All Stories

  1. Host-derived CEACAM-laden vesicles engage enterotoxigenic Escherichia coli for elimination and toxin neutralization

    Article • Proceedings of the National Academy of Sciences, September 2024, Proceedings of the National Academy of Sciences

    Professor James Michael Fleckenstein

  2. CEACAMs serve as toxin-stimulated receptors for enterotoxigenic Escherichia coli

    Article • Proceedings of the National Academy of Sciences, November 2020, Proceedings of the National Academy of Sciences

    Professor James Michael Fleckenstein

  3. Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model

    Article • Infection and Immunity, December 2019, ASM Journals

    Professor James Michael Fleckenstein

  4. Comparative genomic analysis and molecular examination of the diversity of enterotoxigenic Escherichia coli isolates from Chile

    Article • PLoS Neglected Tropical Diseases, November 2019, PLOS

    Professor James Michael Fleckenstein, Dr David A Rasko

  5. Mechanical Stimuli Affect E. Coli Heat Stable Enterotoxin (ST)-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Diarrhea Model

    Article • September 2019, Cold Spring Harbor Laboratory Press

    Professor James Michael Fleckenstein

  6. Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection

    Article • npj Vaccines, August 2019, Springer Science + Business Media

    Professor James Michael Fleckenstein

  7. How genomics can be used to understand host susceptibility to enteric infection, aiding in the development of vaccines and immunotherapeutic interventions

    Article • Vaccine, August 2019, Elsevier

    Professor James Michael Fleckenstein

  8. Enterotoxigenic Escherichia coli–blood group A interactions intensify diarrheal severity

    Article • Journal of Clinical Investigation, July 2019, American Society for Clinical Investigation

    Professor James Michael Fleckenstein

  9. Enterotoxigenic Escherichia coli Infections

    Article • Current Infectious Disease Reports, March 2019, Springer Science + Business Media

    Professor James Michael Fleckenstein

  10. Molecular Determinants of Enterotoxigenic Escherichia coli Heat-Stable Toxin Secretion and Delivery

    Article • Infection and Immunity, August 2018, ASM Journals

    Professor James Michael Fleckenstein

  11. Enterotoxigenic Escherichia coli–blood group A interactions intensify diarrheal severity

    Article • Journal of Clinical Investigation, June 2018, American Society for Clinical Investigation

    Professor James Michael Fleckenstein

  12. Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development

    Article • The Journal of Infectious Diseases, May 2018, Oxford University Press (OUP)

    Professor James Michael Fleckenstein

  13. Molecular determinants of enterotoxigenic Escherichia coli heat-stable toxin secretion and delivery

    Article • April 2018, Cold Spring Harbor Laboratory Press

    Professor James Michael Fleckenstein

  14. A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli

    Article • The Journal of Infectious Diseases, March 2018, Oxford University Press (OUP)

    Professor James Michael Fleckenstein

  15. Characterization of enterotoxigenic Escherichia coli strains isolated from the massive multi-pathogen gastroenteritis outbreak in the Antofagasta region following the Chilean earthquake, 2010

    Article • Infection Genetics and Evolution, August 2017, Elsevier

    Professor James Michael Fleckenstein

  16. Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli

    Article • Scientific Reports, June 2017, Springer Science + Business Media

    Professor James Michael Fleckenstein

  17. Insights into enterotoxigenic Escherichia coli diversity in Bangladesh utilizing genomic epidemiology

    Article • Scientific Reports, June 2017, Springer Science + Business Media

    Professor James Michael Fleckenstein

  18. Providing Structure to Enterotoxigenic Escherichia coli Vaccine Development

    Article • The Journal of Infectious Diseases, May 2017, Oxford University Press (OUP)

    Professor James Michael Fleckenstein

  19. Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions

    Article • PLoS Neglected Tropical Diseases, May 2017, PLOS

    Professor James Michael Fleckenstein

  20. Dynamic Interactions of a Conserved Enterotoxigenic Escherichia coli Adhesin with Intestinal Mucins Govern Epithelium Engagement and Toxin Delivery

    Article • Infection and Immunity, October 2016, ASM Journals

    Professor James Michael Fleckenstein

  21. Blood Group O–Dependent Cellular Responses to Cholera Toxin: Parallel Clinical and Epidemiological Links to Severe Cholera

    Article • American Journal of Tropical Medicine and Hygiene, August 2016, American Society of Tropical Medicine and Hygiene

    Professor James Michael Fleckenstein

  22. Immunogenicity and Protective Efficacy against Enterotoxigenic Escherichia coli Colonization following Intradermal, Sublingual, or Oral Vaccination with EtpA Adhesin

    Article • Clinical and Vaccine Immunology, May 2016, ASM Journals

    Professor James Michael Fleckenstein

  23. Overcoming Enterotoxigenic Escherichia coli Pathogen Diversity: Translational Molecular Approaches to Inform Vaccine Design

    Article • January 2016, Springer Science + Business Media

    Professor James Michael Fleckenstein

  24. Examination of the Enterotoxigenic Escherichia coli Population Structure during Human Infection

    Article • mBio, June 2015, ASM Journals

    Dr David A Rasko, Professor James Michael Fleckenstein

  25. Conservation and Immunogenicity of Novel Antigens in Diverse Isolates of Enterotoxigenic Escherichia coli

    Article • PLoS Neglected Tropical Diseases, January 2015, PLOS

    Dr David A Rasko, Professor James Michael Fleckenstein

  26. Contribution of the Highly Conserved EaeH Surface Protein to Enterotoxigenic Escherichia coli Pathogenesis

    Article • Infection and Immunity, June 2014, ASM Journals

    Professor James Michael Fleckenstein

  27. Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli

    Article • Toxins, June 2014, MDPI AG

    Professor James Michael Fleckenstein

  28. Novel antigens for enterotoxigenicEscherichia colivaccines

    Article • Expert Review of Vaccines, April 2014, Taylor & Francis

    Professor James Michael Fleckenstein

  29. Enterotoxigenic Escherichia coli Secretes a Highly Conserved Mucin-Degrading Metalloprotease To Effectively Engage Intestinal Epithelial Cells

    Article • Infection and Immunity, November 2013, ASM Journals

    Professor James Michael Fleckenstein

  30. EatA, an Immunogenic Protective Antigen of Enterotoxigenic Escherichia coli, Degrades Intestinal Mucin

    Article • Infection and Immunity, November 2013, ASM Journals

    Professor James Michael Fleckenstein

  31. EnterotoxigenicEscherichia coli

    Article • Gut Microbes, September 2013, Taylor & Francis

    Dr David A Rasko, Professor James Michael Fleckenstein

  32. Escherichia coli Sequence Type 131 (ST131) Subclone H30 as an Emergent Multidrug-Resistant Pathogen Among US Veterans

    Article • Clinical Infectious Diseases, August 2013, Oxford University Press (OUP)

    Professor James Michael Fleckenstein

  33. Enterotoxigenic Escherichia coli

    Article • January 2013, Elsevier

    Professor James Michael Fleckenstein

  34. Transcriptional Modulation of Enterotoxigenic Escherichia coli Virulence Genes in Response to Epithelial Cell Interactions

    Article • Infection and Immunity, October 2012, ASM Journals

    Professor James Michael Fleckenstein

  35. Cooperative Role of Antibodies against Heat-Labile Toxin and the EtpA Adhesin in Preventing Toxin Delivery and Intestinal Colonization by Enterotoxigenic Escherichia coli

    Article • Clinical and Vaccine Immunology, August 2012, ASM Journals

    Professor James Michael Fleckenstein

  36. Directed Evaluation of Enterotoxigenic Escherichia coli Autotransporter Proteins as Putative Vaccine Candidates

    Article • PLoS Neglected Tropical Diseases, December 2011, PLOS

    Professor James Michael Fleckenstein

  37. Outer Membrane Vesicles Induce Immune Responses to Virulence Proteins and Protect against Colonization by Enterotoxigenic Escherichia coli

    Article • Clinical and Vaccine Immunology, September 2011, ASM Journals

    Professor James Michael Fleckenstein

  38. Adhesin Degradation Accelerates Delivery of Heat-labile Toxin by EnterotoxigenicEscherichia coli

    Article • Journal of Biological Chemistry, July 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor James Michael Fleckenstein

  39. Infectious Agents of Food- and Water-Borne Illnesses

    Article • The American Journal of the Medical Sciences, September 2010, Elsevier

    Professor James Michael Fleckenstein

  40. Enterotoxigenic Escherichia coli Elicits Immune Responses to Multiple Surface Proteins

    Article • Infection and Immunity, May 2010, ASM Journals

    Professor James Michael Fleckenstein

  41. Lingual Leishmaniasis Complicating Visceral Disease

    Article • Journal of Travel Medicine, May 2010, Oxford University Press (OUP)

    Professor James Michael Fleckenstein

  42. Molecular mechanisms of enterotoxigenic Escherichia coli infection

    Article • Microbes and Infection, February 2010, Elsevier

    Dr David A Rasko, Professor James Michael Fleckenstein

  43. Vaccination with EtpA glycoprotein or flagellin protects against colonization with enterotoxigenic Escherichia coli in a murine model

    Article • Vaccine, July 2009, Elsevier

    Professor James Michael Fleckenstein

  44. Purification of recombinant high molecular weight two-partner secretion proteins from Escherichia coli

    Article • Nature Protocols, July 2009, Springer Science + Business Media

    Professor James Michael Fleckenstein

  45. Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells

    Article • Nature, December 2008, Springer Science + Business Media

    Professor James Michael Fleckenstein

  46. Heat-Labile Enterotoxin Promotes Escherichia coli Adherence to Intestinal Epithelial Cells

    Article • Journal of Bacteriology, October 2008, ASM Journals

    Professor James Michael Fleckenstein

  47. The EtpA Exoprotein of Enterotoxigenic Escherichia coli Promotes Intestinal Colonization and Is a Protective Antigen in an Experimental Model of Murine Infection

    Article • Infection and Immunity, February 2008, ASM Journals

    Professor James Michael Fleckenstein

  48. Directed delivery of heat-labile enterotoxin by enterotoxigenic Escherichia coli

    Article • Cellular Microbiology, September 2006, Wiley

    Professor James Michael Fleckenstein

  49. Identification of a Two-Partner Secretion Locus of Enterotoxigenic Escherichia coli

    Article • Infection and Immunity, April 2006, ASM Journals

    Professor James Michael Fleckenstein

  50. Importance of Heat-Labile Enterotoxin in Colonization of the Adult Mouse Small Intestine by Human Enterotoxigenic Escherichia coli Strains

    Article • Infection and Immunity, February 2006, ASM Journals

    Professor James Michael Fleckenstein

  51. Identification and Molecular Characterization of EatA, an Autotransporter Protein of Enterotoxigenic Escherichia coli

    Article • Infection and Immunity, March 2004, ASM Journals

    Professor James Michael Fleckenstein

  52. Interaction of an Outer Membrane Protein of Enterotoxigenic Escherichia coli with Cell Surface Heparan Sulfate Proteoglycans

    Article • Infection and Immunity, March 2002, ASM Journals

    Professor James Michael Fleckenstein

  53. Breaching the mucosal barrier by stealth: an emerging pathogenic mechanism for enteroadherent bacterial pathogens

    Article • Journal of Clinical Investigation, January 2001, American Society for Clinical Investigation

    Professor James Michael Fleckenstein

  54. Identification of a Gene within a Pathogenicity Island of Enterotoxigenic Escherichia coli H10407 Required for Maximal Secretion of the Heat-Labile Enterotoxin

    Article • Infection and Immunity, May 2000, ASM Journals

    Professor James Michael Fleckenstein

  55. Incidental Discovery of Emphysematous Cystitis

    Article • Southern Medical Journal, August 1998, Southern Medical Association

    Professor James Michael Fleckenstein

  56. Cryptococcal Skull Infection

    Article • Neurosurgery, June 1993, Oxford University Press (OUP)

    Professor James Michael Fleckenstein