All Stories

  1. Preventive Effects of β-Cryptoxanthin, a Potent Antioxidant and Provitamin A Carotenoid, on Lifestyle-Related Diseases—A Central Focus on Its Effects on Non-Alcoholic Fatty Liver Disease (NAFLD)

    Article • Antioxidants, December 2021, MDPI AG

    Professor Hiroyuki Yasui

  2. Exercise Performance Upregulatory Effect of R-α-Lipoic Acid with γ-Cyclodextrin

    Article • Nutrients, December 2021, MDPI AG

    Professor Hiroyuki Yasui

  3. Multi-Omics Analysis to Generate Hypotheses for Mild Health Problems in Monkeys

    Article • Metabolites, October 2021, MDPI AG

    Professor Hiroyuki Yasui

  4. Strong Binding Affinity of d-Allulose and Allulosides to Boronic Acids and the Structural Characterization of Their Sugar-boronate Complexes

    Article • Chemistry Letters, August 2021, The Chemical Society of Japan

    Professor Hiroyuki Yasui

  5. A Putative Single-Photon Emission CT Imaging Tracer for Erythropoietin-Producing Hepatocellular A2 Receptor

    Article • ACS Medicinal Chemistry Letters, July 2021, American Chemical Society (ACS)

    Professor Hiroyuki Yasui

  6. Copper‐mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide

    Article • Journal of Labelled Compounds and Radiopharmaceuticals, May 2021, Wiley

    Professor Hiroyuki Yasui

  7. Analysis of the predictive factors for a critical illness of COVID-19 during treatment － relationship between serum zinc level and critical illness of COVID-19 −

    Article • International Journal of Infectious Diseases, November 2020, Elsevier

    Professor Hiroyuki Yasui

  8. Synthesis of 18F-labeled streptozotocin derivatives and an in-vivo kinetics study using positron emission tomography

    Article • Bioorganic & Medicinal Chemistry Letters, September 2020, Elsevier

    Professor Hiroyuki Yasui

  9. Chelation of zinc(II) with poly(γ-glutamic acid) in aqueous solution: kinetics, binding constant, and its antimicrobial activity

    Article • Polymer Bulletin, March 2020, Springer Science + Business Media

    Professor Hiroyuki Yasui

  10. Effects of exercise on biological trace element concentrations and selenoprotein P expression in rats with fructose-induced glucose intolerance

    Article • Journal of Clinical Biochemistry and Nutrition, March 2020, The Society for Free Radical Research Japan

    Professor Hiroyuki Yasui

  11. Bright and dark sides of exercise effects on biological responses such as energy metabolism and renal function in rats with renal failure and fructose-induced glucose intolerance

    Article • Journal of Clinical Biochemistry and Nutrition, January 2020, The Society for Free Radical Research Japan

    Professor Hiroyuki Yasui

  12. Crystal Structure of Zinc(II) Complexes with 2-Ethyl-3-hydroxy-4H-pyran-4-thione and 2-Ethyl-3-hydroxy-4H-pyran-4-selenone

    Article • Crystallography Reports, December 2019, Pleiades Publishing Ltd

    Professor Hiroyuki Yasui

  13. Pharmacokinetics of Oxaliplatin in a Hemodialysis Patient with Metastatic Colon Cancer

    Article • International Journal of Oncology Research, September 2019, ClinMed International Library

    Professor Hiroyuki Yasui

  14. Potential antidiabetic zinc(II) complexes of novel 5-oxo-2-thioxopyrrolidine derivatives synthesized via an unprecedented reaction

    Article • Tetrahedron Letters, June 2019, Elsevier

    Professor Hiroyuki Yasui

  15. Copper accumulation in the brain causes the elevation of oxidative stress and less anxious behavior in Ts1Cje mice, a model of Down syndrome

    Article • Free Radical Biology and Medicine, April 2019, Elsevier

    Professor Hiroyuki Yasui

  16. In Vivo Effect of Bis(Maltolato)Zinc(II) Complex on Akt Phosphorylation in Adipose Tissues of Mice

    Article • Biological Trace Element Research, January 2019, Springer Science + Business Media

    Professor Hiroyuki Yasui

  17. Predicting organ carotenoids levels from analysis of plasma could lead to errors: A study in cynomolgus monkeys

    Article • Nutrition Research, January 2019, Elsevier

    Professor Hiroyuki Yasui

  18. Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice

    Article • Free Radical Research, October 2018, Taylor & Francis

    Professor Hiroyuki Yasui

  19. Investigating the target organs of novel anti-diabetic zinc complexes with organo‑selenium ligands

    Article • Journal of Inorganic Biochemistry, August 2018, Elsevier

    Professor Hiroyuki Yasui

  20. Efforts to Promote Research Integrity in Academia

    Article • YAKUGAKU ZASSHI, April 2018, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  21. Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide

    Article • Future Medicinal Chemistry, February 2018, Future Science

    Professor Hiroyuki Yasui

  22. Vanadium and zinc anti-diabetics

    Article • New Journal of Chemistry, January 2018, Royal Society of Chemistry

    Professor Franc Perdih, Professor Hiroyuki Yasui

  23. Anti-Diabetic Effect of Organo-Chalcogen (Sulfur and Selenium) Zinc Complexes with Hydroxy-Pyrone Derivatives on Leptin-Deficient Type 2 Diabetes Model ob/ob Mice

    Article • International Journal of Molecular Sciences, December 2017, MDPI AG

    Professor Hiroyuki Yasui

  24. Beneficial Effect of Bis(Hinokitiolato)Zn Complex on High-fat Diet-induced Lipid Accumulation in Mouse Liver and Kidney

    Article • In Vivo, November 2017, International Institute of Anticancer Research

    Professor Hiroyuki Yasui

  25. Expression of human cathelicidin peptide LL-37 in inflammatory bowel disease

    Article • Clinical & Experimental Immunology, September 2017, Wiley

    Professor Hiroyuki Yasui

  26. Vanadium and zinc anti-diabetics

    Article • New Journal of Chemistry, January 2017, Royal Society of Chemistry

    Professor Franc Perdih, Professor Hiroyuki Yasui

  27. Frontier of Development for Metallodrugs on the Basis of Metallomic Pharmacology and Medicinal Inorganic Chemistry

    Article • January 2017, Springer Science + Business Media

    Professor Hiroyuki Yasui

  28. Anti-hyperglycemic Effect of Long-Term Bis(hinokitiolato)zinc Complex ([Zn(hkt)<sub>2</sub>]) Ingestion on Insulin Resistance and Pancreatic Islet Cells Protection in Type 2 Diabetic KK-A<sup>y</sup> Mice

    Article • Biological and Pharmaceutical Bulletin, January 2017, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  29. Development of New Ligands for the Recyclable Catalytic Asymmetric Transfer Hydrogenation in Ionic Liquid

    Article • Heterocycles, January 2017, Japan Institute of Heterocyclic Chemistry

    Professor Hiroyuki Yasui

  30. Investigation of Biodistribution and Speciation Changes of Orally Administered Dual Radiolabeled Complex, Bis(5-chloro-7-[<sup>131</sup>I]iodo-8-quinolinolato)[<sup>65</sup>Zn]zinc

    Article • Biological and Pharmaceutical Bulletin, January 2017, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  31. Reaction and Scavenging Mechanism of β-Carotene and Zeaxanthin with Reactive Oxygen Species

    Article • Journal of Oleo Science, January 2017, Japan Oil Chemists' Society

    Professor Hiroyuki Yasui

  32. Synthesis and biological evaluation of 4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamides and their zinc(ii) complexes as candidate antidiabetic agents

    Article • New Journal of Chemistry, January 2017, Royal Society of Chemistry

    Professor Hiroyuki Yasui

  33. Changes in blood concentrations of trace metals in cancer patients receiving cisplatin-based chemotherapy

    Article • Biomedical Reports, October 2016, Spandidos Publications

    Professor Hiroyuki Yasui

  34. Transport of Azithromycin into Extravascular Space in Rats

    Article • Antimicrobial Agents and Chemotherapy, September 2016, ASM Journals

    Professor Hiroyuki Yasui

  35. Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis

    Article • Biochemical and Biophysical Research Communications, August 2016, Elsevier

    Professor Hiroyuki Yasui

  36. Reaction of Paprika Carotenoids, Capsanthin and Capsorubin, with Reactive Oxygen Species

    Article • Journal of Agricultural and Food Chemistry, June 2016, American Chemical Society (ACS)

    Professor Hiroyuki Yasui

  37. Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) activates Akt/protein kinase B independent of insulin signal transduction

    Article • JBIC Journal of Biological Inorganic Chemistry, June 2016, Springer Science + Business Media

    Professor Hiroyuki Yasui

  38. Anti-Oxidative Activity of Mytiloxanthin, a Metabolite of Fucoxanthin in Shellfish and Tunicates

    Article • Marine Drugs, May 2016, MDPI AG

    Professor Hiroyuki Yasui

  39. Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway

    Article • Cardiovascular Diabetology, May 2016, Springer Science + Business Media

    Professor Hiroyuki Yasui

  40. Analysis of reaction products of astaxanthin and its acetate with reactive oxygen species using LC/PDA ESI-MS and ESR spectrometry

    Article • Tetrahedron Letters, May 2016, Elsevier

    Professor Hiroyuki Yasui

  41. Visualization of biodistribution of Zn complex with antidiabetic activity using semiconductor Compton camera GREI

    Article • Biochemistry and Biophysics Reports, March 2016, Elsevier

    Professor Hiroyuki Yasui

  42. <i>α</i>-Glucosidase Inhibition by New Schiff Base Complexes of Zn(II)

    Article • Open Journal of Inorganic Chemistry, January 2016, Scientific Research Publishing, Inc,

    Professor Hiroyuki Yasui

  43. Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes

    Article • The Journal of Physiological Sciences, October 2015, Springer Science + Business Media

    Professor Hiroyuki Yasui

  44. Isomeric effects of anti-diabetic α-lipoic acid with γ-cyclodextrin

    Article • Life Sciences, September 2015, Elsevier

    Professor Hiroyuki Yasui

  45. Superiority of zinc complex of acetylsalicylic acid to acetylsalicylic acid in preventing postischemic myocardial dysfunction

    Article • Experimental Biology and Medicine, February 2015, SAGE Publications

    Professor Hiroyuki Yasui

  46. Accumulation of Paprika Carotenoids in Human Plasma and Erythrocytes

    Article • Journal of Oleo Science, January 2015, Japan Oil Chemists' Society

    Professor Hiroyuki Yasui

  47. A Cisplatin Derivative that Inhibits Collagen Fibril-Formationin vitro

    Article • Chemical Biology & Drug Design, November 2014, Wiley

    Professor Hiroyuki Yasui

  48. New Insulin-Mimetic and Hypoglycemic Hetero-Binuclear Zinc(II)/ Oxovanadium(IV) Complex

    Article • Current Inorganic Chemistry, September 2014, Bentham Science Publishers

    Professor Hiroyuki Yasui

  49. Bis (Aspirinato) Zinc (II) Complex Successfully Inhibits Carotid Arterial Neointima Formation after Balloon-injury in Rats

    Article • Cardiovascular Drugs and Therapy, August 2014, Springer Science + Business Media

    Professor Hiroyuki Yasui

  50. Development of PEGylated serum albumin with multiple reduced thiols as a long-circulating scavenger of reactive oxygen species for the treatment of fulminant hepatic failure in mice

    Article • Free Radical Biology and Medicine, April 2014, Elsevier

    Professor Hiroyuki Yasui

  51. Zn complex medication provides the morphological and biochemical improvements in type 2 diabetes.

    Article • Metallomics, January 2014, Oxford University Press (OUP)

    Professor Hiroyuki Yasui

  52. Antidiabetic effect of the α-lipoic acid γ-cyclodextrin complex

    Article • Journal of Clinical Biochemistry and Nutrition, January 2014, The Society for Free Radical Research Japan

    Professor Hiroyuki Yasui

  53. Intestinal and Hepatic Expression of Cytochrome P450s and mdr1a in Rats with Indomethacin-Induced Small Intestinal Ulcers

    Article • International Journal of Medical Sciences, January 2014, Ivyspring International Publisher

    Professor Hiroyuki Yasui

  54. Potential of collagen-like triple helical peptides as drug carriers: Their in vivo distribution, metabolism, and excretion profiles in rodents

    Article • Biopolymers, November 2013, Wiley

    Professor Hiroyuki Yasui

  55. Deferasirox Induces Mesenchymal–Epithelial Transition in Crocidolite-Induced Mesothelial Carcinogenesis in Rats

    Article • Cancer Prevention Research, September 2013, American Association for Cancer Research (AACR)

    Professor Hiroyuki Yasui

  56. Development of a novel antidiabetic zinc complex with an organoselenium ligand at the lowest dosage in KK-Ay mice

    Article • Journal of Inorganic Biochemistry, April 2013, Elsevier

    Professor Hiroyuki Yasui

  57. Mechanism of Retinoid X Receptor Partial Agonistic Action of 1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic Acid and Structural Development To Increase Potency

    Article • Journal of Medicinal Chemistry, February 2013, American Chemical Society (ACS)

    Professor Hiroyuki Yasui

  58. Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin

    Article • Journal of Oleo Science, January 2013, Japan Oil Chemists' Society

    Professor Hiroyuki Yasui

  59. Effect of a Peroxynitrite Scavenger, a Manganese-Porphyrin Compound on Airway Remodeling in a Murine Asthma

    Article • Biological and Pharmaceutical Bulletin, January 2013, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  60. Testicular Mineralization in KK-A<sup>y</sup> Mice Treated with an Oxovanadium Complex

    Article • Journal of Toxicologic Pathology, January 2013, Japanese Society of Toxicologic Pathology

    Professor Hiroyuki Yasui

  61. Iron overload signature in chrysotile-induced malignant mesothelioma

    Article • The Journal of Pathology, August 2012, Wiley

    Professor Hiroyuki Yasui

  62. The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis

    Article • Fertility and Sterility, August 2012, Elsevier

    Professor Hiroyuki Yasui

  63. Synthesis and structure–activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents

    Article • Bioorganic & Medicinal Chemistry, July 2012, Elsevier

    Professor Hiroyuki Yasui

  64. RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists

    Article • ACS Medicinal Chemistry Letters, April 2012, American Chemical Society (ACS)

    Professor Hiroyuki Yasui

  65. Transient elevation of serum cystatin C concentrations during perioperative cisplatin-based chemotherapy in esophageal cancer patients

    Article • Cancer Chemotherapy and Pharmacology, March 2012, Springer Science + Business Media

    Professor Hiroyuki Yasui

  66. Zinc Complexes Developed as Metallopharmaceutics for Treating Diabetes Mellitus based on the Bio-Medicinal Inorganic Chemistry

    Article • Current Topics in Medicinal Chemistry, February 2012, Bentham Science Publishers

    Professor Hiroyuki Yasui

  67. Synthesis and Structure–Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure

    Article • Journal of Medicinal Chemistry, January 2012, American Chemical Society (ACS)

    Professor Hiroyuki Yasui

  68. Development of a Highly Sensitive Methodology for Quantitative Determination of Fexofenadine in a Microdose Study by Multiple Injection Method Using Ultra-High Performance Liquid Chromatography with Tandem Mass Spectrometry

    Article • Biological and Pharmaceutical Bulletin, January 2012, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  69. Feasibility of Structural Modification of Retinoid X Receptor Agonists to Separate Blood Glucose-Lowering Action from Adverse Effects: Studies in KKA<sup>y</sup> Type 2 Diabetes Model Mice

    Article • Biological and Pharmaceutical Bulletin, January 2012, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  70. In vitro insulin-mimetic activity and in vivo metallokinetic feature of oxovanadium(IV)porphyrin complexes in healthy rats

    Article • Journal of Porphyrins and Phthalocyanines, January 2012, World Scientific Pub Co Pte Lt

    Professor Hiroyuki Yasui

  71. <i>In Vitro</i> Study on the Transport of Zinc across Intestinal Epithelial Cells Using Caco-2 Monolayers and Isolated Rat Intestinal Membranes

    Article • Biological and Pharmaceutical Bulletin, January 2012, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  72. Pharmacological and Pharmacokinetic Studies of Anti-diabetic Tropolonato–Zn(II) Complexes with Zn(S<sub>2</sub>O<sub>2</sub>) Coordination Mode

    Article • Chemical and Pharmaceutical Bulletin, January 2012, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  73. E10A, an adenovirus-carrying endostatin gene, dramatically increased the tumor drug concentration of metronomic chemotherapy with low-dose cisplatin in a xenograft mouse model for head and neck squamous-cell carcinoma

    Article • Cancer Gene Therapy, November 2011, Springer Science + Business Media

    Professor Hiroyuki Yasui

  74. Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

    Article • Proceedings of the National Academy of Sciences, November 2011, Proceedings of the National Academy of Sciences

    Professor Hiroyuki Yasui

  75. ChemInform Abstract: Challenge of Studies on the Development of New Zn Complexes to Treat Diabetes Mellitus

    Article • ChemInform, October 2011, Wiley

    Professor Hiroyuki Yasui

  76. The disposition and intestinal absorption of zinc in rats

    Article • European Journal of Pharmaceutical Sciences, October 2011, Elsevier

    Professor Hiroyuki Yasui

  77. Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats

    Article • Molecular Neurodegeneration, July 2011, Springer Science + Business Media

    Professor Hiroyuki Yasui

  78. Improved Spectrophotometric Determination of Total Iron and Iron(III) with <i>o</i>-Hydroxyhydroquinonephthalein and Their Characterization

    Article • YAKUGAKU ZASSHI, July 2011, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  79. Novel carotenoid pyropheophorbide A esters from abalone

    Article • Tetrahedron Letters, June 2011, Elsevier

    Professor Hiroyuki Yasui

  80. Challenge of Studies on the Development of New Zn Complexes to Treat Diabetes Mellitus

    Article • YAKUGAKU ZASSHI, June 2011, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  81. Detoxification of 6-hydroxydopamine-induced Parkinsonian neurodegeneration by G-CYPMPO, a novel radical trapper

    Article • Neurochemistry International, May 2011, Elsevier

    Professor Hiroyuki Yasui

  82. Efficient reduction of Cys110 thiyl radical by glutathione in human myoglobin

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, April 2011, Elsevier

    Professor Shun Hirota, Professor Hiroyuki Yasui

  83. Cellular Mechanism of Zinc–Hinokitiol Complexes in Diabetes Mellitus

    Article • Bulletin of the Chemical Society of Japan, March 2011, The Chemical Society of Japan

    Professor Hiroyuki Yasui

  84. Challenge of studies on the development of new Zn complexes (Zn(opt)2) to treat diabetes mellitus

    Article • Metallomics, January 2011, Oxford University Press (OUP)

    Professor Hiroyuki Yasui

  85. Synthesis and in vitro insulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates

    Article • Metallomics, January 2011, Oxford University Press (OUP)

    Professor Hiroyuki Yasui

  86. Effects of Zn(ii) complex with vitamins C and U, and carnitine on metabolic syndrome model rats

    Article • Metallomics, January 2011, Oxford University Press (OUP)

    Professor Hiroyuki Yasui

  87. Development of a Novel High-Throughput Analytical Methodology, Multiple Injection Method, for Quantitative Analysis in Drug Metabolism and Pharmacokinetic Studies Using Liquid Chromatography with Tandem Mass Spectrometry

    Article • Biological and Pharmaceutical Bulletin, January 2011, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  88. Oral Administration of Bis(aspirinato)zinc(II) Complex Ameliorates Hyperglycemia and Metabolic Syndrome-Like Disorders in Spontaneously Diabetic KK-Ay Mice: Structure-Activity Relationship on Zinc-Salicylate Complexes

    Article • Chemical and Pharmaceutical Bulletin, January 2011, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  89. Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole

    Article • Bioorganic & Medicinal Chemistry, January 2011, Elsevier

    Professor Hiroyuki Yasui

  90. Organ distribution of quantum dots after intraperitoneal administration, with special reference to area-specific distribution in the brain

    Article • Nanotechnology, July 2010, Institute of Physics Publishing

    Professor Hiroyuki Yasui

  91. Anti-microtubule ‘plinabulin’ chemical probe KPU-244-B3 labeled both α- and β-tubulin

    Article • Bioorganic & Medicinal Chemistry, May 2010, Elsevier

    Professor Hiroyuki Yasui

  92. Inhibitory effect of CuSO4 on α-glucosidase activity in ddY mice

    Article • Metallomics, January 2010, Oxford University Press (OUP)

    Professor Hiroyuki Yasui

  93. Synthesis of Metal Complexes with 1-Substituted 3-Hydroxy-2(1H)-pyridinethiones and Their Insulin-Mimetic Activities

    Article • Heterocycles, January 2010, Japan Institute of Heterocyclic Chemistry

    Professor Hiroyuki Yasui

  94. Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice

    Article • Neurochemistry International, December 2009, Elsevier

    Professor Hiroyuki Yasui

  95. Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice

    Article • Journal of Controlled Release, November 2009, Elsevier

    Professor Hiroyuki Yasui

  96. Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes

    Article • Biochimie, October 2009, Elsevier

    Professor Hiroyuki Yasui

  97. Evaluation of insulin-mimetic activities of vanadyl and zinc(II) complexes from the viewpoint of heterocyclic bidentate ligands

    Article • Journal of Inorganic Biochemistry, April 2009, Elsevier

    Professor Hiroyuki Yasui

  98. Unidirectional Binding of Clostridial Collagenase to Triple Helical Substrates

    Article • Journal of Biological Chemistry, April 2009, Elsevier

    Professor Hiroyuki Yasui

  99. ChemInform Abstract: Current State for the Development of Metallopharmaceutics and Antidiabetic Metal Complexes

    Article • ChemInform, January 2009, Wiley

    Professor Hiroyuki Yasui

  100. Observing Systems Simulation Experiments on Abnormally High Surface Air Temperatures in the Tokyo Metropolitan Area Using WRF-VAR

    Article • SOLA, January 2009, Meteorological Society of Japan

    Professor Hiroyuki Yasui

  101. Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7

    Article • Journal of Pharmacological Sciences, January 2009, Japanese Pharmacological Society

    Professor Hiroyuki Yasui

  102. Synthesis of Biotin-Tagged Diketopiperazine-Based Anti-Microtubule Agents and Tubulin Photoaffinity Labeling

    Article • January 2009, Springer Science + Business Media

    Professor Hiroyuki Yasui

  103. Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model

    Article • Neuroscience Research, December 2008, Elsevier

    Professor Hiroyuki Yasui

  104. Inhibitory Effects of Short-Chain Fatty Acids on Matrix Metalloproteinase Secretion from Human Colonic Subepithelial Myofibroblasts

    Article • Digestive Diseases and Sciences, July 2008, Springer Science + Business Media

    Professor Hiroyuki Yasui

  105. Photocontrol of Spatial Orientation and DNA Cleavage Activity of Copper(II)-Bound Dipeptides Linked by an Azobenzene Derivative

    Article • Inorganic Chemistry, May 2008, American Chemical Society (ACS)

    Professor Shun Hirota, Professor Halan Prakash, Professor Hiroyuki Yasui

  106. Current state for the development of metallopharmaceutics and anti-diabetic metal complexes

    Article • Chemical Society Reviews, January 2008, Royal Society of Chemistry

    Professor Hiroyuki Yasui

  107. Article • Japanese Journal of Infection Prevention and Control, January 2008, Japanese Society of Environmental Infections

    Professor Hiroyuki Yasui

  108. Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model

    Article • Archives of Dermatological Research, October 2007, Springer Science + Business Media

    Professor Hiroyuki Yasui

  109. Suppressive effect of orally administered copper(II)-aspirinate (Cu2(asp)4) complex on the generation of reactive oxygen species in the skin of animals subjected to UVA exposure

    Article • Experimental Dermatology, September 2007, Wiley

    Professor Hiroyuki Yasui

  110. Metallokinetic characteristics of antidiabetic bis(allixinato)oxovanadium(IV)-related complexes in the blood of rat

    Article • JBIC Journal of Biological Inorganic Chemistry, May 2007, Springer Science + Business Media

    Professor Hiroyuki Yasui

  111. Chemical Structure-Dependent Differential Effects of Flavonoids on the Catalase Activity as Evaluated by a Chemiluminescent Method

    Article • Biological and Pharmaceutical Bulletin, January 2007, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  112. Novel screening method for ultraviolet protection: Combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine

    Article • Pathology International, December 2006, Wiley

    Professor Hiroyuki Yasui

  113. Generation and distribution of reactive oxygen species in the skin of hairless mice under UVA: studies on in vivo chemiluminescent detection and tape stripping methods

    Article • Experimental Dermatology, November 2006, Wiley

    Professor Hiroyuki Yasui

  114. A New Physiologically Based Pharmacokinetic Analysis for In Vivo Organ Disposition of Nitroxyl Spin Probes in Mice as Measured by Multisite Detection L-band ESR (MSD-LESR)

    Article • Chemistry Letters, October 2006, The Chemical Society of Japan

    Professor Hiroyuki Yasui

  115. A novel drug delivery system for type 1 diabetes: Insulin-mimetic vanadyl-poly(γ-glutamic acid) complex

    Article • Journal of Inorganic Biochemistry, September 2006, Elsevier

    Professor Hiroyuki Yasui

  116. Oxovanadium(IV)–Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−)

    Article • Bulletin of the Chemical Society of Japan, August 2006, The Chemical Society of Japan

    Professor Hiroyuki Yasui

  117. Real-time chemiluminescent imaging and detection of reactive oxygen species generated in the UVB-exposed human skin equivalent model

    Article • Biochemical and Biophysical Research Communications, August 2006, Elsevier

    Professor Hiroyuki Yasui

  118. Memory Deficit in Mice Administered Aluminum–maltolate Complex

    Article • BioMetals, February 2006, Springer Science + Business Media

    Professor Hiroyuki Yasui

  119. Suppressive Effect of Caffeic Acid and its Derivatives on the Generation of UVA-induced Reactive Oxygen Species in the Skin of Hairless Mice and Pharmacokinetic Analysis on Organ Distribution of Caffeic Acid in ddY Mice

    Article • Photochemistry and Photobiology, January 2006, Wiley

    Professor Hiroyuki Yasui

  120. Orally active antioxidative copper(II) aspirinate: synthesis, structure characterization, superoxide scavenging activity, and in vitro and in vivo antioxidative evaluations

    Article • JBIC Journal of Biological Inorganic Chemistry, December 2005, Springer Science + Business Media

    Professor Hiroyuki Yasui

  121. Orally active antioxidative copper(II) aspirinate: synthesis, structure characterization, superoxide scavenging activity, and in vitro and in vivo antioxidative evaluations

    Article • JBIC Journal of Biological Inorganic Chemistry, November 2005, Springer Science + Business Media

    Professor Hiroyuki Yasui

  122. A New Type of Orally Active Insulin-mimetic Vanadyl-porphyrin Complex:meso-Tetrakis({4-sulfonatophenyl}porphyrinato)oxovanadium(IV)

    Article • Chemistry Letters, October 2005, The Chemical Society of Japan

    Professor Hiroyuki Yasui

  123. Effect of insulin-mimetic vanadyl sulfate on cytochrome P450 2E1-dependent p-nitrophenol hydroxylation in the liver microsomes of streptozotocin-induced type 1 diabetic rats

    Article • Life Sciences, October 2005, Elsevier

    Professor Hiroyuki Yasui

  124. Detection of reactive oxygen species in the skin of live mice and rats exposed to UVA light: a research review on chemiluminescence and trials for UVA protection

    Article • Photochemical & Photobiological Sciences, September 2005, Springer Science + Business Media

    Professor Hiroyuki Yasui

  125. Improvement of diabetic states in streptozotocin-induced type 1 diabetic rats by vanadyl sulfate in enteric-coated capsules

    Article • Journal of Pharmacy and Pharmacology, May 2005, Oxford University Press (OUP)

    Professor Hiroyuki Yasui

  126. Essential Role of Singlet Oxygen Species in Cytochrome P450-dependent Substrate Oxygenation by Rat Liver Microsomes

    Article • Drug Metabolism and Pharmacokinetics, January 2005, Japanese Society for the Study of Xenobiotics

    Professor Hiroyuki Yasui

  127. Possible Involvement of Singlet Oxygen Species as Multiple Oxidants in P450 Catalytic Reactions

    Article • Drug Metabolism and Pharmacokinetics, January 2005, Japanese Society for the Study of Xenobiotics

    Professor Hiroyuki Yasui

  128. Orally administrated aluminum–maltolate complex enhances oxidative stress in the organs of mice

    Article • Journal of Inorganic Biochemistry, December 2004, Elsevier

    Professor Hiroyuki Yasui

  129. Spinnokinetic Analyses of Blood Disposition and Biliary Excretion of Nitric Oxide (NO)-Fe(II)-N-(Dithiocarboxy)sarcosine Complex in Rats: BCM-ESR and BEM-ESR Studies

    Article • Free Radical Research, October 2004, Taylor & Francis

    Professor Hiroyuki Yasui

  130. Pharmacokinetic Analysis of Ramatroban Using a Recirculatory Model with Enterohepatic Circulation by Measuring Portal and Systemic Blood Concentration Difference in Sprague-Dawley and Eisai Hyperbilirubinemic Rats

    Article • Pharmaceutical Research, June 2004, Springer Science + Business Media

    Professor Hiroyuki Yasui

  131. A new candidate for insulinomimetic vanadium complex: synergism of oxovanadium(IV)porphyrin and sodium ascorbate

    Article • Bioorganic & Medicinal Chemistry Letters, March 2004, Elsevier

    Professor Hiroyuki Yasui

  132. Pharmacokinetic Study and Trial for Preparation of Enteric-Coated Capsule Containing Insulinomimetic Vanadyl Compounds: Implications for Clinical Use

    Article • Mini-Reviews in Medicinal Chemistry, January 2004, Bentham Science Publishers

    Professor Hiroyuki Yasui

  133. Specific Binding of Vanadyl Ion (VO2+) with Thiolate of the Cysteine-34 Residue in Serum Albumin, Demonstrated by CD Spectroscopy and Kinetic Property

    Article • Chemistry Letters, November 2003, The Chemical Society of Japan

    Professor Hiroyuki Yasui

  134. New antidiabetic vanadyl–pyridone complexes: effect of equivalent transformation of coordinating atom in the ligand

    Article • Coordination Chemistry Reviews, October 2003, Elsevier

    Professor Hiroyuki Yasui

  135. Age-dependent generation of reactive oxygen species in the skin of live hairless rats exposed to UVA light

    Article • Experimental Dermatology, September 2003, Wiley

    Professor Hiroyuki Yasui

  136. The therapeutic potential of insulin-mimetic vanadium complexes

    Article • Expert Opinion on Investigational Drugs, July 2003, Informa Healthcare

    Professor Hiroyuki Yasui

  137. A Recirculatory Model with Enterohepatic Circulation by Measuring Portal and Systemic Blood Concentration Difference

    Article • Journal of Pharmacokinetics and Pharmacodynamics, April 2003, Springer Science + Business Media

    Professor Hiroyuki Yasui

  138. Structure-activity relationship of insulinomimetic vanadyl-picolinate complexes in view of their clinical use

    Article • The Journal of Trace Elements in Experimental Medicine, January 2003, Wiley

    Professor Hiroyuki Yasui

  139. A New Determination Method of Nitric Oxide (NO) with a NO-selective Electrode Demonstrated by the Kinetic Analysis of NO Generation and Decomposition

    Article • Chemistry Letters, December 2002, The Chemical Society of Japan

    Professor Hiroyuki Yasui

  140. Structure-dependent metallokinetics of antidiabetic vanadyl-picolinate complexes in rats: studies on solution structure, insulinomimetic activity, and metallokinetics

    Article • Journal of Inorganic Biochemistry, July 2002, Elsevier

    Professor Hiroyuki Yasui

  141. Enteric-coating capsulation of insulinomimetic vanadyl sulfate enhances bioavailability of vanadyl species in rats

    Article • Journal of Pharmacy and Pharmacology, May 2002, Oxford University Press (OUP)

    Professor Hiroyuki Yasui

  142. Antidiabetic vanadium(IV) and zinc(II) complexes

    Article • Coordination Chemistry Reviews, March 2002, Elsevier

    Professor Hiroyuki Yasui

  143. Topological Stability and Self-Association of a Completely Hydrophobic Model Transmembrane Helix in Lipid Bilayers

    Article • Biochemistry, February 2002, American Chemical Society (ACS)

    Professor Hiroyuki Yasui

  144. A Recirculatory Model for Local Absorption and Disposition of Ciprofloxacin by Measuring Portal and Systemic Blood Concentration Difference

    Article • Journal of Pharmaceutical Sciences, January 2002, Elsevier

    Professor Hiroyuki Yasui

  145. Direct Reaction between Shikonin and Thiols Induces Apoptosis in HL60 Cells.

    Article • Biological and Pharmaceutical Bulletin, January 2002, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  146. Evidence for Singlet Oxygen Involvement in Rat and Human Cytochrome P450-dependent Substrate Oxidations

    Article • Drug Metabolism and Pharmacokinetics, January 2002, Japanese Society for the Study of Xenobiotics

    Professor Hiroyuki Yasui

  147. Local Pharmacokinetic Analysis of a Stable Spin Probe in Mice by In Vivo L-band ESR with Surface-coil-type Resonators

    Article • Free Radical Research, January 2002, Taylor & Francis

    Professor Hiroyuki Yasui

  148. Metallokinetic Study of Zinc in the Blood of Normal Rats Given Insulinomimetic Zinc(II) Complexes and Improvement of Diabetes Mellitus in Type 2 Diabetic GK Rats by their Oral Administration

    Article • Drug Metabolism and Pharmacokinetics, January 2002, Japanese Society for the Study of Xenobiotics

    Professor Hiroyuki Yasui

  149. Pharmacokinetic study on gastrointestinal absorption of insulinomimetic vanadyl complexes in rats by ESR spectroscopy

    Article • Journal of Pharmacy and Pharmacology, September 2001, Oxford University Press (OUP)

    Professor Hiroyuki Yasui

  150. A new halogenated antidiabetic vanadyl complex, bis(5-iodopicolinato)oxovanadium(IV): in vitro and in vivo insulinomimetic evaluations and metallokinetic analysis

    Article • JBIC Journal of Biological Inorganic Chemistry, February 2001, Springer Science + Business Media

    Professor Hiroyuki Yasui

  151. Effects of static magnetic field on dissolved oxygen levels in aqueous solutions containing copper(II), iron(II), and heme iron(III) complexes

    Article • Pathophysiology, July 2000, Elsevier

    Professor Hiroyuki Yasui

  152. An orally active antidiabetic vanadyl complex, bis(1-oxy-2-pyridinethiolato)oxovanadium(IV), with VO(S2O2) coordination mode; in vitro and in vivo evaluations in rats

    Article • Journal of Inorganic Biochemistry, May 2000, Elsevier

    Professor Hiroyuki Yasui

  153. Chemiluminescent Detection and Imaging of Reactive Oxygen Species in Live Mouse Skin Exposed to UVA

    Article • Biochemical and Biophysical Research Communications, March 2000, Elsevier

    Professor Hiroyuki Yasui

  154. Metallokinetic analysis of disposition of vanadyl complexes as insulin-mimetics in rats using BCM-ESR method

    Article • Journal of Inorganic Biochemistry, February 2000, Elsevier

    Professor Hiroyuki Yasui

  155. Data Analysis Methods

    Article • January 2000, Springer Science + Business Media

    Professor Hiroyuki Yasui

  156. A New Type of Orally Active Insulin-Mimetic Vanadyl Complex: Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S2O2) Coordination Mode

    Article • Chemistry Letters, September 1999, The Chemical Society of Japan

    Professor Hiroyuki Yasui

  157. Involvement of Singlet Oxygen in Cytochrome P450-Dependent Substrate Oxidations

    Article • Biochemical and Biophysical Research Communications, September 1999, Elsevier

    Professor Hiroyuki Yasui

  158. ESR characterization and metallokinetic analysis of Cr(V) in the blood of rats given carcinogen chromate(VI) compounds

    Article • Journal of Inorganic Biochemistry, July 1999, Elsevier

    Professor Hiroyuki Yasui

  159. Effect of HSP47 on Prolyl 4-Hydroxylation of Collagen Model Peptides.

    Article • Cell Structure and Function, January 1999, Japan Society for Cell Biology

    Professor Hiroyuki Yasui

  160. In vivoL-band ESR and quantitative pharmacokinetic analysis of stable spin probes in rats and mice

    Article • Free Radical Research, January 1999, Taylor & Francis

    Professor Hiroyuki Yasui

  161. Insulin-mimetic vanadyl—dithiocarbamate complexes

    Article • Inorganica Chimica Acta, December 1998, Elsevier

    Professor Hiroyuki Yasui

  162. HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone), an anti-lipid-peroxidative compound: its chemical and biochemical characterizations

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, September 1998, Elsevier

    Professor Hiroyuki Yasui

  163. Moment Analysis of Stereoselective Enterohepatic Circulation and Unidirectional Chiral Inversion of Ketoprofen Enantiomers in Rat

    Article • Journal of Pharmaceutical Sciences, June 1996, American Geophysical Union (AGU)

    Professor Hiroyuki Yasui

  164. Moment Analysis of Stereoselective Biliary Excretion and Chiral Inversion of Ketoprofen Enantiomers in Perfused Rat Liver

    Article • Journal of Pharmaceutical Sciences, November 1995, Elsevier

    Professor Hiroyuki Yasui

  165. New hepatocellular diffusion model for analysis of hepatobiliary transport processes of drugs

    Article • Journal of Pharmacokinetics and Biopharmaceutics, April 1995, Springer Science + Business Media

    Professor Hiroyuki Yasui

  166. Effect of Temperature in Perfusate on Local Hepatic Disposition of BOF-4272, a New Xanthine Oxidase Inhibitor.

    Article • Biological and Pharmaceutical Bulletin, January 1995, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  167. Alternative Continuous Infusion Method for Analysis of Enterohepatic Circulation and Biliary Excretion of Cefixime in the Rat

    Article • Journal of Pharmaceutical Sciences, June 1994, Elsevier

    Professor Hiroyuki Yasui

  168. Moment analysis of hepatic local disposition of allopurinol and oxipurinol: metabolism kinetics from allopurinol to oxipurinol in the rat isolated perfused liver

    Article • Journal of Pharmacy and Pharmacology, June 1994, Oxford University Press (OUP)

    Professor Hiroyuki Yasui

  169. Local Disposition of a New Xanthine Oxidase/Xanthine Dehydrogenase Inhibitor, BOF-4272, in Rat Liver.

    Article • Biological and Pharmaceutical Bulletin, January 1994, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  170. Improved Flow Injection Analysis (FIA) Method for Determining Selenium in Biological Samples, and the Effect of Captopril Administration on Selenium Levels and Glutathione Peroxidase Activity in Rat.

    Article • Biological and Pharmaceutical Bulletin, January 1993, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  171. Synthetic Study on Selenocystine-Containing Peptides.

    Article • Chemical and Pharmaceutical Bulletin, January 1993, Pharmaceutical Society of Japan

    Professor Hiroyuki Yasui

  172. Analysis of arterial–venous blood concentration difference of drugs based on recirculatory theory with fast inverse laplace transform (FILT)

    Article • Journal of Pharmacokinetics and Biopharmaceutics, February 1991, Springer Science + Business Media

    Professor Hiroyuki Yasui