All Stories

  1. A new effLuc/Kate dual reporter allele for tumor imaging in mice

    Article • Disease Models & Mechanisms, January 2025, The Company of Biologists

    Dr Latifa Bakiri

  2. c-Jun and Fra-2 pair up to Myc-anistically drive HCC

    Article • Cell Cycle, November 2024, Taylor & Francis

    Dr Latifa Bakiri

  3. c-Jun and Fra-2 Pair Up to Myc-anistically Drive HCC    

    Article • November 2024, Authorea, Inc.

    Dr Latifa Bakiri

  4. Dual therapeutic targeting of MYC and JUNB transcriptional programs for enhanced anti-myeloma activity

    Article • Blood Cancer Journal, August 2024, Springer Science + Business Media

    Dr Latifa Bakiri

  5. Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc (Author copy)  

    Article • April 2024, Authorea, Inc.

    Dr Latifa Bakiri

  6. Molecular signalling pathway of liver cancer development decoded

    Article • Proceedings of the National Academy of Sciences, April 2024, Proceedings of the National Academy of Sciences

    Dr Latifa Bakiri

  7. Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis

    Article • Annals of the Rheumatic Diseases, September 2023, Elsevier

    Dr Latifa Bakiri

  8. Open Thy Lattice Osteoclast, Resorb me!

    Article • Journal of Cell Biology, March 2023, Rockefeller University Press

    Dr Latifa Bakiri

  9. Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease

    Article • Annals of the Rheumatic Diseases, October 2022, Elsevier

    Dr Latifa Bakiri

  10. An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia

    Article • Proceedings of the National Academy of Sciences, February 2022, Proceedings of the National Academy of Sciences

    Dr Latifa Bakiri

  11. TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages

    Article • The Journal of Immunology, February 2022, Oxford University Press (OUP)

    Dr Latifa Bakiri

  12. Targeting AP-1 transcription factors by CRISPR in the prostate

    Article • Oncotarget, September 2021, Impact Journals, LLC

    Dr Latifa Bakiri

  13. NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

    Article • eLife, August 2021, eLife

    Dr Latifa Bakiri

  14. Calprotectin: from biomarker to biological function

    Article • Gut, June 2021, BMJ

    Dr Latifa Bakiri

  15. Sequestosome 1/p62 enhances chronic skin inflammation

    Article • Journal of Allergy and Clinical Immunology, June 2021, Elsevier

    Dr Latifa Bakiri

  16. JunB is a key regulator of multiple myeloma bone marrow angiogenesis

    Article • Leukemia Supplements, May 2021, Springer Science + Business Media

    Dr Latifa Bakiri

  17. Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells

    Article • EMBO Molecular Medicine, March 2021, EMBO

    Dr Latifa Bakiri

  18. In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun

    Article • Oncogene, March 2021, Springer Science + Business Media

    Dr Latifa Bakiri

  19. Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment

    Article • Cancer Research, February 2021, American Association for Cancer Research (AACR)

    Dr Latifa Bakiri

  20. Wnt signaling and Loxl2 promote aggressive osteosarcoma

    Article • BDJ, July 2020, Springer Science + Business Media

    Dr Latifa Bakiri

  21. Fra-2–expressing macrophages promote lung fibrosis

    Article • Journal of Clinical Investigation, July 2019, American Society for Clinical Investigation

    Dr Latifa Bakiri

  22. EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

    Article • EMBO Molecular Medicine, October 2018, EMBO

    Dr Latifa Bakiri

  23. Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

    Article • Journal of Visualized Experiments, April 2018, MyJove Corporation

    Dr Latifa Bakiri

  24. EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation

    Article • Cell Death and Differentiation, February 2018, Springer Science + Business Media

    Dr Latifa Bakiri

  25. Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas

    Article • Nature, February 2018, Springer Science + Business Media

    Dr Latifa Bakiri

  26. Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function

    Article • AJP Lung Cellular and Molecular Physiology, November 2017, American Physiological Society

    Dr Latifa Bakiri

  27. Transcriptional regulation by NR5A2 couples cell differentiation and inflammation in the pancreas

    Article • October 2017, Cold Spring Harbor Laboratory Press

    Dr Latifa Bakiri

  28. Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation

    Article • Journal of Experimental Medicine, March 2017, Rockefeller University Press

    Dr Latifa Bakiri

  29. The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment

    Article • Leukemia Supplements, November 2016, Springer Science + Business Media

    Dr Latifa Bakiri

  30. Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress

    Article • Cell Death and Disease, November 2016, Springer Science + Business Media

    Dr Latifa Bakiri

  31. News and views on EMT Fra-1 controls EMT in mammary epithelial cells

    Article • Molecular & Cellular Oncology, April 2016, Taylor & Francis

    Dr Latifa Bakiri

  32. Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus

    Article • Development, January 2015, The Company of Biologists

    Dr Latifa Bakiri

  33. Characterization of Mouse Model-Derived Osteosarcoma (OS) Cells In Vitro and In Vivo

    Article • January 2015, Springer Science + Business Media

    Dr Latifa Bakiri

  34. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2

    Article • Genes & Development, December 2014, Cold Spring Harbor Laboratory Press

    Dr Latifa Bakiri

  35. Loss of JUNB/AP-1 promotes invasive prostate cancer

    Article • Cell Death and Differentiation, December 2014, Springer Science + Business Media

    Dr Latifa Bakiri

  36. Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage

    Article • Cancer Cell, December 2014, Elsevier

    Dr Latifa Bakiri

  37. Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression

    Article • Cell Death and Differentiation, October 2014, Springer Science + Business Media

    Dr Latifa Bakiri

  38. A FATal AP-1 dimer switch in hepatosteatosis

    Article • Cell Cycle, March 2014, Taylor & Francis

    Dr Latifa Bakiri

  39. Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers

    Article • Cell Metabolism, January 2014, Elsevier

    Dr Latifa Bakiri

  40. JUNB/AP-1 controls IFN-γ during inflammatory liver disease

    Article • Journal of Clinical Investigation, November 2013, American Society for Clinical Investigation

    Dr Latifa Bakiri

  41. Activator protein 1 transcription factor fos-related antigen 1 (fra-1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism

    Article • Hepatology, October 2013, Wolters Kluwer Health

    Dr Latifa Bakiri

  42. Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos

    Article • Genes & Development, September 2013, Cold Spring Harbor Laboratory Press

    Dr Latifa Bakiri

  43. Hepatitis C virus core+1/ARF protein decreases hepcidin transcription through an AP1 binding site

    Article • Journal of General Virology, July 2013, Society for General Microbiology

    Ralf Bartenschlager, Dr Latifa Bakiri

  44. Mouse models for liver cancer

    Article • Molecular Oncology, February 2013, Wiley

    Dr Latifa Bakiri

  45. Osteoblast-specific expression of Fra-2/AP-1 controls Adiponectin/Osteocalcin expression and affects metabolism

    Article • Journal of Cell Science, January 2013, The Company of Biologists

    Dr Latifa Bakiri

  46. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

    Article • Nature Cell Biology, October 2012, Springer Science + Business Media

    Dr Latifa Bakiri

  47. Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17

    Article • Journal of Clinical Investigation, August 2012, American Society for Clinical Investigation

    Dr Latifa Bakiri

  48. Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation

    Article • Oncogene, August 2011, Springer Science + Business Media

    Dr Latifa Bakiri

  49. Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis

    Article • Oncogene, November 2010, Springer Science + Business Media

    Dr Latifa Bakiri

  50. Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production

    Article • Journal of Cell Biology, September 2010, Rockefeller University Press

    Dr Latifa Bakiri

  51. TNFα shedding and epidermal inflammation are controlled by Jun proteins

    Article • Genes & Development, November 2009, Cold Spring Harbor Laboratory Press

    Dr Latifa Bakiri

  52. JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells

    Article • PLOS One, August 2008, PLOS

    Dr Latifa Bakiri

  53. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

    Article • Nature, June 2008, Springer Science + Business Media

    Dr Latifa Bakiri

  54. c-Jun Controls Histone Modifications, NF-κB Recruitment, and RNA Polymerase II Function To Activate the ccl2 Gene

    Article • Molecular and Cellular Biology, April 2008, ASM Journals

    Dr Latifa Bakiri

  55. p38α: A Suppressor of Cell Proliferation and Tumorigenesis

    Article • Cell Cycle, October 2007, Taylor & Francis

    Dr Latifa Bakiri

  56. Dimer Composition and Promoter Context Contribute to Functional Cooperation between AP-1 and NFAT

    Article • Journal of Molecular Biology, August 2007, Elsevier

    Prof Jonathan B Weitzman, Dr Latifa Bakiri

  57. Targeting c-Jun and JunB proteins as potential anticancer cell therapy

    Article • Oncogene, July 2007, Springer Science + Business Media

    Dr Latifa Bakiri

  58. p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

    Article • Nature Genetics, April 2007, Springer Science + Business Media

    Dr Latifa Bakiri

  59. Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation

    Article • Bone, April 2007, Elsevier

    Dr Latifa Bakiri

  60. Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription

    Article • The EMBO Journal, March 2007, Wiley

    Prof Jonathan B Weitzman, Dr Latifa Bakiri

  61. Essential role of RSK2 in c-Fos–dependent osteosarcoma development

    Article • Journal of Clinical Investigation, March 2005, American Society for Clinical Investigation

    Dr Latifa Bakiri

  62. AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene

    Article • Oncogene, January 2005, Nature

    Prof Jonathan B Weitzman, Dr Latifa Bakiri

  63. Distinct functions of junD in cardiac hypertrophy and heart failure

    Article • Genes & Development, January 2005, Cold Spring Harbor Laboratory Press

    Dr Latifa Bakiri

  64. Fos and Jun Proteins Are Specifically Expressed During Differentiation of Human Keratinocytes

    Article • Journal of Investigative Dermatology, January 2005, Elsevier

    Dr Latifa Bakiri

  65. Promoter Specificity and Biological Activity of Tethered AP-1 Dimers

    Article • Molecular and Cellular Biology, July 2002, ASM Journals

    Dr Latifa Bakiri

  66. Functional cooperation between JunD and NF-κB in rat hepatocytes

    Article • Oncogene, August 2001, Nature

    Prof Jonathan B Weitzman, Dr Latifa Bakiri

  67. Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression

    Article • The EMBO Journal, May 2000, Springer Science + Business Media

    Dr Latifa Bakiri

  68. Stress-activated protein kinases are negatively regulated by cell density

    Article • The EMBO Journal, October 1998, Springer Science + Business Media

    Dr Latifa Bakiri

  69. Induction of apoptosis by the transcription factor c-Jun

    Article • The EMBO Journal, April 1997, Springer Science + Business Media

    Dr Latifa Bakiri

  70. Identification of a Novel 135-kDa Grb2-binding Protein in Osteoclasts

    Article • Journal of Biological Chemistry, December 1996, Elsevier

    Dr Latifa Bakiri