All Stories

  1. Cyclobutane Pyrimidine Dimers Produced with Narrowband UVB Are on Average More Mutagenic than Those with Broadband UVB in Mouse Skin

    Article • Photochemistry and Photobiology, November 2021, Wiley

    Dr Hironobu Ikehata

  2. Seasonal Differences in the UVA/UVB Ratio of Natural Sunlight Influence the Efficiency of the Photoisomerization of (6‐4) Photoproducts into their Dewar Valence Isomers

    Article • Photochemistry and Photobiology, December 2020, Wiley

    Dr Hironobu Ikehata

  3. Nrf2 contributes to the weight gain of mice during space travel

    Article • Communications Biology, September 2020, Springer Science + Business Media

    Dr Hironobu Ikehata

  4. Wavelength‐ and Tissue‐dependent Variations in the Mutagenicity of Cyclobutane Pyrimidine Dimers in Mouse Skin

    Article • Photochemistry and Photobiology, October 2019, Wiley

    Dr Hironobu Ikehata

  5. Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation

    Article • Toxicology and Applied Pharmacology, December 2018, Elsevier

    Dr Hironobu Ikehata

  6. Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation

    Article • Photochemical & Photobiological Sciences, January 2018, Springer Science + Business Media

    Dr Hironobu Ikehata

  7. Quantitative analysis of UV photolesions suggests that cyclobutane pyrimidine dimers produced in mouse skin by UVB are more mutagenic than those produced by UVC

    Article • Photochemical & Photobiological Sciences, January 2018, Springer Science + Business Media

    Dr Hironobu Ikehata

  8. In VivoSpectrum of UVC-induced Mutation in Mouse Skin Epidermis May Reflect the Cytosine Deamination Propensity of Cyclobutane Pyrimidine Dimers

    Article • Photochemistry and Photobiology, October 2015, Wiley

    Dr Hironobu Ikehata

  9. Remarkable induction of UV-signature mutations at the 3′-cytosine of dipyrimidine sites except at 5′-TCG-3′ in the UVB-exposed skin epidermis of xeroderma pigmentosum variant model mice

    Article • DNA Repair, October 2014, Elsevier

    Dr Hironobu Ikehata

  10. Skin can control solar UVR-induced mutations through the epidermis-specific response of mutation induction suppression

    Article • Photochemical & Photobiological Sciences, November 2013, Springer Science + Business Media

    Dr Hironobu Ikehata

  11. Solar-UV-signature mutation prefers TCG to CCG: extrapolative consideration from UVA1-induced mutation spectra in mouse skin

    Article • Photochemical & Photobiological Sciences, August 2013, Springer Science + Business Media

    Dr Hironobu Ikehata

  12. Action Spectrum Analysis of UVR Genotoxicity for Skin: The Border Wavelengths between UVA and UVB Can Bring Serious Mutation Loads to Skin

    Article • Journal of Investigative Dermatology, July 2013, Elsevier

    Dr Hironobu Ikehata

  13. Role of the Msh2 gene in genome maintenance and development in mouse fetuses

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, June 2012, Elsevier

    Dr Hironobu Ikehata

  14. Fully functional global genome repair of (6-4) photoproducts and compromised transcription-coupled repair of cyclobutane pyrimidine dimers in condensed mitotic chromatin

    Article • Experimental Cell Research, March 2012, Elsevier

    Dr Hironobu Ikehata

  15. Effects of calorie restriction on the age-dependent accumulation of mutations in the small intestine of lacZ-transgenic mice

    Article • Mechanisms of Ageing and Development, March 2011, Elsevier

    Dr Hironobu Ikehata

  16. The Mechanisms of UV Mutagenesis

    Article • Journal of Radiation Research, January 2011, Oxford University Press (OUP)

    Dr Hironobu Ikehata

  17. Antigenotoxic effects of p53 on spontaneous and ultraviolet light B-induced deletions in the epidermis of gpt delta transgenic mice

    Article • Environmental and Molecular Mutagenesis, August 2010, Wiley

    Dr Hironobu Ikehata

  18. Influences of p53 deficiency on the apoptotic response, DNA damage removal and mutagenesis in UVB-exposed mouse skin

    Article • Mutagenesis, May 2010, Oxford University Press (OUP)

    Dr Hironobu Ikehata

  19. XPC is involved in genome maintenance through multiple pathways in different tissues

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, November 2009, Elsevier

    Dr Hironobu Ikehata

  20. UVA1 Genotoxicity Is Mediated Not by Oxidative Damage but by Cyclobutane Pyrimidine Dimers in Normal Mouse Skin

    Article • Journal of Investigative Dermatology, September 2008, Elsevier

    Dr Hironobu Ikehata, Dr. Liangcheng 王良誠 Wang

  21. Absence ofKu70Gene Obliterates X-Ray-InducedlacZMutagenesis of Small Deletions in Mouse Tissues

    Article • Radiation Research, August 2008, Radiation Research Society

    Dr Hironobu Ikehata

  22. Chromatin fine structure of the c- MYC insulator element/DNase I-hypersensitive site I is not preserved during mitosis

    Article • Proceedings of the National Academy of Sciences, October 2007, Proceedings of the National Academy of Sciences

    Dr Hironobu Ikehata

  23. A model for triplet mutation formation based on error-prone translesional DNA synthesis opposite UV photolesions

    Article • DNA Repair, May 2007, Elsevier

    Dr Hironobu Ikehata

  24. Frequent recovery of triplet mutations in UVB-exposed skin epidermis of Xpc-knockout mice

    Article • DNA Repair, January 2007, Elsevier

    Dr Hironobu Ikehata

  25. Mutation spectrum in UVB-exposed skin epidermis ofXpa-knockout mice: Frequent recovery of triplet mutations

    Article • Environmental and Molecular Mutagenesis, January 2007, Wiley

    Dr Hironobu Ikehata

  26. Significance of CpG Methylation for Solar UV-induced Mutagenesis and Carcinogenesis in Skin

    Article • Photochemistry and Photobiology, January 2006, Wiley

    Dr Hironobu Ikehata

  27. Mutation spectrum in UVB-exposed skin epidermis of a mildly-affectedXpg-deficient mouse

    Article • Environmental and Molecular Mutagenesis, January 2006, Wiley

    Dr Hironobu Ikehata

  28. Mutation spectrum in sunlight-exposed mouse skin epidermis: small but appreciable contribution of oxidative stress-mediated mutagenesis

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, November 2004, Elsevier

    Dr Hironobu Ikehata

  29. Spontaneous Mutations in Digestive Tract of Old Mice Show Tissue-Specific Patterns of Genomic Instability

    Article • Cancer Research, October 2004, American Association for Cancer Research (AACR)

    Dr Hironobu Ikehata

  30. Absence of Mutagenic Effects of 2.45 GHz Radiofrequency Exposure in Spleen, Liver, Brain, and Testis of lacZ-Transgenic Mouse Exposed in Utero

    Article • The Tohoku Journal of Experimental Medicine, January 2004, Tohoku University Medical Press

    Dr Hironobu Ikehata

  31. UVA induces C->T transitions at methyl-CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB

    Article • Mutagenesis, November 2003, Oxford University Press (OUP)

    Dr Hironobu Ikehata

  32. Molecular nature of mutations induced by irradiation with repeated low doses of X‐rays in spleen, liver, brain and testis oflacZ‐transgenic mice

    Article • International Journal of Radiation Biology, August 2003, Taylor & Francis

    Dr Hironobu Ikehata

  33. Analysis of mutation spectra in UVB-exposed mouse skin epidermis and dermis: Frequent occurrence of C?T transition at methylated CpG-associated dipyrimidine sites

    Article • Environmental and Molecular Mutagenesis, January 2003, Wiley

    Dr Hironobu Ikehata

  34. Mutation theory of aging, assessed in transgenic mice and knockout mice

    Article • Mechanisms of Ageing and Development, November 2002, Elsevier

    Dr Hironobu Ikehata

  35. Mutation induction with UVB in mouse skin epidermis is suppressed in acute high-dose exposure

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, October 2002, Elsevier

    Dr Hironobu Ikehata

  36. Mapping Psoralen Cross-Links at the Nucleotide Level in Mammalian Cells:  Suppression of Cross-Linking at Transcription Factor- or Nucleosome-Binding Sites†

    Article • Biochemistry, April 2001, American Chemical Society (ACS)

    Dr Hironobu Ikehata

  37. Thermolysin improves mutation analysis in skin epidermis from ultraviolet light-irradiated Muta? Mouse

    Article • Environmental and Molecular Mutagenesis, January 2001, Wiley

    Dr Hironobu Ikehata

  38. Characteristics of mutations generated through digestion with restriction enzyme and ligation in plasmid DNA

    Article • Environmental and Molecular Mutagenesis, January 2001, Wiley

    Dr Hironobu Ikehata

  39. Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, February 2000, Elsevier

    Dr Hironobu Ikehata

  40. Distribution of spontaneous CpG-associated G:C ? A:T mutations in thelacZ gene of Muta? mice: Effects of CpG methylation, the sequence context of CpG sites, and severity of mutations on the activity of thelacZ gene product

    Article • Environmental and Molecular Mutagenesis, January 2000, Wiley

    Dr Hironobu Ikehata

  41. X-Ray- and Ultraviolet-Radiation-Induced Mutations in Muta™ Mouse

    Article • Radiation Research, August 1997, JSTOR

    Dr Hironobu Ikehata

  42. Incubation at the nonpermissive temperature induces deficiencies in UV resistance and mutagenesis in mouse mutant cells expressing a temperature-sensitive ubiquitin-activating enzyme (E1).

    Article • Molecular and Cellular Biology, March 1997, ASM Journals

    Dr Hironobu Ikehata

  43. Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age

    Article • Mutation Research/DNAging, October 1995, Elsevier

    Dr Hironobu Ikehata

  44. Comparison of DNA Polymerases .ALPHA., .DELTA., and .EPSILON. of Mouse Cell Line FM3A and Its Temperature-Sensitive Mutant tsFT20.

    Article • The Tohoku Journal of Experimental Medicine, January 1994, Tohoku University Medical Press

    Dr Hironobu Ikehata

  45. Spectrum of spontaneous mutations in a cDNA of the human hprt gene integrated in chromosomal DNA

    Article • November 1989, Springer Science + Business Media

    Dr Hironobu Ikehata

  46. Shuttle vector system for the analysis of mutational events in mammalian chromosomal DNA

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, February 1989, Elsevier

    Dr Hironobu Ikehata