydroamino acids: an application to the synthesis of azabicyclo[X.Y.0]alkanes

    Article • Tetrahedron Letters, March 2004, Elsevier

    Dr Leonardo Manzoni

  45. Synthesis of Conformationally Restricted and Optically Pure Analogues of Serine-Proline Dipeptide via Aldol Condensation

    Article • Synthesis, January 2004, Thieme Publishing Group

    Dr Leonardo Manzoni

  46. Synthesis of Conformationally Restricted and Optically Pure Analogues of Serine­-Proline Dipeptide via Aldol Condensation

    Article • Synthesis, January 2004, Thieme Publishing Group

    Dr Leonardo Manzoni

  47. Design, Synthesis, Conformational Analysis and Application of Azabicyclo­alkane Amino Acids as Constrained Dipeptide Mimics

    Article • Synlett, January 2004, Thieme Publishing Group

    Dr Leonardo Manzoni

  48. Synthesis of substituted conformationally constrained 6,5- and 7,5-fused bicyclic lactams as dipeptide mimics

    Article • Tetrahedron, August 2003, Elsevier

    Dr Leonardo Manzoni

  49. Synthesis of new bicyclic lactam peptidomimetics by ring-closing metathesis reactions

    Article • Tetrahedron, June 2003, Elsevier

    Dr Leonardo Manzoni

  50. Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residueElectronic supplementary information (ESI) available: synthetic details, product characterisations and full NOE contact list. See http://www.rsc.org/suppdata/ob/b2/b21...

    Article • Organic & Biomolecular Chemistry, February 2003, Royal Society of Chemistry

    Professor Anna Bernardi, Dr Leonardo Manzoni

  51. Rapid synthesis of oligosaccharides using an anomeric fluorous silyl protecting groupElectronic supplementary information (ESI) available: experimental data. See http://www.rsc.org/suppdata/cc/b3/b311448a/

    Article • Chemical Communications, January 2003, Royal Society of Chemistry

    Dr Leonardo Manzoni

  52. Stereoselective Synthesis of a Functionalized 2-Oxo-1-azabicyclo[5.3.0]alkane as a Potential Scaffold for Targeted Chemotherapy Strategies

    Article • Synthesis, January 2003, Thieme Publishing Group

    Dr Leonardo Manzoni

  53. Cyclic RGD Peptides Containing Azabicycloalkane Reverse-Turn Mimics

    Article • Helvetica Chimica Acta, December 2002, Wiley

    Dr Leonardo Manzoni

  54. Stereoselective Synthesis of Conformationally Constrained Cyclohexanediols:  A Set of Molecular Scaffolds for the Synthesis of Glycomimetics

    Article • The Journal of Organic Chemistry, September 2001, American Chemical Society (ACS)

    Dr Leonardo Manzoni, Professor Anna Bernardi

  55. Practical stereoselective synthesis of conformationally constrained unnatural proline-based amino acids and peptidomimetics

    Article • Tetrahedron, July 2001, Elsevier

    Dr Leonardo Manzoni

  56. Potent Integrin Antagonists from a Small Library of RGD-Including Cyclic Pseudopeptides

    Article • Organic Letters, April 2001, American Chemical Society (ACS)

    Dr Leonardo Manzoni

  57. Synthesis of spiroazabicycloalkane amino acid scaffolds as reverse-turn inducer dipeptide mimics

    Article • Tetrahedron, January 2001, Elsevier

    Dr Leonardo Manzoni

  58. ChemInform Abstract: Synthesis of 8,5-Fused Bicyclic Lactam by Stereo- and Regioselective Radical Cyclization.

    Article • ChemInform, December 2000, Wiley

    Dr Leonardo Manzoni

  59. Conformational Analysis of Azabicycloalkane Amino Acid Scaffolds as Reverse-Turn Inducer Dipeptide Mimics

    Article • European Journal of Organic Chemistry, July 2000, Wiley

    Dr Leonardo Manzoni

  60. Conformational Analysis of Azabicycloalkane Amino Acid Scaffolds as Reverse-Turn Inducer Dipeptide Mimics

    Article • European Journal of Organic Chemistry, July 2000, Wiley

    Dr Leonardo Manzoni

  61. Synthesis of Azabicycloalkane Amino Acid Scaffolds as Reverse-Turn Inducer Dipeptide Mimics

    Article • European Journal of Organic Chemistry, July 2000, Wiley

    Dr Leonardo Manzoni

  62. Synthesis of Azabicycloalkane Amino Acid Scaffolds as Reverse-Turn Inducer Dipeptide Mimics

    Article • European Journal of Organic Chemistry, July 2000, Wiley

    Dr Leonardo Manzoni

  63. Synthesis of a Pseudo Tetrasaccharide Mimic of Ganglioside GM1

    Article • European Journal of Organic Chemistry, June 1999, Wiley

    Dr Leonardo Manzoni

  64. Solid-Phase Synthesis of Peptides Containing Reverse-Turn Mimetic Bicyclic Lactams

    Article • European Journal of Organic Chemistry, February 1999, Wiley

    Dr Leonardo Manzoni

  65. Synthesis of N-acetylglucosamine containing Lewis A and Lewis X building blocks based on N-tetrachlorophthaloyl protection—synthesis of Lewis X pentasaccharide

    Article • Carbohydrate Research, August 1998, Elsevier

    Dr Leonardo Manzoni

  66. Stereoselective synthesis of 6,5-bicyclic reverse-turn peptidomimetics

    Article • Tetrahedron, May 1998, Elsevier

    Dr Leonardo Manzoni

  67. Synthesis of Lewis a and Lewis X Pentasaccharides Based on N-Trichloroethoxycarbonyl Protection

    Article • Journal of Carbohydrate Chemistry, May 1998, Taylor & Francis

    Dr Leonardo Manzoni

  68. Diastereoselective addition of metal-coordinated and “naked” nucleophilic reagents to norephedrine derived 2-acyl-N-tosyl-oxazolidines

    Article • Tetrahedron, February 1997, Elsevier

    Dr Leonardo Manzoni

  69. N-Trichloroethoxycarbonyl-glucosamine derivatives as glycosyl donors

    Article • Carbohydrate Research, December 1996, Elsevier

    Dr Leonardo Manzoni

  70. A Practical Way to 2,5-Disubstituted Pyrrolidine Derivatives

    Article • Synlett, May 1996, Thieme Publishing Group

    Dr Leonardo Manzoni

  71. Diastereoselective Addition of Organometallic Reagents to Nor-Ephedrine-Derived 2-Acyl-N-Tosyl-Oxazolidines

    Article • Synlett, January 1995, Thieme Publishing Group

    Dr Leonardo Manzoni

  72. Conformationally constrained dipeptides: Synthesis of 7,5- and 6,5-fused bicyclic lactams by stereoselective radical cyclizations

    Article • Tetrahedron Letters, January 1995, Elsevier

    Dr Leonardo Manzoni

  73. Synthesis of 7,5-fused bicyclic lactams by stereoselective radical cyclization

    Article • Tetrahedron Letters, June 1994, Elsevier

    Dr Leonardo Manzoni

  74. The first asymmetric synthesis of enantiopure .alpha.-sulfenyl dithioacetals and .alpha.-sulfenyl aldehydes

    Article • The Journal of Organic Chemistry, May 1993, American Chemical Society (ACS)

    Dr Leonardo Manzoni

  75. Asymmetric Synthesis of Enantiopure α-Sulfenyl Dithioacetals and α-Sulfenyl Aldehydes

    Article • Phosphorus Sulfur and Silicon and the Related Elements, January 1993, Taylor & Francis

    Dr Leonardo Manzoni

  76. Diastereoselective addition of metal-coordinated and ‘naked’ tri-sec-butylborohydrides to a norephedrine-derived 2-acetyloxazolidine

    Article • Journal of the Chemical Society Chemical Communications, January 1992, Royal Society of Chemistry

    Dr Leonardo Manzoni