All Stories

  1. Ethical and social implications of public–private partnerships in the context of genomic/big health data collection
  2. Pour une bonne compréhension et un bon usage du terme « organoïdes »
  3. CELF2 Sustains a Proliferating/OLIG2+ Glioblastoma Cell Phenotype via the Epigenetic Repression of SOX3
  4. Challenges in glioblastoma research: focus on the tumor microenvironment
  5. 2023 : premiers succès et nouveaux enjeux de l’édition du génome en thérapeutique humaine
  6. Challenges in glioblastoma research: focus on the tumor microenvironment
  7. Managing expectations, rights, and duties in large-scale genomics initiatives: a European comparison
  8. Glioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase
  9. Axel Kahn : l’exigence comme nécessité d’une pensée juste
  10. Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine
  11. Sur les épaules des géants qui nous ont précédés
  12. The ethics of genomic medicine: redefining values and norms in the UK and France
  13. The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation
  14. Global citizen deliberation on genome editing
  15. LifeTime and improving European healthcare through cell-based interceptive medicine
  16. ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
  17. Covid-19 : protocoles de soins ou protocoles de recherche ?
  18. Organoïdes : nouvelles perspectives et nouvelles questions éthiques
  19. Capture at the single cell level of metabolic modules distinguishing aggressive and indolent glioblastoma cells
  20. Capture at the single cell level of metabolic modules distinguishing aggressive and indolent glioblastoma cells
  21. The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models
  22. The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity
  23. Genome Editing: Promoting Responsible Research
  24. De retour de Hong Kong ou l’éthique à l’heure d’une génétique d’« augmentation » de la personne humaine
  25. Éléments pour une éthique de la communication des faits scientifiques
  26. ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition
  27. WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3– cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
  28. The tsunami named CRISPR/Cas9
  29. Could Failure in Preimplantation Genetic Diagnosis Justify Editing the Human Embryo Genome?
  30. ARRIGE Arrives: Toward the Responsible Use of Genome Editing
  31. Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation
  32. Les états généraux de la bioéthique de 2018
  33. Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma
  34. Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness
  35. Glut3 addiction is a druggable vulnerability for a molecularly defined subpopulation of glioblastoma
  36. Commentary: Just Say “No”
  37. DOCK4 promotes loss of proliferation in glioblastoma progenitor cells through nuclear beta-catenin accumulation and subsequent miR-302-367 cluster expression
  38. Fostering responsible research with genome editing technologies: a European perspective
  39. Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling
  40. Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth
  41. Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance
  42. Development of a DIPG Orthotopic Model in Mice Using an Implantable Guide-Screw System
  43. A European position on genome editing
  44. A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma
  45. CHD7 promotes proliferation of neural stem cells mediated by MIF
  46. EXTH-09. LOOKING FOR A CURE: DELTA-24-RDG AND RADIOTHERAPY FOR DIPG TREATMENT
  47. Nos jeunes pousses ont du talent !
  48. HG-51DELTA-24-RDG IN COMBINATION WITH RADIOTHERAPY FOR DIPG: OPENING NEW THERAPEUTIC AVENUES
  49. Calcium signaling orchestrates glioblastoma development: Facts and conjunctures
  50. The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway
  51. A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells
  52. La recherche biomédicale pensée en français : Nouvelle année, nouveaux concepts
  53. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression
  54. Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo
  55. Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells
  56. Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis and Fibronectin Expression of Embryonic Neural Cells In Vitro
  57. Une éthique de dialogue science-société
  58. Les années 2010
  59. Les années 2000
  60. Data in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study
  61. 30 ans déjà, et demain ?
  62. Depuis 30 ans, aujourd’hui et demain : transmettre la science biomédicale en langue française
  63. Metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study
  64. A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)
  65. Lamarck en invité spécial du 30eanniversaire dem/s
  66. SIRT2, une déacétylase aux multiples talents
  67. Endothelial Secreted Factors Suppress Mitogen Deprivation-Induced Autophagy and Apoptosis in Glioblastoma Stem-Like Cells
  68. Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets
  69. À quoi sert donc une revue scientifique en langue française ?
  70. A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype
  71. The relationship between brain tumor cell invasion of engineered neural tissues and in vivo features of glioblastoma
  72. Sirtuin-2 Activity is Required for Glioma Stem Cell Proliferation Arrest but not Necrosis Induced by Resveratrol
  73. Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis and favors glioblastoma resistance to etoposide
  74. Tumorigenic Potential of miR-18A* in Glioma Initiating Cells Requires NOTCH-1 Signaling
  75. Critical multiple angiogenic factors secreted by glioblastoma stem-like cells underline the need for combinatorial anti-angiogenic therapeutic strategies
  76. médecine/sciences2013
  77. Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation
  78. Differential Proteomic Analysis of Human Glioblastoma and Neural Stem Cells Reveals HDGF as a Novel Angiogenic Secreted Factor
  79. Antiproliferative Activity of trans- Avicennol from Zanthoxylum chiloperone var. angustifolium against Human Cancer Stem Cells
  80. Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells
  81. médecine/sciencesacteur de la bioéconomie responsable
  82. Proteomic analysis of oligodendrogliomas expressing a mutant isocitrate dehydrogenase-1
  83. The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network
  84. Does Cognitive Enhancement Fit with the Physiology of Our Cognition?
  85. Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway
  86. Alternative Lengthening of Telomeres in Human Glioma Stem Cells
  87. Clinical Relevance of Tumor Cells with Stem-Like Properties in Pediatric Brain Tumors
  88. Cerveau préservé, réparé, amélioré
  89. Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells
  90. médecine/sciences2011
  91. Plasticité du phénotype cellulaire ou une certaine fin de l’insouciance du déterminisme
  92. NG2+/Olig2+Cells are the Major Cycle-Related Cell Population of the Adult Human Normal Brain
  93. CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors
  94. An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients
  95. Neurosciences et neuroéthique
  96. Astrocytes Reverted to a Neural Progenitor-like State with Transforming Growth Factor Alpha Are Sensitized to Cancerous Transformation
  97. Calcium fingerprints induced by Calmodulin interactors in eukaryotic cells
  98. Development of Human Nervous Tissue upon Differentiation of Embryonic Stem Cells in Three-Dimensional Culture
  99. DLG1/SAP97 modulates transforming growth factor α bioavailability
  100. GFAPδ immunostaining improves visualization of normal and pathologic astrocytic heterogeneity
  101. Médecine/Scienceset les passerelles du temps
  102. Dans la lumière et les ombres
  103. Trop court traité de l’âme :Court Traité de l’âme(Philippe Lazar)
  104. Voyage autour du monde dans le regard de l’autre :L’homme pluriel
  105. Quand l’art rencontre la science
  106. The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway
  107. Une dimension de plus en plus individualisée du rapport bénéfice/risque
  108. Contrats et vivant  : le droit de la circulation des ressources biologiques Florence Bellivier, Christine Noiville
  109. PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic  -Cells
  110. Phosphoprotein Enriched in Astrocytes-15 kDa Expression Inhibits Astrocyte Migration by a Protein Kinase Cδ-dependent Mechanism
  111. Transforming growth factor α promotes sequential conversion of mature astrocytes into neural progenitors and stem cells
  112. Do Secretin and Vasoactive Intestinal Peptide Have Independent Receptors on Striatal Neurons and Glial Cells in Primary Cultures?
  113. Akt Down-Regulates ERK1/2 Nuclear Localization and Angiotensin II-induced Cell Proliferation through PEA-15
  114. Transforming growth factor alpha acts as a gliatrophin for mouse and human astrocytes
  115. Chroniques bioéthiques (13) : Enfin, les cellules souches embryonnaires humaines françaises ont leur décret d’application !
  116. Cloningate? La publication scientifique et le clonage thérapeutique face à la mystification Hwang
  117. Et l’épilepsie devint une maladie de l’astrocyte
  118. Mise en évidence de cellules souches tumorales au sein des tumeurs glio-neuronales malignes (TGNM)
  119. Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila
  120. Brève esquisse neurophysiologique de l'excitation : des neurones, des astrocytes et des images
  121. New Variants of Malignant Glioneuronal Tumors: A Clinicopathological Study of 40 Cases
  122. p38/SAPK2 controls gap junction closure in astrocytes
  123. The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15 kDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain
  124. PEA-15 Modulates TNFα Intracellular Signaling in Astrocytes
  125. The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes
  126. Sur les rivages de la misère
  127. Sur les sentiers escarpés des montagnes de bioéthique
  128. Dans les grandes plaines de la génomique
  129. Sur les sentiers escarpés des montagnes de bioéthique
  130. Sur les sentiers escarpés des montagnes de bioéthique
  131. Cellular Expression, Developmental Regulation, and Phylogenic Conservation of PEA-15, the Astrocytic Major Phosphoprotein and Protein Kinase C Substrate
  132. Endothelin Induces a Calcium-Dependent Phosphorylation of PEA-15 in Intact Astrocytes: Identification of Ser104 and Ser116 Phosphorylated, Respectively, by Protein Kinase C and Calcium/Calmodulin Kinase II In Vitro
  133. Les astrocytes contrôlent la neurogenèse dans le système nerveux central adulte
  134. PEA-15 Mediates Cytoplasmic Sequestration of ERK MAP Kinase
  135. Keeping TNF-induced apoptosis under control in astrocytes: PEA-15 as a ‘double key’ on caspase-dependent and MAP-kinase-dependent pathways
  136. Death Effector Domain Protein PEA-15 Potentiates Ras Activation of Extracellular Signal Receptor-activated Kinase by an Adhesion-independent Mechanism
  137. Regulation of Expression of Phospholipase D1 and D2 by PEA-15, a Novel Protein That Interacts with Them
  138. Knock-Out of the Neural Death Effector Domain Protein PEA-15 Demonstrates That Its Expression Protects Astrocytes from TNFα-Induced Apoptosis
  139. Polyneuropathy in autosomal dominant cerebellar ataxias: Phenotype-genotype correlation
  140. Molecular and Clinical Correlations in Spinocerebellar Ataxia 2: A Study of 32 Families
  141. Percevoir n'est pas voir.
  142. The Major Astrocytic Phosphoprotein PEA-15 Is Encoded by Two mRNAs Conserved on Their Full Length in Mouse and Human
  143. Autosomal dominant cerebellar ataxia type I in Martinique (French West Indies): Genetic analysis of three unrelated SCA2 families
  144. Spinocerebellar ataxia 3 and machado-joseph disease: Clinical, molecular, and neuropathological features
  145. Autosomal dominant cerebellar ataxia type I in Martinique (French West Indies): genetic analysis of three unrelated SCA2 families
  146. Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse
  147. SCA2 is not a major locus for ADCA type I in French families
  148. Gender equality in Machado–Joseph disease
  149. Analysis of the SCAI CAG repeat in a large number of families with dominant ataxia: Clinical and molecular correlations
  150. Autosomal dominant cerebellar ataxia type I in Martinique (French West Indies)
  151. Is DRPLA also linked to 14q?
  152. Phenotypic variability in autosomal dominant cerebellar ataxia type I is unrelated to genetic heterogeneity
  153. Chromosomal assignment of the second locus for autosomal dominant cerebellar ataxia (SCA2) to chromosome 12q23–24.1
  154. Expression of transfected stathmin cDNA reveals novel phosphorylated forms associated with developmental and functional cell regulation
  155. Stathmin Phosphorylation Is Regulated in Striatal Neurons by Vasoactive Intestinal Peptide and Monoamines via Multiple Intracellular Pathways
  156. Cyclic AMP Accumulation Induces a Rapid Desensitization of the Cyclic AMP-Dependent Protein Kinase in Mouse Striatal Neurons
  157. Stathmin phosphorylation patterns discriminate between distinct transduction pathways of human T lymphocyte activation through CD2 triggering
  158. Dopamine-induced homologous and heterologous desensitizations of adenylate cyclase-coupled receptors on striatal neurons
  159. CD2 triggers protein phosphorylations related to proliferation in PKC-down regulated human T lymphocytes
  160. Stathmin Is a Major Phosphoprotein and Cyclic AMP-Dependent Protein Kinase Substrate in Mouse Brain Neurons but Not in Astrocytes in Culture: Regulation During Ontogenesis
  161. Cyclic AMP reduces adhesion of isolated neuronal growth cones from developing rat forebrain to an astrocytic cell line from embryonic mouse striatum
  162. Cyclic-amp dependent protein kinase in mouse striatal neurones and astrocytes in primary culture: development, subcellular distribution and stimulation of endogenous phosphorylation
  163. Somatostatin receptors on cortical neurones and adenohypophysis: comparison between specific binding and adenylate cyclase inhibition
  164. Two simian virus 40 (SV40)-transformed cell lines from the mouse striatum and mesencephalon presenting astrocytic characters. I. Immunological and pharmacological properties
  165. Modulation by Monoamines of Somatostatin-Sensitive Adenylate Cyclase on Neuronal and Glial Cells from the Mouse Brain in Primary Cultures
  166. Vasoactive Intestinal Polypeptide Receptors Linked to an Adenylate Cyclase, and Their Relationship with Biogenic Amine- and Somatostatin-Sensitive Adenylate Cyclases on Central Neuronal and Glial Cells in Primary Cultures
  167. VIP and secretin receptors linked to an adenylate cyclase on central neuronal and glial cells in primary cultures
  168. Biogenic amine-sensitive adenylate cyclases in primary culture of neuronal or glial cells from mesencephalon