All Stories

  1. The long chain α-tocopherol metabolite α-13’-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180

    Article • Molecular Nutrition & Food Research, November 2016, Wiley

    Maren Podszun, Professor Jan Frank

  2. Prenylated chalcones and flavonoids for the prevention and treatment of cancer

    Article • Nutrition, November 2016, Elsevier

    Professor Jan Frank

  3. Effects of Long-Term Rice Bran Extract Supplementation on Survival, Cognition and Brain Mitochondrial Function in Aged NMRI Mice

    Article • NeuroMolecular Medicine, June 2016, Springer Science + Business Media

    Professor Jan Frank

  4. Intratumoral Concentrations and Effects of Orally Administered Micellar Curcuminoids in Glioblastoma Patients

    Article • Nutrition and Cancer, June 2016, Taylor & Francis

    Professor Jan Frank

  5. Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals

    Article • Molecular Nutrition & Food Research, May 2016, Wiley

    Professor Jan Frank

  6. Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB- and the beta-catenin pathways

    Article • Oncotarget, November 2015, Impact Journals, LLC

    Professor Jan Frank

  7. Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice – Impact on bioavailability

    Article • Neurochemistry International, October 2015, Elsevier

    Professor Jan Frank

  8. Tocopherols and tocotrienols in serum and liver of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation

    Article • Journal of Dairy Science, October 2015, American Dairy Science Association

    Professor Jan Frank

  9. Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components

    Article • Molecules, September 2015, MDPI AG

    Professor Jan Frank

  10. Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice

    Article • Nutritional Neuroscience, August 2015, Taylor & Francis

    Professor Jan Frank

  11. Epigenetic activities of flavonoids in the prevention and treatment of cancer

    Article • Clinical Epigenetics, July 2015, Springer Science + Business Media

    Professor Jan Frank

  12. A new bridge between the nutrition and food sciences

    Article • NFS Journal, June 2015, Elsevier

    Professor Jan Frank

  13. Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice

    Article • NFS Journal, June 2015, Elsevier

    Professor Jan Frank

  14. The oral bioavailability of curcuminoids in healthy humans is markedly enhanced by micellar solubilisation but not further improved by simultaneous ingestion of sesamin, ferulic acid, naringenin and xanthohumol

    Article • Journal of Functional Foods, April 2015, Elsevier

    Professor Jan Frank

  15. Non-targeted1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats

    Article • Food & Function, January 2015, Royal Society of Chemistry

    Professor Jan Frank

  16. Vitamin E–drug interactions: molecular basis and clinical relevance

    Article • Nutrition Research Reviews, September 2014, Cambridge University Press

    Professor Jan Frank

  17. The use of total antioxidant capacity as surrogate marker for food quality and its effect on health is to be discouraged

    Article • Nutrition, July 2014, Elsevier

    Dr Helmut Sies, Professor Jan Frank

  18. Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid accumulation and down-regulate CD36 protein in the liver of guinea pigs

    Article • The Journal of Nutritional Biochemistry, May 2014, Elsevier

    Professor Jan Frank

  19. Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin

    Article • Genes & Nutrition, March 2014, Springer Science + Business Media

    Professor Jan Frank

  20. Rapid Method for Glutathione Quantitation Using High-Performance Liquid Chromatography with Coulometric Electrochemical Detection

    Article • Journal of Agricultural and Food Chemistry, January 2014, American Chemical Society (ACS)

    Professor Jan Frank

  21. α-Tocopherol transfer protein is not required for the discrimination against γ-tocopherol in vivo but protects it from side-chain degradation in vitro

    Article • Molecular Nutrition & Food Research, January 2014, Wiley

    Professor Jan Frank

  22. High oral bioavailability of curcumin from micelles

    Article • Molecular Nutrition & Food Research, January 2014, Wiley

    Professor Jan Frank

  23. Dietary exposure to continuous small doses of α-cypermethrin in the presence or absence of dietary curcumin does not induce oxidative stress in male Wistar rats

    Article • Toxicology Reports, January 2014, Elsevier

    Professor Jan Frank

  24. Curcumin may impair iron status when fed to mice for six months

    Article • Redox Biology, January 2014, Elsevier

    Professor Jan Frank

  25. Rice bran extract protects from mitochondrial dysfunction in guinea pig brains

    Article • Pharmacological Research, October 2013, Elsevier

    Professor Jan Frank

  26. The senescence-accelerated mouse-prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals

    Article • Pharmacological Research, August 2013, Elsevier

    Professor Jan Frank

  27. Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death

    Article • APOPTOSIS, June 2013, Springer Science + Business Media

    Professor Jan Frank

  28. A validated method for the determination of selected phenolics in olive oil using high-performance liquid chromatography with coulometric electrochemical detection and a fused-core column

    Article • Food Chemistry, June 2013, Elsevier

    Professor Jan Frank

  29. Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms

    Article • Nutrition Metabolism and Cardiovascular Diseases, May 2013, Elsevier

    Professor Jan Frank

  30. Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8

    Article • Neurochemistry International, April 2013, Elsevier

    Professor Jan Frank

  31. High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs

    Article • Toxicology and Applied Pharmacology, February 2013, Elsevier

    Professor Jan Frank

  32. Comprehensive Analysis of Polyphenols in 55 Extra Virgin Olive Oils by HPLC-ECD and Their Correlation with Antioxidant Activities

    Article • Plant Foods for Human Nutrition, October 2012, Springer Science + Business Media

    Professor Jan Frank

  33. Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8

    Article • AGE, July 2012, Springer Science + Business Media

    Professor Jan Frank

  34. Rapid baseline-separation of all eight tocopherols and tocotrienols by reversed-phase liquid-chromatography with a solid-core pentafluorophenyl column and their sensitive quantification in plasma and liver

    Article • Journal of Chromatography A, June 2012, Elsevier

    Professor Jan Frank

  35. Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans

    Article • Zeitschrift für Ernährungswissenschaft, February 2012, Springer Science + Business Media

    Professor Jan Frank

  36. A Diet Rich in Olive Oil Phenolics Reduces Oxidative Stress in the Heart of SAMP8 Mice by Induction of Nrf2-Dependent Gene Expression

    Article • Rejuvenation Research, February 2012, Mary Ann Liebert Inc

    Professor Jan Frank

  37. Do tocotrienols have potential as neuroprotective dietary factors?

    Article • Ageing Research Reviews, January 2012, Elsevier

    Professor Jan Frank

  38. Comparison of tetrahydrofuran, fetal calf serum, and Tween 40 for the delivery of astaxanthin and canthaxanthin to HepG2 cells

    Article • Cytotechnology, December 2010, Springer Science + Business Media

    Professor Jan Frank

  39. Cardiac Oxidative Stress and Inflammation are Similar in SAMP8 and SAMR1 Mice and Unaltered by Curcumin and Ginkgo biloba Extract Intake

    Article • Current Pharmaceutical Biotechnology, December 2010, Bentham Science Publishers

    Professor Jan Frank

  40. Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo

    Article • British Journal Of Nutrition, November 2010, Cambridge University Press

    Professor Jan Frank

  41. Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver

    Article • British Journal Of Nutrition, May 2010, Cambridge University Press

    Professor Jan Frank

  42. A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection

    Article • Analytical and Bioanalytical Chemistry, April 2010, Springer Science + Business Media

    Professor Jan Frank

  43. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study

    Article • British Journal Of Nutrition, April 2009, Cambridge University Press

    Professor Jan Frank

  44. Vitamin E in Disease Prevention – A Critical Appraisal of Vitamin E Supplementation Trials

    Article • Aktuelle Ernährungsmedizin, April 2009, Thieme Publishing Group

    Professor Jan Frank

  45. Dietary flavonoids do not affect vitamin E status in growing rats

    Article • Journal of Animal Physiology and Animal Nutrition, March 2009, Wiley

    Professor Jan Frank

  46. Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats

    Article • British Journal Of Nutrition, January 2009, Cambridge University Press

    Professor Jan Frank

  47. Daily Consumption of an Aqueous Green Tea Extract Supplement Does Not Impair Liver Function or Alter Cardiovascular Disease Risk Biomarkers in Healthy Men

    Article • Journal of Nutrition, December 2008, American Society for Nutrition

    Professor Jan Frank

  48. Dietary green tea polyphenols do not affect vitamin E status, antioxidant capacity and meat quality of growing pigs

    Article • Journal of Animal Physiology and Animal Nutrition, December 2008, Wiley

    Professor Jan Frank

  49. Vitamin E dependent microRNA regulation in rat liver

    Article • FEBS Letters, September 2008, Wiley

    Professor Jan Frank

  50. Influence of apolipoprotein E genotype and dietary α-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice

    Article • British Journal Of Nutrition, July 2008, Cambridge University Press

    Professor Jan Frank

  51. Dietary isoflavones in the prevention of cardiovascular disease – A molecular perspective

    Article • Food and Chemical Toxicology, April 2008, Elsevier

    Professor Jan Frank

  52. Dietary flavonoids with a catechol structure increase  -tocopherol in rats and protect the vitamin from oxidation in vitro

    Article • Journal of Lipid Research, October 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Jan Frank

  53. Comparative quantification of pharmacodynamic parameters of chiral compounds (RRR- vs. all-rac-α tocopherol) by global gene expression profiling

    Article • Journal of Plant Physiology, July 2005, Elsevier

    Professor Jan Frank

  54. Beyond vitamin E supplementation: An alternative strategy to improve vitamin E status

    Article • Journal of Plant Physiology, July 2005, Elsevier

    Professor Jan Frank

  55. Consumption of Sesame Oil Muffins Decreases the Urinary Excretion of γ-Tocopherol Metabolites in Humans

    Article • Annals of the New York Academy of Sciences, December 2004, Wiley

    Professor Jan Frank

  56. Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats

    Article • British Journal Of Nutrition, July 2004, Cambridge University Press

    Professor Jan Frank

  57. The Dietary Hydroxycinnamate Caffeic Acid and Its Conjugate Chlorogenic Acid Increase Vitamin E and Cholesterol Concentrations in Sprague−Dawley Rats

    Article • Journal of Agricultural and Food Chemistry, April 2003, American Chemical Society (ACS)

    Professor Jan Frank

  58. Effects of Dietary Anthocyanins on Tocopherols and Lipids in Rats

    Article • Journal of Agricultural and Food Chemistry, December 2002, American Chemical Society (ACS)

    Professor Jan Frank

  59. Nutrigenomics

    Article • Wiley

    Professor Jan Frank