All Stories

  1. A single-chain variable fragment selected against a conformational epitope of a recombinantly produced snake toxin using phage display

    Article • New Biotechnology, September 2023, Elsevier

    Lars Ellgaard

  2. High-resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus

    Article • Acta Crystallographica Section F Structural Biology Communications, August 2023, International Union of Crystallography

    Lars Ellgaard

  3. Structure, function and evolution of a newly discovered conotoxin

    Article • PLoS Biology, August 2023, PLOS

    Lars Ellgaard

  4. Production of an Active, Human Membrane Protein in Saccharomyces cerevisiae: Full-Length FICD

    Article • International Journal of Molecular Sciences, February 2022, MDPI AG

    Lars Ellgaard

  5. DisCoTune: versatile auxiliary plasmids for the production of disulphide‐containing proteins and peptides in the E. coli T7 system

    Article • Microbial Biotechnology, August 2021, Wiley

    Lars Ellgaard

  6. Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

    Article • Biomedicines, July 2020, MDPI AG

    Lars Ellgaard

  7. Cellular functions and molecular mechanisms of non-lysine ubiquitination

    Article • Open Biology, September 2019, Royal Society Publishing

    Lars Ellgaard

  8. A granulin fold arising from a common ICK cysteine framework

    Article • Journal of Biological Chemistry, April 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  9. Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

    Article • International Journal of Molecular Sciences, October 2018, MDPI AG

    Lars Ellgaard

  10. CHAPTER 2.1. Evolutionary Adaptations to Cysteine-rich Peptide Folding

    Article • January 2018, Royal Society of Chemistry

    Lars Ellgaard

  11. How Are Proteins Reduced in the Endoplasmic Reticulum?

    Article • Trends in Biochemical Sciences, November 2017, Elsevier

    Lars Ellgaard

  12. Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

    Article • Nature Communications, June 2016, Nature

    Lars Ellgaard

  13. Co- and Post-Translational Protein Folding in the ER

    Article • Traffic, April 2016, Wiley

    Lars Ellgaard

  14. Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

    Article • Proceedings of the National Academy of Sciences, March 2016, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell, Lars Ellgaard

  15. Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

    Article • PeerJ, February 2016, PeerJ

    Lars Ellgaard

  16. Specialized insulin is used for chemical warfare by fish-hunting cone snails

    Article • Proceedings of the National Academy of Sciences, January 2015, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell, Lars Ellgaard

  17. The Selenium Metabolite Methylselenol Regulates the Expression of Ligands That Trigger Immune Activation through the Lymphocyte Receptor NKG2D

    Article • Journal of Biological Chemistry, September 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  18. GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

    Article • Free Radical Biology and Medicine, May 2014, Elsevier

    Lars Ellgaard

  19. Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262

    Article • Bioscience Reports, March 2014, Portland Press Ltd.

    Lars Ellgaard

  20. HUWE1 and TRIP12 Collaborate in Degradation of Ubiquitin-Fusion Proteins and Misframed Ubiquitin

    Article • PLoS ONE, November 2012, PLOS

    Lars Ellgaard

  21. Hyperactivity of the Ero1  Oxidase Elicits Endoplasmic Reticulum Stress but No Broad Antioxidant Response

    Article • Journal of Biological Chemistry, October 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  22. The Human Selenoprotein VCP-interacting Membrane Protein (VIMP) Is Non-globular and Harbors a Reductase Function in an Intrinsically Disordered Region

    Article • Journal of Biological Chemistry, June 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  23. Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

    Article • FEBS Journal, January 2012, Wiley

    Lars Ellgaard

  24. Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

    Article • The EMBO Journal, November 2011, Wiley

    Lars Ellgaard

  25. Multiple ways to make disulfides

    Article • Trends in Biochemical Sciences, September 2011, Elsevier

    Lars Ellgaard

  26. Identification of the PDI-Family Member ERp90 as an Interaction Partner of ERFAD

    Article • PLoS ONE, February 2011, PLOS

    Lars Ellgaard

  27. Disulphide production by Ero1α–PDI relay is rapid and effectively regulated

    Article • The EMBO Journal, August 2010, Wiley

    Lars Ellgaard

  28. A Male with Unilateral Microphthalmia Reveals a Role for TMX3 in Eye Development

    Article • PLoS ONE, May 2010, PLOS

    Lars Ellgaard

  29. A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4

    Article • Biochemical Journal, January 2010, Portland Press Ltd.

    Lars Ellgaard

  30. A luminal flavoprotein in endoplasmic reticulum-associated degradation

    Article • Proceedings of the National Academy of Sciences, September 2009, Proceedings of the National Academy of Sciences

    Lars Ellgaard

  31. A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells

    Article • The EMBO Journal, October 2008, Wiley

    Lars Ellgaard

  32. The human PDI family: Versatility packed into a single fold

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, April 2008, Elsevier

    Lars Ellgaard

  33. In Vivo Reduction-Oxidation State of Protein Disulfide Isomerase: The Two Active Sites Independently Occur in the Reduced and Oxidized Forms

    Article • Antioxidants & Redox Signaling, January 2008, Mary Ann Liebert Inc

    Lars Ellgaard

  34. Simian Virus 40 Depends on ER Protein Folding and Quality Control Factors for Entry into Host Cells

    Article • Cell, November 2007, Elsevier

    Lars Ellgaard

  35. Structure-Function Analysis of the Endoplasmic Reticulum Oxidoreductase TMX3 Reveals Interdomain Stabilization of the N-terminal Redox-active Domain

    Article • Journal of Biological Chemistry, September 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  36. Domain Architecture of Protein-disulfide Isomerase Facilitates Its Dual Role as an Oxidase and an Isomerase in Ero1p-mediated Disulfide Formation

    Article • Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  37. The human protein disulphide isomerase family: substrate interactions and functional properties

    Article • EMBO Reports, January 2005, EMBO

    Lars Ellgaard

  38. Identification and Characterization of a Novel Thioredoxin-related Transmembrane Protein of the Endoplasmic Reticulum

    Article • Journal of Biological Chemistry, December 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  39. Catalysis of disulphide bond formation in the endoplasmic reticulum

    Article • Biochemical Society Transactions, November 2004, Portland Press Ltd.

    Lars Ellgaard

  40. Calnexin, Calreticulin, and ERp57: Teammates in Glycoprotein Folding

    Article • ChemInform, April 2004, Wiley

    Lars Ellgaard

  41. ERp57 Is a Multifunctional Thiol-Disulfide Oxidoreductase

    Article • Journal of Biological Chemistry, February 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  42. Mutational Analysis Provides Molecular Insight into the Carbohydrate-Binding Region of Calreticulin:  Pivotal Roles of Tyrosine-109 and Aspartate-135 in Carbohydrate Recognition †

    Article • Biochemistry, January 2004, American Chemical Society (ACS)

    Lars Ellgaard

  43. Quality control in the endoplasmic reticulum

    Article • Nature Reviews Molecular Cell Biology, March 2003, Nature

    Lars Ellgaard

  44. Calnexin, Calreticulin, and ERp57: Teammates in Glycoprotein Folding

    Article • Cell Biochemistry and Biophysics, January 2003, Springer Science + Business Media

    Lars Ellgaard

  45. A Chaperone System for Glycoprotein Folding: The Calnexin/Calreticulin Cycle

    Article • January 2003, Springer Science + Business Media

    Lars Ellgaard

  46. Interactions of Substrate with Calreticulin, an Endoplasmic Reticulum Chaperone

    Article • Journal of Biological Chemistry, December 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  47. NMR Structures of 36 and 73-residue Fragments of the Calreticulin P-domain

    Article • Journal of Molecular Biology, September 2002, Elsevier

    Lars Ellgaard

  48. TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain

    Article • Proceedings of the National Academy of Sciences, February 2002, Proceedings of the National Academy of Sciences

    Lars Ellgaard

  49. ER quality control: towards an understanding at the molecular level

    Article • Current Opinion in Cell Biology, August 2001, Elsevier

    Lars Ellgaard

  50. NMR structure of the calreticulin P-domain

    Article • Proceedings of the National Academy of Sciences, March 2001, Proceedings of the National Academy of Sciences

    Lars Ellgaard

  51. Three-dimensional structure topology of the calreticulin P-domain based on NMR assignment

    Article • FEBS Letters, January 2001, Wiley

    Lars Ellgaard

  52. Setting the Standards: Quality Control in the Secretory Pathway

    Article • Science, December 1999, American Association for the Advancement of Science

    Lars Ellgaard, Maurizio Molinari

  53. Ligand Binding Properties of the Very Low Density Lipoprotein Receptor: ABSENCE OF THE THIRD COMPLEMENT-TYPE REPEAT ENCODED BY EXON 4 IS ASSOCIATED WITH REDUCED BINDING OF M r 40,000 RECEPTOR-ASSOCIATED PROTEIN

    Article • Journal of Biological Chemistry, March 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars Ellgaard

  54. Article • Journal of Protein Chemistry, January 1999, Springer Science + Business Media

    Lars Ellgaard

  55. The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin

    Article • FEBS Letters, June 1998, Wiley

    Lars Ellgaard

  56. The Role of α2Macroglobulin Receptor Associated Protein as a Chaperone for Multifunctional Receptors

    Article • January 1998, Springer Science + Business Media

    Lars Ellgaard

  57. The solution structure of the N-terminal domain of α2-macroglobulin receptor-associated protein

    Article • Proceedings of the National Academy of Sciences, July 1997, Proceedings of the National Academy of Sciences

    Lars Ellgaard

  58. Dissection of the Domain Architecture of the alpha2macroglobulin-Receptor-Associated Protein

    Article • European Journal of Biochemistry, March 1997, Wiley

    Lars Ellgaard

  59. Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of α2-macroglobulin receptor and urokinase receptor expression

    Article • Molecular and Cellular Endocrinology, April 1995, Elsevier

    Lars Ellgaard

  60. Nested sets of protein fragments and their use in epitope mapping: characterization of the epitope for the S4D5 monoclonal antibody binding to receptor associated protein

    Article • Journal of Immunological Methods, March 1995, Elsevier

    Lars Ellgaard