All Stories

  1. Huntingtin Levels are Elevated in Hippocampal Post-Mortem Samples of Alzheimer’s Disease Brain

    Article • Current Alzheimer Research, January 2021, Bentham Science Publishers

    Dr Lars O Tjernberg, Michael Axenhus, Sophia Schedin Weiss

  2. Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer’s Disease Pathology

    Article • Journal of Alzheimer s Disease, May 2020, IOS Press

    Dr Lars O Tjernberg, Sophia Schedin Weiss

  3. A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer’s Disease

    Article • Journal of Alzheimer s Disease, October 2019, IOS Press

    Dr Lars O Tjernberg

  4. Systemic AA amyloidosis in the red fox (Vulpes vulpes )

    Article • Protein Science, September 2017, Wiley

    Dr Lars O Tjernberg

  5. Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage

    Article • FEBS Journal, July 2015, Wiley

    Dr Lars O Tjernberg

  6. Human brain proteins showing neuron-specific interactions with γ-secretase

    Article • FEBS Journal, July 2015, Wiley

    Dr Lars O Tjernberg

  7. Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells

    Article • Molecular Neurobiology, October 2014, Springer Science + Business Media

    Dr Lars O Tjernberg

  8. A GLYCOMICS APPROACH FOR ANALYZING CEREBROSPINAL FLUID

    Article • Alzheimer s & Dementia, July 2014, Elsevier

    Dr Lars O Tjernberg

  9. SYNAPTIC ALTERATIONS IN APP KNOCKOUT NEURONS

    Article • Alzheimer s & Dementia, July 2014, Elsevier

    Dr Lars O Tjernberg

  10. NEURON-SELECTIVE GAMMA-SECRETASE INTERACTIONS WITH PROTEINS EXPRESSED IN HUMAN BRAIN

    Article • Alzheimer s & Dementia, July 2014, Elsevier

    Dr Lars O Tjernberg

  11. DISTINCT LOCALIZATION OF BETA- AND GAMMA-SECRETASE IN RAT BRAIN SYNAPSES

    Article • Alzheimer s & Dementia, July 2014, Elsevier

    Dr Lars O Tjernberg

  12. REGULATION OF APP PROCESSING BY POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED ION CHANNEL 2

    Article • Alzheimer s & Dementia, July 2014, Elsevier

    Dr Lars O Tjernberg

  13. Activity-independent release of the amyloid β-peptide from rat brain nerve terminals

    Article • Neuroscience Letters, April 2014, Elsevier

    Dr Lars O Tjernberg

  14. Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

    Article • FEBS Open Bio, January 2014, Wiley

    Dr Lars O Tjernberg

  15. The role of protein glycosylation in Alzheimer disease

    Article • FEBS Journal, November 2013, Wiley

    Dr Lars O Tjernberg

  16. Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on γ-Secretase

    Article • PLoS ONE, May 2013, PLOS

    Dr Lars O Tjernberg

  17. Correction: The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease

    Article • PLoS ONE, May 2013, PLOS

    Dr Lars O Tjernberg

  18. Correction: The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease

    Article • PLoS ONE, May 2013, PLOS

    Dr Lars O Tjernberg

  19. The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease

    Article • PLoS ONE, February 2013, PLOS

    Dr Lars O Tjernberg

  20. Monoamine oxidase B is associated with γ-secretase in cultured neurons and in brain

    Article • Molecular Neurodegeneration, January 2013, Springer Science + Business Media

    Dr Lars O Tjernberg

  21. Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production

    Article • Biochemical and Biophysical Research Communications, August 2012, Elsevier

    Dr Lars O Tjernberg

  22. Analysis of microdissected neurons by 18O mass spectrometry reveals altered protein expression in Alzheimer's disease

    Article • Journal of Cellular and Molecular Medicine, July 2012, Wiley

    Dr Lars O Tjernberg

  23. In-solution analysis of beta-amyloid

    Article • Alzheimer s & Dementia, July 2012, Elsevier

    Dr Lars O Tjernberg

  24. Monoamine oxidase B interacts with gamma-secretase: Confirmation with a new approach to the proximity ligation assay

    Article • Alzheimer s & Dementia, July 2012, Elsevier

    Dr Lars O Tjernberg

  25. The proximity ligation assay shows interaction between HCN2 and gamma-secretase

    Article • Alzheimer s & Dementia, July 2012, Elsevier

    Dr Lars O Tjernberg

  26. Erlin-2 is associated with active gamma-secretase in brain

    Article • Alzheimer s & Dementia, July 2012, Elsevier

    Dr Lars O Tjernberg

  27. The role of presenilin 1 familial Alzheimer's disease mutations for gamma-secretase activity and changed structural conformation

    Article • Alzheimer s & Dementia, July 2012, Elsevier

    Dr Lars O Tjernberg

  28. Identification of two novel synaptic γ-secretase associated proteins that affect amyloid β-peptide levels without altering Notch processing

    Article • Neurochemistry International, July 2012, Elsevier

    Dr Lars O Tjernberg

  29. The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ

    Article • Neurobiology of Aging, May 2012, Elsevier

    Dr Lars O Tjernberg

  30. A novel approach for Aβ1–40 quantification using immuno-PCR

    Article • Journal of Neuroscience Methods, April 2012, Elsevier

    Dr Lars O Tjernberg

  31. Identification of Novel  -Secretase-associated Proteins in Detergent-resistant Membranes from Brain

    Article • Journal of Biological Chemistry, February 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  32. γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ42/Aβ40 ratio

    Article • Journal of Cellular and Molecular Medicine, September 2011, Wiley

    Dr Lars O Tjernberg

  33. Mutations in Nicastrin Protein Differentially Affect Amyloid  -Peptide Production and Notch Protein Processing

    Article • Journal of Biological Chemistry, July 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  34. Altered protein expression in pyramidal neurons in Alzheimer's disease

    Article • Alzheimer s & Dementia, July 2011, Elsevier

    Dr Lars O Tjernberg

  35. Screening method of Amyloid β oligomerization inhibitors using a novel FRET probe

    Article • Alzheimer s & Dementia, July 2011, Elsevier

    Dr Lars O Tjernberg

  36. Affinity pulldown of γ-secretase and associated proteins from human and rat brain

    Article • Journal of Cellular and Molecular Medicine, November 2010, Wiley

    Dr Lars O Tjernberg

  37. The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: clinical report and quantification of Aβ in different brain regions

    Article • European Journal of Human Genetics, July 2010, Springer Science + Business Media

    Dr Lars O Tjernberg

  38. A highly sensitive ELISA reveals intracellular accumulation of Aβ42 in microdissected human Purkinje neurons from Alzheimer brains

    Article • Alzheimer s & Dementia, July 2010, Elsevier

    Dr Lars O Tjernberg

  39. Gamma-secretase–associated proteins in detergent resistant membranes from brain

    Article • Alzheimer s & Dementia, July 2010, Elsevier

    Dr Lars O Tjernberg

  40. Affinity pulldown of gamma-secretase and associated proteins from human and rat brain

    Article • Alzheimer s & Dementia, July 2010, Elsevier

    Dr Lars O Tjernberg

  41. Affinity purification of gamma-secretase associated proteins in synaptic membranes and synaptic vesicles

    Article • Alzheimer s & Dementia, July 2010, Elsevier

    Dr Lars O Tjernberg

  42. γ-Secretase Dependent Production of Intracellular Domains Is Reduced in Adult Compared to Embryonic Rat Brain Membranes

    Article • PLoS ONE, March 2010, PLOS

    Dr Lars O Tjernberg

  43. Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology

    Article • Acta Neuropathologica, March 2010, Springer Science + Business Media

    Dr Lars O Tjernberg

  44. Gene therapy in Alzheimer’s disease - potential for disease modification

    Article • Journal of Cellular and Molecular Medicine, February 2010, Wiley

    Dr Lars O Tjernberg

  45. Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain

    Article • PLoS ONE, January 2010, PLOS

    Dr Lars O Tjernberg

  46. CD147, a γ-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2

    Article • Neurochemistry International, January 2010, Elsevier

    Dr Lars O Tjernberg

  47. Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains

    Article • Journal of Neurochemistry, July 2009, Wiley

    Dr Lars O Tjernberg

  48. Amyloid, The Amyloid β-Peptide and Alzheimer's Disease: Structural Considerations

    Article • April 2009, World Scientific Pub Co Pte Lt

    Dr Lars O Tjernberg

  49. P1-451: The oligomerization of amyloid-β peptide

    Article • Alzheimer s & Dementia, July 2008, Elsevier

    Dr Lars O Tjernberg

  50. P1-469: Long amyloid-β peptide variants in Alzheimer's disease brains

    Article • Alzheimer s & Dementia, July 2008, Elsevier

    Dr Lars O Tjernberg

  51. P4-200: Active γ-secretase is enriched in synaptic membranes prepared from rat brain

    Article • Alzheimer s & Dementia, July 2008, Elsevier

    Dr Lars O Tjernberg

  52. P3-328: Cleavage of endogenous substrates by γ-secretase in rat brain membranes

    Article • Alzheimer s & Dementia, July 2008, Elsevier

    Dr Lars O Tjernberg

  53. P1-480: Amyloid β-peptide levels in laser capture microdissected CA1 pyramidal neurons of Alzheimer's brain

    Article • Alzheimer s & Dementia, July 2008, Elsevier

    Dr Lars O Tjernberg

  54. Amyloid β-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimerʼs brain

    Article • Neuroreport, July 2008, Wolters Kluwer Health

    Dr Lars O Tjernberg

  55. P4-201: Inhibitor pulldown of γ-secretase and associated components from human and rat brain

    Article • Alzheimer s & Dementia, July 2008, Elsevier

    Dr Lars O Tjernberg

  56. P4-202: Active γ-secretase is localized to detergent resistant membranes in human brain

    Article • Alzheimer s & Dementia, July 2008, Elsevier

    Dr Lars O Tjernberg

  57. Active γ-secretase is localized to detergent-resistant membranes in human brain

    Article • FEBS Journal, February 2008, Wiley

    Dr Lars O Tjernberg

  58. Unwinding fibril formation of medin, the peptide of the most common form of human amyloid

    Article • Biochemical and Biophysical Research Communications, October 2007, Elsevier

    Dr Lars O Tjernberg

  59. Rat Brain γ-Secretase Activity Is Highly Influenced by Detergents †

    Article • Biochemistry, June 2007, American Chemical Society (ACS)

    Dr Lars O Tjernberg

  60. Analysis of Single Alzheimer Solid Plaque Cores by Laser Capture Microscopy and Nanoelectrospray/Tandem Mass Spectrometry

    Article • Biochemistry, July 2006, American Chemical Society (ACS)

    Dr Lars O Tjernberg

  61. Degradation of the Amyloid beta-Protein by the Novel Mitochondrial Peptidasome, PreP

    Article • Journal of Biological Chemistry, July 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  62. P3-414

    Article • Alzheimer s & Dementia, July 2006, Elsevier

    Dr Lars O Tjernberg

  63. CLAC Binds to Aggregated Aβ and Aβ Fragments, and Attenuates Fibril Elongation

    Article • Biochemistry, November 2005, American Chemical Society (ACS)

    Dr Lars O Tjernberg

  64. Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates

    Article • FEBS Journal, April 2005, Wiley

    Dr Lars O Tjernberg

  65. Characterization of the Alzheimer's Disease-associated CLAC Protein and Identification of an Amyloid  -Peptide-binding Site

    Article • Journal of Biological Chemistry, November 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  66. Nicastrin, Presenilin, APH-1, and PEN-2 Form Active  -Secretase Complexes in Mitochondria

    Article • Journal of Biological Chemistry, September 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  67. P1-163 Autophagic vacuoles contain high beta and gamma secretase activities

    Article • Neurobiology of Aging, July 2004, Elsevier

    Dr Lars O Tjernberg

  68. P1-185 Analysis of single Alzheimer plaque cores by laser-capture microscopy and nano-electrospray/tandem mass spectrometry

    Article • Neurobiology of Aging, July 2004, Elsevier

    Dr Lars O Tjernberg

  69. P1-233 Biochemical characterization of Alzheimer's related CLAC protein and binding to amyloid-β peptide

    Article • Neurobiology of Aging, July 2004, Elsevier

    Dr Lars O Tjernberg

  70. P4-258 Localization of nicastrin/presenilin/APH-1/PEN-2 complexes to mitochondria

    Article • Neurobiology of Aging, July 2004, Elsevier

    Dr Lars O Tjernberg

  71. Folding into a β-Hairpin Can Prevent Amyloid Fibril Formation †

    Article • Biochemistry, April 2004, American Chemical Society (ACS)

    Dr Lars O Tjernberg

  72. Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid ?-peptide

    Article • Cellular and Molecular Life Sciences, February 2004, Springer Science + Business Media

    Dr Lars O Tjernberg

  73. Partial Purification and Characterization of  -Secretase from Post-mortem Human Brain

    Article • Journal of Biological Chemistry, April 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  74. No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients

    Article • Neuroscience Letters, February 2003, Elsevier

    Dr Lars O Tjernberg

  75. High-Resolution Separation of Amyloid β-Peptides: Structural Variants Present in Alzheimer's Disease Amyloid

    Article • Journal of Neurochemistry, November 2002, Wiley

    Dr Lars O Tjernberg

  76. Charge Attraction and beta Propensity Are Necessary for Amyloid Fibril Formation from Tetrapeptides

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  77. Assembling amyloid fibrils from designed structures containing a significant amyloid β-peptide fragment

    Article • Biochemical Journal, August 2002, Portland Press Ltd.

    Dr Lars O Tjernberg

  78. Controlling Polymerization of  -Amyloid and Prion-derived Peptides with Synthetic Small Molecule Ligands

    Article • Journal of Biological Chemistry, January 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  79. Medin: An integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid

    Article • Proceedings of the National Academy of Sciences, July 1999, Proceedings of the National Academy of Sciences

    Dr Lars O Tjernberg

  80. Endogenous Proteins Controlling Amyloid  -Peptide Polymerization: POSSIBLE IMPLICATIONS FOR  -AMYLOID FORMATION IN THE CENTRAL NERVOUS SYSTEM AND IN PERIPHERAL TISSUES

    Article • Journal of Biological Chemistry, June 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  81. Binding of amyloid β-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease

    Article • FEBS Letters, May 1999, Wiley

    Dr Lars O Tjernberg

  82. A Molecular Model of Alzheimer Amyloid  -Peptide Fibril Formation

    Article • Journal of Biological Chemistry, April 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  83. Amyloid β-peptide polymerization studied using fluorescence correlation spectroscopy

    Article • Chemistry & Biology, January 1999, Elsevier

    Dr Lars O Tjernberg

  84. Controlling Amyloid beta -Peptide Fibril Formation with Protease-stable Ligands

    Article • Journal of Biological Chemistry, May 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  85. Generation of Alzheimer Amyloid   Peptide through Nonspecific Proteolysis

    Article • Journal of Biological Chemistry, January 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  86. Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand

    Article • Journal of Biological Chemistry, April 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lars O Tjernberg

  87. Characterization of stable complexes involving apolipoprotein E and the amyloid β peptide in Alzheimer's disease brain

    Article • Neuron, July 1995, Elsevier

    Dr Lars O Tjernberg

  88. The Metabolic Pathway Generating p3, an Aβ-Peptide Fragment, Is Probably Non-Amyloidogenic

    Article • Biochemical and Biophysical Research Communications, October 1994, Elsevier

    Dr Lars O Tjernberg

  89. Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.

    Article • Proceedings of the National Academy of Sciences, August 1994, Proceedings of the National Academy of Sciences

    Dr Lars O Tjernberg