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  1. The Potential Diagnostic Utility of SMAD4 and ACCS in the Context of Inflammation in Type 2 Diabetes Mellitus Patients

    Article • Biomedicines, September 2024, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim, Agata Stanek

  2. A multivariate generalized linear model of the effect of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in end-stage renal disease

    Article • Current Issues in Pharmacy and Medical Sciences, June 2024, De Gruyter

    Prof.Dr. Hussein Kadhem Al-Hakeim

  3. In Parkinson’s disease, affective and chronic fatigue syndrome symptoms are associated with neuronal damage markers

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  4. Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to Long COVID

    Article • April 2024, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  5. Reactivation of herpesvirus type 6 and IgA/IgM-mediated responses to activin-A underpin long COVID, including affective symptoms and chronic fatigue syndrome

    Article • Acta Neuropsychiatrica, April 2024, Cambridge University Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  6. Correlation between Galanin and its receptor with the serum electrolytes in Long-COVID patients

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  7. In children with transfusion-dependent thalassemia, inflammation and neuronal damage biomarkers are associated with affective and chronic fatigue symptoms

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  8. PREDICTION OF INFLAMMATION IN HEMODIALYSIS PATIENTS USING NEURAL NETWORK ANALYSIS

    Article • Russian Journal of Infection and Immunity, October 2023, SPb RAACI

    Prof.Dr. Hussein Kadhem Al-Hakeim

  9. Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms.

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  10. Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia

    Article • Biomolecules, September 2023, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim, Agata Stanek

  11. Increased AGE–RAGE axis stress in methamphetamine abuse and methamphetamine‐induced psychosis: Associations with oxidative stress and increased atherogenicity

    Article • Addiction Biology, September 2023, Wiley

    Prof.Dr. Hussein Kadhem Al-Hakeim

  12. Reactivation of herpesvirus type-6 and IgA/IgM-mediated responses to activin-A underpin Long COVID, including affective symptoms and chronic fatigue syndrome

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  13. Mood Symptoms and Chronic Fatigue Syndrome due to Relapsing-Remitting Multiple Sclerosis Are Associated with Immune Activation and Aberrations in the Erythron

    Article • Brain Sciences, July 2023, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  14. Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID

    Article • Frontiers in Molecular Neuroscience, June 2023, Frontiers

    Prof.Dr. Hussein Kadhem Al-Hakeim

  15. In Transfusion-Dependent Thalassemia Children, Increased Iron Overload is Associated with Lower Serum Alpha-Klotho, Which is Strongly Associated with Lower Total and Ionized Calcium Concentrations

    Article • Current Molecular Medicine, June 2023, Bentham Science Publishers

    Prof.Dr. Hussein Kadhem Al-Hakeim, Dr. Shatha Rouf Moustafa

  16. The physio-affective phenome of major depression is strongly associated with biomarkers of astroglial and neuronal projection toxicity which in turn are associated with peripheral inflammation, insulin resistance and lowered calcium

    Article • Journal of Affective Disorders, June 2023, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  17. Neuronal damage and inflammatory biomarkers are associated with the affective and chronic fatigue-like symptoms due to end-stage renal disease.

    Article • May 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  18. Anxiety due to Long COVID is partially driven by activation of the tryptophan catabolite (TRYCAT) pathway

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  19. T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  20. Reverse cholesterol transport and lipid peroxidation biomarkers in major depression and bipolar disorder: a systematic review and meta-analysis

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  21. Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in Long COVID

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  22. A Causal-Pathway Phenotype of Chronic Fatigue Syndrome due to Hemodialysis in Patients with End-Stage Renal Disease

    Article • CNS & Neurological Disorders - Drug Targets, February 2023, Bentham Science Publishers

    Prof.Dr. Hussein Kadhem Al-Hakeim

  23. Increased AGE-RAGE axis stress in methamphetamine (MA) abuse and MA-induced psychosis: associations with oxidative stress and increased atherogenicity

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  24. In end-stage kidney disease, inflammation, erythron abnormalities and declined kidney function tests are accompanied by increased affective symptoms, chronic-fatigue, and fibromyalgia

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  25. Chronic Fatigue, Depression and Anxiety Symptoms in Long COVID Are Strongly Predicted by Neuroimmune and Neuro-Oxidative Pathways Which Are Caused by the Inflammation during Acute Infection

    Article • Journal of Clinical Medicine, January 2023, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  26. Increased insulin resistance is associated with depressive symptoms due to Long COVID

    Article • Brazilian Journal of Psychiatry, January 2023, FRACTAL EDITORA LTDA

    Prof.Dr. Hussein Kadhem Al-Hakeim

  27. Review on the neuron damage parameters in patients with end-stage renal disease

    Article • January 2023, SynthesisHub Advance Scientific Research

    Prof.Dr. Hussein Kadhem Al-Hakeim

  28. Mood symptoms and chronic fatigue syndrome due to relapsing remitting multiple sclerosis are associated with immune activation and aberrations in the erythron

    Article • December 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  29. Chronic fatigue and affective symptoms in acute and long COVID are attributable to immune‐inflammatory pathways

    Article • Psychiatry and Clinical Neurosciences, December 2022, Wiley

    Prof.Dr. Hussein Kadhem Al-Hakeim

  30. Increased insulin resistance due to Long COVID is associated with depressive symptoms and partly predicted by the inflammatory response during acute infection

    Article • December 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  31. Increased Lipid Peroxidation and Lowered Antioxidant Defenses Predict Methamphetamine Induced Psychosis

    Article • Cells, November 2022, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  32. In Schizophrenia, the Effects of the IL-6/IL-23/Th17 Axis on Health-Related Quality of Life and Disabilities Are Partly Mediated by Generalized Cognitive Decline and the Symptomatome

    Article • International Journal of Environmental Research and Public Health, November 2022, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  33. Increased lipid peroxidation and lowered antioxidant defenses predict methamphetamine induced psychosis

    Article • October 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  34. Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study

    Article • Molecular Psychiatry, October 2022, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  35. The interleukin-6/interleukin-23/T helper 17-axis as a driver of neuro-immune toxicity in the major neurocognitive psychosis or deficit schizophrenia: A precision nomothetic psychiatry analysis

    Article • PLoS ONE, October 2022, PLOS

    Prof.Dr. Hussein Kadhem Al-Hakeim

  36. The Tryptophan Catabolite or Kynurenine Pathway in a Major Depressive Episode with Melancholia, Psychotic Features and Suicidal Behaviors: A Systematic Review and Meta-Analysis

    Article • Cells, October 2022, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  37. High mobility group box 1 and Dickkopf-related protein 1 as biomarkers of glucose toxicity, atherogenicity, and lower β cell function in patients with type 2 diabetes mellitus

    Article • Growth Factors, September 2022, Taylor & Francis

    Prof.Dr. Hussein Kadhem Al-Hakeim

  38. Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach

    Article • Acta Neuropsychiatrica, September 2022, Cambridge University Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  39. Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways

    Article • International Journal of Environmental Research and Public Health, August 2022, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  40. The Tryptophan Catabolite or Kynurenine Pathway in Alzheimer’s Disease: A Systematic Review and Meta-Analysis

    Article • Journal of Alzheimer’s Disease, August 2022, IOS Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  41. The tryptophan catabolite or kynurenine pathway in a major depressive episode with melancholia, psychotic features and suicidal behaviors; a systematic review and meta-analysis

    Article • August 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  42. Lowered quality of life in Long COVID is strongly predicted by affective symptoms and chronic fatigue syndrome which are associated with inflammatory processes during the acute infectious phase and consequent neuroimmunotoxic pathways

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  43. The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis

    Article • BMC Infectious Diseases, July 2022, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  44. The physio-affective phenome of major depression is strongly associated with biomarkers of astroglial and neuronal projection toxicity which in turn are associated with peripheral inflammation, insulin resistance and lowered calcium

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  45. Chronic fatigue, depression and anxiety symptoms in Long COVID are strongly predicted by neuroimmune and neuro-oxidative pathways which are caused by the inflammation during acute infection

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  46. The tryptophan catabolite or kynurenine pathway in major depressive and bipolar disorder: a systematic review and meta-analysis

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  47. In schizophrenia, the effects of the IL-6/IL-23/Th17 axis on health-related quality of life and disabilities are partly mediated by generalized cognitive decline and the symptomatome

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  48. Long-COVID post-viral chronic fatigue syndrome and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study

    Article • April 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  49. The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments

    Article • Molecular Psychiatry, April 2022, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  50. Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to LONG COVID: a precision nomothetic approach

    Article • April 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  51. The tryptophan catabolite or kynurenine pathway in Alzheimer’s disease: a systematic review and meta-analysis

    Article • March 2022, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  52. Increased ACE2, sRAGE, and immune activation, but lowered calcium and magnesium in COVID-19.

    Article • Recent Advances in Inflammation & Allergy Drug Discovery, March 2022, Bentham Science Publishers

    Prof.Dr. Hussein Kadhem Al-Hakeim

  53. Pathway Phenotypes Underpinning Depression, Anxiety, and Chronic Fatigue Symptoms Due to Acute Rheumatoid Arthritis: A Precision Nomothetic Psychiatry Analysis

    Article • Journal of Personalized Medicine, March 2022, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  54. Inflammatory and bone biomarkers/composites as a predictive tool for clinical characteristics of rheumatoid arthritis patients

    Article • Acta Biologica Szegediensis, February 2022, University of Szeged

    Prof.Dr. Hussein Kadhem Al-Hakeim

  55. Inflammatory and bone biomarkers/composites as a predictive tool for clinical characteristics of rheumatoid arthritis patients

    Article • Acta Biologica Szegediensis, February 2022, University of Szeged

    Prof.Dr. Hussein Kadhem Al-Hakeim

  56. Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety, and chronic fatigue syndrome-like symptoms due to COVID-19: A nomothetic network approach

    Article • Journal of Affective Disorders, January 2022, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  57. Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach

    Article • Journal of Personalized Medicine, January 2022, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  58. The Tryptophan Catabolite or Kynurenine Pathway in Schizophrenia: Meta-Analysis Reveals Dissociations Between Central, Serum and Plasma Compartments

    Article • December 2021, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  59. The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum and plasma compartments

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  60. Serum Biomarkers of Bone and Immune Function for Diagnosis of Rheumatoid Arthritis

    Article • Egyptian Journal of Chemistry, November 2021, Egypts Presidential Specialized Council for Education and Scientific Research

    Prof.Dr. Hussein Kadhem Al-Hakeim

  61. Increased Serum Thromboxane A2 and Prostacyclin but Lower Complement C3 and C4 Levels in COVID-19: Associations with Chest CT Scan Anomalies and Lowered Peripheral Oxygen Saturation

    Article • COVID, October 2021, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  62. Wnt/β-catenin pathway proteins in end-stage renal disease

    Article • Biomarkers in Medicine, October 2021, Future Medicine

    Prof.Dr. Hussein Kadhem Al-Hakeim

  63. Depression, anxiety, and chronic fatigue symptoms in acute rheumatoid arthritis are associated with immune-inflammatory, autoimmune, endogenous opioid system and lactosylceramide signaling pathways: a nomothetic network approach

    Article • September 2021, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  64. Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

    Article • September 2021, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  65. Intersections between Pneumonia, Lowered Oxygen Saturation Percentage and Immune Activation Mediate Depression, Anxiety and Chronic Fatigue Syndrome-like Symptoms due to COVID-19: A Nomothetic Network Approach

    Article • June 2021, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  66. A pathway phenotype linking metabolic, immune, oxidative, and opioid pathways with comorbid depression, atherosclerosis, and unstable angina

    Article • CNS Spectrums, May 2021, Cambridge University Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  67. Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach

    Article • May 2021, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  68. Cytokine dependent hematopoietic cell linker (CLNK) is highly elevated in blood transfusion dependent beta-thalassemia major patients

    Article • Transfusion Clinique et Biologique, May 2021, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  69. In schizophrenia, immune-inflammatory pathways are strongly associated with depressive and anxiety symptoms, which are part of a latent trait which comprises neurocognitive impairments and schizophrenia symptoms.

    Article • Journal of Affective Disorders, May 2021, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  70. Increased zinc and albumin but lowered copper in children with transfusion-dependent thalassemia

    Article • Journal of Trace Elements in Medicine and Biology, May 2021, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  71. Increased serum thromboxane A2 and prostacyclin but lower complement C3 and C4 levels in COVID-19: associations with chest CT-scan anomalies and lowered peripheral oxygen saturation

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  72. Increased Serum Thromboxane A2 and Prostacyclin but Lower Complement C3 and C4 levels in COVID-19: Associations with Chest CT-scan Anomalies and Lowered Peripheral Oxygen Saturation

    Article • April 2021, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  73. Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments

    Article • Brazilian Journal of Psychiatry, April 2021, FapUNIFESP (SciELO)

    Prof.Dr. Hussein Kadhem Al-Hakeim

  74. Increased Angiotensin-Converting Enzyme 2, sRAGE and iMmune Activation, but Lowered Calcium and Magnesium In COVID-19: Association With Chest CT Abnormalities and Lowered Peripheral Oxygen Saturation

    Article • March 2021, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  75. Increased angiotensin-converting enzyme 2, sRAGE and immune activation, but lowered calcium and magnesium in COVID-19: association with chest CT abnormalities and lowered peripheral oxygen saturation

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  76. Subgrouping of Type 2 Diabetes Mellitus Based on Proteinuria and Diabetic Control for Treatment and Follow-Up

    Article • Egyptian Journal of Chemistry, March 2021, Egypts Presidential Specialized Council for Education and Scientific Research

    Prof.Dr. Hussein Kadhem Al-Hakeim

  77. In End-Stage Renal Disease, the Effects of Hemodialysis on Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Mediated via Inflammatory Biomarkers, Copper and Wnt/Catenin Pathway Proteins

    Article • March 2021, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  78. Anticancer And Antiangiogenic Activities Of Alkaloids Isolated From Lantana Camara By Adsorption On The Magnetic Nanoparticles

    Article • Karbala International Journal of Modern Science, March 2021, rbala International Journal of Modern Science - KIJOMS

    Prof.Dr. Hussein Kadhem Al-Hakeim

  79. Construction of an exposure-pathway-phenotype in children with depression due to transfusion-dependent thalassemia: Results of (un)supervised machine learning.

    Article • Journal of Affective Disorders, March 2021, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  80. Osmotic fragility in essential hypertension revisited: A correlation with Iron status and lipid profile

    Article • Journal of Physics Conference Series, March 2021, Institute of Physics Publishing

    Prof.Dr. Hussein Kadhem Al-Hakeim

  81. Trace element, immune and opioid biomarkers of unstable angina, increased atherogenicity and insulin resistance: Results of machine learning

    Article • Journal of Trace Elements in Medicine and Biology, March 2021, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  82. In schizophrenia, non-remitters and partial remitters to treatment with antipsychotics are qualitatively distinct classes with respect to neurocognitive deficits and neuro-immune biomarkers: results of soft independent modeling of class analogy

    Article • Metabolic Brain Disease, February 2021, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  83. Wnt/β-Catenin Pathway Proteins in End-Stage Renal Disease

    Article • February 2021, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  84. In Schizophrenia, Depression and Anxiety Symptoms Are Driven by Immune-Inflammatory Pathways.

    Article • December 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  85. Investigation of Anticancer Drug Activity 5-Fluorouracil and Some Analog Derivatives by QSAR: Theoretical Study

    Article • Journal of Physics Conference Series, November 2020, Institute of Physics Publishing

    Prof.Dr. Hussein Kadhem Al-Hakeim

  86. Hereditary haematologic disorders in Najaf province-Iraq

    Article • Transfusion Clinique et Biologique, October 2020, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  87. High Mobility Group Protein 1 and Dickkopf-Related Protein 1 in Schizophrenia and Treatment-Resistant Schizophrenia: Associations With Interleukin-6, Symptom Domains, and Neurocognitive Impairments

    Article • Schizophrenia Bulletin, September 2020, Oxford University Press (OUP)

    Prof.Dr. Hussein Kadhem Al-Hakeim

  88. Chronic fatigue syndrome and fibromyalgia-like symptoms are an integral component of the phenome of schizophrenia: neuro-immune and opioid system correlates

    Article • Metabolic Brain Disease, September 2020, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  89. A Nomothetic Network Model Disclosing the Comorbidity of Depression and Unstable Angina: Effects of Atherogenicity, Insulin Resistance, Immune Activation, Antioxidants, the Endogenous Opioid System, Trace Elements, and Macrominerals

    Article • September 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  90. The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors Are Associated with Interleukin-6

    Article • Diagnostics, August 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  91. Chronic fatigue and fibromyalgia symptoms are key components of deficit schizophrenia and are strongly associated with activated immune-inflammatory pathways

    Article • Schizophrenia Research, August 2020, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  92. Serum cytokine dependent hematopoietic cell linker (CLNK) as a predictor for the duration of illness in type 2 diabetes mellitus

    Article • Journal of Diabetes & Metabolic Disorders, July 2020, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  93. In Transfusion-dependent Thalassemia, Increased Iron Overload is Associated with Lower Serum Alpha-klotho, Which is Strongly Associated with Lower Total and Ionized Calcium Concentrations

    Article • July 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  94. Trace Element, Immune and Opioid Biomarkers of Unstable Angina, Increased Atherogenicity and Insulin Resistance: Results of Machine Learning

    Article • July 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  95. Evaluation of Erythroferrone, Hepcidin, and Iron Overload Status in Iraqi Transfusion-Dependent β-Thalassemia Major Patients

    Article • Hemoglobin, July 2020, Taylor & Francis

    Prof.Dr. Hussein Kadhem Al-Hakeim

  96. Construction of an Exposure-Pathway-Phenotype in Children with Depression due to Transfusion-Dependent Thalassemia: Results of (Un)supervised Machine Learning

    Article • June 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  97. Serum apelin and galectin-3 in preeclampsia in Iraq

    Article • Hypertension in Pregnancy, June 2020, Taylor & Francis

    Prof.Dr. Hussein Kadhem Al-Hakeim

  98. Carbon Nanotubes Inhibit the Pepsin Activity at High Ionic Strength

    Article • Current Enzyme Inhibition, June 2020, Bentham Science Publishers

    Prof.Dr. Hussein Kadhem Al-Hakeim

  99. High Mobility Group Box 1 and Dickkopf-Related Protein 1 as New Biomarkers of Type 2 Diabetes Mellitus: Associations with Increased Glucose Toxicity and Atherogenicity and Lower β Cell Function

    Article • June 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  100. Increased Zinc and Albumin but Lowered Copper in Children with Transfusion-dependent Thalassemia

    Article • June 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  101. Schizophrenia phenomenology revisited: positive and negative symptoms are strongly related reflective manifestations of an underlying single trait indicating overall severity of schizophrenia

    Article • CNS Spectrums, May 2020, Cambridge University Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  102. Construction of a Neuro-Immune-Cognitive Pathway-Phenotype Underpinning the Phenome of Deficit Schizophrenia

    Article • Current Topics in Medicinal Chemistry, May 2020, Bentham Science Publishers

    Prof.Dr. Hussein Kadhem Al-Hakeim

  103. Plasma Indoleamine-2,3-Dioxygenase (IDO) is Increased in Drug-Naï ve Major Depressed Patients and Treatment with Sertraline and Ketoprofen Normalizes IDO in Association with Pro-Inflammatory and Immune- Regulatory Cytokines

    Article • CNS & Neurological Disorders - Drug Targets, April 2020, Bentham Science Publishers

    Prof.Dr. Hussein Kadhem Al-Hakeim, Ahmed Twayej

  104. Serum Cytokine Dependent Hematopoietic Cell Linker (CLNK) as a Predictor for the Duration of Illness in Type 2 Diabetes Mellitus

    Article • April 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  105. Major Depression in Children with Transfusion-Dependent Thalassemia Is Strongly Associated with the Combined Effects of Blood Transfusion Rate, Iron Overload, and Increased Pro-inflammatory Cytokines

    Article • Neurotoxicity Research, April 2020, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  106. Hereditary Hematologic Disorders in Najaf Province-Iraq

    Article • April 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  107. Pathway-Phenotypes of Non-responders and Partial Responders to Treatment With Antipsychotics in Schizophrenia: A Machine Learning Study

    Article • April 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  108. Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

    Article • March 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  109. Lowered Serum Cesium Levels in Schizophrenia: Association with Immune-Inflammatory Biomarkers and Cognitive Impairments

    Article • February 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  110. In major depression, increased kappa and mu opioid receptor levels are associated with immune activation

    Article • Acta Neuropsychiatrica, January 2020, Cambridge University Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  111. The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors are Associated with Interleukin-6

    Article • January 2020, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  112. The Neuroimmune and Neurotoxic Fingerprint of Major Neurocognitive Psychosis or Deficit Schizophrenia: a Supervised Machine Learning Study

    Article • Neurotoxicity Research, January 2020, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  113. Activity and stability of urease enzyme immobilized on Amberlite resin

    Article • Ovidius University Annals of Chemistry, January 2020, De Gruyter

    Mustafa Rabeea, Prof.Dr. Hussein Kadhem Al-Hakeim

  114. Serum chemerin and visfatin levels and their ratio as possible diagnostic parameters of rheumatoid arthritis

    Article • Reumatologia/Rheumatology, January 2020, Termedia Sp. z.o.o.

    Prof.Dr. Hussein Kadhem Al-Hakeim

  115. Evaluation of Erythroferrone, Hepcidin, and Iron Overload Status in Iraqi Transfusion-dependent β-Thalassemia Major Patients

    Article • December 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  116. High Mobility Group Protein 1 and Dickkopf-Related Protein 1 in Schizophrenia and Treatment-Resistant Schizophrenia: Associations with Interleukin-6, Symptom Domains, and Neurocognitive Impairments

    Article • December 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  117. Serum agrin and talin are increased in major depression while agrin and creatine phosphokinase are associated with chronic fatigue and fibromyalgia symptoms in depression

    Article • Metabolic Brain Disease, November 2019, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  118. Activity and Stability of Urease Enzyme Immobilized on Amberlite Resin

    Article • October 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  119. Estimation of Serum Chemerin, Visfatin Levels and Their Ratio as A Possible Diagnostic Parameters of Rheumatoid Arthritis

    Article • October 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  120. Serum Apelin and Galactin-3 in Preeclampsia in Iraq

    Article • October 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  121. Construction of a Neuro-Immune-Cognitive Pathway-Phenotype Underpinning the Phenome of Deficit Schizophrenia

    Article • October 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  122. Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia

    Article • September 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  123. Osmotic Fragility in Essential Hypertension Revisited: A Correlation with Iron Status and Lipid Profile

    Article • September 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  124. Major Depression in Children with β-Thalassemia Major is Strongly Associated with the Number of Blood Transfusions, Iron Overload and Increased Levels of Interleukin-1β

    Article • September 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  125. Chronic Fatigue and Fibromyalgia Symptoms are Key Components of Deficit Schizophrenia and are Strongly Associated with Activated Immune-Inflammatory Pathways

    Article • July 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  126. Schizophrenia Phenomenology Revisited: Positive and Negative Symptoms are Strongly Related Reflective Manifestations of an Underlying Single Trait Indicating Overall Severity of Schizophrenia

    Article • July 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  127. Total and ionized calcium and magnesium are significantly lowered in drug-naïve depressed patients: effects of antidepressants and associations with immune activation

    Article • Metabolic Brain Disease, July 2019, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  128. Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

    Article • June 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  129. Lowered zinc and copper levels in drug-naïve patients with major depression: Effects of antidepressants, ketoprofen and immune activation

    Article • The World Journal of Biological Psychiatry, May 2019, Taylor & Francis

    Prof.Dr. Hussein Kadhem Al-Hakeim, Ahmed Twayej

  130. The Neuro-Immune Fingerprint of Major Neuro-Cognitive Psychosis or Deficit Schizophrenia: A Supervised Machine Learning Study

    Article • May 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  131. Development of a Novel Neuro-immune and Opioid-Associated Fingerprint with a Cross-Validated Ability to Identify and Authenticate Unknown Patients with Major Depression: Far Beyond Differentiation, Discrimination, and Classification

    Article • Molecular Neurobiology, May 2019, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  132. In Major Depression, Increased Serum Dynorphin and Kappa Opioid Receptor Levels are Positively Associated with Mu Opioid Receptor Levels and Immune Activation and Are Attenuated by Nicotine Dependence

    Article • April 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  133. Cytokine Dependent Hematopoietic Cell Linker (CLNK) is Highly Elevated in Blood Transfusion Dependent Beta-Thalassemia Major Patients

    Article • April 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  134. Total and Ionized Calcium and Magnesium Are Significantly Lowered in Drug-Naïve Depressed Patients: Effects of Antidepressants and Associations with Immune Activation

    Article • February 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  135. IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

    Article • European Psychiatry, January 2019, Cambridge University Press

    Prof.Dr. Hussein Kadhem Al-Hakeim

  136. Lowered Zinc and Copper Levels in Drug-Naïve patients with Major Depression: Effects of Antidepressants, Ketoprofen and Immune Activation

    Article • January 2019, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  137. Cytokine Dependent Hematopoietic Cell Linker (CLNK) Is Highly Elevated in Blood Transfusion Dependent Beta-Thalassemia Major Patients

    Article • SSRN Electronic Journal, January 2019, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  138. Ketoprofen as an Add-on Treatment to Sertraline for Drug-Naïve Major Depressed Patients: Normalization of Plasma Levels of Indoleamine-2,3-Dioxygenase in Association with Pro-Inflammatory and Immune Regulatory Cytokines

    Article • December 2018, MDPI AG

    Prof.Dr. Hussein Kadhem Al-Hakeim

  139. Reduction in serum IL-1β, IL-6, and IL-18 levels and Beck Depression Inventory-II score by combined sertraline and ketoprofen administration in major depressive disorder: A clinical trial

    Article • Neurology Psychiatry and Brain Research, December 2018, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  140. Serum Cesium, Rhenium, and Rubidium in Rheumatoid Arthritis Patients

    Article • Biological Trace Element Research, August 2018, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  141. Stability of Anticancer Drug 5-Fluorouracil in Aqueous Solution: An Assessment of Kinetic Behavior

    Article • Nano Biomedicine and Engineering, August 2018, OAhost

    Prof.Dr. Hussein Kadhem Al-Hakeim

  142. Serum Interleukin Levels And Insulin Resistance In Major Depressive Disorder

    Article • CNS & Neurological Disorders - Drug Targets, July 2018, Bentham Science Publishers

    Prof.Dr. Hussein Kadhem Al-Hakeim

  143. Effect of serum fibroblast growth factor receptor 2 and CAPS proteins on calcium status in β-thalassaemia major patients who are free from overt inflammation

    Article • Growth Factors, July 2018, Taylor & Francis

    Prof.Dr. Hussein Kadhem Al-Hakeim

  144. Anticancer Drug 5-Fluorouracil in Aqueous Solution by Differential Pulse Polarography: An Assessment of Optimum Conditions

    Article • Nano Biomedicine and Engineering, April 2018, OAhost

    Prof.Dr. Hussein Kadhem Al-Hakeim

  145. Anti-pepsin activity of silicon dioxide nanoparticles

    Article • Revista Colombiana de Química, September 2016, Universidad Nacional de Colombia

    Prof.Dr. Hussein Kadhem Al-Hakeim

  146. High Ionic Strength Enhances the Anti-Pepsin Activity of Titanium Dioxide Nanoparticles

    Article • Nano Biomedicine and Engineering, August 2016, OAhost

    Prof.Dr. Hussein Kadhem Al-Hakeim

  147. Immobilization of urease enzyme on nanoceria modifies secondary and tertiary protein structures

    Article • Acta Chimica Slovaca, January 2016, De Gruyter

    Prof.Dr. Hussein Kadhem Al-Hakeim

  148. procalcitonin

    Article • Acta Facultatis Medicae Naissensis, January 2016, De Gruyter

    Prof.Dr. Hussein Kadhem Al-Hakeim

  149. Adsorption of LH, FSH, and TSH on Magnetic Nanoparticles

    Article • Journal of Bionanoscience, December 2015, American Scientific Publishers

    Prof.Dr. Hussein Kadhem Al-Hakeim

  150. IL-6, IL-18, sIL-2R, and TNFα proinflammatory markers in depression and schizophrenia patients who are free of overt inflammation

    Article • Journal of Affective Disorders, August 2015, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim

  151. Procalcitonin, Calcium, and Magnesium in Patients with Febrile Seizure during One-Hour Attack

    Article • British Journal of Medicine and Medical Research, January 2015, Sciencedomain International

    Prof.Dr. Hussein Kadhem Al-Hakeim

  152. Proteinuria as the Most Relevant Parameter Affecting Fetuin-A Levels in Preeclampsia

    Article • Acta Facultatis Medicae Naissensis, January 2015, De Gruyter

    Prof.Dr. Hussein Kadhem Al-Hakeim

  153. Correlation Between Glycated Hemoglobin and Homa Indices in Type 2 Diabetes Mellitus: Prediction of Beta-Cell Function from Glycated Hemoglobin / Korelacija Između Glikoliziranog Hemoglobina I Homa Indeksa U Dijabetes Melitusu Tipa 2: Predviđanje Funkc...

    Article • January 2015, De Gruyter Open Sp. z o.o.

    Prof.Dr. Hussein Kadhem Al-Hakeim

  154. Green biosynthesis of silver nanoparticles using Callicarpa maingayi stem bark extraction

    Article • Nova Biotechnologica et Chimica, January 2015, De Gruyter

    Prof.Dr. Hussein Kadhem Al-Hakeim, Dr, Emad Al-Mulla

  155. Correlation of Hepcidin Level with Insulin Resistance and Endocrine Glands Function in Major Thalassemia

    Article • Advances in Clinical and Experimental Medicine, January 2015, Wroclaw Medical University

    Prof.Dr. Hussein Kadhem Al-Hakeim

  156. Lack of correlation between non-labile iron parameters, total carbonyl and malondialdehyde in major thalassemia

    Article • Journal of Clinical Biochemistry and Nutrition, January 2014, The Society for Free Radical Research Japan

    Prof.Dr. Hussein Kadhem Al-Hakeim

  157. Evaluation of the Biological Activity of a New Hydrocortisone Derivative against Some Pathogenic Skin Fungi

    Article • Clinical Medicine Insights Dermatology, May 2012, CrossRef Test Account

    Prof.Dr. Hussein Kadhem Al-Hakeim

  158. Correlation Between Iron Status Parameters and Hormone Levels in Women with Polycystic Ovary Syndrome

    Article • Clinical Medicine Insights Women s Health, March 2012, SAGE Publications

    Prof.Dr. Hussein Kadhem Al-Hakeim

  159. Study of the effect of iron overload on the function of endocrine glands in male thalassemia patients

    Article • Asian Journal of Transfusion Science, January 2011, Medknow

    Prof.Dr. Hussein Kadhem Al-Hakeim

  160. Serum levels of lipids, calcium and magnesium in women with hypothyroidism and cardiovascular diseases

    Article • Journal of Laboratory Physicians, January 2009, Medknow

    Prof.Dr. Hussein Kadhem Al-Hakeim

  161. Serum cortisol, immunoglobulins and some complements among depressed patients

    Article • Indian Journal of Clinical Biochemistry, January 2008, Springer Science + Business Media

    Prof.Dr. Hussein Kadhem Al-Hakeim

  162. Stability of reconstituted urokinase solutions

    Article • Current Therapeutic Research, January 2000, Elsevier

    Prof.Dr. Hussein Kadhem Al-Hakeim