All Stories

  1. MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells

    Article • Cell Reports, October 2019, Elsevier

    HISAAKI Shinohara

  2. Oscillation dynamics underlie functional switching of NF-κB for B-cell activation

    Article • npj Systems Biology and Applications, October 2016, Springer Science + Business Media

    HISAAKI Shinohara

  3. TAK1maintains the survival of immunoglobulin λ-chain-positive B cells

    Article • Genes to Cells, October 2016, Wiley

    HISAAKI Shinohara

  4. TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation

    Article • FEBS Letters, August 2016, Wiley

    HISAAKI Shinohara

  5. Stimulus-Dependent Inhibitor of Apoptosis Protein Expression Prolongs the Duration of B Cell Signalling

    Article • Scientific Reports, June 2016, Springer Science + Business Media

    HISAAKI Shinohara

  6. LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation

    Article • Scientific Reports, May 2016, Nature

    HISAAKI Shinohara

  7. Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation

    Article • Immunology and Cell Biology, April 2016, Nature

    HISAAKI Shinohara

  8. AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation

    Article • Cell Communication and Signaling, July 2014, Springer Science + Business Media

    HISAAKI Shinohara

  9. Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF- B Activation

    Article • Science, May 2014, American Association for the Advancement of Science

    HISAAKI Shinohara

  10. PDK1 controls upstream PI3K expression and PIP3 generation

    Article • Oncogene, July 2013, Nature

    HISAAKI Shinohara

  11. Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

    Article • The EMBO Journal, December 2010, Wiley

    HISAAKI Shinohara

  12. B Cell Signaling and Fate Decision

    Article • Annual Review of Immunology, March 2010, Annual Reviews

    HISAAKI Shinohara

  13. MAGUK-Controlled Ubiquitination of CARMA1 Modulates Lymphocyte NF-κB Activity

    Article • Molecular and Cellular Biology, December 2009, ASM Journals

    HISAAKI Shinohara

  14. Comprehending the complex connection between PKCβ, TAK1, and IKK in BCR signaling

    Article • Immunological Reviews, November 2009, Wiley

    HISAAKI Shinohara

  15. Regulation of NF-κB-dependent T cell activation and development by MEKK3

    Article • International Immunology, February 2009, Oxford University Press (OUP)

    HISAAKI Shinohara

  16. Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

    Article • The Journal of Experimental Medicine, March 2008, Rockefeller University Press

    HISAAKI Shinohara

  17. IκB kinase β–induced phosphorylation of CARMA1 contributes to CARMA1–Bcl10–MALT1 complex formation in B cells

    Article • The Journal of Experimental Medicine, December 2007, Rockefeller University Press

    HISAAKI Shinohara

  18. PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

    Article • The Journal of Experimental Medicine, November 2005, Rockefeller University Press

    HISAAKI Shinohara

  19. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling

    Article • The Journal of Experimental Medicine, February 2005, Rockefeller University Press

    HISAAKI Shinohara

  20. Role of Dok-1 and Dok-2 in Myeloid Homeostasis and Suppression of Leukemia

    Article • The Journal of Experimental Medicine, December 2004, Rockefeller University Press

    HISAAKI Shinohara

  21. Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding

    Article • Genes to Cells, June 2004, Wiley

    HISAAKI Shinohara

  22. Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase

    Article • FEBS Letters, February 2003, Wiley

    HISAAKI Shinohara

  23. A Protective Role of PKCϵ against TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis in Glioma Cells

    Article • Biochemical and Biophysical Research Communications, June 2001, Elsevier

    HISAAKI Shinohara

  24. Regulatory Domain of Protein Stability of Human P51/TAP63, a P53 Homologue

    Article • Biochemical and Biophysical Research Communications, May 2001, Elsevier

    HISAAKI Shinohara

  25. The observation of time-course cytopathologic changes in human embryo lung fibroblast cells infected with human cytomegalovirus.

    Article • The Journal of the Japanese Society of Clinical Cytology, January 1996, The Japanese Society of Clinical Cytology

    HISAAKI Shinohara

  26. Genetic analysis of B cell signaling

    Article • Springer Science + Business Media

    HISAAKI Shinohara