All Stories

  1. The Antioxidant Properties of Red Sour Cherry (Prunus cerasus L.) Extracts: Laboratory Assessment of Antioxidant Activity and Antioxidant Compounds under Temperature Variations

    Article • Current Nutrition & Food Science, May 2015, Bentham Science Publishers

    Dr. John J. Haddad

  2. Hypoxia Upregulates MAPKp38/MAPKERK Phosphorylation In Vitro: Neuroimmunological Differential Time-Dependent Expression of MAPKs

    Article • Protein and Peptide Letters, February 2014, Bentham Science Publishers

    Dr. John J. Haddad

  3. The Immunomodulatory, Antimicrobial and Bactericidal Efficacy of Commonly Used Commercial Household Disinfectants, Sterilizers and Antiseptics in Vitro: Putative Anti-Inflammatory Infection Control Mechanisms and Comparative Bioche...

    Article • American Journal of Medical and Biological Research, October 2013, Science and Education Publishing Co., Ltd.

    Dr. John J. Haddad

  4. Current Opinion on 3-[2-[(2-Tert-Butyl-Phenylaminooxalyl)-Amino]-Propionylamino]- 4-Oxo-5-(2,3,5,6-Tetrafluoro-Phenoxy)-Pentanoic Acid, an Investigational Drug Targeting Caspases and Caspase-Like Proteases: The Clinical Trials in Sight and Recent Anti-...

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, July 2013, Bentham Science Publishers

    Dr. John J. Haddad

  5. Structural Peculiarities of the Proximal Femur Meta-Epiphysis in the Idiopathic Coxarthrosis According to Localization

    Article • American Journal of Medical and Biological Research, July 2013, Science and Education Publishing Co., Ltd.

    Dr. John J. Haddad

  6. The Antimicrobial Activity of Black Sour Cherry (Prunus cerasus L.) Extracts: I. Measurement of Sensitivity and Attenuation of Gram-Positive and Gram-Negative Bacteria and C. albicans in Culture

    Article • Current Nutrition & Food Science, July 2013, Bentham Science Publishers

    Dr. John J. Haddad

  7. The Antimicrobial Activity of Red Sour Cherry (Prunus cerasus L.) Extracts: II. Measurement of Sensitivity and Attenuation of Gram-Positive and Gram-Negative Bacteria and C. albicans in Culture

    Article • Current Nutrition & Food Science, July 2013, Bentham Science Publishers

    Dr. John J. Haddad

  8. The Antimicrobial Activity and MICs of Black/Red Sour Cherry (Prunus cerasus L.) Extracts: III. Measurement of Sensitivity and Attenuation of Gram-Positive and Gram-Negative Bacteria and C. albicans in Culture

    Article • Current Nutrition & Food Science, July 2013, Bentham Science Publishers

    Dr. John J. Haddad

  9. Measurement of Antioxidant Activity and Antioxidant Compounds under Versatile Extraction Conditions: II. The Immuno-Biochemical Antioxidant Properties of Black Sour Cherry (Prunus cerasus) Extracts

    Article • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, July 2013, Bentham Science Publishers

    Dr. John J. Haddad

  10. The Bioanalytical Molecular Pharmacology of the N-methyl-D-Aspartate (NMDA) Receptor Nexus and the Oxygen-Responsive Transcription Factor HIF-1α : Putative Mechanisms and Regulatory Pathways Unravel the Intimate Hypoxia Connection

    Article • Current Molecular Pharmacology, July 2013, Bentham Science Publishers

    Dr. John J. Haddad

  11. Complicated Gastric Ulcer and Jejunal Hematoma with Concomitant Warfarin Use: Analytical and Biomedical Case Study Report

    Article • American Journal of Medical and Biological Research, June 2013, Science and Education Publishing Co., Ltd.

    Dr. John J. Haddad

  12. The Anti-Inflammatory and Immunomodulatory Activity of Thymulin Peptide is NF-κB-Dependent and Involves the Downregulation of IκB-α

    Article • American Journal of Medical and Biological Research, May 2013, Science and Education Publishing Co., Ltd.

    Dr. John J. Haddad

  13. On the Cellular and Molecular Regulatory Transcriptional Mechanisms and Responsive Putative Pathways to Inflammatory Oxidative Stress Revisited: Current Immunological Breakthroughs and Views at a Glance

    Article • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, May 2013, Bentham Science Publishers

    Dr. John J. Haddad

  14. Measurement of Antioxidant Activity and Antioxidant Compounds under Versatile Extraction Conditions: I. The Immuno-Biochemical Antioxidant Properties of Sweet Cherry (Prunus avium) Extracts

    Article • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, May 2013, Bentham Science Publishers

    Dr. John J. Haddad

  15. A Surgical Opinion on Hyperalgesia/Nociception, Inflammatory/Neurogenic Pain and Anti-inflammatory Responses and Drug Interventions Revisited: Current Breakthroughs and Views

    Article • Current Immunology Reviews, January 2013, Bentham Science Publishers

    Dr. John J. Haddad

  16. The Antimicrobial Activity of Sweet Cherry (Prunus avium) Extracts: I. Measurement of Sensitivity and Attenuation of Gram-Positive and Gram- Negative Bacteria and C. albicans in Culture

    Article • Current Nutrition & Food Science, November 2012, Bentham Science Publishers

    Dr. John J. Haddad

  17. The Antimicrobial Activity of Sweet Cherry (Prunus avium) Extracts: II. Measurement of Sensitivity and Attenuation of Gram-Positive and Gram- Negative Bacteria and C. albicans in Culture

    Article • Current Nutrition & Food Science, November 2012, Bentham Science Publishers

    Dr. John J. Haddad

  18. A Surgical Opinion on Hyperalgesia/Nociception, Inflammatory/Neurogenic Pain and Anti-inflammatory Responses and Drug Interventions Revisited: Current Breakthroughs and Views

    Article • Current Immunology Reviews, November 2012, Bentham Science Publishers

    Dr. John J. Haddad

  19. The immunopharmacologic potential of Semaxanib and new generation directed therapeutic drugs: Receptor tyrosine kinase regulation with anti-tumorigenensis/angiogenesis properties

    Article • Saudi Pharmaceutical Journal, April 2012, Elsevier

    Dr. John J. Haddad

  20. NF-κB cellular and molecular regulatory mechanisms and pathways: Therapeutic pattern or pseudoregulation?

    Article • Cellular Immunology, January 2011, Elsevier

    Dr. John J. Haddad

  21. A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: Modulation by glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium

    Article • Cellular Immunology, January 2011, Elsevier

    Dr. John J. Haddad

  22. Thymulin and zinc (Zn2+)-mediated inhibition of endotoxin-induced production of proinflammatory cytokines and NF-κB nuclear translocation and activation in the alveolar epithelium: Unraveling the molecular immunomodulatory, anti-inflammatory effect of ...

    Article • Molecular Immunology, December 2009, Elsevier

    Dr. John J. Haddad

  23. The Regulation of Neuroimmune-Endocrine Interactions: Mechanisms,Molecular Pathways Unraveled and the Pivotal Role of Cytokines – A Unsung Putative Bidirectional Interdependence between the Immune and Neuroendocrine Interfaces

    Article • Current Immunology Reviews, August 2008, Bentham Science Publishers

    Dr. John J. Haddad

  24. On the mechanisms and putative pathways involving neuroimmune interactions

    Article • Biochemical and Biophysical Research Communications, June 2008, Elsevier

    Dr. John J. Haddad

  25. Multi-organ damage induced by anabolic steroid supplements: a case report and literature review

    Article • Journal of Medical Case Reports, January 2008, Springer Science + Business Media

    Dr. John J. Haddad

  26. Asymmetry and structural system analysis of the proximal femur meta-epiphysis: osteoarticular anatomical pathology

    Article • Journal of Orthopaedic Surgery and Research, January 2008, Springer Science + Business Media

    Dr. John J. Haddad

  27. Cellular and Molecular Regulation of Inflammatory Pain, Nociception and Hyperalgesia - The Role of the Transcription Factor NF-κB as the Lynchpin Nocisensor: Hyperalgesic or Analgesic Effect?

    Article • Current Immunology Reviews, May 2007, Bentham Science Publishers

    Dr. John J. Haddad

  28. The Role of Bax/Bcl-2 and Pro-Caspase Peptides in Hypoxia/Reperfusion-Dependent Regulation of MAPKERK: Discordant Proteomic Effect of MAPKp38

    Article • Protein and Peptide Letters, April 2007, Bentham Science Publishers

    Dr. John J. Haddad

  29. Discordant Tissue-Specific Expression of SAPK/MAPKJNK-Related Cofactors in Hypoxia and Hypoxia/Reoxygenation in a Model of Anoxia-Tolerance

    Article • Protein and Peptide Letters, April 2007, Bentham Science Publishers

    Dr. John J. Haddad

  30. On the enigma of pain and hyperalgesia: A molecular perspective

    Article • Biochemical and Biophysical Research Communications, February 2007, Elsevier

    Dr. John J. Haddad

  31. Biomechanical and system analysis of the human femoral bone: correlation and anatomical approach

    Article • Journal of Orthopaedic Surgery and Research, January 2007, Springer Science + Business Media

    Dr. John J. Haddad

  32. l-γ-Glutamyl-l-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)?

    Article • Molecular Immunology, May 2005, Elsevier

    Dr. John J. Haddad

  33. Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α

    Article • International Immunopharmacology, March 2005, Elsevier

    Dr. John J. Haddad

  34. Amiloride and the regulation of NF-κB: an unsung crosstalk and missing link between fluid dynamics and oxidative stress-related inflammation—controversy or pseudo-controversy?

    Article • Biochemical and Biophysical Research Communications, February 2005, Elsevier

    Dr. John J. Haddad

  35. Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects

    Article • Biochemical and Biophysical Research Communications, October 2004, Elsevier

    Dr. John J. Haddad

  36. Hypoxia and the regulation of mitogen-activated protein kinases: gene transcription and the assessment of potential pharmacologic therapeutic interventions

    Article • International Immunopharmacology, October 2004, Elsevier

    Dr. John J. Haddad

  37. On the antioxidant mechanisms of Bcl-2: a retrospective of NF-κB signaling and oxidative stress

    Article • Biochemical and Biophysical Research Communications, September 2004, Elsevier

    Dr. John J. Haddad

  38. Cytokines in the Central Nervous System: Targets for Therapeutic Intervention

    Article • Current Drug Targets - CNS & Neurological Disorders, August 2004, Bentham Science Publishers

    Dr. John J. Haddad

  39. Mitogen-activated protein kinases and the evolution of Alzheimer’s: a revolutionary neurogenetic axis for therapeutic intervention?

    Article • Progress in Neurobiology, August 2004, Elsevier

    Dr. John J. Haddad

  40. Oxygen sensing and oxidant/redox-related pathways

    Article • Biochemical and Biophysical Research Communications, April 2004, Elsevier

    Dr. John J. Haddad

  41. Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment

    Article • International Immunopharmacology, April 2004, Elsevier

    Dr. John J. Haddad

  42. Interleukin-10 and the regulation of mitogen-activated protein kinases: are these signalling modules targets for the anti-inflammatory action of this cytokine?

    Article • Cellular Signalling, March 2003, Elsevier

    Dr. John J. Haddad

  43. Cytokines and neuro–immune–endocrine interactions: a role for the hypothalamic–pituitary–adrenal revolving axis

    Article • Journal of Neuroimmunology, December 2002, Elsevier

    Dr. John J. Haddad, Professor Rainbow Tin Hung Ho

  44. Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors

    Article • Cellular Signalling, November 2002, Elsevier

    Dr. John J. Haddad

  45. Cytokines and related receptor-mediated signaling pathways

    Article • Biochemical and Biophysical Research Communications, October 2002, Elsevier

    Dr. John J. Haddad

  46. Pharmaco-redox regulation of cytokine-related pathways: from receptor signaling to pharmacogenomics

    Article • Free Radical Biology and Medicine, October 2002, Elsevier

    Dr. John J. Haddad

  47. Oxygen homeostasis, thiol equilibrium and redox regulation of signalling transcription factors in the alveolar epithelium

    Article • Cellular Signalling, October 2002, Elsevier

    Dr. John J. Haddad

  48. Inhibition of glutathione-related enzymes augments LPS-mediated cytokine biosynthesis: involvement of an IκB/NF-κB-sensitive pathway in the alveolar epithelium

    Article • International Immunopharmacology, October 2002, Elsevier

    Dr. John J. Haddad

  49. Redox- and oxidant-mediated regulation of interleukin-10: an anti-inflammatory, antioxidant cytokine?

    Article • Biochemical and Biophysical Research Communications, September 2002, Elsevier

    Dr. John J. Haddad

  50. Redox regulation of pro-inflammatory cytokines and IκB-α/NF-κB nuclear translocation and activation

    Article • Biochemical and Biophysical Research Communications, August 2002, Elsevier

    Dr. John J. Haddad

  51. Nuclear factor (NF)-κB blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1β biosynthesis in alveolar epithelial cells

    Article • Biochemical and Biophysical Research Communications, April 2002, Elsevier

    Dr. John J. Haddad

  52. Nuclear Factor-κB-Independent Regulation of Lipopolysaccharide-Mediated Interleukin-6 Biosynthesis

    Article • Biochemical and Biophysical Research Communications, March 2002, Elsevier

    Dr. John J. Haddad

  53. RECOMBINANT TNF-α MEDIATED REGULATION OF THE IκB-α/NF-κB SIGNALING PATHWAY: EVIDENCE FOR THE ENHANCEMENT OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN ALVEOLAR EPITHELIAL CELLS

    Article • Cytokine, March 2002, Elsevier

    Dr. John J. Haddad

  54. Redox regulation of TNF-α biosynthesis: Augmentation by irreversible inhibition of γ-glutamylcysteine synthetase and the involvement of an IκB-α/NF-κB-independent pathway in alveolar epithelial cells

    Article • Cellular Signalling, March 2002, Elsevier

    Dr. John J. Haddad

  55. Redox Signaling-Mediated Regulation of Lipopolysaccharide-Induced Proinflammatory Cytokine Biosynthesis in Alveolar Epithelial Cells

    Article • Antioxidants & Redox Signaling, February 2002, Mary Ann Liebert Inc

    Dr. John J. Haddad

  56. The involvement of l-γ-glutamyl-l-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signaling mediating MAPKp38-dependent regulation of pro-inflammatory cytokine production

    Article • Biochemical Pharmacology, January 2002, Elsevier

    Dr. John J. Haddad

  57. Oxygen-sensitive pro-inflammatory cytokines, apoptosis signaling and redox-responsive transcription factors in development and pathophysiology

    Article • Cytokines Cellular & Molecular Therapy, January 2002, Taylor & Francis

    Dr. John J. Haddad

  58. Amiloride Blockades Lipopolysaccharide-Induced Proinflammatory Cytokine Biosynthesis in an I κ B- α /NF- κ B–Dependent Mechanism

    Article • American Journal of Respiratory Cell and Molecular Biology, January 2002, American Thoracic Society

    Dr. John J. Haddad

  59. A non-hypoxic, ROS-sensitive pathway mediates TNF-α-dependent regulation of HIF-1α

    Article • FEBS Letters, August 2001, Wiley

    Dr. John J. Haddad

  60. Nuclear Factor-κB Blockade Attenuates but Does Not Abrogate Lipopolysaccharide-Dependent Tumor Necrosis Factor-α Biosynthesis in Alveolar Epithelial Cells

    Article • Biochemical and Biophysical Research Communications, July 2001, Elsevier

    Dr. John J. Haddad

  61. α-Melanocyte-related tripeptide, Lys-d-Pro-Val, ameliorates endotoxin-induced nuclear factor κB translocation and activation: evidence for involvement of an interleukin-1β193–195 receptor antagonism in the alveolar epithelium

    Article • Biochemical Journal, April 2001, Portland Press Ltd.

    Dr. John J. Haddad

  62. α-Melanocyte-related tripeptide, Lys-d-Pro-Val, ameliorates endotoxin-induced nuclear factor κB translocation and activation: evidence for involvement of an interleukin-1β193‒195 receptor antagonism in the alveolar epithelium

    Article • Biochemical Journal, April 2001, Portland Press Ltd.

    Dr. John J. Haddad

  63. NF-κB Blockade Reduces the O2-Evoked Rise in Na+ Conductance in Fetal Alveolar Cells

    Article • Biochemical and Biophysical Research Communications, March 2001, Elsevier

    Dr. John J. Haddad

  64. CHEMIOXYEXCITATION (Δp O2/ROS)-DEPENDENT RELEASE OF IL-1β, IL-6 AND TNF-α: EVIDENCE OF CYTOKINES AS OXYGEN-SENSITIVE MEDIATORS IN THE ALVEOLAR EPITHELIUM

    Article • Cytokine, February 2001, Elsevier

    Dr. John J. Haddad

  65. The ex Vivo Differential Expression of Apoptosis Signaling Cofactors in the Developing Perinatal Lung: Essential Role of Oxygenation During the Transition from Placental to Pulmonary-Based Respiration

    Article • Biochemical and Biophysical Research Communications, February 2001, Elsevier

    Dr. John J. Haddad

  66. Immunomodulatory Potential of Thymulin–Zn2+ in the Alveolar Epithelium: Amelioration of Endotoxin-Induced Cytokine Release and Partial Amplification of a Cytoprotective IL-10-Sensitive Pathway

    Article • Biochemical and Biophysical Research Communications, August 2000, Elsevier

    Dr. John J. Haddad

  67. The Differential Expression of Apoptosis Factors in the Alveolar Epithelium Is Redox Sensitive and Requires NF-κB (RelA)-Selective Targeting

    Article • Biochemical and Biophysical Research Communications, April 2000, Elsevier

    Dr. John J. Haddad

  68. Glutathione Depletion is Associated with Augmenting a Proinflammatory Signal: Evidence for an Antioxidant/Pro-oxidant Mechanism Regulating Cytokines in the Alveolar Epithelium

    Article • Cytokines Cellular & Molecular Therapy, January 2000, Taylor & Francis

    Dr. John J. Haddad

  69. Interleukin-1 beta inhibits the intestinal transport of [14C] 3-O-methylglucose in the rat

    Article • Life Sciences, October 1998, Elsevier

    Dr. John J. Haddad

  70. Involvement of interleukin-1β , nerve growth factor and prostaglandin E2 in endotoxin-induced localized inflammatory hyperalgesia

    Article • British Journal of Pharmacology, August 1997, Wiley

    Dr. John J. Haddad

  71. Endotoxin-induced local inflammation and hyperalgesia in rats and mice: a new model for inflammatory pain

    Article • Pain, August 1996, Wolters Kluwer Health

    Dr. John J. Haddad

  72. Thymulin reduces hyperalgesia induced by peripheral endotoxin injection in rats and mice

    Article • Brain Research, April 1996, Elsevier

    Dr. John J. Haddad

  73. Neuroimmunology

    Article • Springer Science + Business Media

    Dr. John J. Haddad