All Stories

  1. Unveiling the Secrets of Neuronal Communication: How Arc Protein Manages Its Message Delivery

    Article • Proceedings of the National Academy of Sciences, August 2024, Proceedings of the National Academy of Sciences

    Kai Zhang, Kritika Mehta

  2. Sustainable synthesis of carbon dots via bio‐waste recycling for biomedical imaging

    Article • Smart Medicine, July 2024, Wiley

    Kai Zhang

  3. Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization

    Article • Journal of Molecular Biology, July 2024, Elsevier

    Kai Zhang

  4. Gene Delivery and Analysis of Optogenetic Induction of Lytic Cell Death

    Article • Current Protocols, April 2024, Wiley

    Kai Zhang

  5. Phosphatidylinositol 3-phosphate mediates Arc capsids secretion through the multivesicular body pathway

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Kai Zhang, Kritika Mehta

  6. The clinical potential of optogenetic interrogation of pathogenesis

    Article • Clinical and Translational Medicine, May 2023, Wiley

    Kai Zhang

  7. Precise modulation of embryonic development through optogenetics

    Article • genesis, December 2022, Wiley

    Kai Zhang

  8. The expanding role of split protein complementation in opsin-free optogenetics

    Article • Current Opinion in Pharmacology, August 2022, Elsevier

    Kai Zhang

  9. Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts

    Article • Nature Communications, July 2022, Springer Science + Business Media

    Kai Zhang, Kritika Mehta

  10. Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development

    Article • Journal of Molecular Biology, September 2021, Elsevier

    Kai Zhang

  11. Steering Molecular Activity with Optogenetics: Recent Advances and Perspectives

    Article • Advanced Biology, January 2021, Wiley

    Kai Zhang

  12. UV-trained and metal-enhanced fluorescence of biliverdin and biliverdin nanoparticles

    Article • Nanoscale, January 2021, Royal Society of Chemistry

    Kai Zhang, Kritika Mehta

  13. A dual-labeling probe to track functional mitochondria–lysosome interactions in live cells

    Article • Nature Communications, December 2020, Springer Science + Business Media

    Kai Zhang

  14. Comparative Determination of Cytotoxicity of Sub-10 nm Copper Nanoparticles to Prokaryotic and Eukaryotic Systems

    Article • ACS Applied Materials & Interfaces, October 2020, American Chemical Society (ACS)

    Kai Zhang

  15. Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

    Article • eLife, October 2020, eLife

    Kai Zhang

  16. Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair‐Follicle‐Derived Stem Cells to Differentiate into Neurons and Glia

    Article • Advanced Biology, September 2020, Wiley

    Kai Zhang

  17. Enabling Versatile Control of Molecular Activity with Small Molecules and Light

    Article • Journal of Molecular Biology, September 2020, Elsevier

    Kai Zhang

  18. Syntaxin Clustering and Optogenetic Control for Synaptic Membrane Fusion

    Article • Journal of Molecular Biology, August 2020, Elsevier

    Kai Zhang

  19. Early But Not Delayed Optogenetic RAF Activation Promotes Astrocytogenesis in Mouse Neural Progenitors

    Article • Journal of Molecular Biology, July 2020, Elsevier

    Kai Zhang

  20. Chromatin accessibility and histone acetylation in the regulation of competence in early development

    Article • Developmental Biology, June 2020, Elsevier

    Kai Zhang

  21. Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS inDrosophila

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Kai Zhang

  22. A Generalizable Optogenetic Strategy to Regulate Receptor Tyrosine Kinases during Vertebrate Embryonic Development

    Article • Journal of Molecular Biology, May 2020, Elsevier

    Kai Zhang

  23. Molecular Orientation Determination in Nanodiscs at the Single-Molecule Level

    Article • Analytical Chemistry, December 2019, American Chemical Society (ACS)

    Kai Zhang, Kritika Mehta

  24. Coaction of Electrostatic and Hydrophobic Interactions: Dynamic Constraints on Disordered TrkA Juxtamembrane Domain

    Article • The Journal of Physical Chemistry B, November 2019, American Chemical Society (ACS)

    Kai Zhang

  25. Repurposing Protein Degradation for Optogenetic Modulation of Protein Activities

    Article • ACS Synthetic Biology, October 2019, American Chemical Society (ACS)

    Kai Zhang

  26. Influence of Electron Acceptor and Electron Donor on the Photophysical Properties of Carbon Dots: A Comparative Investigation at the Bulk‐State and Single‐Particle Level

    Article • Advanced Functional Materials, July 2019, Wiley

    Kai Zhang

  27. Single-vesicle measurement of protein-induced membrane tethering

    Article • Colloids and Surfaces B Biointerfaces, May 2019, Elsevier

    Kai Zhang

  28. Bulk-state and single-particle imaging are central to understanding carbon dot photo-physics and elucidating the effects of precursor composition and reaction temperature

    Article • Carbon, April 2019, Elsevier

    Kai Zhang

  29. Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discovery

    Article • Nano Research, March 2019, Tsinghua University Press

    Kai Zhang

  30. Optogenetic Delineation of Receptor Tyrosine Kinase Subcircuits in PC12 Cell Differentiation

    Article • Cell Chemical Biology, March 2019, Elsevier

    Kai Zhang

  31. Novel functions of the ubiquitin-independent proteasome system in regulatingXenopusgermline development

    Article • Development, January 2019, The Company of Biologists

    Kai Zhang

  32. Reversible Optogenetic Control of Growth Factor Signaling During Cell Differentiation and Vertebrate Embryonic Development

    Article • January 2019, Optical Society of America (OSA)

    Kai Zhang

  33. Chemical physics in living cells — Using light to visualize and control intracellular signal transduction

    Article • Chinese Journal of Chemical Physics, August 2018, American Institute of Physics

    Kai Zhang

  34. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTRin Nociception

    Article • Journal of Neuroscience, February 2018, Society for Neuroscience

    Kai Zhang

  35. Carbon dots with induced surface oxidation permits imaging at single-particle level for intracellular studies

    Article • Nanoscale, January 2018, Royal Society of Chemistry

    Kai Zhang

  36. Applications of Optobiology in Intact Cells and Multicellular Organisms

    Article • Journal of Molecular Biology, October 2017, Elsevier

    Kai Zhang

  37. Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and <em>Xenopus</em> Embryonic Development

    Article • Journal of Visualized Experiments, June 2017, MyJove Corporation

    Kai Zhang

  38. Single-Particle Tracking Reveals a Dynamic Role of Actin Filaments in Assisting Long-Range Axonal Transport in Neurons

    Article • Bulletin of the Chemical Society of Japan, March 2017, Oxford University Press (OUP)

    Kai Zhang

  39. Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells

    Article • Frontiers in Molecular Neuroscience, January 2017, Frontiers

    Kai Zhang

  40. Reversible optogenetic control of kinase activity during differentiation and embryonic development

    Article • Development, November 2016, The Company of Biologists

    Kai Zhang

  41. Simultaneous Removal of Multiple DNA Segments by Polymerase Chain Reactions

    Article • September 2016, Springer Science + Business Media

    Kai Zhang

  42. The Timing of Raf/ERK and AKT Activation in Protecting PC12 Cells against Oxidative Stress

    Article • PLoS ONE, April 2016, PLOS

    Kai Zhang

  43. Polymerase chain reaction-based gene removal from plasmids

    Article • Data in Brief, September 2015, Elsevier

    Kai Zhang

  44. Multiplex gene removal by two-step polymerase chain reactions

    Article • Analytical Biochemistry, July 2015, Elsevier

    Kai Zhang

  45. The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells

    Article • ACS Synthetic Biology, June 2015, American Chemical Society (ACS)

    Kai Zhang

  46. Retrograde NGF Axonal Transport—Motor Coordination in the Unidirectional Motility Regime

    Article • Biophysical Journal, June 2015, Elsevier

    Kai Zhang

  47. Optogenetic Control of Molecular Motors and Organelle Distributions in Cells

    Article • Chemistry & Biology, May 2015, Elsevier

    Kai Zhang

  48. Optogenetic control of intracellular signaling pathways

    Article • Trends in Biotechnology, February 2015, Elsevier

    Kai Zhang

  49. U0126 Protects Cells against Oxidative Stress Independent of Its Function as a MEK Inhibitor

    Article • ACS Chemical Neuroscience, January 2015, American Chemical Society (ACS)

    Kai Zhang

  50. Visualizing Directional Rab7 and TrkA Cotrafficking in Axons by pTIRF Microscopy

    Article • January 2015, Springer Science + Business Media

    Kai Zhang

  51. Lighting up FGFR Signaling

    Article • Chemistry & Biology, July 2014, Elsevier

    Kai Zhang

  52. Light-Mediated Kinetic Control Reveals the Temporal Effect of the Raf/MEK/ERK Pathway in PC12 Cell Neurite Outgrowth

    Article • PLoS ONE, March 2014, PLOS

    Kai Zhang

  53. Defective Axonal Transport of Rab7 GTPase Results in Dysregulated Trophic Signaling

    Article • Journal of Neuroscience, April 2013, Society for Neuroscience

    Kai Zhang

  54. Functional characterization and axonal transport of quantum dot labeled BDNF

    Article • Integrative Biology, January 2012, Oxford University Press (OUP)

    Kai Zhang

  55. Automated image analysis for tracking cargo transport in axons

    Article • Microscopy Research and Technique, October 2010, Wiley

    Kai Zhang

  56. Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport

    Article • Science, October 2010, American Association for the Advancement of Science

    Kai Zhang

  57. Single-molecule imaging of NGF axonal transport in microfluidic devices

    Article • Lab on a Chip, January 2010, Royal Society of Chemistry

    Kai Zhang

  58. Optically Resolving Individual Microtubules in Live Axons

    Article • Structure, November 2009, Elsevier

    Kai Zhang

  59. Bipolar cellular morphology of malignant melanoma in unstained human melanoma skin tissue

    Article • Journal of Biomedical Optics, January 2009, SPIE

    Kai Zhang

  60. Single Quantum Dots as Local Temperature Markers

    Article • Nano Letters, August 2007, American Chemical Society (ACS)

    Kai Zhang

  61. Continuous Distribution of Emission States from Single CdSe/ZnS Quantum Dots

    Article • Nano Letters, March 2006, American Chemical Society (ACS)

    Kai Zhang

  62. Three-Dimensional Chiral Imaging by Sum-Frequency Generation

    Article • Journal of the American Chemical Society, February 2006, American Chemical Society (ACS)

    Kai Zhang

  63. Photon-by-Photon Determination of Emission Bursts from Diffusing Single Chromophores

    Article • The Journal of Physical Chemistry B, October 2005, American Chemical Society (ACS)

    Kai Zhang