All Stories

  1. Synthetic cysteine-based tools for probing protein posttranslational modifications
  2. Distinguishing Oligosaccharide Isomers Using Far-Infrared Ion Spectroscopy: Identification of Biomarkers for Inborn Errors of Metabolism
  3. Probing Polar‐π Interactions Between Tetrazoles and Aromatic Rings**
  4. Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain
  5. Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
  6. Investigation of in vitro histone H3 glycosylation using H3 tail peptides
  7. Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II
  8. Through-Space Stabilization of an Imidazolium Cation by Aromatic Rings
  9. Probing Noncovalent Interactions in [3,3]Metaparacyclophanes
  10. Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin
  11. Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins
  12. Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1
  13. Probing the Lewis Acidity of Boronic Acids through Interactions with Arene Substituents
  14. Probing lysine posttranslational modifications by unnatural amino acids
  15. Importance of Ile71 in β-actin on histidine methyltransferase SETD3 catalysis
  16. Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases
  17. Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins
  18. Substrate Specificity for Human Histidine Methyltransferase SETD3
  19. Characterization of Cyclic N ‐Acyliminium Ions by Infrared Ion Spectroscopy
  20. Metabolite Identification Using Infrared Ion Spectroscopy─Novel Biomarkers for Pyridoxine-Dependent Epilepsy
  21. Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy
  22. β‐Actin Peptide‐Based Inhibitors of Histidine Methyltransferase SETD3
  23. Do Sulfonamides Interact with Aromatic Rings?
  24. Substrate Scope for Human Histone Lysine Acetyltransferase KAT8
  25. Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides
  26. γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases
  27. Trimethyllysine: From Carnitine Biosynthesis to Epigenetics
  28. Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
  29. Probing Halogen−π versus CH−π Interactions in Molecular Balance
  30. Effect of lysine side chain length on histone lysine acetyltransferase catalysis
  31. Front Cover: Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols (ChemPhysChem 11/2020)
  32. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  33. Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger
  34. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  35. Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins
  36. Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
  37. Exploring the Histone Acylome through Incorporation of γ-Thialysine on Histone Tails
  38. Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases
  39. Lysine Ethylation by Histone Lysine Methyltransferases
  40. The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis
  41. Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2
  42. Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
  43. γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones
  44. Catalytic Staudinger Reduction at Room Temperature
  45. Investigating the active site of human trimethyllysine hydroxylase
  46. Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation
  47. Probing Through-Space Polar−π Interactions in 2,6-Diarylphenols
  48. Mechanistic Insight into the Catalytic Staudinger Ligation
  49. Catalytic transport of molecular cargo using diffusive binding along a polymer track
  50. Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
  51. Importance of the main chain of lysine for histone lysine methyltransferase catalysis
  52. Biomolecular Recognition of Methylated Histones
  53. LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2
  54. Structure-Activity Relationship Studies on (R )-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7
  55. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II)
  56. 2OG regulates binding of hydroxylated HIF to PHD2
  57. Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins
  58. Sustainable organophosphorus-catalysed Staudinger reduction
  59. Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis
  60. Stabilization of 2,6-Diarylanilinum Cation by Through-Space Cation−π Interactions
  61. Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-Nε-trimethyllysine
  62. Fluorinated trimethyllysine as a19F NMR probe for trimethyllysine hydroxylase catalysis
  63. Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation
  64. Investigatingd-lysine stereochemistry for epigenetic methylation, demethylation and recognition
  65. Multicolor Photoluminescence Including White-Light Emission by a Single Host–Guest Complex
  66. Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  67. Natural supramolecular protein assemblies
  68. Substrate scope for trimethyllysine hydroxylase catalysis
  69. ChemInform Abstract: Chemoselective Calcium-Catalyzed Direct Amidation of Carboxylic Esters.
  70. ChemInform Abstract: Natural Supramolecular Protein Assemblies
  71. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  72. ChemInform Abstract: Zirconium-Catalyzed Direct Amide Bond Formation Between Carboxylic Esters and Amines.
  73. Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins
  74. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain
  75. Zirconium-catalyzed direct amide bond formation between carboxylic esters and amines
  76. Chemoselective calcium-catalysed direct amidation of carboxylic esters
  77. ChemInform Abstract: Triphenylphosphine-Catalyzed Amide Bond Formation Between Carboxylic Acids and Amines.
  78. Thermodynamic investigation of Z33-antibody interaction leads to selective purification of human antibodies
  79. Stabilisation of 2,6-Diarylpyridinium Cation by Through-Space Polar-π Interactions
  80. Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines
  81. Catenane versus ring: do both assemblies of CS2 hydrolase exhibit the same stability and catalytic activity?
  82. Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS2 hydrolase
  83. The Effect of the Length of Histone H3K4me3 on Recognition by Reader Proteins
  84. Hydroxylamine as an oxygen nucleophile: substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides
  85. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
  86. Evidence that the catenane form of CS2 hydrolase is not an artefact
  87. Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams
  88. Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase
  89. Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic Anhydrase
  90. Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)
  91. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates
  92. 104 Upregulation of hypoxia-inducible factor 1α by di-methyl oxalyl glycine promotes angiogenesis within ischaemic myocardium in a porcine coronary occlusion model
  93. UPREGULATION OF HYPOXIA-INDUCIBLE FACTOR BY DI-METHYL OXALYL GLYCINE (DMOG) INCREASES NEOVASCULARIZATION WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL
  94. Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches
  95. Therapeutic Manipulation of the HIF Hydroxylases
  96. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
  97. 2-Oxoglutarate oxygenases are inhibited by a range of transition metals
  98. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2
  99. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2
  100. A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
  101. Direct Analysis of Enzyme-Catalyzed DNA Demethylation
  102. Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism
  103. Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
  104. ChemInform Abstract: Triflic Anhydride Mediated Synthesis of Oxazoles.
  105. Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure
  106. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  107. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  108. Triflic anhydride-mediated synthesis of oxazoles
  109. Evidence for a Stereoelectronic Effect in Human Oxygen Sensing
  110. Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline
  111. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)
  112. Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases ⊥
  113. ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site
  114. Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases
  115. Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
  116. 3-(Dimethylamino)propenoate-based Regioselective Synthesis of 1,4-Disubstituted 5-Hydroxy-1H-pyrazoles