All Stories

  1. Use of oxygen-loaded nanobubbles to improve tissue oxygenation: Bone-relevant mechanisms of action and effects on osteoclast differentiation

    Article • Biomaterials, March 2024, Elsevier

    Dr Helen J Knowles

  2. A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups

    Article • Cells, December 2022, MDPI AG

    Dr Helen J Knowles

  3. Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone

    Article • Cell Death and Differentiation, August 2022, Springer Science + Business Media

    Dr Helen J Knowles

  4. Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function

    Article • Scientific Reports, December 2020, Springer Science + Business Media

    Dr Helen J Knowles

  5. Osteoblast–Osteoclast Coculture Amplifies Inhibitory Effects of FG‐4592 on Human Osteoclastogenesis and Reduces Bone Resorption

    Article • JBMR Plus, May 2020, Oxford University Press (OUP)

    Dr Helen J Knowles

  6. Osteoblast-osteoclast co-culture amplifies inhibitory effects of FG-4592 on osteoclast formation and reduces bone resorption activity

    Article • December 2019, Cold Spring Harbor Laboratory Press

    Dr Helen J Knowles

  7. Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

    Article • Nature Communications, October 2019, Springer Science + Business Media

    Dr Helen J Knowles

  8. The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments

    Article • Cells, June 2019, MDPI AG

    Dr Helen J Knowles

  9. BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

    Article • Proceedings of the National Academy of Sciences, August 2018, Proceedings of the National Academy of Sciences

    Dr Helen J Knowles

  10. Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis

    Article • BMC Cancer, May 2018, Springer Science + Business Media

    Dr Helen J Knowles

  11. Hypoxia‐inducible factor 1‐alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl‐4‐hydroxylase 2

    Article • The Journal of Pathology, May 2017, Wiley

    Dr Helen J Knowles

  12. Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone

    Article • Calcified Tissue International, January 2017, Springer Science + Business Media

    Dr Helen J Knowles

  13. Hypoxic regulation of osteoclasts

    Article • Hypoxia, November 2015, Dove Medical Press

    Dr Helen J Knowles

  14. Angiopoietin-Like 4 Is Over-Expressed in Rheumatoid Arthritis Patients: Association with Pathological Bone Resorption

    Article • PLOS One, October 2014, PLOS

    Dr Helen J Knowles

  15. Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure

    Article • Cell Death and Disease, February 2014, Springer Science + Business Media

    Dr Helen J Knowles

  16. Investigation of osteoclastogenic signalling of the RANKL substitute LIGHT

    Article • Experimental and Molecular Pathology, April 2013, Elsevier

    Dr Helen J Knowles

  17. Differential regulation of HIF ‐mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts

    Article • The Journal of Pathology, March 2013, Wiley

    Dr Helen J Knowles

  18. KRAS p.G13D mutations are associated with sensitivity to anti-EGFR antibody treatment in colorectal cancer cell lines

    Article • Journal of Cancer Research and Clinical Oncology, September 2012, Springer Science + Business Media

    Dr Helen J Knowles

  19. VEGF, FLT3 ligand, PlGF and HGF can substitute for M-CSF to induce human osteoclast formation: implications for giant cell tumour pathobiology

    Article • Laboratory Investigation, August 2012, Springer Science + Business Media

    Dr Helen J Knowles

  20. Chondroclasts are mature osteoclasts which are capable of cartilage matrix resorption

    Article • Virchows Archiv, July 2012, Springer Science + Business Media

    Dr Helen J Knowles

  21. CD14− mononuclear stromal cells support (CD14+) monocyte–osteoclast differentiation in aneurysmal bone cyst

    Article • Laboratory Investigation, February 2012, Springer Science + Business Media

    Dr Helen J Knowles

  22. The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease

    Article • Clinical Sarcoma Research, January 2012, Springer Science + Business Media

    Dr Helen J Knowles, Professor Pancras C.W. Hogendoorn

  23. In Vitro Generation of Mature Human Osteoclasts

    Article • Calcified Tissue International, September 2011, Springer Science + Business Media

    Dr Helen J Knowles

  24. Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone

    Article • Histopathology, September 2011, Wiley

    Dr Helen J Knowles

  25. Osteoclast formation and function in pigmented villonodular synovitis

    Article • The Journal of Pathology, June 2011, Wiley

    Dr Helen J Knowles

  26. Ewing sarcoma cells express RANKL and support osteoclastogenesis

    Article • The Journal of Pathology, May 2011, Wiley

    Dr Helen J Knowles

  27. RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II

    Article • Bone, April 2011, Elsevier

    Dr Helen J Knowles

  28. Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4

    Article • The FASEB Journal, December 2010, Federation of American Societies For Experimental Biology (FASEB)

    Dr Helen J Knowles

  29. Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor

    Article • BMC Cancer, July 2010, Springer Science + Business Media

    Dr Helen J Knowles

  30. Ewing's Sarcoma Cells Promote Osteoclast Formation

    Article • Bone, March 2010, Elsevier

    Dr Helen J Knowles

  31. Hypoxia-Inducible Factor (HIF) regulates Osteoclast-Mediated Bone Resorption via Angiopoietin-like 4 (ANGPTL4)

    Article • Bone, March 2010, Elsevier

    Dr Helen J Knowles

  32. Tendinopathy and tears of the rotator cuff are associated with hypoxia and apoptosis

    Article • Journal of Bone and Joint Surgery - British Volume, March 2010, Bone & Joint

    Dr Helen J Knowles

  33. Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis

    Article • The Journal of Pathology, June 2009, Wiley

    Dr Helen J Knowles

  34. Effects of hypoxia on osteoclast formation and function: A balance between enhanced resorptive activity and increased apoptosis

    Article • Bone, March 2008, Elsevier

    Dr Helen J Knowles

  35. Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte–osteoclast differentiation via induction of VEGF

    Article • The Journal of Pathology, January 2008, Wiley

    Dr Helen J Knowles

  36. Macrophages and the hypoxic tumour microenvironment

    Article • Frontiers in Bioscience, January 2007, Frontiers in Bioscience

    Dr Helen J Knowles

  37. Normoxic Stabilization of Hypoxia-Inducible Factor-1α by Modulation of the Labile Iron Pool in Differentiating U937 Macrophages: Effect of Natural Resistance–Associated Macrophage Protein 1

    Article • Cancer Research, March 2006, American Association for Cancer Research (AACR)

    Dr Helen J Knowles

  38. Niacin induces PPARγ expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways

    Article • Biochemical Pharmacology, February 2006, Elsevier

    Dr Helen J Knowles

  39. Novel Mechanism of Action for Hydralazine

    Article • Circulation Research, July 2004, Wolters Kluwer Health

    Dr Helen J Knowles

  40. Hypoxia and oxidative stress in breast cancer Hypoxia and tumourigenesis

    Article • Breast Cancer Research, July 2001, Springer Science + Business Media

    Dr Helen J Knowles

  41. Macrophage Infiltration and Angiogenesis in Human Malignancy

    Article • Wiley

    Dr Helen J Knowles