All Stories

  1. Triggering Toll-Like Receptor 5 signaling during pneumococcal superinfection prevents the selection of antibiotic resistance

    Article • The Journal of Infectious Diseases, May 2024, Oxford University Press (OUP)

    Dr Jean-Claude SIRARD

  2. Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, March 2024, ASM Journals

    Dr Jean-Claude SIRARD

  3. A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection

    Article • Cell Host & Microbe, March 2024, Elsevier

    Dr Jean-Claude SIRARD

  4. Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity

    Article • Infection and Immunity, February 2023, ASM Journals

    Dr Jean-Claude SIRARD

  5. Competence enhances adherence of pneumococcus by exposing virulence factors on the cell surface.

    Article • PLoS Biology, January 2023, PLOS

    Vikrant Minhas, Dr Jean-Claude SIRARD

  6. Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors

    Article • August 2022, Cold Spring Harbor Laboratory Press

    Dr Jean-Claude SIRARD

  7. TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium

    Article • Journal of Cystic Fibrosis, March 2022, Elsevier

    Dr Jean-Claude SIRARD

  8. Live attenuated Bordetella pertussis vaccine candidate BPZE1 transiently protects against lethal pneumococcal disease in mice

    Article • Vaccine, March 2022, Elsevier

    Dr Jean-Claude SIRARD

  9. Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

    Article • September 2021, Cold Spring Harbor Laboratory Press

    Dr Jean-Claude SIRARD

  10. ChronicPseudomonas aeruginosaLung Infection Is IL-1R Independent, but Relies on MyD88 Signaling

    Article • ImmunoHorizons, May 2021, The American Association of Immunologists

    Dr Jean-Claude SIRARD

  11. mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

    Article • Mucosal Immunology, May 2021, Elsevier

    Dr Jean-Claude SIRARD

  12. The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia

    Article • Pharmaceutics, April 2021, MDPI AG

    Dr Jean-Claude SIRARD

  13. Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

    Article • PLoS Pathogens, April 2021, PLOS

    Wanhai Qin, Dr Jean-Claude SIRARD

  14. The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced infection in cigarette smoke-exposed mice

    Article • PLoS ONE, March 2021, PLOS

    Philippe Gosset, Dr Jean-Claude SIRARD

  15. A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice

    Article • Pharmaceutics, March 2021, MDPI AG

    Dr Jean-Claude SIRARD

  16. Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae

    Article • Proceedings of the National Academy of Sciences, October 2020, Proceedings of the National Academy of Sciences

    Dr Jean-Claude SIRARD, Vikrant Minhas

  17. The GM-CSF Released by Airway Epithelial Cells Orchestrates the Mucosal Adjuvant Activity of Flagellin

    Article • The Journal of Immunology, October 2020, The American Association of Immunologists

    Dr Jean-Claude SIRARD

  18. Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq

    Article • Cell Host & Microbe, October 2020, Elsevier

    Dr Jean-Claude SIRARD

  19. Boosting the IL‐22 response using flagellin prevents bacterial infection in cigarette smoke‐exposed mice

    Article • Clinical & Experimental Immunology, May 2020, Wiley

    Dr Jean-Claude SIRARD

  20. Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Dr Jean-Claude SIRARD

  21. Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4

    Article • The Journal of Immunology, November 2019, The American Association of Immunologists

    Dr Jean-Claude SIRARD

  22. Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response

    Article • Mucosal Immunology, October 2019, Springer Science + Business Media

    Dr Jean-Claude SIRARD

  23. Toll‐like receptor 4 signaling in hematopoietic‐lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01

    Article • European Journal of Immunology, September 2019, Wiley

    Dr Jean-Claude SIRARD

  24. A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume

    Article • Talanta, August 2019, Elsevier

    Dr Jean-Claude SIRARD, Robin Michelet

  25. Toll-like receptor 5 agonist flagellin reduces Influenza A Virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir

    Article • Antiviral Research, May 2019, Elsevier

    Dr Jean-Claude SIRARD

  26. Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia

    Article • Frontiers in Immunology, April 2019, Frontiers

    Dr Jean-Claude SIRARD

  27. Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants

    Article • Vaccine, January 2019, Elsevier

    Dr Jean-Claude SIRARD

  28. Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection

    Article • PLoS Pathogens, October 2018, PLOS

    Dr Jean-Claude SIRARD

  29. Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae

    Article • Frontiers in Immunology, October 2018, Frontiers

    Dr Jean-Claude SIRARD

  30. Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation

    Article • Frontiers in Immunology, July 2018, Frontiers

    Dr Jean-Claude SIRARD

  31. Review on the TLR5 agonist flagellin

    Article • Trends in Microbiology, November 2017, Elsevier

    Dr Jean-Claude SIRARD

  32. Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections

    Article • Mucosal Immunology, July 2017, Elsevier

    Dr Jean-Claude SIRARD

  33. Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella

    Article • Protein Science, March 2017, Wiley

    Dr Jean-Claude SIRARD

  34. Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages

    Article • Immunity, March 2017, Elsevier

    Dr Jean-Claude SIRARD

  35. Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22

    Article • Infection and Immunity, February 2017, ASM Journals

    Dr Jean-Claude SIRARD, Christophe CARNOY

  36. Flagellins as Adjuvants of Vaccines

    Article • January 2017, Elsevier

    Dr Jean-Claude SIRARD

  37. Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model

    Article • Frontiers in Immunology, December 2016, Frontiers

    Dr Analia G Abraham, Dr Jean-Claude SIRARD

  38. Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

    Article • PLoS ONE, November 2016, PLOS

    Dr Jean-Claude SIRARD

  39. Characterization of the protective immune response to Yersinia pseudotuberculosis infection in mice vaccinated with an LcrV-secreting strain of Lactococcus lactis

    Article • Vaccine, November 2016, Elsevier

    Dr Jean-Claude SIRARD

  40. Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion

    Article • Future Microbiology, September 2016, Future Medicine

    Dr Jean-Claude SIRARD

  41. Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

    Article • Immunobiology, October 2015, Elsevier

    Dr Jean-Claude SIRARD, Dr Analia G Abraham

  42. New treatment of bacterial pneumonia

    Article • Antimicrobial Agents and Chemotherapy, July 2015, ASM Journals

    Dr Jean-Claude SIRARD

  43. Indirect activation of respiratory dendritic cells

    Article • Vaccine, June 2015, Elsevier

    Dr Jean-Claude SIRARD

  44. Superantigenic Yersinia pseudotuberculosis Induces the Expression of Granzymes and Perforin by CD4+T Cells

    Article • Infection and Immunity, March 2015, ASM Journals

    Dr Jean-Claude SIRARD, Christophe CARNOY

  45. Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

    Article • Proceedings of the National Academy of Sciences, January 2015, Proceedings of the National Academy of Sciences

    Dr Jean-Claude SIRARD

  46. First description of contribution of ILC3 and IL-22 in lung infections

    Article • The Journal of Infectious Diseases, February 2014, Oxford University Press (OUP)

    Dr Jean-Claude SIRARD

  47. Transgenic Mouse Model Harboring the Transcriptional Fusion Ccl20-Luciferase as a Novel Reporter of Pro-Inflammatory Response

    Article • PLoS ONE, November 2013, PLOS

    Dr Jean-Claude SIRARD

  48. NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium

    Article • PLoS ONE, October 2013, PLOS

    Dr Jean-Claude SIRARD

  49. Airway structural cells regulate TLR5-mediated mucosal adjuvant activity

    Article • Mucosal Immunology, September 2013, Nature

    Dr Jean-Claude SIRARD

  50. Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection

    Article • Microbes and Infection, September 2013, Elsevier

    Dr Jean-Claude SIRARD

  51. The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon

    Article • PLoS ONE, June 2013, PLOS

    Professor Peter Liljeström, Dr Jean-Claude SIRARD

  52. Interleukin-22 Reduces Lung Inflammation during Influenza A Virus Infection and Protects against Secondary Bacterial Infection

    Article • Journal of Virology, April 2013, ASM Journals

    Dr Jean-Claude SIRARD

  53. Inheritance of the Lysozyme Inhibitor Ivy Was an Important Evolutionary Step by Yersinia pestis to Avoid the Host Innate Immune Response

    Article • The Journal of Infectious Diseases, February 2013, Oxford University Press (OUP)

    Dr Florent Sebbane, Dr Jean-Claude SIRARD

  54. Using immunopotentiating capacity of flagellin for sublingual immunotherapy.

    Article • Frontiers in Immunology, January 2013, Frontiers

    Dr Jean-Claude SIRARD

  55. In Vivo Germination of Bacillus anthracis Spores During Murine Cutaneous Infection

    Article • The Journal of Infectious Diseases, November 2012, Oxford University Press (OUP)

    Dr Jean-Claude SIRARD

  56. Key Role for Respiratory CD103+ Dendritic Cells, IFN- , and IL-17 in Protection Against Streptococcus pneumoniae Infection in Response to  -Galactosylceramide

    Article • The Journal of Infectious Diseases, June 2012, Oxford University Press (OUP)

    Dr Jean-Claude SIRARD

  57. Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity

    Article • Immunobiology, April 2012, Elsevier

    Dr Jean-Claude SIRARD

  58. IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality

    Article • European Journal of Immunology, March 2011, Wiley

    Dr Jean-Claude SIRARD

  59. IL-17A/F-Signaling Does Not Contribute to the Initial Phase of Mucosal Inflammation Triggered by S. Typhimurium

    Article • PLoS ONE, November 2010, PLOS

    Dr Jean-Claude SIRARD

  60. The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea

    Article • PLoS Pathogens, September 2010, PLOS

    Dr Jean-Claude SIRARD

  61. Boosting innate immunity for prevention of bacterial pneumonia

    Article • Infection and Immunity, July 2010, ASM Journals

    Dr Jean-Claude SIRARD

  62. Activation of ILC3 by flagellin

    Article • The Journal of Immunology, June 2010, The American Association of Immunologists

    Dr Jean-Claude SIRARD

  63. The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells

    Article • Journal of Hepatology, May 2010, Elsevier

    Dr Jean-Claude SIRARD

  64. Compartmentalization of TLR5 signaling to radioresistant cells

    Article • European Journal of Immunology, June 2009, Wiley

    Dr Jean-Claude SIRARD

  65. Toll-like receptor 5- and lymphotoxin β receptor-dependent epithelial Ccl20 expression involves the same NF-κB binding site but distinct NF-κB pathways and dynamics

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, May 2009, Elsevier

    Dr Jean-Claude SIRARD

  66. Toll-like receptor 2 is critical for induction of Reg3  expression and intestinal clearance of Yersinia pseudotuberculosis

    Article • Gut, January 2009, BMJ

    Dr Jean-Claude SIRARD

  67. Deletion of Flagellin's Hypervariable Region Abrogates Antibody-Mediated Neutralization and Systemic Activation of TLR5-Dependent Immunity

    Article • The Journal of Immunology, July 2008, The American Association of Immunologists

    Dr Jean-Claude SIRARD

  68. Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection

    Article • Journal of Experimental Medicine, January 2008, Rockefeller University Press

    Dr Jean-Claude SIRARD

  69. Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells

    Article • Microbiology, April 2007, Society for General Microbiology

    Dr Jean-Claude SIRARD

  70. A Key Role of Dendritic Cells in Probiotic Functionality

    Article • PLoS ONE, March 2007, PLOS

    Dr Jean-Claude SIRARD

  71. Nod-Like Receptors: Cytosolic Watchdogs for Immunity against Pathogens

    Article • PLoS Pathogens, January 2007, PLOS

    Dr Jean-Claude SIRARD

  72. Delayed Expansion and Contraction of CD8+ T Cell Response during Infection with Virulent Salmonella typhimurium

    Article • The Journal of Immunology, July 2006, The American Association of Immunologists

    Dr Jean-Claude SIRARD

  73. Mucosal interplay among commensal and pathogenic bacteria: Lessons from flagellin and Toll-like receptor 5

    Article • FEBS Letters, April 2006, Wiley

    Dr Jean-Claude SIRARD

  74. Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide

    Article • Molecular and Cellular Biology, February 2006, ASM Journals

    Dr Jean-Claude SIRARD

  75. Pathogen-specific TLR signaling in mucosa: Mutual contribution of microbial TLR agonists and virulence factors

    Article • European Journal of Immunology, February 2006, Wiley

    Dr Jean-Claude SIRARD

  76. Dendritic Cells Rapidly Recruited into Epithelial Tissues via CCR6/CCL20 Are Responsible for CD8+ T Cell Crosspriming In Vivo

    Article • Immunity, February 2006, Elsevier

    Dr Jean-Claude SIRARD

  77. Intestinal epithelial barrier and mucosal immunity

    Article • Cellular and Molecular Life Sciences, June 2005, Springer Science + Business Media

    Dr Jean-Claude SIRARD

  78. Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells

    Article • European Journal of Biochemistry, December 2004, Wiley

    Dr Jean-Claude SIRARD

  79. How the Gut Links Innate and Adaptive Immunity

    Article • Annals of the New York Academy of Sciences, December 2004, Wiley

    Dr Jean-Claude SIRARD

  80. Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa

    Article • Trends in Microbiology, November 2004, Elsevier

    Dr Jean-Claude SIRARD

  81. Attenuated poxviruses expressing a synthetic HIV protein stimulate HLA-A2-restricted cytotoxic T-cell responses

    Article • Vaccine, September 2004, Elsevier

    Dr Jean-Claude SIRARD

  82. Flagellin Promotes Myeloid Differentiation Factor 88-Dependent Development of Th2-Type Response

    Article • The Journal of Immunology, May 2004, The American Association of Immunologists

    Dr Jean-Claude SIRARD

  83. Interaction of pathogenic bacteria with rabbit appendix M cells: bacterial motility is a key feature in vivo

    Article • Microbes and Infection, May 2004, Elsevier

    Dr Jean-Claude SIRARD

  84. Dendritic cells: the host Achille's heel for mucosal pathogens?

    Article • Trends in Microbiology, February 2004, Elsevier

    Dr Jean-Claude SIRARD

  85. Role of Toll-like receptors in costimulating cytotoxic T cell responses

    Article • European Journal of Immunology, June 2003, Wiley

    Dr Jean-Claude SIRARD

  86. How the gut senses its content

    Article • Cellular Microbiology, February 2002, Wiley

    Dr Jean-Claude SIRARD

  87. Innate response of intestinal epithelial cells to TLR signaling

    Article • Proceedings of the National Academy of Sciences, November 2001, Proceedings of the National Academy of Sciences

    Dr Jean-Claude SIRARD

  88. Nasal immunisation with Salmonella typhimurium producing rotavirus VP2 and VP6 antigens stimulates specific antibody response in serum and milk but fails to protect offspring

    Article • Vaccine, July 2001, Elsevier

    Dr Jean-Claude SIRARD

  89. Entry and survival ofSalmonella typhimuriumin dendritic cells and presentation of recombinant antigens do not require macrophage-specific virulence factors

    Article • Proceedings of the National Academy of Sciences, December 2000, Proceedings of the National Academy of Sciences

    Dr Jean-Claude SIRARD

  90. Nasal Immunization of Mice with Virus-Like Particles Protects Offspring against Rotavirus Diarrhea

    Article • Journal of Virology, October 2000, ASM Journals

    Dr Jean-Claude SIRARD

  91. Protective Antigen-Mediated Antibody Response against a Heterologous Protein Produced In Vivo by Bacillus anthracis

    Article • Infection and Immunity, October 2000, ASM Journals

    Dr Jean-Claude SIRARD

  92. Characterization of a plasmid region involved in Bacillus anthracis toxin production and pathogenesis

    Article • International Journal of Medical Microbiology, October 2000, Elsevier

    Dr Jean-Claude SIRARD

  93. Role of Toxin Functional Domains in Anthrax Pathogenesis

    Article • Infection and Immunity, April 2000, ASM Journals

    Dr Jean-Claude SIRARD

  94. Live attenuated Salmonella: a paradigm of mucosal vaccines

    Article • Immunological Reviews, October 1999, Wiley

    Dr Jean-Claude SIRARD

  95. Antigen delivery by attenuated Bacillus anthracis: new prospects in veterinary vaccines

    Article • Journal of Applied Microbiology, August 1999, Wiley

    Dr Jean-Claude SIRARD

  96. Identification and characterization of a germination operon on the virulence plasmid pXOl of Bacillus anthracis

    Article • Molecular Microbiology, July 1999, Wiley

    Dr Jean-Claude SIRARD

  97. Functional Analysis of the Carboxy-Terminal Domain of Bacillus anthracis Protective Antigen

    Article • Infection and Immunity, February 1999, ASM Journals

    Dr Jean-Claude SIRARD

  98. The atxA gene product activates transcription of the anthrax toxin genes and is essential for virulence

    Article • Molecular Microbiology, June 1995, Wiley

    Dr Jean-Claude SIRARD

  99. Protective immunity induced by Bacillus anthracis toxin-deficient strains

    Article • Infection and Immunity, April 1995, ASM Journals

    Dr Jean-Claude SIRARD

  100. Molecular tools for the study of transcriptional regulation in Bacillus anthracis

    Article • Research in Microbiology, January 1995, Elsevier

    Dr Jean-Claude SIRARD

  101. Characterization of the Bacillus anthracis S-layer: cloning and sequencing of the structural gene.

    Article • Journal of Bacteriology, January 1995, ASM Journals

    Dr Jean-Claude SIRARD

  102. Bacillus anthracis pXO1 virulence plasmid encodes a type 1 DNA topoisomerase

    Article • Molecular Microbiology, February 1994, Wiley

    Dr Jean-Claude SIRARD

  103. The three Bacillus anthracis toxin genes are coordinately regulated by bicarbonate and temperature.

    Article • Journal of Bacteriology, January 1994, ASM Journals

    Dr Jean-Claude SIRARD