All Stories

  1. In fruit flies, a diet containing folic acid could improve the function of mitochondria.

    Article • Cell Death and Disease, March 2019, Springer Science + Business Media

    Dr L. Miguel Martins

  2. This research suggests a simple blood test could improve the early detection of lung cancer

    Article • Disease Models & Mechanisms, February 2019, The Company of Biologists

    Dr L. Miguel Martins

  3. A method to improve the detection of cancer-associated mutations in the KRAS gene

    Article • Matters, July 2017, Sciencematters

    Dr L. Miguel Martins

  4. Folinic acid protects neurons

    Article • Matters, March 2017, Sciencematters

    Dr L. Miguel Martins, Dr Susann Lehmann, Dr Juan Garrido-Maraver

  5. dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective

    Article • Cell Death and Differentiation, February 2017, Nature

    Dr L. Miguel Martins, Dr Ana C Costa, Dr Susann Lehmann

  6. The neurodegeneration that occurs in Parkinson’s disease can be prevented with a form of vitamin B3

    Article • Biology Open, December 2016, The Company of Biologists

    Dr L. Miguel Martins, Dr Susann Lehmann

  7. Paraquat-induced metabolic stress signature in human foetal mesencephalic cells

    Article • Matters, December 2016, Sciencematters

    Dr L. Miguel Martins

  8. Mitochondrial dysfunction triggers ER stress in Parkinson's models

    Article • Cell Death and Disease, June 2016, Nature

    Dr L. Miguel Martins, Dr Susann Lehmann

  9. Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease

    Article • Cell Death and Disease, March 2016, Nature

    Dr L. Miguel Martins, Dr Susann Lehmann

  10. PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1

    Article • Nature Communications, July 2014, Nature

    Dr L. Miguel Martins

  11. Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

    Article • Cell Death and Disease, April 2014, Nature

    Dr L. Miguel Martins

  12. Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress

    Article • Neuropharmacology, February 2014, Elsevier

    Dr L. Miguel Martins

  13. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

    Article • Nature, January 2014, Nature

    Dr L. Miguel Martins, Dr Susann Lehmann

  14. Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson’s Disease Model

    Article • PLoS ONE, December 2013, PLOS

    Dr L. Miguel Martins

  15. Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants

    Article • Cell Death and Disease, October 2013, Nature

    Dr L. Miguel Martins

  16. Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease

    Article • Cell Death and Disease, January 2013, Nature

    Dr L. Miguel Martins

  17. HtrA2 Peptidase

    Article • January 2013, Elsevier

    Dr L. Miguel Martins

  18. The Drosophila inner-membrane protein PMI controls crista biogenesis and mitochondrial diameter

    Article • Journal of Cell Science, December 2012, The Company of Biologists

    Dr L. Miguel Martins

  19. HtrA2 deficiency causes mitochondrial uncoupling through the F1F0-ATP synthase and consequent ATP depletion

    Article • Cell Death and Disease, June 2012, Nature

    Dr L. Miguel Martins

  20. Neurodegeneration

    Article • April 2012, IntechOpen

    Dr L. Miguel Martins

  21. Emerging Concepts Linking Mitochondrial Stress Signalling and Parkinson's Disease

    Article • April 2012, IntechOpen

    Dr L. Miguel Martins

  22. Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster

    Article • Cell Death and Differentiation, February 2012, Nature

    Dr L. Miguel Martins

  23. Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease

    Article • International Journal of Cell Biology, January 2012, Hindawi Publishing Corporation

    Dr L. Miguel Martins

  24. Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice

    Article • PLoS ONE, December 2011, PLOS

    Professor Tiago F Outeiro, Dr L. Miguel Martins

  25. Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function

    Article • Cell Death and Differentiation, June 2011, Nature

    Dr L. Miguel Martins

  26. PINK1 cleavage at position A103 by the mitochondrial protease PARL

    Article • Human Molecular Genetics, December 2010, Oxford University Press (OUP)

    Dr L. Miguel Martins

  27. Drosophila happyhour modulates JNK-dependent apoptosis

    Article • Cell Death and Disease, August 2010, Nature

    Dr L. Miguel Martins

  28. Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

    Article • Experimental Cell Research, April 2010, Elsevier

    Dr L. Miguel Martins

  29. Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

    Article • Cell Death and Differentiation, March 2009, Nature

    Dr L. Miguel Martins

  30. Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

    Article • Cell Death and Differentiation, November 2008, Nature

    Dr L. Miguel Martins

  31. Accumulation of HtrA2/Omi in Neuronal and Glial Inclusions in Brains With α-Synucleinopathies

    Article • Journal of Neuropathology & Experimental Neurology, October 2008, Oxford University Press (OUP)

    Dr L. Miguel Martins, Prof. Herbert Budka

  32. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1

    Article • Nature, September 2007, Nature

    Dr L. Miguel Martins

  33. Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

    Article • Human Molecular Genetics, June 2005, Oxford University Press (OUP)

    Dr L. Miguel Martins

  34. The Tumor Suppressor RASSF1A and MAP-1 Link Death Receptor Signaling to Bax Conformational Change and Cell Death

    Article • Molecular Cell, June 2005, Elsevier

    Dr L. Miguel Martins

  35. Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

    Article • Molecular and Cellular Biology, November 2004, ASM Journals

    Dr L. Miguel Martins

  36. Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/Omi

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr L. Miguel Martins

  37. The serine protease Omi/HtrA2: a second mammalian protein with a Reaper-like function

    Article • Cell Death and Differentiation, July 2002, Nature

    Dr L. Miguel Martins

  38. Analysis of Caspase Activation During Apoptosis

    Article • Current Protocols in Cell Biology, July 2001, Wiley

    Dr L. Miguel Martins

  39. Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis

    Article • Current Biology, September 1999, Elsevier

    Dr L. Miguel Martins

  40. Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

    Article • Annual Review of Biochemistry, June 1999, Annual Reviews

    Dr L. Miguel Martins

  41. Methods Used to Study Protease Activation During Apoptosis

    Article • December 1998, Taylor & Francis

    Dr L. Miguel Martins