All Stories

  1. Targeting Retinaldehyde Dehydrogenases to Enhance Temozolomide Therapy in Glioblastoma
  2. Multimodal HOCl-responsive MEH-PPV nanoparticles for anti-inflammatory imaging and therapy
  3. Mussel-Inspired Multifunctional Polyethylene Glycol Nanoparticle Interfaces
  4. Square‐Planar Copper(II) complexes from a Zwitterionic Schiff‐Base N2/N2/2‐Donor Ligand: DNA Interaction and Cytotoxicity
  5. Metal–Organic Framework‐Based Antimicrobial Touch Surfaces to Prevent Cross‐Contamination
  6. CogiTx1: A novel subtilisin A inhibitor isolated from the sea anemone Condylactis gigantea belonging to the defensin 4 protein family
  7. Platinum-Based Nanoformulations for Glioblastoma Treatment: The Resurgence of Platinum Drugs?
  8. Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
  9. Roadmap on nanomedicine for the central nervous system
  10. Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly
  11. Cell-penetrating peptide-conjugated copper complexes for redox-mediated anticancer therapy
  12. Advances in Preclinical/Clinical Glioblastoma Treatment: Can Nanoparticles Be of Help?
  13. Enhanced Production of ECM Proteins for Pharmaceutical Applications Using Mammalian Cells and Sodium Heparin Supplementation
  14. Synthesis and In Vitro Studies of Photoactivatable Semisquaraine-type Pt(II) Complexes
  15. Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy
  16. Synthesis and Validation of a Bioinspired Catechol-Functionalized Pt(IV) Prodrug for Preclinical Intranasal Glioblastoma Treatment
  17. Functionalized azobenzene platinum(II) complexes as putative anticancer compounds
  18. Bioinspired Theranostic Coordination Polymer Nanoparticles for Intranasal Dopamine Replacement in Parkinson’s Disease
  19. Copper(II) N,N,O-Chelating Complexes as Potential Anticancer Agents
  20. Carboxypeptidase inhibition by NvCI suppresses airway hyperreactivity in a mouse asthma model
  21. Study and Preparation of Multifunctional Poly(L-Lysine)@Hyaluronic Acid Nanopolyplexes for the Effective Delivery of Tumor Suppressive MiR-34a into Triple-Negative Breast Cancer Cells
  22. Substrate Specificity and Structural Modeling of Human Carboxypeptidase Z: A Unique Protease with a Frizzled-Like Domain
  23. Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells
  24. Cover Feature: Time‐Dependent Cytotoxic Properties of Terpyridine‐Based Copper Complexes (ChemBioChem 16/2020)
  25. Time‐Dependent Cytotoxic Properties of Terpyridine‐Based Copper Complexes
  26. Iridium(III) coordination of N(6) modified adenine derivatives with aminoacid chains
  27. Magnetic, fluorescent and hybrid nanoparticles: From synthesis to application in biosystems
  28. Nanoscale coordination polymers for medicine and sensors
  29. Surface engineering of silica nanoparticles with a gadolinium–PCTA complex for efficient T1-weighted MRI contrast agents
  30. Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T2 Weighted Magnetic Resonance Imaging
  31. Characterization, Recombinant Production and Structure-Function Analysis of NvCI, A Picomolar Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita versicolor
  32. Studying the reactivity of “old” Cu(II) complexes for “novel” anticancer purposes
  33. Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells
  34. New Cyclams and Their Copper(II) and Iron(III) Complexes: Synthesis and Potential Application as Anticancer Agents
  35. Adding value to the chia (Salvia hispanica L.) expeller: Production of bioactive peptides with antioxidant properties by enzymatic hydrolysis with Papain
  36. Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles: Towards new protein scavengers and smart drug delivery carriers
  37. Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes
  38. Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy
  39. Crystal structures of N6-modified-amino acid related nucleobase analogs (II): hybrid adenine-β-alanine and adenine-GABA molecules
  40. Squaramide-Based Pt(II) Complexes as Potential Oxygen-Regulated Light-Triggered Photocages
  41. Dual T1/T2 Nanoscale Coordination Polymers as Novel Contrast Agents for MRI: A Preclinical Study for Brain Tumor
  42. Design and synthesis of new antitumor agents with the 1,7-epoxycyclononane framework. Study of their anticancer action mechanism by a model compound
  43. Pt(IV)-based nanoscale coordination polymers: Antitumor activity, cellular uptake and interactions with nuclear DNA
  44. Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues
  45. Biochemical characterization of the YBPCI miniprotein, the first carboxypeptidase inhibitor isolated from Yellow Bell Pepper ( Capsicum annuum L). A novel contribution to the knowledge of miniproteins stability
  46. Biochemical and MALDI-TOF Mass Spectrometric Characterization of a Novel Native and Recombinant Cystine Knot Miniprotein from Solanum tuberosum subsp. andigenum cv. Churqueña
  47. Evaluation of the metal-dependent cytotoxic behaviour of coordination compounds
  48. Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging
  49. New iron cyclopentadienyl complexes bearing different phosphane co -ligands: Structural factors vs. cytotoxicity
  50. Substrate specificity of human metallocarboxypeptidase D: Comparison of the two active carboxypeptidase domains
  51. Conserved effects and altered trafficking of Cetuximab antibodies conjugated to gold nanoparticles with precise control of their number and orientation
  52. Identification of Carboxypeptidase Substrates by C-Terminal COFRADIC
  53. The molecular shape and the field similarities as criteria to interpret SAR studies for fragment-based design of platinum(IV) anticancer agents. Correlation of physicochemical properties with cytotoxicity
  54. pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate
  55. Biocompatible polydopamine-like particles for the removal of heavy metals at extremely low concentrations
  56. Microplate Assay to Study Carboxypeptidase A Inhibition in Andean Potatoes
  57. Biochemical characterization of a novel carboxypeptidase inhibitor from a variety of Andean potatoes
  58. Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands
  59. Vanadium(IV) and copper(II) complexes of salicylaldimines and aromatic heterocycles: Cytotoxicity, DNA binding and DNA cleavage properties
  60. Biocatalytic synthesis, antimicrobial properties and toxicity studies of arginine derivative surfactants
  61. Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles
  62. Synthesis, Culture Medium Stability, and In Vitro and In Vivo Zebrafish Embryo Toxicity of Metal-Organic Framework Nanoparticles
  63. C-terminomics Screen for Natural Substrates of Cytosolic Carboxypeptidase 1 Reveals Processing of Acidic Protein C termini
  64. Amyloid Formation by Human Carboxypeptidase D Transthyretin-like Domain under Physiological Conditions
  65. Carboxyl Group (CO2H) Functionalized Coordination Polymer Nanoparticles as Efficient Platforms for Drug Delivery
  66. The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids
  67. Amorphous Coordination Polymer Particles for Biomedicine
  68. A novel quinoline molecular probe and the derived functionalized gold nanoparticles: Sensing properties and cytotoxicity studies in MCF-7 human breast cancer cells
  69. Synthesis, biological evaluation and SAR studies of novel bicyclic antitumor platinum(IV) complexes
  70. Influence of PPh3 moiety in the anticancer activity of new organometallic ruthenium complexes
  71. New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells
  72. El degradoma y sus inhibidores como dianas terapéuticas
  73. Relaxometry Studies of a Highly Stable Nanoscale Metal–Organic Framework Made of Cu(II), Gd(III), and the Macrocyclic DOTP
  74. Non-toxic fluorescent alanine–fluorescein probe with green emission for dual colorimetric/fluorimetric sensing
  75. Proteome-derived Peptide Libraries to Study the Substrate Specificity Profiles of Carboxypeptidases
  76. [RuCl2(η6-p-cymene)(P*)] and [RuCl2(κ-P*-η6-arene)] Complexes Containing P-Stereogenic Phosphines. Activity in Transfer Hydrogenation and Interactions with DNA
  77. Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism
  78. DNA binding studies of a series of cis-[Pt(Am)2X2] complexes (Am=inert amine, X=labile carboxylato ligand)
  79. Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
  80. Synthesis of Co–Organosilane–Au Nanocomposites via a Controlled Interphasic Reduction
  81. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs)
  82. Engineered nonviral nanocarriers for intracellular gene delivery applications
  83. Facile Preparation of Cationic Gold Nanoparticle-Bioconjugates for Cell Penetration and Nuclear Targeting
  84. The novel structure of a cytosolic M14 metallocarboxypeptidase (CCP) from Pseudomonas aeruginosa: a model for mammalian CCPs
  85. Metallo-carboxypeptidase from Pseudomonas Aeruginosa
  86. METALLO-CARBOXYPEPTIDASE FROM PSEUDOMONAS AUREGINOSA IN COMPLEX WITH L-BENZYLSUCCINIC ACID
  87. Integrated approach to produce a recombinant, his-tagged human α-galactosidase a in mammalian cells
  88. DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands
  89. Vanadium polypyridyl compounds as potential antiparasitic and antitumoral agents: New achievements
  90. Integrated Approach to Optimize Transient Gene Expression in Mammalian Cells: Production of a Recombinant Human Alpha-galactosidase A
  91. New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy
  92. Structure–Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver
  93. Influence of specific growth rate over the secretory expression of recombinant potato carboxypeptidase inhibitor in fed-batch cultures of Escherichia coli
  94. Structure of Drosophila melanogaster carboxypeptidase D isoform 1B short
  95. Human carboxypeptidase A4: Characterization of the substrate specificity and implications for a role in extracellular peptide processing
  96. Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands
  97. A novel vanadyl complex with a polypyridyl DNA intercalator as ligand: A potential anti-protozoa and anti-tumor agent
  98. Insights into the Two-Domain Architecture of the Metallocarboxypeptidase Inhibitor from theAscarisParasite Inferred from the Mechanism of Its Oxidative Folding
  99. Cytotoxicity studies of [PtCl2(H2bim)] (H2bim=2,2′-biimidazole): Study of its interaction with a small protein PCI (potato carboxypeptidase inhibitor)
  100. Internalization of cystatin C in human cell lines
  101. New Palladium(II) and Platinum(II) Complexes with 9-Aminoacridine: Structures, Luminiscence, Theoretical Calculations, and Antitumor Activity
  102. Study by HPLC-MS of the interaction of platinum antitumor complexes with potato carboxypeptidase inhibitor (PCI)
  103. Synthesis, DNA interaction and cytotoxicity studies of cis-{[1, 2-bis(aminomethyl)cyclohexane]dihalo}platinum(II) complexes
  104. Synthesis, characterization and antiproliferative studies of the enantiomers of cis-[(1,2-camphordiamine)dichloro]platinum(II) complexes
  105. DNA interaction and antiproliferative behavior of the water soluble platinum supramolecular squares [(en)Pt(N–N)]4(NO3)8 (en=ethylenediamine, N–N=4,4′-bipyridine or 1,4-bis(4-pyridyl)tetrafluorobenzene)
  106. Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily
  107. Influence of the position of substituents in the cytotoxic activity of trans platinum complexes with hydroxymethyl pyridines
  108. Palladium(II) and Platinum(II) Organometallic Complexes with the Model Nucleobase Anions of Thymine, Uracil, and Cytosine:  Antitumor Activity and Interactions with DNA of the Platinum Compounds○
  109. Synthesis, Characterization and Biological Activity of trans-Platinum(II) and trans-Platinum(IV) Complexes with 4-Hydroxymethylpyridine
  110. New Palladium(II) and Platinum(II) Complexes with the Model Nucleobase 1-Methylcytosine:  Antitumor Activity and Interactions with DNA
  111. Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker
  112. The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
  113. A Carboxypeptidase Inhibitor from the TickRhipicephalus bursa
  114. Water-soluble platinum(II) complexes of diamine chelating ligands bearing amino-acid type substituents: the effect of the linked amino acid and the diamine chelate ring size on antitumor activity, and interactions with 5′-GMP and DNA
  115. Role of Kinetic Intermediates in the Folding of Leech Carboxypeptidase Inhibitor
  116. Secondary Binding Site of the Potato Carboxypeptidase Inhibitor. Contribution to Its Structure, Folding, and Biological Properties†
  117. Platinum complexes of diaminocarboxylic acids and their ethyl ester derivatives: the effect of the chelate ring size on antitumor activity and interactions with GMP and DNA
  118. Human pancreatic ribonuclease 1