All Stories

  1. Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma

    Article • Nanomedicine Nanotechnology Biology and Medicine, January 2015, Elsevier

    Professor Jacek Jemielity

  2. Gold-decorated polymer vessel structures as carriers of mRNA cap analogs

    Article • Polymer, January 2015, Elsevier

    Professor Jacek Jemielity

  3. Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding

    Article • Biochemical and Biophysical Research Communications, January 2015, Elsevier

    Professor Jacek Jemielity

  4. Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

    Article • Nucleic Acids Research, August 2014, Oxford University Press (OUP)

    Professor Jacek Jemielity

  5. Cap analogs containing 6-thioguanosine – reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Jacek Jemielity

  6. Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5′,5′-triphosphate bridge

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Jacek Jemielity

  7. Synthesis and evaluation of stability of m3G-CAP analogues in serum-supplemented medium and cytosolic extract

    Article • Bioorganic & Medicinal Chemistry, December 2013, Elsevier

    Professor Jacek Jemielity

  8. Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding

    Article • FEBS Journal, October 2013, Wiley

    Professor Jacek Jemielity

  9. The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation

    Article • Bioorganic & Medicinal Chemistry Letters, July 2013, Elsevier

    Professor Jacek Jemielity

  10. Potential therapeutic applications of RNA cap analogs

    Article • Future Medicinal Chemistry, June 2013, Future Science

    Professor Jacek Jemielity

  11. Magnetic-Nanoparticle-Decorated Polypyrrole Microvessels: Toward Encapsulation of mRNA Cap Analogues

    Article • Biomacromolecules, May 2013, American Chemical Society (ACS)

    Professor Jacek Jemielity

  12. A fast and simple method enabling synthesis of nucleotide sugars.

    Article • European Journal of Organic Chemistry, February 2013, Wiley

    Professor Jacek Jemielity, Pawel Dabrowski-Tumanski

  13. Synthesis and evaluation of fluorescent cap analogues for mRNA labelling

    Article • RSC Advances, January 2013, Royal Society of Chemistry

    Professor Jacek Jemielity

  14. mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end

    Article • RNA, November 2012, Cold Spring Harbor Laboratory Press

    Professor Jacek Jemielity

  15. Synthetic mRNAs with Superior Translation and Stability Properties

    Article • November 2012, Springer Science + Business Media

    Professor Jacek Jemielity

  16. 7-Methylguanosine Diphosphate (m7GDP) Is Not Hydrolyzed but Strongly Bound by Decapping Scavenger (DcpS) Enzymes and Potently Inhibits Their Activity

    Article • Biochemistry, September 2012, American Chemical Society (ACS)

    Professor Jacek Jemielity

  17. Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P-Imidazolides and Microwaves

    Article • Organic Letters, September 2012, American Chemical Society (ACS)

    Professor Jacek Jemielity

  18. Synthesis of nucleoside phosphosulfates

    Article • Bioorganic & Medicinal Chemistry Letters, June 2012, Elsevier

    Professor Jacek Jemielity

  19. Affinity resins containing enzymatically resistant mRNA cap analogs--a new tool for the analysis of cap-binding proteins

    Article • RNA, May 2012, Cold Spring Harbor Laboratory Press

    Professor Jacek Jemielity

  20. Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

    Article • Bioorganic & Medicinal Chemistry, March 2012, Elsevier

    Professor Jacek Jemielity

  21. Synthesis of biotin labelled cap analogue – incorporable into mRNA transcripts and promoting cap-dependent translation

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Professor Jacek Jemielity

  22. Structural analysis of 5′-mRNA–cap interactions with the human AGO2 MID domain

    Article • EMBO Reports, April 2011, Wiley

    Professor Jacek Jemielity

  23. Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH

    Article • RNA, March 2011, Cold Spring Harbor Laboratory Press

    Professor Jacek Jemielity

  24. Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies

    Article • FEBS Journal, July 2010, Wiley

    Professor Jacek Jemielity

  25. Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

    Article • Gene Therapy, April 2010, Springer Science + Business Media

    Professor Jacek Jemielity

  26. Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

    Article • New Journal of Chemistry, January 2010, Royal Society of Chemistry

    Professor Jacek Jemielity

  27. Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins

    Article • New Journal of Chemistry, January 2010, Royal Society of Chemistry

    Professor Jacek Jemielity

  28. Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

    Article • New Journal of Chemistry, January 2010, Royal Society of Chemistry

    Professor Jacek Jemielity

  29. Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5′-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP)

    Article • FEBS Letters, November 2009, Wiley

    Professor Jacek Jemielity

  30. Phosphoroselenoate Dinucleotides for Modification of mRNA 5′ End

    Article • ChemBioChem, October 2009, Wiley

    Professor Jacek Jemielity

  31. Drosophila miR2 Primarily Targets the m7GpppN Cap Structure for Translational Repression

    Article • Molecular Cell, September 2009, Elsevier

    Professor Jacek Jemielity

  32. Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: Substrate specificity studies on the recombinant and endogenous proteins

    Article • RNA, June 2009, Cold Spring Harbor Laboratory Press

    Professor Jacek Jemielity

  33. Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

    Article • Bioorganic & Medicinal Chemistry Letters, April 2009, Elsevier

    Professor Jacek Jemielity

  34. Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′,5′ bridge containing methylenebis(phosphonate) modification

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Professor Jacek Jemielity

  35. Adenosine 5′-Tetraphosphate Is a Highly Potent Purinergic Endothelium-Derived Vasoconstrictor

    Article • Circulation Research, November 2008, Wolters Kluwer Health

    Professor Jacek Jemielity

  36. Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

    Article • RNA, April 2008, Cold Spring Harbor Laboratory Press

    Professor Jacek Jemielity

  37. mRNA Decapping Is Promoted by an RNA-Binding Channel in Dcp2

    Article • Molecular Cell, February 2008, Elsevier

    Professor Jacek Jemielity

  38. Solid-Supported Synthesis of 5′-mRNA CAP-4 from Trypanosomatids

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Professor Jacek Jemielity

  39. Assignment of the Absolute Configuration of P-Chiral 5′Mrna Cap Analogues Containing Phosphorothioate Moiety

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Professor Jacek Jemielity

  40. Synthesis of3H and13C Labeled Mrna Cap Dinucleotides—Useful Tools for Nmr, Biochemical, and Biological Studies

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Professor Jacek Jemielity

  41. Synthesis ofLeishmaniaCap-4 Intermediates, Cap-2 and Cap-3

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Professor Jacek Jemielity

  42. Affinity of Dinucleotide Cap Analogues for Human Decapping Scavenger (hDcpS)

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Professor Jacek Jemielity

  43. Kinetics of C. Elegans DcpS Cap Hydrolysis Studied by Fluorescence Spectroscopy

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Professor Jacek Jemielity

  44. Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

    Article • RNA, August 2007, Cold Spring Harbor Laboratory Press

    Professor Jacek Jemielity

  45. A simple and rapid synthesis of nucleotide analogues containing a phosphorothioate moiety at the terminal position of the phosphate chain

    Article • Tetrahedron Letters, July 2007, Elsevier

    Professor Jacek Jemielity

  46. Interaction of human decapping scavenger with 5′ mRNA cap analogues: structural requirements for catalytic activity

    Article • Journal of Physics Condensed Matter, June 2007, Institute of Physics Publishing

    Professor Jacek Jemielity

  47. Weak binding affinity of human 4EHP for mRNA cap analogs

    Article • RNA, May 2007, Cold Spring Harbor Laboratory Press

    Professor Jacek Jemielity

  48. Synthesis of Anti‐Reverse Cap Analogs (ARCAs) and their Applications in mRNA Translation and Stability

    Article • January 2007, Elsevier

    Professor Jacek Jemielity

  49. Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme

    Article • Bioorganic & Medicinal Chemistry, May 2006, Elsevier

    Professor Jacek Jemielity

  50. Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases

    Article • FEBS Journal, February 2006, Wiley

    Professor Jacek Jemielity

  51. Differential Inhibition of mRNA Degradation Pathways by Novel Cap Analogs

    Article • Journal of Biological Chemistry, October 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Jacek Jemielity

  52. A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides

    Article • Tetrahedron Letters, April 2005, Elsevier

    Professor Jacek Jemielity

  53. A NOVEL APPROACH TO SOLID PHASE CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDE mRNA CAP ANALOGS

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2005, Taylor & Francis

    Professor Jacek Jemielity

  54. SYNTHESIS AND PROPERTIES OF mRNA CAP ANALOGS CONTAINING PHOSPHOROTHIOATE MOIETY IN 5′,5′-TRIPHOSPHATE CHAIN

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2005, Taylor & Francis

    Professor Jacek Jemielity

  55. SYNTHESIS AND ENZYMATIC CHARACTERIZATION OF METHYLENE ANALOGS OF ADENOSINE 5′-TETRAPHOSPHATE (P4A)

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2005, Taylor & Francis

    Professor Jacek Jemielity

  56. SYNTHESIS AND BIOCHEMICAL PROPERTIES OF NOVEL mRNA 5′ CAP ANALOGS RESISTANT TO ENZYMATIC HYDROLYSIS

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2005, Taylor & Francis

    Professor Jacek Jemielity

  57. NOVEL DINUCLEOSIDE 5′,5′-TRIPHOSPHATE CAP ANALOGUES. SYNTHESIS AND AFFINITY FOR MURINE TRANSLATION FACTOR eIF4E

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2005, Taylor & Francis

    Professor Jacek Jemielity

  58. Influence of Electric Charge Variation at Residues 209 and 159 on the Interaction of eIF4E with the mRNA 5‘ Terminus

    Article • Biochemistry, April 2004, American Chemical Society (ACS)

    Professor Jacek Jemielity

  59. Influence of the Length of the Phosphate Chain in mRNA 5′ Cap Analogues on Their Interaction with Eukaryotic Initiation Factor 4E

    Article • ChemInform, February 2004, Wiley

    Professor Jacek Jemielity

  60. Synthesis of Novel mRNA 5′ Cap-Analogues: Dinucleoside P1, P3-Tri-, P1, P4-Tetra-, and P1, P5-Pentaphosphates

    Article • Nucleosides Nucleotides & Nucleic Acids, October 2003, Taylor & Francis

    Professor Jacek Jemielity

  61. Binding Studies of Eukaryotic Initiation Factor eIF4E with Novel mRNA Dinucleotide Cap Analogues

    Article • Nucleosides Nucleotides & Nucleic Acids, October 2003, Taylor & Francis

    Professor Jacek Jemielity

  62. Influence of the Length of the Phosphate Chain in mRNA 5′ Cap Analogues on Their Interaction with Eukaryotic Initiation Factor 4E

    Article • Nucleosides Nucleotides & Nucleic Acids, October 2003, Taylor & Francis

    Professor Jacek Jemielity

  63. Interaction Between Yeast Eukaryotic Initiation Factor eIF4E and mRNA 5′ Cap Analogues Differs from That for Murine eIF4E

    Article • Nucleosides Nucleotides & Nucleic Acids, October 2003, Taylor & Francis

    Professor Jacek Jemielity

  64. Novel "anti-reverse" cap analogs with superior translational properties

    Article • RNA, September 2003, Cold Spring Harbor Laboratory Press

    Professor Jacek Jemielity

  65. Synthesis of tritium labeled isotopomers of L‐tyrosine

    Article • Journal of Labelled Compounds and Radiopharmaceuticals, April 2002, Wiley

    Professor Jacek Jemielity

  66. Synthesis of tritium labeled [3R‐3H]‐, and [3S‐3H]‐L‐phenylalanine

    Article • Journal of Labelled Compounds, March 2001, Wiley

    Professor Jacek Jemielity

  67. Synthesis of tritium labeled [3R‐3H]‐, and [3S‐3H]‐L‐phenylalanine

    Article • Journal of Labelled Compounds and Radiopharmaceuticals, March 2001, Wiley

    Professor Jacek Jemielity

  68. Tritium Secondary Kinetic Isotope Effect on Phenylalanine Ammonia-Lyase-Catalyzed Reaction

    Article • Archives of Biochemistry and Biophysics, October 1999, Elsevier

    Professor Piotr Paneth, Professor Jacek Jemielity

  69. Enzymatic Synthesis of [1-13C]- and [1-14C]-L-Phenyl-Alanine

    Article • Isotopes in Environmental and Health Studies, December 1998, Taylor & Francis

    Professor Jacek Jemielity