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  1. The histamine H4 receptor antagonist 1-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]-4-methyl-piperazine(LINS01007) prevents the development of DSS-induced colitis in mice

    Article • International Immunopharmacology, May 2024, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  2. Therapeutic potential of LINS01 histamine H3 receptor antagonists as antineoplastic agents for triple negative breast cancer

    Article • Biomedicine & Pharmacotherapy, May 2024, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  3. Investigation of Structure–Activity Relationships for Benzoyl and Cinnamoyl Piperazine/Piperidine Amides as Tyrosinase Inhibitors

    Article • ACS Omega, November 2023, American Chemical Society (ACS)

    Dr Joao Paulo dos Santos Fernandes

  4. Piperazine amides with desirable solubility, physicochemical and drug-like properties: Synthesis and evaluation of the anti-Trypanosoma cruzi activity

    Article • Saudi Pharmaceutical Journal, July 2023, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  5. Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments

    Article • European Journal of Medicinal Chemistry, May 2023, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  6. Lethal action of Licarin A derivatives in Leishmania (L.) infantum: Imbalance of calcium and bioenergetic metabolism

    Article • Biochimie, May 2023, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  7. Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi

    Article • Life, February 2023, MDPI AG

    Dr Joao Paulo dos Santos Fernandes

  8. Esterification of p-Coumaric Acid Improves the Control over Melanoma Cell Growth

    Article • Biomedicines, January 2023, MDPI AG

    Dr Joao Paulo dos Santos Fernandes

  9. Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H3 and dopamine D3 receptors

    Article • Bioorganic & Medicinal Chemistry, January 2023, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  10. Neurotoxicity Assessment of 1-[(2,3-Dihydro-1-Benzofuran-2-yl)Methyl]Piperazine (LINS01 Series) Derivatives and their Protective Effect on Cocaine-Induced Neurotoxicity Model in SH-SY5Y Cell Culture

    Article • Neurotoxicity Research, November 2022, Springer Science + Business Media

    Dr Joao Paulo dos Santos Fernandes

  11. Orofacial myofunctional assessment and quality of life of individuals with Parkinson's disease

    Article • Special Care in Dentistry, September 2022, Wiley

    Dr Joao Paulo dos Santos Fernandes

  12. Evaluation of the histamine H3 receptor antagonists from LINS01 series as cholinesterases inhibitors: Enzymatic and modeling studies

    Article • Chemical Biology & Drug Design, September 2022, Wiley

    Dr Joao Paulo dos Santos Fernandes

  13. Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS)

    Article • Inflammation Research, June 2022, Springer Science + Business Media

    Dr Joao Paulo dos Santos Fernandes

  14. Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi

    Article • European Journal of Pharmaceutical Sciences, April 2022, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  15. Bioisosteric modification on benzylidene‐carbonyl compounds improved the drug‐likeness and maintained the antifungal activity against Sporothrix brasiliensis

    Article • Chemical Biology & Drug Design, December 2021, Wiley

    Dr Joao Paulo dos Santos Fernandes

  16. Histamine H3 receptor and cholinesterases as synergistic targets for cognitive decline: Strategies to the rational design of multitarget ligands

    Article • Chemical Biology & Drug Design, June 2021, Wiley

    Dr Joao Paulo dos Santos Fernandes

  17. Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses

    Article • PLoS ONE, February 2021, PLOS

    Dr Joao Paulo dos Santos Fernandes

  18. Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands – Functional characterization and modeling studies on H3 and H4 receptors

    Article • Bioorganic & Medicinal Chemistry, January 2021, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  19. Assessment of the Physicochemical Properties and Stability for Pharmacokinetic Prediction of Pyrazinoic Acid Derivatives

    Article • Current Drug Metabolism, December 2020, Bentham Science Publishers

    Dr Joao Paulo dos Santos Fernandes , Taisa Franchin

  20. Relationship between polypharmacy, xerostomia, gustatory sensitivity, and swallowing complaints in the elderly: A multidisciplinary approach

    Article • Journal of Texture Studies, November 2020, Wiley

    Dr Joao Paulo dos Santos Fernandes

  21. The Novel H4R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma

    Article • Cellular Physiology and Biochemistry, November 2020, Cell Physiol Biochem Press GmbH and Co KG

    Dr Joao Paulo dos Santos Fernandes

  22. Total Parenteral Nutrition and Neuroleptic Malignant-Like Syndrome in Parkinson Disease

    Article • American Journal of Therapeutics, October 2020, Wolters Kluwer Health

    Dr Joao Paulo dos Santos Fernandes

  23. Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity

    Article • European Journal of Pharmaceutical Sciences, October 2020, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  24. Coumaric acid derivatives as tyrosinase inhibitors: Efficacy studies through in silico, in vitro and ex vivo approaches

    Article • Bioorganic Chemistry, October 2020, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  25. Benzylidene-carbonyl compounds are active against itraconazole-susceptible and itraconazole-resistant Sporothrix brasiliensis

    Article • Folia Microbiologica, August 2020, Springer Science + Business Media

    Dr Joao Paulo dos Santos Fernandes

  26. Natural Products: Key Prototypes to Drug Discovery Against Neglected Diseases Caused by Trypanosomatids

    Article • Current Medicinal Chemistry, April 2020, Bentham Science Publishers

    Dr Joao Paulo dos Santos Fernandes

  27. Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A

    Article • Scientific Reports, March 2020, Springer Science + Business Media

    Dr Joao Paulo dos Santos Fernandes

  28. Novel potent vasodilating agents: Evaluation of the activity and potency of LINS01005 and derivatives in rat aorta

    Article • European Journal of Pharmaceutical Sciences, February 2020, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  29. Differential contribution of H3R antagonism by LINS01 compounds on memory, anxiety-like behaviour and spontaneous locomotor activity in healthy rats

    Article • Behavioural Brain Research, January 2020, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  30. Profiling of LINS01 compounds at human dopamine D2 and D3 receptors

    Article • Journal of Chemical Sciences, December 2019, Springer Science + Business Media

    Dr Joao Paulo dos Santos Fernandes

  31. Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives

    Article • Bioorganic Chemistry, August 2019, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  32. Targeting the Histamine H4 Receptor: Future Drugs for Inflammatory Diseases

    Article • Current Organic Chemistry, October 2018, Bentham Science Publishers

    Dr Joao Paulo dos Santos Fernandes

  33. Pyrazinoates as antiparasitic agents against Trypanosoma cruzi

    Article • Archiv der Pharmazie, October 2018, Wiley

    Dr Joao Paulo dos Santos Fernandes

  34. Antiparasitic activity of new gibbilimbol analogues and SAR analysis through efficiency and statistical methods

    Article • European Journal of Pharmaceutical Sciences, September 2018, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  35. Pharmacological and SAR analysis of the LINS01 compounds at the human histamine H1 , H2 and H3 receptors

    Article • August 2018, Wiley

    Dr Joao Paulo dos Santos Fernandes

  36. QSAR Modeling of Histamine H3R Antagonists/inverse Agonists as Future Drugs for Neurodegenerative Diseases

    Article • Current Neuropharmacology, June 2018, Bentham Science Publishers

    Dr Joao Paulo dos Santos Fernandes

  37. The Importance of Medicinal Chemistry Knowledge in the Clinical Pharmacist’s Education

    Article • American Journal of Pharmaceutical Education, March 2018, American Journal of Pharmaceutical Education

    Dr Joao Paulo dos Santos Fernandes

  38. Anti-Sporothrix brasiliensis activity of different pyrazinoic acid prodrugs: a repurposing evaluation

    Article • January 2018, FapUNIFESP (SciELO)

    Dr Joao Paulo dos Santos Fernandes

  39. Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential

    Article • Frontiers in Pharmacology, November 2017, Frontiers

    Dr Joao Paulo dos Santos Fernandes

  40. Evaluation of β-Aminocarboxylic Acid Derivatives in Hippocampal Excitatory Synaptic Transmission

    Article • Archiv der Pharmazie, September 2017, Wiley

    Dr Joao Paulo dos Santos Fernandes

  41. New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum

    Article • Chemical Biology & Drug Design, May 2017, Wiley

    Dr Joao Paulo dos Santos Fernandes

  42. 1-[(2,3-Dihydro-1-benzofuran-2-yl) methyl]piperazines as novel anti-inflammatory compounds: Synthesis and evaluation on H3R/H4R

    Article • Chemical Biology & Drug Design, February 2017, Wiley

    Dr Joao Paulo dos Santos Fernandes , PhD Lanfranco R. P. Troncone

  43. Factorial study to assess an ultrasonic methodology for the allylation of 4-chloroaniline

    Article • Green Processing and Synthesis, January 2017, De Gruyter

    Dr Joao Paulo dos Santos Fernandes

  44. Antimycobacterial activity of pyrazinoate prodrugs in replicating and non-replicating Mycobacterium tuberculosis

    Article • Tuberculosis, July 2016, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  45. Pyrazinamide and Pyrazinoic Acid Derivatives Directed to Mycobacterial Enzymes Against Tuberculosis

    Article • Current Protein and Peptide Science, March 2016, Bentham Science Publishers

    Dr Joao Paulo dos Santos Fernandes

  46. Gibbilimbol analogues as antiparasitic agents—Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum

    Article • Bioorganic & Medicinal Chemistry Letters, February 2016, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  47. Factorial design study to access the “green” iodocyclization reaction of 2-allylphenols

    Article • Green Processing and Synthesis, January 2016, De Gruyter

    Dr Joao Paulo dos Santos Fernandes

  48. Histamine H4 Receptor Ligands: Future Applications and State of Art

    Article • Chemical Biology & Drug Design, October 2014, Wiley

    Dr Joao Paulo dos Santos Fernandes

  49. Synthesis and evaluation of a pyrazinoic acid prodrug in Mycobacterium tuberculosis

    Article • Saudi Pharmaceutical Journal, September 2014, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  50. Estudo das relações entre estrutura e atividade de parabenos: uma aula prática

    Article • Química Nova, January 2013, FapUNIFESP (SciELO)

    Dr Joao Paulo dos Santos Fernandes

  51. Cytotoxicity evaluation ofCurcuma zedoaria(Christm.) Roscoe fluid extract used in oral hygiene products

    Article • Acta Odontologica Scandinavica, January 2012, Taylor & Francis

    Dr Joao Paulo dos Santos Fernandes

  52. Optimization of the ultrasound-assisted synthesis of allyl 1-naphthyl ether using response surface methodology

    Article • Ultrasonics Sonochemistry, March 2011, Elsevier

    Dr Joao Paulo dos Santos Fernandes

  53. Molecular modeling and QSAR studies of a set of indole and benzimidazole derivatives as H4 receptor antagonists

    Article • Journal of Molecular Modeling, July 2010, Springer Science + Business Media

    Dr Joao Paulo dos Santos Fernandes

  54. QSAR Modeling of a Set of Pyrazinoate Esters as Antituberculosis Prodrugs

    Article • Archiv der Pharmazie, January 2010, Wiley

    Dr Joao Paulo dos Santos Fernandes

  55. Simple and Efficient Access to 3-Ethoxycarbonylpyrroles, Benzofurans, and Naphthofurans

    Article • Synthesis, October 2009, Thieme Publishing Group

    Dr Joao Paulo dos Santos Fernandes

  56. Evaluation of the influence of base and alkyl bromide on synthesis of pyrazinoic acid esters through fatorial design

    Article • Química Nova, January 2009, FapUNIFESP (SciELO)

    Dr Joao Paulo dos Santos Fernandes

  57. Planejamento e sintese de compostos potencialmente ligantes dos receptores 5-HT2C e H4

    Article • Universidade de Sao Paulo Sistema Integrado de Bibliotecas - SIBiUSP

    Dr Joao Paulo dos Santos Fernandes

  58. Síntese e atividade antimicobacteriana de ésteres do ácido pirazinóico e quinolonas

    Article • Universidade de Sao Paulo Sistema Integrado de Bibliotecas - SIBiUSP

    Dr Joao Paulo dos Santos Fernandes