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  1. Scandium Ion-Promoted Electron-Transfer Disproportionation of 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-Oxide (PTIO•) in Acetonitrile and Its Regeneration Induced by Water

    Article • International Journal of Molecular Sciences, April 2024, MDPI AG

    Dr Ikuo Nakanishi

  2. Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress—Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol?

    Article • Biomolecules, January 2024, MDPI AG

    Dr Ikuo Nakanishi

  3. Hair Follicle Damage after 100 mGy Low-Dose Fractionated X-Ray Irradiation and the Protective Effects of TEMPOL, a Stable Nitroxide Radical, against Radiation

    Article • Radiation Research, January 2024, Radiation Research Society

    Dr Ikuo Nakanishi

  4. Enhanced Inhibition of Cancer Cell Migration by a Planar Catechin Analog

    Article • ACS Medicinal Chemistry Letters, January 2024, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  5. Photodynamic Therapy for X-ray-Induced Radiation-Resistant Cancer Cells

    Article • Pharmaceutics, October 2023, MDPI AG

    Dr Ikuo Nakanishi

  6. Anti-cancer Effect of a Planar Catechin Analog through the Decrease in Mitochondrial Membrane Potential

    Article • ACS Medicinal Chemistry Letters, October 2023, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  7. In vitro radical-scavenging mechanism of melatonin and its in vivo protective effect against radiation-induced lipid peroxidation

    Article • Redox Biochemistry and Chemistry, July 2023, Elsevier

    Dr Ikuo Nakanishi

  8. Effects of X-ray irradiation on the redox status of mouse colorectal tissues

    Article • Advances in Redox Research, July 2023, Elsevier

    Dr Ikuo Nakanishi

  9. Water-Induced Regeneration of a 2,2-Diphenyl-1-picrylhydrazyl Radical after Its Scandium Ion-Promoted Electron-Transfer Disproportionation in an Aprotic Medium

    Article • Molecules, June 2023, MDPI AG

    Dr Ikuo Nakanishi

  10. Evidence of Nrf2/Keap1 Signaling Regulation by Mitochondria-Generated Reactive Oxygen Species in RGK1 Cells

    Article • Biomolecules, February 2023, MDPI AG

    Dr Ikuo Nakanishi

  11. DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination

    Article • Antioxidants, January 2023, MDPI AG

    Dr Ikuo Nakanishi

  12. Effects of selenium deficiency on biological results of X-ray and carbon-ion beam irradiation in mice

    Article • Journal of Clinical Biochemistry and Nutrition, January 2023, The Society for Free Radical Research Japan

    Dr Ikuo Nakanishi

  13. Importance of Locations of Iron Ions to Elicit Cytotoxicity Induced by a Fenton-Type Reaction

    Article • Cancers, July 2022, MDPI AG

    Dr Ikuo Nakanishi

  14. Effect of Magnesium Ion on the Radical-Scavenging Rate of Pterostilbene in an Aprotic Medium: Mechanistic Insight into the Antioxidative Reaction of Pterostilbene

    Article • Antioxidants, February 2022, MDPI AG

    Dr Ikuo Nakanishi

  15. Estimation of the Local Concentration of the Markedly Dense Hydroxyl Radical Generation Induced by X-rays in Water

    Article • Molecules, January 2022, MDPI AG

    Dr Ikuo Nakanishi

  16. Simplifying quantitative measurement of free radical species using an X-band EPR spectrometer

    Article • Journal of Clinical Biochemistry and Nutrition, January 2022, The Society for Free Radical Research Japan

    Dr Ikuo Nakanishi

  17. Electrochemical redox behavior of 2,2-diphenyl-1-picrylhydrazyl radical solubilized by β-cyclodextrin in water

    Article • Electrochemistry Communications, January 2022, Elsevier

    Dr Ikuo Nakanishi

  18. Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging

    Article • Antioxidants & Redox Signaling, January 2022, Mary Ann Liebert Inc

    Dr Ikuo Nakanishi

  19. Tunneling in the Hydrogen-Transfer Reaction from a Vitamin E Analog to an Inclusion Complex of 2,2-Diphenyl-1-picrylhydrazyl Radical with β-Cyclodextrin in an Aqueous Buffer Solution at Ambient Temperature

    Article • Antioxidants, December 2021, MDPI AG

    Dr Ikuo Nakanishi

  20. Effects of LET on oxygen-dependent and-independent generation of hydrogen peroxide in water irradiated by carbon-ion beams

    Article • Free Radical Research, June 2021, Taylor & Francis

    Dr Ikuo Nakanishi

  21. Protective Effects of Amino Acids on Plasmid DNA Damage Induced by Therapeutic Carbon Ions

    Article • Radiation Research, May 2021, Radiation Research Society

    Dr Ikuo Nakanishi

  22. Effects of loading a magnetic field longitudinal to the linear particle-beam track on yields of reactive oxygen species in water

    Article • Free Radical Research, May 2021, Taylor & Francis

    Dr Ikuo Nakanishi

  23. Relationship between the radical-scavenging activity of selected flavonols and thermodynamic parameters calculated by density functional theory

    Article • Free Radical Research, July 2020, Taylor & Francis

    Dr Ikuo Nakanishi

  24. A large kinetic isotope effect in the reaction of ascorbic acid with 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO˙) in aqueous buffer solutions

    Article • Chemical Communications, January 2020, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  25. Synthesis and radical-scavenging activity of C-methylated fisetin analogues

    Article • Bioorganic & Medicinal Chemistry, February 2019, Elsevier

    Dr Ikuo Nakanishi

  26. Effect of plateau carbon-ion beams

    Article • Organic & Biomolecular Chemistry, January 2018, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  27. Efficient protective activity of a planar catechin analogue against radiation-induced apoptosis in rat thymocytes

    Article • RSC Advances, January 2018, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  28. Enhanced radical scavenging activity of a procyanidin B3 analogue comprised of a dimer of planar catechin

    Article • Bioorganic & Medicinal Chemistry Letters, October 2017, Elsevier

    Dr Ikuo Nakanishi

  29. Synthesis and antioxidant activity of a procyanidin B3 analogue

    Article • Bioorganic & Medicinal Chemistry Letters, February 2017, Elsevier

    Dr Ikuo Nakanishi

  30. Synthesis of methylated quercetin analogues for enhancement of radical-scavenging activity

    Article • RSC Advances, January 2017, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  31. A facile and rapid access to resveratrol derivatives and their radioprotective activity

    Article • Bioorganic & Medicinal Chemistry Letters, August 2016, Elsevier

    Dr Ikuo Nakanishi

  32. Aluminium ion-promoted radical-scavenging reaction of methylated hydroquinone derivatives

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  33. Solubilisation of a 2,2-diphenyl-1-picrylhydrazyl radical in water by β-cyclodextrin to evaluate the radical-scavenging activity of antioxidants in aqueous media

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  34. Synthesis and radical-scavenging activity of a dimethyl catechin analogue

    Article • Bioorganic & Medicinal Chemistry Letters, June 2014, Elsevier

    Dr Ikuo Nakanishi

  35. Disproportionation of a 2,2-diphenyl-1-picrylhydrazyl radical as a model of reactive oxygen species catalysed by Lewis and/or Brønsted acids

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  36. Scavenging of reactive oxygen species induced by hyperthermia in biological fluid

    Article • Journal of Clinical Biochemistry and Nutrition, January 2014, The Society for Free Radical Research Japan

    Dr Ikuo Nakanishi

  37. High-Throughput Screening of Radioprotectors Using Rat Thymocytes

    Article • Analytical Chemistry, August 2013, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  38. Effects of ionic radius of redox-inactive bio-related metal ions on the radical-scavenging activity of flavonoids evaluated using photometric titration

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  39. Method for assessing X-ray-induced hydroxyl radical-scavenging activity of biological compounds/materials

    Article • Journal of Clinical Biochemistry and Nutrition, January 2013, The Society for Free Radical Research Japan

    Dr Ikuo Nakanishi

  40. Comparison of in vivo and in vitro antioxidative parameters for eleven food factors

    Article • RSC Advances, January 2013, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  41. Radical-Scavenging Reactions of Ascorbic Acid and Its Analogue in the Presence of a Redox-Inactive Metal Ion

    Article • Free Radical Biology and Medicine, November 2012, Elsevier

    Dr Ikuo Nakanishi

  42. Comparison of Blood-Brain-Barrier Permeable Nitroxyl Contrast Agents for Magnetic Resonance Brain Redox Imaging

    Article • Free Radical Biology and Medicine, November 2012, Elsevier

    Dr Ikuo Nakanishi

  43. Kinetics and Mechanism for the Scavenging Reaction of the 2,2-Diphenyl-1-picrylhydrazyl Radical by Synthetic Artepillin C Analogues

    Article • Bulletin of the Chemical Society of Japan, August 2012, The Chemical Society of Japan

    Dr Ikuo Nakanishi

  44. Chlorine atom substitution influences radical scavenging activity of 6-chromanol

    Article • Bioorganic & Medicinal Chemistry, July 2012, Elsevier

    Dr Ikuo Nakanishi

  45. Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE

    Article • Free Radical Research, June 2012, Taylor & Francis

    Dr Ikuo Nakanishi

  46. ChemInform Abstract: Synthesis and Enhanced Radical Scavenging Activity of a Conformationally Constrained Epigallocatechin Analogue (III).

    Article • ChemInform, April 2012, Wiley

    Dr Ikuo Nakanishi

  47. The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

    Article • RSC Advances, January 2012, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  48. Efficient Method for Hydroxyl Radical Scavenging Activity of Antioxidants

    Article • Free Radical Biology and Medicine, November 2011, Elsevier

    Dr Ikuo Nakanishi

  49. Radica-Scavenging Activity of 6-Chromanol Derivatives with Various Substituents

    Article • Free Radical Biology and Medicine, November 2011, Elsevier

    Dr Ikuo Nakanishi

  50. Synthesis and Enhanced Radical Scavenging Activity of a Conformationally Constrained Epigallocatechin Analogue

    Article • Chemistry Letters, January 2011, Chemical Society of Japan

    Dr Ikuo Nakanishi

  51. Temperature-dependent free radical reaction in water

    Article • Journal of Clinical Biochemistry and Nutrition, January 2011, The Society for Free Radical Research Japan

    Dr Ikuo Nakanishi

  52. Synthesis of Conformationally Constrained Epigallocatechin Analogue as a Promising Antioxidant

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Dr Ikuo Nakanishi

  53. Electron Transfer from Stable Superoxide Complex to Electron Acceptors as Benzoquinone Derivatives

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Dr Ikuo Nakanishi

  54. Reaction of Nitroxyl Radicals and GSH; pH Dependence

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Dr Ikuo Nakanishi

  55. Potent 2,2-Diphenyl-1-picrylhydrazyl Radical-Scavenging Activity of Novel Antioxidants, Double-Stranded Tyrosine Residues Conjugating Pyrocatechol

    Article • Chemical and Pharmaceutical Bulletin, January 2010, Pharmaceutical Society of Japan

    Dr Ikuo Nakanishi

  56. Electron-Transfer Properties of the Phenolate Anion Derived from a Vitamin E Model in the Presence of a Strong Base in an Aprotic Medium

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Dr Ikuo Nakanishi

  57. Novel ninhydrin adduct of catechin with potent antioxidative activity

    Article • Tetrahedron Letters, December 2009, Elsevier

    Dr Ikuo Nakanishi

  58. Intracellular and Extracellular Redox Environments Surrounding Redox-Sensitive Contrast Agents under Oxidative Atmosphere

    Article • Biological and Pharmaceutical Bulletin, January 2009, Pharmaceutical Society of Japan

    Dr Ikuo Nakanishi

  59. Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative bearing a lysine moiety

    Article • Chemical Communications, January 2009, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  60. Effect of Methyl Substitution on the Antioxidative Property and Genotoxicity of Resveratrol

    Article • Chemical Research in Toxicology, February 2008, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  61. Enhanced radical-scavenging activity of naturally-oriented artepillin C derivatives

    Article • Chemical Communications, January 2008, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  62. Involvement of Electron Transfer in the Radical-scavenging Reaction of Resveratrol

    Article • Chemistry Letters, October 2007, The Chemical Society of Japan

    Dr Ikuo Nakanishi

  63. Effect of Solvent Polarity on the One-electron Oxidation of Cyclic Nitroxyl Radicals

    Article • Chemistry Letters, July 2007, The Chemical Society of Japan

    Dr Ikuo Nakanishi

  64. A Long-lived o-Semiquinone Radical Anion is Formed from N- -alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), an Insect-derived Antibacterial Substance

    Article • The Journal of Biochemistry, April 2007, Oxford University Press (OUP)

    Dr Ikuo Nakanishi

  65. Scandium Ion-accelerated Scavenging Reaction of Cumylperoxyl Radical by a Cyclic Nitroxyl Radical via Electron Transfer

    Article • Chemistry Letters, March 2007, The Chemical Society of Japan

    Dr Ikuo Nakanishi

  66. Nitroxyl radicals: electrochemical redox behaviour and structure–activity relationships

    Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  67. Planar Catechin Analogues with Alkyl Side Chains:  A Potent Antioxidant and an α-Glucosidase Inhibitor

    Article • Journal of the American Chemical Society, May 2006, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  68. Comparison of stable nitroxide, 3-substituted 2,2,5,5-tetramethylpyrrolidine-N-oxyls, with respect to protection from radiation, prevention of DNA damage, and distribution in mice

    Article • Free Radical Biology and Medicine, April 2006, Elsevier

    Dr Ikuo Nakanishi

  69. Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II)

    Article • Bioorganic & Medicinal Chemistry, March 2006, Elsevier

    Dr Ikuo Nakanishi

  70. Reaction ofpara-hydroxybenzoic acid esters with singlet oxygen in the presence of glutathione produces glutathione conjugates of hydroquinone, potent inducers of oxidative stress

    Article • Free Radical Research, January 2006, Taylor & Francis

    Dr Ikuo Nakanishi

  71. Electron-transfer mechanism in radical-scavenging reactions by a vitamin E model in a protic medium

    Article • Organic & Biomolecular Chemistry, January 2005, Royal Society of Chemistry

    Shinobu Itoh, Dr Ikuo Nakanishi

  72. Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue

    Article • Organic & Biomolecular Chemistry, January 2005, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  73. EPR Study on Stable Magnesium Complexes of the Phenoxyl Radicals Derived from a Vitamin E Model and Its Deuterated Derivatives

    Article • Bulletin of the Chemical Society of Japan, January 2004, Chemical Society of Japan

    Shinobu Itoh, Dr Ikuo Nakanishi

  74. A Planar Catechin Analogue Having a More Negative Oxidation Potential than (+)-Catechin as an Electron Transfer Antioxidant against a Peroxyl Radical

    Article • Chemical Research in Toxicology, January 2004, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  75. Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism

    Article • Organic & Biomolecular Chemistry, April 2003, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  76. Kinetic study of the electron-transfer oxidation of the phenolate anion of a vitamin E model by molecular oxygen generating superoxide anion in an aprotic mediumElectronic supplementary information (ESI) available: the cyclic voltammogram of 1? and the...

    Article • Organic & Biomolecular Chemistry, January 2003, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  77. A Planar Catechin Analogue as a Promising Antioxidant with Reduced Prooxidant Activity

    Article • Chemical Research in Toxicology, January 2003, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  78. Effects of Metal Ions Distinguishing between One-Step Hydrogen- and Electron-Transfer Mechanisms for the Radical-Scavenging Reaction of (+)-Catechin

    Article • The Journal of Physical Chemistry A, November 2002, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  79. Direct detection of superoxide anion generated in C60-photosensitized oxidation of NADH and an analogue by molecular oxygen

    Article • Journal of the Chemical Society Perkin Transactions 2, September 2002, Royal Society of Chemistry

    Dr Ikuo Nakanishi

  80. Effects of magnesium ion on kinetic stability and spin distribution of phenoxyl radical derived from a vitamin E analogue: mechanistic insight into antioxidative hydrogen-transfer reaction of vitamin EElectronic supplementary information available: cal...

    Article • Journal of the Chemical Society Perkin Transactions 2, July 2002, Royal Society of Chemistry

    Shinobu Itoh, Dr Ikuo Nakanishi

  81. Enhanced Radical-Scavenging Activity of a Planar Catechin Analogue

    Article • Journal of the American Chemical Society, May 2002, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  82. DNA Cleavage via Superoxide Anion Formed in Photoinduced Electron Transfer from NADH to γ-Cyclodextrin-Bicapped C 60 in an Oxygen-Saturated Aqueous Solution

    Article • The Journal of Physical Chemistry, March 2002, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  83. ChemInform Abstract: Hydroxylation of Nitrated Naphthalenes with KO2/Crown Ether.

    Article • ChemInform, March 2001, Wiley

    Dr Ikuo Nakanishi

  84. ChemInform Abstract: Reactive Species Responsible for Biological Actions of Photoexcited Fullerenes

    Article • ChemInform, February 2001, Wiley

    Dr Ikuo Nakanishi

  85. Base Control of Electron-Transfer Reactions of Manganese(III) Porphyrins

    Article • European Journal of Inorganic Chemistry, July 2000, Wiley

    Dr Ikuo Nakanishi

  86. Hydroxylation of Nitrated Naphthalenes with KO2/Crown Ether.

    Article • Chemical and Pharmaceutical Bulletin, January 2000, Pharmaceutical Society of Japan

    Dr Ikuo Nakanishi

  87. Multielectron Oxidation of Anthracenes with a One-Electron Oxidant via Water-Accelerated Electron-Transfer Disproportionation of the Radical Cations as the Rate-Determining Step

    Article • The Journal of Physical Chemistry A, December 1999, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  88. Migration Reactivities of σ-Bonded Ligands of Organoiron and Organocobalt Porphyrins Depending on Different High Oxidation States

    Article • Inorganic Chemistry, November 1999, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  89. Electron-Transfer Properties of Active Aldehydes of Thiamin Coenzyme Models, and Mechanism of Formation of the Reactive Intermediates

    Article • Chemistry - A European Journal, October 1999, Wiley

    Dr Ikuo Nakanishi

  90. Synthesis and Electrochemical Studies of a Series of Fluorinated Dodecaphenylporphyrins

    Article • Inorganic Chemistry, May 1999, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  91. Decreased Electron Transfer Rates of Manganese Porphyrins with Conformational Distortion of the Macrocycle

    Article • Angewandte Chemie International Edition, April 1999, Wiley

    Dr Ikuo Nakanishi

  92. Electron-Transfer Properties of C60 and tert-Butyl-C60 Radical

    Article • Journal of the American Chemical Society, March 1999, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  93. Electron-Transfer Kinetics for Generation of Organoiron(IV) Porphyrins and the Iron(IV) Porphyrin π Radical Cations

    Article • Journal of the American Chemical Society, February 1999, American Chemical Society (ACS)

    Dr Ikuo Nakanishi

  94. Formation of Radical Anions in the Reaction of p-Benzoquinone and C60 with Alkoxide Ions

    Article • Journal of the American Chemical Society, June 1998, American Chemical Society (ACS)

    Shinobu Itoh, Dr Ikuo Nakanishi

  95. Direct Observation of Radical Intermediates While Investigating the Redox Behavior of Thiamin Coenzyme Models

    Article • Angewandte Chemie International Edition, April 1998, Wiley

    Dr Ikuo Nakanishi

  96. Direkte Beobachtung radikalischer Zwischenstufen bei Untersuchungen zum Redoxverhalten von Modellen des Coenzyms Thiamin

    Article • Angewandte Chemie, April 1998, Wiley

    Dr Ikuo Nakanishi

  97. Redox Behavior of Active Aldehydes Derived from Thiamin Coenzyme Analogs.

    Article • Chemistry Letters, January 1997, Chemical Society of Japan

    Shinobu Itoh, Dr Ikuo Nakanishi

  98. Electron transfer properties of active aldehydes derived from thiamin coenzyme analogues

    Article • Chemical Communications, January 1997, Royal Society of Chemistry

    Shinobu Itoh, Dr Ikuo Nakanishi