All Stories

  1. Receptor Interacting Ser/Thr-Protein Kinase 2 as a New Therapeutic Target

    Article • Journal of Medicinal Chemistry, October 2023, American Chemical Society (ACS)

    Laurent Dubuquoy

  2. An extended transcription factor regulatory network controls hepatocyte identity

    Article • EMBO Reports, July 2023, EMBO

    Laurent Dubuquoy

  3. Starch nanoparticles improve curcumin-induced production of anti-inflammatory cytokines in intestinal epithelial cells

    Article • International Journal of Pharmaceutics X, December 2022, Elsevier

    Laurent Dubuquoy

  4. Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice

    Article • Environmental Research, September 2022, Elsevier

    Laurent Dubuquoy

  5. Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist

    Article • Life Science Alliance, July 2022, Life Science Alliance, LLC

    Laurent Dubuquoy

  6. Starch-based NP act as antigen delivery systems without immunomodulating effect

    Article • PLoS ONE, July 2022, PLOS

    Laurent Dubuquoy

  7. MicroRNAs, Tristetraprolin Family Members and HuR: A Complex Interplay Controlling Cancer-Related Processes

    Article • Cancers, July 2022, MDPI AG

    Laurent Dubuquoy

  8. Murine in utero exposure to simulated complex urban air pollution disturbs offspring gut maturation and microbiota during intestinal suckling-to-weaning transition in a sex-dependent manner

    Article • Particle and Fibre Toxicology, June 2022, Springer Science + Business Media

    Laurent Dubuquoy

  9. Exposure to atmospheric Ag, TiO2, Ti and SiO2 engineered nanoparticles modulates gut inflammatory response and microbiota in mice

    Article • Ecotoxicology and Environmental Safety, May 2022, Elsevier

    Laurent Dubuquoy

  10. The PPARγ-dependent effect of flavonoid luteolin against damage induced by the chemotherapeutic irinotecan in human intestinal cells

    Article • Chemico-Biological Interactions, January 2022, Elsevier

    Laurent Dubuquoy

  11. Loss of hepatocyte identity following aberrant YAP activation: A key mechanism in alcoholic hepatitis

    Article • Journal of Hepatology, October 2021, Elsevier

    Laurent Dubuquoy

  12. Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis

    Article • Gastroenterology, April 2021, Elsevier

    Laurent Dubuquoy

  13. The Impact of Modern Chemotherapy and Chemotherapy-Associated Liver Injuries (CALI) on Liver Function: Value of 99mTc-Labelled-Mebrofenin SPECT-Hepatobiliary Scintigraphy

    Article • Annals of Surgical Oncology, August 2020, Springer Science + Business Media

    Laurent Dubuquoy

  14. IL-33/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis

    Article • Journal of Hepatology, June 2020, Elsevier

    Laurent Dubuquoy

  15. Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

    Article • British Journal of Pharmacology, February 2020, Wiley

    Laurent Dubuquoy

  16. Severe SARS‐CoV‐2 patients develop a higher specific T‐cell response

    Article • Clinical & Translational Immunology, January 2020, Wiley

    Laurent Dubuquoy

  17. A Novel Mouse Model of Acute‐on‐Chronic Cholestatic Alcoholic Liver Disease: A Systems Biology Comparison With Human Alcoholic Hepatitis

    Article • Alcoholism Clinical and Experimental Research, November 2019, Wiley

    Laurent Dubuquoy

  18. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

    Article • Nature Communications, July 2019, Springer Science + Business Media

    Laurent Dubuquoy

  19. Contribution of the Gut Microbiota in P28GST-Mediated Anti-Inflammatory Effects: Experimental and Clinical Insights

    Article • Cells, June 2019, MDPI AG

    Laurent Dubuquoy

  20. Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules

    Article • Journal of Hepatology, June 2019, Elsevier

    Laurent Dubuquoy

  21. Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis

    Article • Hepatology, March 2019, Wiley

    Laurent Dubuquoy

  22. Treatment with P28GST, a schistosome-derived enzyme, after acute colitis induction in mice: Decrease of intestinal inflammation associated with a down regulation of Th1/Th17 responses

    Article • PLoS ONE, December 2018, PLOS

    Laurent Dubuquoy

  23. β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway

    Article • Journal of Hepatology, September 2018, Elsevier

    Laurent Dubuquoy

  24. Cholesterol-enriched membrane microdomains are needed for insulin signaling and proliferation in hepatic cells

    Article • AJP Gastrointestinal and Liver Physiology, July 2018, American Physiological Society

    Laurent Dubuquoy

  25. High carriage of adherent invasive E. coli in wildlife and healthy individuals

    Article • Gut Pathogens, June 2018, Springer Science + Business Media

    Laurent Dubuquoy

  26. Cross regulation between mTOR signaling and O-GlcNAcylation

    Article • Journal of Bioenergetics and Biomembranes, March 2018, Springer Science + Business Media

    Laurent Dubuquoy

  27. Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis

    Article • Gastroenterology, March 2018, Elsevier

    Laurent Dubuquoy

  28. Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models

    Article • BMC Complementary and Alternative Medicine, January 2018, Springer Science + Business Media

    Laurent Dubuquoy

  29. One- or Two-Step Synthesis of C-8 and N-9 Substituted Purines

    Article • The Journal of Organic Chemistry, December 2017, American Chemical Society (ACS)

    Laurent Dubuquoy

  30. Peroxisome proliferator‐activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut

    Article • EMBO Molecular Medicine, September 2017, EMBO

    Daniel Metzger, Laurent Dubuquoy

  31. The Expression of the Short Isoform of Thymic Stromal Lymphopoietin in the Colon Is Regulated by the Nuclear Receptor Peroxisome Proliferator Activated Receptor-Gamma and Is Impaired during Ulcerative Colitis

    Article • Frontiers in Immunology, September 2017, Frontiers

    Laurent Dubuquoy

  32. Chronic bowel inflammation and inflammatory joint disease: Pathophysiology

    Article • Joint Bone Spine, July 2017, Elsevier

    Laurent Dubuquoy

  33. Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination

    Article • Gut Pathogens, February 2017, Springer Science + Business Media

    Laurent Dubuquoy

  34. Whole transcriptome analysis of ductular reaction from patients with alcoholic hepatitis. Similarities to ductular reaction in DDC mouse model

    Article • Journal of Hepatology, January 2017, Elsevier

    Laurent Dubuquoy

  35. Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease

    Article • American Journal Of Pathology, December 2016, Elsevier

    Laurent Dubuquoy

  36. Microbiote intestinal et développement des maladies inflammatoires chroniques de l’intestin

    Article • médecine/sciences, November 2016, EDP Sciences

    Laurent Dubuquoy

  37. Periodontal manifestations of inflammatory bowel disease: emerging epidemiologic and biologic evidence

    Article • Journal of Periodontal Research, September 2016, Wiley

    Laurent Dubuquoy

  38. Erratum: Corrigendum: Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients

    Article • Scientific Reports, September 2016, Springer Science + Business Media

    Laurent Dubuquoy

  39. Inflammation chronique de l’intestin et rhumatismes inflammatoires : physiopathologie

    Article • Revue du Rhumatisme Monographies, September 2016, Elsevier

    Laurent Dubuquoy

  40. Short fungal fractions of β-1,3 glucans affect platelet activation

    Article • AJP Heart and Circulatory Physiology, September 2016, American Physiological Society

    Laurent Dubuquoy

  41. Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients

    Article • Scientific Reports, July 2016, Springer Science + Business Media

    Laurent Dubuquoy

  42. MicroRNA in alcoholic hepatitis: implications for pathophysiology and treatment

    Article • Gut, June 2016, BMJ

    Laurent Dubuquoy

  43. Tu1881 HLA B27 Transgenic Rat: A New Animal Model of Postsurgical Ileitis in Inflammatory Bowel Disease

    Article • Gastroenterology, April 2016, Elsevier

    Laurent Dubuquoy

  44. Sa1866 Mesenteric Lymphatic and Venous Vasculopathy in Crohn's Disease

    Article • Gastroenterology, April 2016, Elsevier

    Laurent Dubuquoy

  45. 979 Modulating Peroxisome Proliferator-Activated Receptor Gamma (PPARγ): A Potential New Therapeutic Strategy for Lactose Intolerance

    Article • Gastroenterology, April 2016, Elsevier

    Laurent Dubuquoy

  46. Mo1923 Polymorphisms in the Mannose Binding Lectin Gene Are Associated With the Defect of the Mannose Binding Lectin Functional Activity in Crohn's Disease Patients

    Article • Gastroenterology, April 2016, Elsevier

    Laurent Dubuquoy

  47. Sa1846 The Expression of the Short Isoform of TSLP in the Colon Is Regulated by the Nuclear Receptor PPARγ and Is Impaired During Ulcerative Colitis

    Article • Gastroenterology, April 2016, Elsevier

    Laurent Dubuquoy

  48. Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis

    Article • Inflammatory Bowel Diseases, February 2016, Oxford University Press (OUP)

    Laurent Dubuquoy

  49. Intestinal steroidogenesis

    Article • Steroids, November 2015, Elsevier

    Laurent Dubuquoy

  50. Role of mannose-binding lectin in intestinal homeostasis and fungal elimination

    Article • Mucosal Immunology, October 2015, Springer Science + Business Media

    Laurent Dubuquoy

  51. Controlled delivery of a new broad spectrum antibacterial agent against colitis: In vitro and in vivo performance

    Article • European Journal of Pharmaceutics and Biopharmaceutics, October 2015, Elsevier

    Laurent Dubuquoy

  52. The schistosome glutathione S-transferase P28GST, a unique helminth protein, prevents intestinal inflammation in experimental colitis through a Th2-type response with mucosal eosinophils

    Article • Mucosal Immunology, July 2015, Springer Science + Business Media

    Prof Mohamed M. El Nady, Laurent Dubuquoy

  53. Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier

    Article • Scientific Reports, May 2015, Springer Science + Business Media

    Laurent Dubuquoy

  54. Escherichia coli LF82 Differentially Regulates ROS Production and Mucin Expression in Intestinal Epithelial T84 Cells

    Article • Inflammatory Bowel Diseases, May 2015, Oxford University Press (OUP)

    Laurent Dubuquoy

  55. Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis

    Article • Gut, March 2015, BMJ

    Laurent Dubuquoy

  56. In vivo efficacy of microbiota-sensitive coatings for colon targeting: A promising tool for IBD therapy

    Article • Journal of Controlled Release, January 2015, Elsevier

    Laurent Dubuquoy

  57. Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration

    Article • AJP Gastrointestinal and Liver Physiology, August 2014, American Physiological Society

    Laurent Dubuquoy

  58. Intestinal steroidogenesis controls PPARγ expression in the colon and is impaired during ulcerative colitis

    Article • Gut, July 2014, BMJ

    Laurent Dubuquoy

  59. O139 ALCOHOLIC HEPATITIS RESISTANT TO MEDICAL THERAPY IS CHARACTERIZED BY AN ALTERED DIFFERENTIATION OF HEPATIC PROGENITORS UNDER THE INFLUENCE OF EXTRACELLULAR MATRIX

    Article • Journal of Hepatology, April 2014, Elsevier

    Laurent Dubuquoy

  60. P084 Dissecting the role of PPARgamma in intestinal fibrosis: EMT-activator ZEB1 as new molecular target

    Article • Journal of Crohn s and Colitis, February 2014, Oxford University Press (OUP)

    PhD Vincenzo Flati, Laurent Dubuquoy

  61. ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading

    Article • Journal of Hepatology, October 2013, Elsevier

    Laurent Dubuquoy

  62. Functional Polymorphisms in the Regulatory Regions of the VNN1 Gene Are Associated with Susceptibility to Inflammatory Bowel Diseases

    Article • Inflammatory Bowel Diseases, October 2013, Oxford University Press (OUP)

    Laurent Dubuquoy

  63. Decreased Lymphatic Vessel Density Is Associated With Postoperative Endoscopic Recurrence in Crohn’s Disease

    Article • Inflammatory Bowel Diseases, September 2013, Oxford University Press (OUP)

    Laurent Dubuquoy

  64. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ

    Article • Carcinogenesis, July 2013, Oxford University Press (OUP)

    Laurent Dubuquoy

  65. Colonic Inflammation in Mice Is Improved by Cigarette Smoke through iNKT Cells Recruitment

    Article • PLoS ONE, April 2013, PLOS

    Laurent Dubuquoy

  66. In vivoimaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice

    Article • Experimental Dermatology, January 2013, Wiley

    Laurent Dubuquoy

  67. Modulation of Intestinal Inflammation by Yeasts and Cell Wall Extracts: Strain Dependence and Unexpected Anti-Inflammatory Role of Glucan Fractions

    Article • PLoS ONE, July 2012, PLOS

    Laurent Dubuquoy

  68. Variants of NOD1 and NOD2 genes display opposite associations with familial risk of crohnʼs disease and anti-saccharomyces cerevisiae antibody levels

    Article • Inflammatory Bowel Diseases, March 2012, Wolters Kluwer Health

    Professor Boualem Sendid, Laurent Dubuquoy

  69. Visceral fat and gut inflammation

    Article • Nutrition, February 2012, Elsevier

    Laurent Dubuquoy

  70. Murine Model of Dextran Sulfate Sodium-induced Colitis RevealsCandida glabrataVirulence and Contribution of β-Mannosyltransferases

    Article • Journal of Biological Chemistry, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Laurent Dubuquoy

  71. Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease

    Article • Gut, September 2011, BMJ

    Laurent Dubuquoy

  72. Increased lymphatic vessel density and lymphangiogenesis in inflammatory bowel disease

    Article • Alimentary Pharmacology & Therapeutics, July 2011, Wiley

    Laurent Dubuquoy

  73. Obesity, visceral fat and Crohnʼs disease

    Article • Current Opinion in Clinical Nutrition & Metabolic Care, September 2010, Wolters Kluwer Health

    Laurent Dubuquoy

  74. 274 Sacharomyces Cerevisiae Cncm I-3856 Decreases Intestinal Pain Through PPAR Alpha Activation in the Gut

    Article • Gastroenterology, May 2010, Elsevier

    Laurent Dubuquoy

  75. Neutrophil Migration During Liver Injury Is Under Nucleotide-Binding Oligomerization Domain 1 Control

    Article • Gastroenterology, April 2010, Elsevier

    Laurent Dubuquoy

  76. PPARγ agonists as a new class of effective treatment for ulcerative colitis

    Article • Inflammatory Bowel Diseases, June 2009, Oxford University Press (OUP)

    Laurent Dubuquoy

  77. Peroxisome Proliferator-Activated Receptors in HBV-Related Infection

    Article • PPAR Research, January 2009, Hindawi Publishing Corporation

    Laurent Dubuquoy

  78. Peroxisome Proliferator-Activated Receptors in HCV-Related Infection

    Article • PPAR Research, January 2009, Hindawi Publishing Corporation

    Laurent Dubuquoy

  79. Resistin-like molecule β regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice

    Article • Inflammatory Bowel Diseases, July 2008, Oxford University Press (OUP)

    Laurent Dubuquoy

  80. Récepteurs nucléaires PPAR et hépatologie : implications physiopathologiques et thérapeutiques

    Article • Gastroentérologie Clinique et Biologique, March 2008, Elsevier

    Laurent Dubuquoy

  81. NOD2: a potential target for regulating liver injury

    Article • Laboratory Investigation, January 2008, Springer Science + Business Media

    Laurent Dubuquoy

  82. 32 SERUM PROTEIN PROFILING OF ALCOHOLIC HEPATITIS USING MASS SPECTROMETRY (SELDI-TOF MS PROTEINCHIP): IDENTIFICATION OF A BIOMARKER OF RESPONSE TO CORTICOSTEROIDS

    Article • Journal of Hepatology, January 2008, Elsevier

    Laurent Dubuquoy

  83. LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

    Article • Proceedings of the National Academy of Sciences, August 2007, Proceedings of the National Academy of Sciences

    Laurent Dubuquoy

  84. [30] INVOLVEMENT OF NOD SIGNALLING IN HEPATOCYTE AND IMMUNE CELLS DURING HEPATITIS

    Article • Journal of Hepatology, April 2007, Elsevier

    Laurent Dubuquoy

  85. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

    Article • Nature Reports Stem Cells, December 2006, Springer Science + Business Media

    Laurent Dubuquoy

  86. PPAR  as a new therapeutic target in inflammatory bowel diseases

    Article • Gut, September 2006, BMJ

    Laurent Dubuquoy

  87. The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine

    Article • The Journal of Experimental Medicine, August 2006, Rockefeller University Press

    Laurent Dubuquoy

  88. No Evidence for an Involvement of the P38 and JNK Mitogen-Activated Protein in Inflammatory Bowel Diseases

    Article • Digestive Diseases and Sciences, July 2006, Springer Science + Business Media

    Laurent Dubuquoy

  89. Implication of TNF-Related Apoptosis-Inducing Ligand in Inflammatory Intestinal Epithelial Lesions

    Article • Gastroenterology, June 2006, Elsevier

    Laurent Dubuquoy, Professor Jean-François Beaulieu

  90. Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity

    Article • Journal of Molecular Endocrinology, December 2005, Bioscientifica

    Laurent Dubuquoy

  91. Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ

    Article • The Journal of Experimental Medicine, April 2005, Rockefeller University Press

    Laurent Dubuquoy

  92. Impaired expression of the peroxisome proliferator–activated receptor alpha during hepatitis C virus infection

    Article • Gastroenterology, February 2005, Elsevier

    Laurent Dubuquoy

  93. Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

    Article • Proceedings of the National Academy of Sciences, January 2005, Proceedings of the National Academy of Sciences

    Laurent Dubuquoy

  94. Yersinia pseudotuberculosis Anti-Inflammatory Components Reduce Trinitrobenzene Sulfonic Acid-Induced Colitis in the Mouse

    Article • Infection and Immunity, April 2004, ASM Journals

    Laurent Dubuquoy

  95. Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis

    Article • Gastroenterology, May 2003, Elsevier

    Laurent Dubuquoy

  96. Role of peroxisome proliferator-activated receptor γ and retinoid X receptor heterodimer in hepatogastroenterological diseases

    Article • The Lancet, November 2002, Elsevier

    Laurent Dubuquoy

  97. A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity

    Article • Molecular Cell, October 2001, Elsevier

    Laurent Dubuquoy

  98. Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator–Activated Receptor γ (Pparγ) Heterodimer

    Article • The Journal of Experimental Medicine, April 2001, Rockefeller University Press

    Laurent Dubuquoy

  99. Article • PLOS

    Laurent Dubuquoy

  100. Article • PLOS

    Laurent Dubuquoy

  101. Article • PLOS

    Laurent Dubuquoy

  102. Article • PLOS

    Laurent Dubuquoy