All Stories

  1. Triggering Toll-Like Receptor 5 signaling during pneumococcal superinfection prevents the selection of antibiotic resistance
  2. Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of Pseudomonas aeruginosa
  3. A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection
  4. Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity
  5. Competence enhances adherence of pneumococcus by exposing virulence factors on the cell surface.
  6. Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors
  7. TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium
  8. Live attenuated Bordetella pertussis vaccine candidate BPZE1 transiently protects against lethal pneumococcal disease in mice
  9. Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq
  10. ChronicPseudomonas aeruginosaLung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
  11. mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin
  12. The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia
  13. Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection
  14. The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced infection in cigarette smoke-exposed mice
  15. A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice
  16. Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae
  17. The GM-CSF Released by Airway Epithelial Cells Orchestrates the Mucosal Adjuvant Activity of Flagellin
  18. Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq
  19. Boosting the IL‐22 response using flagellin prevents bacterial infection in cigarette smoke‐exposed mice
  20. Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia
  21. Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4
  22. Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response
  23. Toll‐like receptor 4 signaling in hematopoietic‐lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01
  24. A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume
  25. Toll-like receptor 5 agonist flagellin reduces Influenza A Virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir
  26. Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia
  27. Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants
  28. Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection
  29. Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae
  30. Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation
  31. Review on the TLR5 agonist flagellin
  32. Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections
  33. Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella
  34. Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages
  35. Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22
  36. Flagellins as Adjuvants of Vaccines
  37. Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model
  38. Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner
  39. Characterization of the protective immune response to Yersinia pseudotuberculosis infection in mice vaccinated with an LcrV-secreting strain of Lactococcus lactis
  40. Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion
  41. Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells
  42. New treatment of bacterial pneumonia
  43. Indirect activation of respiratory dendritic cells
  44. Superantigenic Yersinia pseudotuberculosis Induces the Expression of Granzymes and Perforin by CD4+T Cells
  45. Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
  46. First description of contribution of ILC3 and IL-22 in lung infections
  47. Transgenic Mouse Model Harboring the Transcriptional Fusion Ccl20-Luciferase as a Novel Reporter of Pro-Inflammatory Response
  48. NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium
  49. Airway structural cells regulate TLR5-mediated mucosal adjuvant activity
  50. Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection
  51. The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon
  52. Interleukin-22 Reduces Lung Inflammation during Influenza A Virus Infection and Protects against Secondary Bacterial Infection
  53. Inheritance of the Lysozyme Inhibitor Ivy Was an Important Evolutionary Step by Yersinia pestis to Avoid the Host Innate Immune Response
  54. Using immunopotentiating capacity of flagellin for sublingual immunotherapy.
  55. In Vivo Germination of Bacillus anthracis Spores During Murine Cutaneous Infection
  56. Key Role for Respiratory CD103+ Dendritic Cells, IFN- , and IL-17 in Protection Against Streptococcus pneumoniae Infection in Response to  -Galactosylceramide
  57. Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity
  58. IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality
  59. IL-17A/F-Signaling Does Not Contribute to the Initial Phase of Mucosal Inflammation Triggered by S. Typhimurium
  60. The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea
  61. Boosting innate immunity for prevention of bacterial pneumonia
  62. Activation of ILC3 by flagellin
  63. The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells
  64. Compartmentalization of TLR5 signaling to radioresistant cells
  65. Toll-like receptor 5- and lymphotoxin β receptor-dependent epithelial Ccl20 expression involves the same NF-κB binding site but distinct NF-κB pathways and dynamics
  66. Toll-like receptor 2 is critical for induction of Reg3  expression and intestinal clearance of Yersinia pseudotuberculosis
  67. Deletion of Flagellin's Hypervariable Region Abrogates Antibody-Mediated Neutralization and Systemic Activation of TLR5-Dependent Immunity
  68. Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection
  69. Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells
  70. A Key Role of Dendritic Cells in Probiotic Functionality
  71. Nod-Like Receptors: Cytosolic Watchdogs for Immunity against Pathogens
  72. Delayed Expansion and Contraction of CD8+ T Cell Response during Infection with Virulent Salmonella typhimurium
  73. Mucosal interplay among commensal and pathogenic bacteria: Lessons from flagellin and Toll-like receptor 5
  74. Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide
  75. Pathogen-specific TLR signaling in mucosa: Mutual contribution of microbial TLR agonists and virulence factors
  76. Dendritic Cells Rapidly Recruited into Epithelial Tissues via CCR6/CCL20 Are Responsible for CD8+ T Cell Crosspriming In Vivo
  77. Intestinal epithelial barrier and mucosal immunity
  78. Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells
  79. How the Gut Links Innate and Adaptive Immunity
  80. Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa
  81. Attenuated poxviruses expressing a synthetic HIV protein stimulate HLA-A2-restricted cytotoxic T-cell responses
  82. Flagellin Promotes Myeloid Differentiation Factor 88-Dependent Development of Th2-Type Response
  83. Interaction of pathogenic bacteria with rabbit appendix M cells: bacterial motility is a key feature in vivo
  84. Dendritic cells: the host Achille's heel for mucosal pathogens?
  85. Role of Toll-like receptors in costimulating cytotoxic T cell responses
  86. How the gut senses its content
  87. Innate response of intestinal epithelial cells to TLR signaling
  88. Nasal immunisation with Salmonella typhimurium producing rotavirus VP2 and VP6 antigens stimulates specific antibody response in serum and milk but fails to protect offspring
  89. Entry and survival ofSalmonella typhimuriumin dendritic cells and presentation of recombinant antigens do not require macrophage-specific virulence factors
  90. Nasal Immunization of Mice with Virus-Like Particles Protects Offspring against Rotavirus Diarrhea
  91. Protective Antigen-Mediated Antibody Response against a Heterologous Protein Produced In Vivo by Bacillus anthracis
  92. Characterization of a plasmid region involved in Bacillus anthracis toxin production and pathogenesis
  93. Role of Toxin Functional Domains in Anthrax Pathogenesis
  94. Live attenuated Salmonella: a paradigm of mucosal vaccines
  95. Antigen delivery by attenuated Bacillus anthracis: new prospects in veterinary vaccines
  96. Identification and characterization of a germination operon on the virulence plasmid pXOl of Bacillus anthracis
  97. Functional Analysis of the Carboxy-Terminal Domain of Bacillus anthracis Protective Antigen
  98. The atxA gene product activates transcription of the anthrax toxin genes and is essential for virulence
  99. Protective immunity induced by Bacillus anthracis toxin-deficient strains
  100. Molecular tools for the study of transcriptional regulation in Bacillus anthracis
  101. Characterization of the Bacillus anthracis S-layer: cloning and sequencing of the structural gene.
  102. Bacillus anthracis pXO1 virulence plasmid encodes a type 1 DNA topoisomerase
  103. The three Bacillus anthracis toxin genes are coordinately regulated by bicarbonate and temperature.