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  1. Repositioning Oxybutynin Hydrochloride: State of the Art in Synthesis, Mode of Action, Metabolism, and Formulations

    Article • Drugs and Drug Candidates, October 2023, MDPI AG

    Dr Jean Jacques Vanden Eynde

  2. Drugs and Drug Candidates: A Challenging Project

    Article • Drugs and Drug Candidates, July 2022, MDPI AG

    Dr Jean Jacques Vanden Eynde

  3. COVID-19: Failure of the DisCoVeRy Clinical Trial, and Now–New Hopes?

    Article • Pharmaceuticals, July 2021, MDPI AG

    Dr Jean Jacques Vanden Eynde

  4. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

    Article • Molecules, June 2020, MDPI AG

    Assoc. Prof. Alfonso T. Garcia-Sosa, Prof Andrea Trabocchi, Dr Jean Jacques Vanden Eynde

  5. COVID-19: An Update about the Discovery Clinical Trial

    Article • Pharmaceuticals, May 2020, MDPI AG

    Dr Jean Jacques Vanden Eynde

  6. COVID-19: A Brief Overview of the Discovery Clinical Trial

    Article • Pharmaceuticals, April 2020, MDPI AG

    Dr Jean Jacques Vanden Eynde

  7. 2019: An Awesome Year for Pharmaceuticals

    Article • Pharmaceuticals, January 2020, MDPI AG

    Dr Jean Jacques Vanden Eynde

  8. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

    Article • Molecules, December 2019, MDPI AG

    Assoc. Prof. Alfonso T. Garcia-Sosa, Prof Andrea Trabocchi, Dr Jean Jacques Vanden Eynde

  9. Tafenoquine: A 2018 Novel FDA-Approved Prodrug for the Radical Cure of Plasmodium vivax Malaria and Prophylaxis of Malaria

    Article • Pharmaceuticals, July 2019, MDPI AG

    Dr Jean Jacques Vanden Eynde

  10. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

    Article • Molecules, June 2019, MDPI AG

    Dr Jean Jacques Vanden Eynde

  11. Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues

    Article • ACS Omega, June 2019, American Chemical Society (ACS)

    Dr Jean Jacques Vanden Eynde

  12. Baricitinib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Janus Kinases

    Article • Pharmaceuticals, March 2019, MDPI AG

    Dr Jean Jacques Vanden Eynde

  13. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–4

    Article • Molecules, December 2018, MDPI AG

    Dr Jean Jacques Vanden Eynde

  14. Correction to: Affinity capillary electrophoresis for identification of active drug candidates in myotonic dystrophy type 1

    Article • Analytical and Bioanalytical Chemistry, November 2018, Springer Science + Business Media

    Dr Jean Jacques Vanden Eynde

  15. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

    Article • Molecules, June 2018, MDPI AG

    Dr Jean Jacques Vanden Eynde

  16. Third International Electronic Conference on Medicinal Chemistry (ECMC-3)

    Article • Pharmaceuticals, February 2018, MDPI AG

    Dr Jean Jacques Vanden Eynde

  17. 2017: A Fruitful Year for Pharmaceuticals

    Article • Pharmaceuticals, December 2017, MDPI AG

    Dr Jean Jacques Vanden Eynde

  18. Designing a high performance, stable spectroscopic biosensor for the binding of large and small molecules

    Article • Journal of Colloid and Interface Science, December 2017, Elsevier

    Dr Jean Jacques Vanden Eynde

  19. Pharmaceuticals: Impact Factor or CiteScore™

    Article • Pharmaceuticals, July 2017, MDPI AG

    Dr Jean Jacques Vanden Eynde

  20. Announcing the 2017 Pharmaceuticals Travel Award for Young Post-Doctoral Researchers

    Article • Pharmaceuticals, May 2017, MDPI AG

    Dr Jean Jacques Vanden Eynde

  21. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes

    Article • Molecules, May 2017, MDPI AG

    Dr Jean Jacques Vanden Eynde

  22. Potential of bisbenzimidazole-analogs toward metronidazole-resistant Trichomonas vaginalis isolates

    Article • Chemical Biology & Drug Design, April 2017, Wiley

    Emmanuel Bujans, Dr Jean Jacques Vanden Eynde

  23. Second International Electronic Conference on Medicinal Chemistry (ECMC-2)

    Article • Pharmaceuticals, January 2017, MDPI AG

    Professor Marc Le Borgne, Dr Jean Jacques Vanden Eynde

  24. Progress Confirmed for Pharmaceuticals in 2016

    Article • Pharmaceuticals, December 2016, MDPI AG

    Dr Jean Jacques Vanden Eynde

  25. Evaluation of bisbenzamidines as inhibitors for matriptase-2

    Article • Bioorganic & Medicinal Chemistry Letters, August 2016, Elsevier

    Dr Jean Jacques Vanden Eynde

  26. Announcing the 2016 Pharmaceuticals Travel Award for Young Investigators

    Article • Pharmaceuticals, June 2016, MDPI AG

    Dr Jean Jacques Vanden Eynde

  27. How Efficient Is My (Medicinal) Chemistry?

    Article • Pharmaceuticals, May 2016, MDPI AG

    Dr Jean Jacques Vanden Eynde

  28. Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

    Article • Pharmaceuticals, April 2016, MDPI AG

    Dr Jean Jacques Vanden Eynde

  29. First International Electronic Conference on Medicinal Chemistry (ECMC-1)

    Article • Pharmaceuticals, March 2016, MDPI AG

    Dr Jean Jacques Vanden Eynde

  30. 2015: A Transition Year for Pharmaceuticals?

    Article • Pharmaceuticals, January 2016, MDPI AG

    Dr Jean Jacques Vanden Eynde

  31. Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors

    Article • Bioorganic & Medicinal Chemistry, August 2015, Elsevier

    Dr Jean Jacques Vanden Eynde

  32. Pharmaceuticals Best Paper Award 2015

    Article • Pharmaceuticals, June 2015, MDPI AG

    Dr Jean Jacques Vanden Eynde

  33. Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study

    Article • Molecules, July 2014, MDPI AG

    Dr Jean Jacques Vanden Eynde

  34. Ultra high performance liquid chromatography method for the determination of pentamidine and analog in rat biological fluids

    Article • Journal of Pharmaceutical and Biomedical Analysis, July 2014, Elsevier

    Dr Jean Jacques Vanden Eynde

  35. Some non-conventional biomolecular targets for diamidines. A short survey

    Article • Bioorganic & Medicinal Chemistry, April 2014, Elsevier

    Dr Jean Jacques Vanden Eynde

  36. Third Component 1,3-Dicarbonyl Compound (with Ammonia or Amines: Hantzsch Pyridine Synthesis)

    Article • January 2014, Thieme Publishing Group

    Dr Jean Jacques Vanden Eynde

  37. Design and Synthesis of N1,N5-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs

    Article • Molecules, September 2013, MDPI AG

    Dr Jean Jacques Vanden Eynde

  38. Diamidines versus Monoamidines as Anti-Pneumocystis Agents: An in Vivo Study

    Article • Pharmaceuticals, July 2013, MDPI AG

    Dr Jean Jacques Vanden Eynde

  39. Biological evaluation of bisbenzaldehydes against four Mycobacterium species

    Article • European Journal of Medicinal Chemistry, May 2013, Elsevier

    Dr Jean Jacques Vanden Eynde

  40. Quantification of the trichothecene Verrucarin-A in environmental samples using an antibody-based spectroscopic biosensor

    Article • Sensors and Actuators B Chemical, May 2012, Elsevier

    Dr Jean Jacques Vanden Eynde

  41. Fragment-Based Design of Symmetrical Bis-benzimidazoles as Selective Inhibitors of the Trimethoprim-Resistant, Type II R67 Dihydrofolate Reductase

    Article • Journal of Medicinal Chemistry, March 2012, American Chemical Society (ACS)

    Dr Jean Jacques Vanden Eynde

  42. 1,4–Diarylpiperazines and analogs as anti-tubercular agents: Synthesis and biological evaluation

    Article • European Journal of Medicinal Chemistry, March 2012, Elsevier

    Dr Jean Jacques Vanden Eynde

  43. PPARs: Interference with Warburg’ Effect and Clinical Anticancer Trials

    Article • PPAR Research, January 2012, Hindawi Publishing Corporation

    Dr Jean Jacques Vanden Eynde

  44. Bis(oxyphenylene)benzimidazoles: A novel class of anti-Plasmodium falciparum agents

    Article • Bioorganic & Medicinal Chemistry, December 2011, Elsevier

    Dr Jean Jacques Vanden Eynde

  45. The α-asarone/clofibrate hybrid compound, 2-methoxy-4-(2-propenyl)phenoxyacetic acid (MPPA), is endowed with neuroprotective and anticonvulsant potentialities

    Article • Biomedicine & Aging Pathology, October 2011, Elsevier

    Dr Jean Jacques Vanden Eynde

  46. Three optimized and validated (using accuracy profiles) LC methods for the determination of pentamidine and new analogs in rat plasma

    Article • Talanta, January 2011, Elsevier

    Dr Jean Jacques Vanden Eynde

  47. 1,2-Ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action

    Article • European Journal of Medicinal Chemistry, July 2010, Elsevier

    Dr Jean Jacques Vanden Eynde

  48. Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?

    Article • Molecules, June 2010, MDPI AG

    Dr Jean Jacques Vanden Eynde

  49. Synthesis of 3,5-disubstituted 1,2,4-oxadiazoles using ionic liquid-phase organic synthesis (IoLiPOS) methodology

    Article • Tetrahedron, January 2010, Elsevier

    Dr Jean Jacques Vanden Eynde

  50. Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity

    Article • Bioorganic & Medicinal Chemistry Letters, October 2009, Elsevier

    Dr Jean Jacques Vanden Eynde

  51. Synthesis and application of ionic liquid phase-supported β-aminocrotonate for access to asymmetric 1,4-dihydropyridines.

    Article • Heterocyclic Communications, January 2009, De Gruyter

    Dr Jean Jacques Vanden Eynde

  52. Ionic liquid phase organic synthesis (IoLiPOS) methodology applied to the preparation of new 3,4-dihydropyrimidine-2(1H)-ones bearing bioisostere group in N-3 position

    Article • Tetrahedron, May 2008, Elsevier

    Dr Jean Jacques Vanden Eynde

  53. Novel bisbenzimidazoles with antileishmanial effectiveness

    Article • Bioorganic & Medicinal Chemistry Letters, April 2008, Elsevier

    Dr Jean Jacques Vanden Eynde

  54. Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug

    Article • International Journal of Antimicrobial Agents, December 2007, Elsevier

    Dr Jean Jacques Vanden Eynde

  55. Sequential synthesis of a new analogue of amlodipine bearing a short amino polyethyleneglycol chain

    Article • Tetrahedron, November 2007, Elsevier

    Dr Jean Jacques Vanden Eynde

  56. A new approach to N-3 functionalized 3,4-dihydropyrimidine-2(1H)-ones with 1,2,4-oxadiazole group as amide isostere via ionic liquid-phase technology

    Article • Tetrahedron Letters, February 2007, Elsevier

    Dr Jean Jacques Vanden Eynde

  57. Liquid-Phase Synthesis of Polyhydroquinoline Using Task-Specific Ionic Liquid Technology

    Article • Journal of Combinatorial Chemistry, November 2006, American Chemical Society (ACS)

    Dr Jean Jacques Vanden Eynde

  58. Anti-plasmodial and anti-leishmanial activity of conformationally restricted pentamidine congeners

    Article • Journal of Pharmacy and Pharmacology, August 2006, Wiley

    Dr Jean Jacques Vanden Eynde

  59. Ionic liquid phase technology supported the three component synthesis of Hantzsch 1,4-dihydropyridines and Biginelli 3,4-dihydropyrimidin-2(1H)-ones under microwave dielectric heating

    Article • Tetrahedron, December 2005, Elsevier

    Dr Jean Jacques Vanden Eynde

  60. Antitumor and Anti-Pneumocystis Carinii Activities of Novel Bisbenzamidines

    Article • Medicinal Chemistry Research, April 2005, Springer Science + Business Media

    Dr Jean Jacques Vanden Eynde

  61. Highly Active Anti-Pneumocystis carinii Compounds in a Library of Novel Piperazine-Linked Bisbenzamidines and Related Compounds

    Article • Antimicrobial Agents and Chemotherapy, November 2004, ASM Journals

    Dr Jean Jacques Vanden Eynde

  62. Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia

    Article • Bioorganic & Medicinal Chemistry Letters, September 2004, Elsevier

    Dr Jean Jacques Vanden Eynde

  63. Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents

    Article • European Journal of Medicinal Chemistry, June 2004, Elsevier

    Dr Jean Jacques Vanden Eynde

  64. Parallel Solution-Phase Synthesis of Conformationally Restricted Congeners of Pentamidine and Evaluation of Their Antiplasmodial Activities

    Article • Journal of Medicinal Chemistry, May 2004, American Chemical Society (ACS)

    Dr Jean Jacques Vanden Eynde

  65. Synthesis of π-Conjugated Systems from Methyldiazines and Aromatic Aldehydes under PTC Conditions and without Organic Solvent

    Article • Letters in Organic Chemistry, April 2004, Bentham Science Publishers

    Dr Jean Jacques Vanden Eynde

  66. Evidences for the formation of bisbenzamidine–heme complexes in cell-free systems

    Article • Bioorganic & Medicinal Chemistry Letters, April 2004, Elsevier

    Dr Jean Jacques Vanden Eynde

  67. Ionic liquid phase organic synthesis (IoLiPOS) methodology applied to the three component preparation of 2-thioxo tetrahydropyrimidin-4-(1H)-ones under microwave dielectric heating

    Article • Tetrahedron, April 2004, Elsevier

    Dr Jean Jacques Vanden Eynde

  68. Synthesis and Aromatization of Hantzsch 1,4-Dihydropyridines under Microwave Irradiation

    Article • ChemInform, March 2004, Wiley

    Dr Jean Jacques Vanden Eynde

  69. Optical and thermal properties of novel diazine-based oligo(phenylene vinylene)s

    Article • e-Polymers, December 2003, De Gruyter

    Dr Jean Jacques Vanden Eynde

  70. Synthesis and Characterization of Novelpara- andmeta-Phenylenevinylene Derivatives:  Fine Tuning of the Electronic and Optical Properties of Conjugated Materials

    Article • The Journal of Physical Chemistry B, June 2002, American Chemical Society (ACS)

    Dr Jean Jacques Vanden Eynde

  71. Synthesis and characterization of novel oligo(phenylenevinylene) derivatives

    Article • Synthetic Metals, March 2001, Elsevier

    Dr Jean Jacques Vanden Eynde

  72. Microwave-mediated regioselective synthesis of novel pyrimido[1,2- a ]pyrimidines under solvent-free conditions

    Article • Tetrahedron, February 2001, Elsevier

    Dr Jean Jacques Vanden Eynde

  73. QUATERNARY AMMONIUM SALT-ASSISTED SYNTHESIS OF EXTENDED π-SYSTEMS FROM METHYLDIAZINES AND AROMATIC ALDEHYDES1

    Article • Synthetic Communications, January 2001, Taylor & Francis

    Dr Jean Jacques Vanden Eynde

  74. QUATERNARY AMMONIUM SALT-ASSISTED ORGANIC REACTIONS IN WATER: ALKYLATION OF PHENOLS

    Article • Synthetic Communications, January 2001, Taylor & Francis

    Dr Jean Jacques Vanden Eynde

  75. Surfactant-assisted organic reactions in water. Effect of ultrasound on condensation reactions between active methylene compounds and arylaldehydes

    Article • Ultrasonics Sonochemistry, January 2001, Elsevier

    Dr Jean Jacques Vanden Eynde

  76. Chemistry of N-(1-haloalkyl)heteroarylium salts

    Article • January 2000, Elsevier

    Dr Jean Jacques Vanden Eynde

  77. Microwave-mediated derivatization of poly(styrene-co-allyl alcohol), a key step for the soluble polymer-assisted synthesis of heterocycles

    Article • Tetrahedron, February 1999, Elsevier

    Dr Jean Jacques Vanden Eynde

  78. 1-(Arylchloromethyl)pyridinium chlorides. Investigation by X-ray single crystal diffraction and semiempirical (PM3, AM1, MNDO) calculations

    Article • Journal of Molecular Structure, February 1998, Elsevier

    Dr Jean Jacques Vanden Eynde

  79. Microwave-Mediated Domino Reactions in Dry Medium. Preparation of Dihydropyridinones and Pyridinones Structurally Related to Hantzsch Esters.

    Article • Synthetic Communications, November 1997, Taylor & Francis

    Dr Jean Jacques Vanden Eynde

  80. Old reagents, new results: Aromatization of Hantzsch 1,4-dihydropyridines with manganese dioxide and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone

    Article • Tetrahedron, June 1995, Elsevier

    Dr Jean Jacques Vanden Eynde

  81. 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, a mild catalyst for the formation of carbon-nitrogen bonds

    Article • Tetrahedron, May 1995, Elsevier

    Dr Jean Jacques Vanden Eynde

  82. Ultrasound-promoted benzylation of arenes in the presence of zinc chloride mixed with a K10 clay

    Article • Tetrahedron Letters, May 1995, Elsevier

    Dr Jean Jacques Vanden Eynde

  83. Potassium permanganate, a versatile reagent for the aromatization of Hantzsch 1,4-dihydropyridines

    Article • Tetrahedron, February 1994, Elsevier

    Dr Jean Jacques Vanden Eynde

  84. An Unusual Aromatization of Hantzsch-type 4-Antipyryl-1,4-dihydropyridines

    Article • Heterocycles, January 1994, Japan Institute of Heterocyclic Chemistry

    Dr Jean Jacques Vanden Eynde

  85. Rate‐Determining Effects in the Formation of Hantzsch 1,4‐Dihydropyridines from N ‐(1‐Haloalkyl)azinium Halides and Methyl 3‐Amino‐2‐butenoate

    Article • Chemische Berichte, May 1993, Wiley

    Dr Jean Jacques Vanden Eynde

  86. A novel application of the oxidizing properties of pyridinium chlorochromate : aromatization of Hantzsch 1,4-dihydropyridines

    Article • Tetrahedron, January 1992, Elsevier

    Dr Jean Jacques Vanden Eynde

  87. Novel syntheses of heterocycles with N-(1-Haloalkyl)azinium Halides. Part 2. Preparation of N-Unsubstituted 1,4-Dihydropyridines

    Article • Tetrahedron, January 1992, Elsevier

    Dr Jean Jacques Vanden Eynde

  88. Rate‐Determining Effects in the Formation of N ‐(1‐Haloalkyl)heteroarylium Halides

    Article • Chemische Berichte, September 1991, Wiley

    Dr Jean Jacques Vanden Eynde

  89. Ultrasound-promoted aromatization of hantzsch 1,4-Dihydropyridines by clay-supported cuptic nitrate

    Article • Tetrahedron Letters, July 1991, Elsevier

    Dr Jean Jacques Vanden Eynde

  90. N ‐[(2‐Naphthyloxy)methyl] benzazoles: Synthesis and Investigation by X‐ray Analysis and by Semiempirical MO Calculations

    Article • Chemische Berichte, May 1990, Wiley

    Dr Jean Jacques Vanden Eynde

  91. N-(1-haloalkyl)pyridinium salts: preparation and use for new syntheses of other N-(1-substituted-alkyl)pyridinium salts, N,N'-(1-alkylidene)bisamines, and N,N'-(1-alkylidene)bisbenzazoles

    Article • The Journal of Organic Chemistry, September 1989, American Chemical Society (ACS)

    Dr Jean Jacques Vanden Eynde

  92. The chemistry of N-substituted benzotriazoles. Part 20. Mono-N-t-butylation of aromatic and heteroaromatic amines

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1989, Royal Society of Chemistry

    Dr Jean Jacques Vanden Eynde

  93. Synthesis of 5-amino-4, 5-dihydropyrazolo [3,4-d] pyrimidin-4-ones and related isomeric systems

    Article • Tetrahedron, January 1987, Elsevier

    Dr Jean Jacques Vanden Eynde

  94. Synthesis of 5-amino-4,5-dihydropyrazolo [3,4-d] pyrimidin-4-ones and related isomeric systems

    Article • Tetrahedron, January 1987, Elsevier

    Dr Jean Jacques Vanden Eynde

  95. Synthèse de 1H-pyrazolo[3,4-b] pyridines et de pyrazolo[1,5-a] pyrimidines

    Article • Journal of Heterocyclic Chemistry, June 1979, Wiley

    Dr Jean Jacques Vanden Eynde

  96. Etudes spectroscopiques d'enaminones N-substituees par un cycle pyrazolique

    Article • Journal of Molecular Structure, January 1979, Elsevier

    Dr Jean Jacques Vanden Eynde