All Stories

  1. Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions

    Article • PLoS ONE, April 2020, PLOS

    Jonathan Paul Mochel

  2. Serum Vitamin B12, and Related MTRR and Cubilin Genotypes, Predict Neural Outcomes across the AD Spectrum

    Article • British Journal Of Nutrition, March 2020, Cambridge University Press

    Jonathan Paul Mochel

  3. Investigation of Schirmer tear test-1 for measurement of tear production in cats in various environmental settings and with different test durations

    Article • Journal of the American Veterinary Medical Association, March 2020, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  4. Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors

    Article • PLoS Computational Biology, February 2020, PLOS

    Jonathan Paul Mochel

  5. Apparent total tract digestibility, fecal characteristics, and blood parameters of healthy adult dogs fed high-fat diets

    Article • Journal of Animal Science, February 2020, Oxford University Press (OUP)

    Jonathan Paul Mochel

  6. Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs

    Article • Frontiers in Pharmacology, January 2020, Frontiers

    Jonathan Paul Mochel

  7. Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease

    Article • PLoS ONE, December 2019, PLOS

    Jonathan Paul Mochel

  8. Kinetics of Fluorescein in Tear Film After Eye Drop Instillation in Beagle Dogs: Does Size Really Matter?

    Article • Frontiers in Veterinary Science, December 2019, Frontiers

    Jonathan Paul Mochel

  9. Nerve growth factor in dogs: Assessment of two immunoassays and selected ocular parameters following a nicergoline challenge per os

    Article • Veterinary Ophthalmology, November 2019, Wiley

    Jonathan Paul Mochel

  10. In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs

    Article • Frontiers in Veterinary Science, November 2019, Frontiers

    Jonathan Paul Mochel

  11. Aging-related changes in fluid intelligence, muscle and adipose mass, and sex-specific immunologic mediation: A longitudinal UK Biobank study

    Article • Brain Behavior and Immunity, November 2019, Elsevier

    Jonathan Paul Mochel

  12. Re: “Evaluation of Enrofloxacin for Use in Cryopreservation of Zebu Bull (Bos indicus) Semen” by Ishaq et al. (Biopreserv Biobank 2019;[Epub ahead of print]; DOI: 10.1089/bio.2018.0133)

    Article • Biopreservation and Biobanking, November 2019, Mary Ann Liebert Inc

    Jonathan Paul Mochel

  13. Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs

    Article • Frontiers in Veterinary Science, October 2019, Frontiers

    Jonathan Paul Mochel

  14. Fluorophotometric Assessment of Tear Volume and Turnover Rate in Healthy Dogs and Cats

    Article • Journal of Ocular Pharmacology and Therapeutics, August 2019, Mary Ann Liebert Inc

    Jonathan Paul Mochel

  15. Clinicopathologic, hemodynamic, and echocardiographic effects of short-term oral administration of anti-inflammatory doses of prednisolone to systemically normal cats

    Article • American Journal of Veterinary Research, August 2019, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  16. Nonlinear mixed‐effects pharmacokinetic modeling of the novel COX‐2 selective inhibitor vitacoxib in dogs

    Article • Journal of Veterinary Pharmacology and Therapeutics, August 2019, Wiley

    Jonathan Paul Mochel

  17. Pharmacokinetic Modeling of Ceftiofur Sodium Using Nonlinear Mixed-Effects in Healthy Beagle Dogs

    Article • July 2019, MDPI AG

    Jonathan Paul Mochel

  18. Histamine-Induced Conjunctivitis and Breakdown of Blood–Tear Barrier in Dogs: A Model for Ocular Pharmacology and Therapeutics

    Article • Frontiers in Pharmacology, July 2019, Frontiers

    Jonathan Paul Mochel

  19. Microbiota-Related Changes in Unconjugated Fecal Bile Acids Are Associated With Naturally Occurring, Insulin-Dependent Diabetes Mellitus in Dogs

    Article • Frontiers in Veterinary Science, June 2019, Frontiers

    Jonathan Paul Mochel

  20. The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

    Article • Frontiers in Aging Neuroscience, June 2019, Frontiers

    Jonathan Paul Mochel

  21. A reduced Gompertz model for predicting tumor age using a population approach

    Article • June 2019, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  22. Effects of experimentally induced respiratory disease on the pharmacokinetics and tissue residues of tulathromycin in meat goats

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2019, Wiley

    Jonathan Paul Mochel

  23. Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy

    Article • PLoS ONE, June 2019, PLOS

    Jonathan Paul Mochel, Edward Hall

  24. Interleukin‐13 and interleukin‐33 mRNA are underexpressed in the duodenal mucosa of German Shepherd dogs with chronic enteropathy

    Article • Journal of Veterinary Internal Medicine, June 2019, Wiley

    Jonathan Paul Mochel, Edward Hall

  25. Paper spray high-resolution accurate mass spectrometry for quantitation of voriconazole in equine tears

    Article • Analytical and Bioanalytical Chemistry, May 2019, Springer Science + Business Media

    Jonathan Paul Mochel

  26. Tear Fluid Pharmacokinetics Following Oral Prednisone Administration in Dogs With and Without Conjunctivitis

    Article • Journal of Ocular Pharmacology and Therapeutics, May 2019, Mary Ann Liebert Inc

    Jonathan Paul Mochel

  27. Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non‐Small Cell Lung Cancer

    Article • CPT Pharmacometrics & Systems Pharmacology, May 2019, Wiley

    Jonathan Paul Mochel

  28. Derivation of adult canine intestinal organoids for translational research in gastroenterology

    Article • BMC Biology, April 2019, Springer Science + Business Media

    Jonathan Paul Mochel

  29. CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies

    Article • The AAPS Journal, April 2019, Springer Science + Business Media

    Jonathan Paul Mochel

  30. A Review of Relevant Therapeutic Targets for the Management of Congestive Heart Failure in Dogs: Present and Future Directions

    Article • March 2019, MDPI AG

    Jonathan Paul Mochel

  31. Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  32. Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation

    Article • European Journal of Pharmaceutical Sciences, February 2019, Elsevier

    Jonathan Paul Mochel

  33. The Role of the Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

    Article • January 2019, MDPI AG

    Jonathan Paul Mochel

  34. Pharmacokinetics of Ertapenem in Sheep (Ovis aries) with Experimentally Induced Urinary Tract Infection

    Article • Comparative Medicine, January 2019, American Association for Laboratory Animal Science

    Jonathan Paul Mochel

  35. Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease

    Article • Veterinary Pathology, December 2018, SAGE Publications

    Jonathan Paul Mochel

  36. CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds against Hematological Malignancies

    Article • November 2018, MDPI AG

    Jonathan Paul Mochel

  37. Relative Oral Bioavailability of Two Amoxicillin–Clavulanic Acid Formulations in Healthy Dogs: A Pilot Study

    Article • Journal of the American Animal Hospital Association, November 2018, American Animal Hospital Association

    Jonathan Paul Mochel

  38. Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes)

    Article • Journal of Feline Medicine and Surgery, November 2018, SAGE Publications

    Jonathan Paul Mochel

  39. Adult Canine Intestinal Derived Organoids: A Novel In Vitro System for Translational Research in Comparative Gastroenterology

    Article • November 2018, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  40. Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of gastrointestinal stromal tumors of dogs

    Article • Journal of Veterinary Internal Medicine, October 2018, Wiley

    Jonathan Paul Mochel

  41. Sacubitril/valsartan (LCZ696) Significantly Reduces Aldosterone and Increases cGMP Circulating Levels in a Canine Model of RAAS Activation

    Article • October 2018, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  42. Comparative plasma and interstitial fluid pharmacokinetics and tissue residues of ceftiofur crystalline-free acid in cattle with induced coliform mastitis

    Article • Journal of Veterinary Pharmacology and Therapeutics, July 2018, Wiley

    Jonathan Paul Mochel

  43. Adverse reactions to fentanyl transdermal patches in calves: a preliminary clinical and pharmacokinetic study

    Article • Veterinary Anaesthesia and Analgesia, July 2018, Elsevier

    Jonathan Paul Mochel

  44. Impact of Flow Rate, Collection Devices, and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats

    Article • Journal of Ocular Pharmacology and Therapeutics, July 2018, Mary Ann Liebert Inc

    Jonathan Paul Mochel

  45. Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation

    Article • Journal of Veterinary Pharmacology and Therapeutics, May 2018, Wiley

    Marilyn Martinez, Jonathan Paul Mochel

  46. Effects of short-term anti-inflammatory glucocorticoid treatment on clinicopathologic, echocardiographic, and hemodynamic variables in systemically healthy dogs

    Article • American Journal of Veterinary Research, April 2018, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  47. Pharmacokinetics of fentanyl citrate and norfentanyl in Holstein calves and effect of analytical performances on fentanyl parameter estimation

    Article • Journal of Veterinary Pharmacology and Therapeutics, March 2018, Wiley

    Jonathan Paul Mochel

  48. Effect of tear collection on lacrimal total protein content in dogs and cats: a comparison between Schirmer strips and ophthalmic sponges

    Article • BMC Veterinary Research, March 2018, Springer Science + Business Media

    Jonathan Paul Mochel

  49. Comparison of milk and plasma pharmacokinetics of meloxicam in postpartum versus mid-lactation Holstein cows

    Article • Journal of Veterinary Pharmacology and Therapeutics, February 2018, Wiley

    Jonathan Paul Mochel

  50. Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences

    Article • Journal of Veterinary Pharmacology and Therapeutics, December 2017, Wiley

    Jonathan Paul Mochel

  51. Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research

    Article • The AAPS Journal, December 2017, American Association of Pharmaceutical Scientists (AAPS)

    Jonathan Paul Mochel

  52. Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics

    Article • Journal of Veterinary Pharmacology and Therapeutics, December 2017, Wiley

    Marilyn Martinez, Jonathan Paul Mochel

  53. Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative

    Article • CPT Pharmacometrics & Systems Pharmacology, November 2017, Wiley

    Iñaki F. Troconiz, Jonathan Paul Mochel

  54. Tear fluid collection in dogs and cats using ophthalmic sponges

    Article • Veterinary Ophthalmology, August 2017, Wiley

    Jonathan Paul Mochel

  55. Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats

    Article • CPT Pharmacometrics & Systems Pharmacology, October 2016, Wiley

    Jonathan Paul Mochel

  56. Multiple comparison procedure and modeling: a versatile tool for evaluating dose-response relationships in veterinary pharmacology - a case study with furosemide

    Article • Journal of Veterinary Pharmacology and Therapeutics, May 2016, Wiley

    Dr Bruno Bieth, Jonathan Paul Mochel

  57. Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment

    Article • Journal of Veterinary Pharmacology and Therapeutics, April 2016, Wiley

    Jonathan Paul Mochel

  58. Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics

    Article • Journal of Veterinary Pharmacology and Therapeutics, November 2015, Wiley

    Jonathan Paul Mochel

  59. Chronobiology and Pharmacologic Modulation of the Renin–Angiotensin–Aldosterone System in Dogs: What Have We Learned?

    Article • January 2015, Springer Science + Business Media

    Jonathan Paul Mochel

  60. Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs

    Article • Pharmaceutical Research, December 2014, Springer Science + Business Media

    Jonathan Paul Mochel

  61. FIRST-IN-CLASS ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR LCZ696 MODULATES THE DYNAMICS OF THE RENIN CASCADE AND NATRIURETIC PEPTIDES SYSTEM WITH SIGNIFICANT REDUCTION OF ALDOSTERONE EXPOSURE

    Article • Journal of the American College of Cardiology, April 2014, Elsevier

    Jonathan Paul Mochel

  62. Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs

    Article • Chronobiology International, March 2014, Taylor & Francis

    Jonathan Paul Mochel

  63. Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis

    Article • Research in Veterinary Science, October 2013, Elsevier

    Jonathan Paul Mochel

  64. Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology

    Article • Chronobiology International, August 2013, Taylor & Francis

    Jonathan Paul Mochel

  65. Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

    Article • Journal of Veterinary Pharmacology and Therapeutics, May 2013, Wiley

    Jonathan Paul Mochel

  66. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs

    Article • Journal of Veterinary Pharmacology and Therapeutics, May 2012, Wiley

    Jonathan Paul Mochel