All Stories

  1. Inhibition of lipid droplet formation by Ser/Thr protein phosphatase PPM1D inhibitor, SL-176

    Article • PLoS ONE, February 2019, PLOS

    Professor Kazuyasu Sakaguchi

  2. Synergic Strategies for the Enhanced Self-Assembly of Biomineralization Peptides for the Synthesis of Functional Nanomaterials

    Article • Protein and Peptide Letters, April 2018, Bentham Science Publishers

    Dr. Jose Isagani B Janairo, Professor Kazuyasu Sakaguchi

  3. Quantitative Single Cell Analysis for Transcriptional Activity of p53 Hetero-tetramers between Wild-type Protein and Oligomerization Domain

    Article • Chemistry Letters, February 2018, The Chemical Society of Japan

    Professor Kazuyasu Sakaguchi

  4. Abstract 1945: PPM1D/Wip1, promising new target in childhood cancers neuroblastoma and medulloblastoma

    Article • Cancer Research, July 2017, American Association for Cancer Research (AACR)

    Professor Kazuyasu Sakaguchi

  5. Inhibition of Ser/Thr phosphatase PPM1D induces neutrophil differentiation in HL-60 cells

    Article • The Journal of Biochemistry, May 2017, Oxford University Press (OUP)

    Professor Kazuyasu Sakaguchi

  6. Oligomerization enhances the binding affinity of a silver biomineralization peptide and catalyzes nanostructure formation

    Article • Scientific Reports, May 2017, Springer Science + Business Media

    Professor Kazuyasu Sakaguchi

  7. Heterochiral Jun and Fos bZIP peptides form a coiled-coil heterodimer that is competent for DNA binding

    Article • Journal of Peptide Science, February 2017, Wiley

    Professor Kazuyasu Sakaguchi

  8. PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin

    Article • Scientific Reports, September 2016, Nature

    Professor Kazuyasu Sakaguchi

  9. Patterning nanofibrils through the templated growth of multiple modified amyloid peptides

    Article • Scientific Reports, August 2016, Nature

    Professor Kazuyasu Sakaguchi

  10. Effective Cellular Morphology Analysis for Differentiation Processes by a Fluorescent 1,3a,6a-Triazapentalene Derivative Probe in Live Cells

    Article • PLoS ONE, August 2016, PLOS

    Professor Kazuyasu Sakaguchi

  11. Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

    Article • Biopolymers, July 2016, Wiley

    Professor Kazuyasu Sakaguchi

  12. Quantitative Correlation between the Protein Expression Level in Escherichia Coli and Thermodynamic Stability of Protein In Vitro

    Article • Chemistry Letters, February 2016, The Chemical Society of Japan

    Professor Kazuyasu Sakaguchi

  13. Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation

    Article • Bioorganic & Medicinal Chemistry, October 2015, Elsevier

    Professor Kazuyasu Sakaguchi

  14. Antiproliferative Activity of Silver Nanoplates on Human Promyelocytic Leukemia Cell Lines

    Article • Chemistry Letters, March 2015, The Chemical Society of Japan

    Professor Kazuyasu Sakaguchi

  15. Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line

    Article • Bioorganic & Medicinal Chemistry Letters, December 2014, Elsevier

    Professor Kazuyasu Sakaguchi

  16. Effects of Buffer on the Structure and Catalytic Activity of Palladium Nanomaterials Formed by Biomineralization

    Article • Chemistry Letters, August 2014, The Chemical Society of Japan

    Professor Kazuyasu Sakaguchi

  17. Effects of biomineralization peptide topology on the structure and catalytic activity of Pd nanomaterials

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Professor Kazuyasu Sakaguchi

  18. Inhibition of tumor suppressor protein p53-dependent transcription by a tetramerization domain peptide via hetero-oligomerization

    Article • Bioorganic & Medicinal Chemistry Letters, April 2012, Elsevier

    Professor Kazuyasu Sakaguchi

  19. A small molecule inhibitor of p53-inducible protein phosphatase PPM1D

    Article • Bioorganic & Medicinal Chemistry Letters, January 2012, Elsevier

    Professor Kazuyasu Sakaguchi

  20. Phosphatase assay for multi-phosphorylated substrates using phosphatase specific-motif antibody

    Article • The Journal of Biochemistry, May 2011, Oxford University Press (OUP)

    Professor Kazuyasu Sakaguchi

  21. Probing phenylalanine environments in oligomeric structures with pentafluorophenylalanine and cyclohexylalanine

    Article • Biopolymers, January 2011, Wiley

    Professor Kazuyasu Sakaguchi

  22. ChemInform Abstract: Chemical Synthesis and Applications of Phosphopeptides

    Article • ChemInform, August 2010, Wiley

    Professor Kazuyasu Sakaguchi

  23. Enhancement of transcriptional activity of mutant p53 tumor suppressor protein through stabilization of tetramer formation by calix[6]arene derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, August 2010, Elsevier

    Professor Kazuyasu Sakaguchi

  24. Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors

    Article • Bioorganic & Medicinal Chemistry, January 2010, Elsevier

    Professor Kazuyasu Sakaguchi

  25. Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain

    Article • Cell Cycle, October 2009, Taylor & Francis

    Professor Kazuyasu Sakaguchi

  26. SMAR1 Forms a Ternary Complex with p53-MDM2 and Negatively Regulates p53-mediated Transcription

    Article • Journal of Molecular Biology, May 2009, Elsevier

    Professor Kazuyasu Sakaguchi

  27. Evaluation of transcriptional activity of p53 in individual living mammalian cells

    Article • Analytical Biochemistry, April 2009, Elsevier

    Professor Kazuyasu Sakaguchi

  28. Oxidation of methionine residue at hydrophobic core destabilizes p53 tetrameric structure

    Article • Biopolymers, January 2009, Wiley

    Professor Kazuyasu Sakaguchi

  29. PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression

    Article • The Journal of Biochemistry, October 2008, Oxford University Press (OUP)

    Professor Kazuyasu Sakaguchi

  30. Differential Recognition of Phosphorylated Transactivation Domains of p53 by Different p300 Domains

    Article • Journal of Molecular Biology, February 2008, Elsevier

    Professor Kazuyasu Sakaguchi

  31. DNA damage activates p53 through a phosphorylation-acetylation cascade

    Article • Genes & Development, September 1998, Cold Spring Harbor Laboratory Press

    Professor Kazuyasu Sakaguchi

  32. DNA damage induces phosphorylation of the amino terminus of p53

    Article • Genes & Development, December 1997, Cold Spring Harbor Laboratory Press

    Professor Kazuyasu Sakaguchi

  33. Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Suppressor Protein p53

    Article • Biochemistry, August 1997, American Chemical Society (ACS)

    Professor Kazuyasu Sakaguchi

  34. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

    Article • Proceedings of the National Academy of Sciences, June 1997, Proceedings of the National Academy of Sciences

    Professor Kazuyasu Sakaguchi

  35. Chemical Synthesis and Applications of Phosphopeptides

    Article • January 1996, Springer Science + Business Media

    Professor Kazuyasu Sakaguchi

  36. Interhelical angles in the solution structure of the oligomerization domain of p53: correction

    Article • Science, March 1995, American Association for the Advancement of Science

    Professor Kazuyasu Sakaguchi

  37. The P53 Tumor Suppressor Protein

    Article • January 1995, Springer Science + Business Media

    Dr G. Marius Clore, Professor Kazuyasu Sakaguchi

  38. Analysis of MHC-Specific Peptide Motifs

    Article • January 1995, Springer Science + Business Media

    Professor Kazuyasu Sakaguchi

  39. THE HIGH RESOLUTION STRUCTURE OF THE PERIPHERAL SUBUNIT-BINDING DOMAIN OF DIHYDROLIPOAMIDE ACETYLTRANSFERASE FROM THE PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX OF BACILLUS STEAROTHERMOPHILUS

    Article • December 1994, Protein Data Bank, Rutgers University

    Professor Kazuyasu Sakaguchi

  40. THE HIGH RESOLUTION STRUCTURE OF THE PERIPHERAL SUBUNIT-BINDING DOMAIN OF DIHYDROLIPOAMIDE ACETYLTRANSFERASE FROM THE PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX OF BACILLUS STEAROTHERMOPHILUS

    Article • December 1994, Protein Data Bank, Rutgers University

    Professor Kazuyasu Sakaguchi

  41. The human DNA-activated protein kinase, DNA-PK: Substrate specificity

    Article • November 1994, Office of Scientific and Technical Information (OSTI)

    Professor Kazuyasu Sakaguchi

  42. High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

    Article • Science, July 1994, American Association for the Advancement of Science

    Professor Kazuyasu Sakaguchi

  43. Direct identification of an endogenous peptide recognized by multiple HLA-A2.1-specific cytotoxic T cells.

    Article • Proceedings of the National Academy of Sciences, November 1993, Proceedings of the National Academy of Sciences

    Professor Kazuyasu Sakaguchi

  44. Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.

    Article • Proceedings of the National Academy of Sciences, July 1993, Proceedings of the National Academy of Sciences

    Professor Kazuyasu Sakaguchi

  45. Sequence of a cdna encoding bovine apolipoprotein h

    Article • Gene, April 1993, Elsevier

    Professor Kazuyasu Sakaguchi

  46. Structure-activity relationships of a tethered peptide ligand of the human thrombin receptor

    Article • January 1993, Springer Science + Business Media

    Professor Kazuyasu Sakaguchi

  47. Sequence Analysis of Peptides Presented to the Immune System by Class I and Class II MHC Molecules

    Article • January 1993, Springer Science + Business Media

    Professor Kazuyasu Sakaguchi

  48. Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad

    Article • Science, June 1992, American Association for the Advancement of Science

    Professor Kazuyasu Sakaguchi

  49. HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation

    Article • Science, March 1992, American Association for the Advancement of Science

    Professor Kazuyasu Sakaguchi

  50. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry

    Article • Science, March 1992, American Association for the Advancement of Science

    Professor Kazuyasu Sakaguchi

  51. Syntheses and chemotactic activities of [2,3-methanophenylalanine3]chemotactic peptides

    Article • January 1992, Springer Science + Business Media

    Professor Kazuyasu Sakaguchi

  52. The Role of HSP90 in Tumor Specific Immunity

    Article • January 1991, Springer Science + Business Media

    Professor Kazuyasu Sakaguchi

  53. Zinc Fingers Involved in MHC Class I Gene Regulation: Use of Synthetic Peptides for Structural Analysis

    Article • January 1991, Springer Science + Business Media

    Professor Kazuyasu Sakaguchi

  54. Characterization of tachykinin receptors in endothelial cells of porcine artery

    Article • Neuroscience Letters, March 1990, Elsevier

    Professor Kazuyasu Sakaguchi

  55. Effects of mutations on tetramer formation of tumor suppressor protein p53

    Article • Springer Science + Business Media

    Professor Kazuyasu Sakaguchi