All Stories

  1. Craniofacial bone anomalies related to cholesterol synthesis defects

    Article • Scientific Reports, March 2024, Springer Science + Business Media

    Dr Junichi Iwata

  2. Response to Letter, “Autophagy Plays a Crucial Role in Ameloblast Differentiation”

    Article • Journal of Dental Research, February 2024, SAGE Publications

    Dr Junichi Iwata

  3. Single-cell multiomics decodes regulatory programs for mouse secondary palate development

    Article • Nature Communications, January 2024, Springer Science + Business Media

    Dr Junichi Iwata

  4. Loss of Sc5d results in micrognathia due to a failure in osteoblast differentiation

    Article • Journal of Advanced Research, December 2023, Elsevier

    Dr Junichi Iwata

  5. Editorial: Animal models and transgenic technology in Craniofacial biology

    Article • Frontiers in Physiology, October 2023, Frontiers

    Dr Junichi Iwata

  6. Autophagy Plays a Crucial Role in Ameloblast Differentiation

    Article • Journal of Dental Research, May 2023, SAGE Publications

    Dr Junichi Iwata

  7. MicroRNAs and Gene Regulatory Networks Related to Cleft Lip and Palate

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Dr Junichi Iwata

  8. FaceBase: A Community-Driven Hub for Data-Intensive Research

    Article • Journal of Dental Research, July 2022, SAGE Publications

    Dr Junichi Iwata

  9. Spatiotemporal MicroRNA-Gene Expression Network Related to Orofacial Clefts

    Article • Journal of Dental Research, June 2022, SAGE Publications

    Dr Junichi Iwata

  10. Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren’s syndrome-like exocrinopathy

    Article • Cellular and Molecular Life Sciences, May 2022, Springer Science + Business Media

    Dr Junichi Iwata

  11. Micro-computed tomography assessment of bone structure in aging mice

    Article • Scientific Reports, May 2022, Springer Science + Business Media

    Dr Junichi Iwata

  12. Suppression of microRNA 124-3p and microRNA 340-5p ameliorates retinoic acid-induced cleft palate in mice

    Article • Development, May 2022, The Company of Biologists

    Dr Junichi Iwata

  13. Crucial Roles of microRNA-16-5p and microRNA-27b-3p in Ameloblast Differentiation Through Regulation of Genes Associated With Amelogenesis Imperfecta

    Article • Frontiers in Genetics, March 2022, Frontiers

    Dr Junichi Iwata

  14. CleftGeneDB: a resource for annotating genes associated with cleft lip and cleft palate

    Article • Science Bulletin, December 2021, Elsevier

    Dr Junichi Iwata

  15. Dexamethasone Suppresses Palatal Cell Proliferation through miR-130a-3p

    Article • International Journal of Molecular Sciences, November 2021, MDPI AG

    Dr Junichi Iwata

  16. MicroRNA-124-3p Plays a Crucial Role in Cleft Palate Induced by Retinoic Acid

    Article • Frontiers in Cell and Developmental Biology, June 2021, Frontiers

    Dr Junichi Iwata

  17. Identification of microRNAs and gene regulatory networks in cleft lip common in humans and mice

    Article • Human Molecular Genetics, June 2021, Oxford University Press (OUP)

    Dr Junichi Iwata

  18. Amino acid metabolism and autophagy in skeletal development and homeostasis

    Article • Bone, May 2021, Elsevier

    Dr Junichi Iwata

  19. Phenytoin Inhibits Cell Proliferation through microRNA-196a-5p in Mouse Lip Mesenchymal Cells

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Dr Junichi Iwata

  20. Excessive All-Trans Retinoic Acid Inhibits Cell Proliferation Through Upregulated MicroRNA-4680-3p in Cultured Human Palate Cells

    Article • Frontiers in Cell and Developmental Biology, January 2021, Frontiers

    Dr Junichi Iwata

  21. Cell signaling regulation in salivary gland development

    Article • Cellular and Molecular Life Sciences, January 2021, Springer Science + Business Media

    Dr Junichi Iwata

  22. Role of Metabolism in Bone Development and Homeostasis

    Article • International Journal of Molecular Sciences, November 2020, MDPI AG

    Dr Junichi Iwata

  23. Gene–environment interplay and MicroRNAs in cleft lip and cleft palate

    Article • Oral Science International, June 2020, Wiley

    Dr Junichi Iwata

  24. Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and homeostasis through primary cilium formation

    Article • Bone Research, January 2020, Springer Science + Business Media

    Dr Junichi Iwata

  25. A developmental stage specific network approach for studying dynamic transcription factor-microRNA co-regulation during craniofacial development

    Article • Development, January 2020, The Company of Biologists

    Dr Junichi Iwata

  26. Critical microRNAs and regulatory motifs in cleft palate identified by a conserved miRNA–TF–gene network approach in humans and mice

    Article • Briefings in Bioinformatics, October 2019, Oxford University Press (OUP)

    Dr Junichi Iwata

  27. MicroRNA-655-3p and microRNA-497-5p inhibit cell proliferation in cultured human lip cells through the regulation of genes related to human cleft lip

    Article • BMC Medical Genomics, May 2019, Springer Science + Business Media

    Dr Junichi Iwata

  28. Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands

    Article • Development, January 2019, The Company of Biologists

    Dr Junichi Iwata

  29. Molecular Regulatory Mechanism of Exocytosis in the Salivary Glands

    Article • International Journal of Molecular Sciences, October 2018, MDPI AG

    Dr Junichi Iwata

  30. Gene datasets associated with mouse cleft palate

    Article • Data in Brief, June 2018, Elsevier

    Dr Junichi Iwata

  31. Molecular mechanisms of midfacial developmental defects

    Article • Developmental Dynamics, December 2015, Wiley

    Dr Junichi Iwata

  32. Mouse genetic models for temporomandibular joint development and disorders

    Article • Oral Diseases, July 2015, Wiley

    Dr Junichi Iwata

  33. Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development

    Article • Developmental Biology, April 2015, Elsevier

    Dr Junichi Iwata

  34. WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets

    Article • Molecular and Cellular Biology, March 2015, ASM Journals

    Dr Junichi Iwata

  35. TGF  regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate

    Article • Development, February 2014, The Company of Biologists

    Dr Junichi Iwata

  36. Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice

    Article • Human Molecular Genetics, August 2013, Oxford University Press (OUP)

    Dr Junichi Iwata

  37. Noncanonical Transforming Growth Factor   (TGF ) Signaling in Cranial Neural Crest Cells Causes Tongue Muscle Developmental Defects

    Article • Journal of Biological Chemistry, August 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Junichi Iwata

  38. CTGF Mediates Smad-Dependent Transforming Growth Factor β Signaling To Regulate Mesenchymal Cell Proliferation during Palate Development

    Article • Molecular and Cellular Biology, July 2013, ASM Journals

    Dr Junichi Iwata

  39. Abstract 76

    Article • Plastic & Reconstructive Surgery, May 2013, Wolters Kluwer Health

    Dr Junichi Iwata

  40. Abstract 75

    Article • Plastic & Reconstructive Surgery, May 2013, Wolters Kluwer Health

    Dr Junichi Iwata

  41. Mice with Tak1 Deficiency in Neural Crest Lineage Exhibit Cleft Palate Associated with Abnormal Tongue Development

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Junichi Iwata

  42. Identification of candidate downstream targets of TGFβ signaling during palate development by genome‐wide transcript profiling

    Article • Journal of Cellular Biochemistry, February 2013, Wiley

    Dr Junichi Iwata

  43. Smad4-Irf6 genetic interaction and TGF -mediated IRF6 signaling cascade are crucial for palatal fusion in mice

    Article • Development, February 2013, The Company of Biologists

    Dr Junichi Iwata

  44. Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice

    Article • Journal of Clinical Investigation, March 2012, American Society for Clinical Investigation

    Dr Junichi Iwata

  45. Fibroblast Growth Factor 9 (FGF9)-Pituitary Homeobox 2 (PITX2) Pathway Mediates Transforming Growth Factor   (TGF ) Signaling to Regulate Cell Proliferation in Palatal Mesenchyme during Mouse Palatogenesis

    Article • Journal of Biological Chemistry, November 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Junichi Iwata

  46. The FaceBase Consortium: A comprehensive program to facilitate craniofacial research

    Article • Developmental Biology, July 2011, Elsevier

    Dr Junichi Iwata, Dr. Benedikt Hallgrimsson

  47. Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

    Article • Autophagy, July 2011, Taylor & Francis

    Dr Junichi Iwata

  48. Tgf-β-mediated FasL-Fas-Caspase Pathway Is Crucial during Palatogenesis

    Article • Journal of Dental Research, May 2011, SAGE Publications

    Dr Junichi Iwata

  49. 154: TGF-BETA-MEDIATED FGF9-PITX2 SIGNALING REGULATES CELL PROLIFERATION DURING PALATE FORMATION

    Article • Plastic & Reconstructive Surgery, May 2011, Wolters Kluwer Health

    Dr Junichi Iwata

  50. The mechanism of TGF-β signaling during palate development

    Article • Oral Diseases, March 2011, Wiley

    Dr Junichi Iwata

  51. Msx1 and Dlx5 function synergistically to regulate frontal bone development

    Article • genesis, November 2010, Wiley

    Dr Junichi Iwata

  52. 137A: TGF-BETA MEDIATED FGF9 SIGNALING REGULATES CELL PROLIFERATION IN PALATAL MESENCHYMAL CELLS

    Article • Plastic & Reconstructive Surgery, June 2010, Wolters Kluwer Health

    Dr Junichi Iwata

  53. TGF-β mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue–tissue interactions during tongue morphogenesis

    Article • Developmental Biology, May 2010, Elsevier

    Dr Junichi Iwata

  54. TGF-²-induced Shc Signaling Persists In The Absence Of The Type II Receptor

    Article • May 2010, American Thoracic Society

    Dr Junichi Iwata

  55. Transforming Growth Factor-  Regulates Basal Transcriptional Regulatory Machinery to Control Cell Proliferation and Differentiation in Cranial Neural Crest-derived Osteoprogenitor Cells

    Article • Journal of Biological Chemistry, December 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Junichi Iwata

  56. Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

    Article • Cell, December 2007, Elsevier

    Dr Junichi Iwata

  57. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

    Article • Proceedings of the National Academy of Sciences, September 2007, Proceedings of the National Academy of Sciences

    Dr Junichi Iwata

  58. Loss of autophagy in the central nervous system causes neurodegeneration in mice

    Article • April 2006, Nature

    Dr Junichi Iwata