All Stories

  1. Different effect of media opacity on automated and manual measurement of foveal avascular zone of optical coherence tomography angiographies

    Article • British Journal of Ophthalmology, July 2020, BMJ

    Haoyu Chen

  2. Ellipsoid zone optical intensity reduction as an early biomarker for retinitis pigmentosa

    Article • Acta Ophthalmologica, July 2020, Wiley

    Haoyu Chen

  3. The Healing Process and Functional Recovery of Neuroretina after Idiopathic Macular Hole Surgery without Internal Limiting Membrane Reversal Tamponade

    Article • Journal of Ophthalmology, May 2020, Hindawi Publishing Corporation

    Haoyu Chen

  4. Reduced photoreceptor outer segment layer thickness in mild commotio retinae without ellipsoid zone disruption

    Article • Graefe s Archive for Clinical and Experimental Ophthalmology, April 2020, Springer Science + Business Media

    Haoyu Chen

  5. Identification of TIE2 as a susceptibility gene for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

    Article • British Journal of Ophthalmology, March 2020, BMJ

    Haoyu Chen

  6. Reliability of foveal avascular zone metrics automatically measured by Cirrus optical coherence tomography angiography in healthy subjects

    Article • International Ophthalmology, December 2019, Springer Science + Business Media

    Haoyu Chen

  7. Response to Comment on: Quantification of anterior chamber reaction after intravitreal injections of conbercept and ranibizumab: a pilot study

    Article • Eye, October 2019, Springer Science + Business Media

    Haoyu Chen

  8. Prognostic factors associated with visual outcome of salvageable eyes with posttraumatic endophthalmitis

    Article • Scientific Reports, September 2019, Springer Science + Business Media

    Haoyu Chen

  9. Quantification of anterior chamber reaction after intravitreal injections of conbercept and ranibizumab: a pilot study

    Article • Eye, July 2019, Springer Science + Business Media

    Haoyu Chen

  10. Whole exome sequencing identifies novel USH2A mutations and confirms Usher syndrome 2 diagnosis in Chinese retinitis pigmentosa patients

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Prof. Tsz Kin Ng, Haoyu Chen

  11. Intravitreal Injection of Hydrogen Peroxide Induces Acute Retinal Degeneration, Apoptosis, and Oxidative Stress in Mice

    Article • Oxidative Medicine and Cellular Longevity, November 2018, Hindawi Publishing Corporation

    Haoyu Chen, Prof. Tsz Kin Ng

  12. Macular Pigment Optical Density Measured by a Single Wavelength Reflection Photometry with and without Mydriasis

    Article • Current Eye Research, October 2018, Taylor & Francis

    Haoyu Chen

  13. Tractional Descemet’s membrane detachment after ocular alkali burns: case reports and review of literature

    Article • BMC Ophthalmology, September 2018, Springer Science + Business Media

    Haoyu Chen

  14. Association of coding and UTR variants in the known regions with wet age-related macular degeneration in Han Chinese population

    Article • Journal of Human Genetics, July 2018, Springer Science + Business Media

    Haoyu Chen

  15. Relationship between Optical Intensity on Optical Coherence Tomography and Retinal Ischemia in Branch Retinal Vein Occlusion

    Article • Scientific Reports, June 2018, Springer Science + Business Media

    Haoyu Chen

  16. Prevalence and risk factors for diabetic retinopathy in China: a multi-hospital-based cross-sectional study

    Article • British Journal of Ophthalmology, August 2017, BMJ

    Haoyu Chen

  17. Automated framework for intraretinal cystoid macular edema segmentation in three-dimensional optical coherence tomography images with macular hole

    Article • Journal of Biomedical Optics, July 2017, SPIE

    Haoyu Chen

  18. Reply

    Article • Retina, May 2017, Wolters Kluwer Health

    Haoyu Chen

  19. Automated boundary segmentation and wound analysis for longitudinal corneal OCT images

    Article • March 2017, SPIE

    Haoyu Chen

  20. Longitudinal Evaluation of Wound Healing after Penetrating Corneal Injury: Anterior Segment Optical Coherence Tomography Study

    Article • Current Eye Research, February 2017, Taylor & Francis

    Haoyu Chen

  21. Graph search: active appearance model based automated segmentation of retinal layers for optic nerve head centered OCT images

    Article • February 2017, SPIE

    Haoyu Chen

  22. Nonrigid registration of 3D longitudinal optical coherence tomography volumes with choroidal neovascularization

    Article • February 2017, SPIE

    Haoyu Chen, Professor Dehui Xiang

  23. Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations

    Article • Investigative Ophthalmology & Visual Science, February 2017, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  24. 3D Choroid Neovascularization Growth Prediction with Combined Hyperelastic Biomechanical Model and Reaction-Diffusion Model

    Article • January 2017, Springer Science + Business Media

    Haoyu Chen

  25. Choroid Neovascularization Growth Prediction with Treatment Based on Reaction-Diffusion Model in 3D OCT Images

    Article • IEEE Journal of Biomedical and Health Informatics, January 2017, Institute of Electrical & Electronics Engineers (IEEE)

    Haoyu Chen

  26. A Framework for Classification and Segmentation of Branch Retinal Artery Occlusion in SD-OCT

    Article • IEEE Transactions on Image Processing, January 2017, Institute of Electrical & Electronics Engineers (IEEE)

    Haoyu Chen

  27. Reduced Macular Vascular Density in Myopic Eyes

    Article • Chinese Medical Journal, January 2017, Medknow

    Haoyu Chen

  28. Change in flash visual evoked potentials in New Zealand albino rabbits after sub-tenon’s anesthesia

    Article • Cutaneous and Ocular Toxicology, December 2016, Taylor & Francis

    Haoyu Chen

  29. Protective effects of an HTRA1 insertion–deletion variant against age-related macular degeneration in the Chinese populations

    Article • Laboratory Investigation, November 2016, Nature

    Haoyu Chen, Prof. Tsz Kin Ng

  30. Severe Traumatic Eyes with No Light Perception

    Article • November 2016, Springer Science + Business Media

    Haoyu Chen

  31. Association of ABCG1 With Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Chinese and Japanese

    Article • Investigative Ophthalmology & Visual Science, October 2016, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  32. Repeatability, reproducibility and agreement of intraocular pressure measurement in rabbits by the TonoVet and Tono-Pen

    Article • Scientific Reports, October 2016, Nature

    Haoyu Chen

  33. CORRELATION OF OPTICAL INTENSITY ON OPTICAL COHERENCE TOMOGRAPHY AND VISUAL OUTCOME IN CENTRAL RETINAL ARTERY OCCLUSION

    Article • Retina, October 2016, Wolters Kluwer Health

    Haoyu Chen

  34. Change of Optical Intensity during Healing Process of Corneal Wound on Anterior Segment Optical Coherence Tomography

    Article • Scientific Reports, August 2016, Nature

    Haoyu Chen

  35. HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration

    Article • Scientific Reports, June 2016, Nature

    Haoyu Chen, Prof. Tsz Kin Ng

  36. Risk factors for endophthalmitis requiring evisceration or enucleation

    Article • Scientific Reports, June 2016, Nature

    Haoyu Chen

  37. Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts

    Article • PLoS Genetics, June 2016, PLOS

    Haoyu Chen, Prof. Tsz Kin Ng

  38. Automatic Three-dimensional Detection of Photoreceptor Ellipsoid Zone Disruption Caused by Trauma in the OCT

    Article • Scientific Reports, May 2016, Nature

    Haoyu Chen

  39. A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

    Article • Nature Genetics, April 2016, Nature

    Haoyu Chen

  40. Identification ofPGFas a New Gene for Neovascular Age-Related Macular Degeneration in a Chinese Population

    Article • Investigative Ophthalmology & Visual Science, April 2016, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  41. 3D choroid neovascularization growth prediction based on reaction-diffusion model

    Article • March 2016, SPIE

    Haoyu Chen

  42. A framework for classification and segmentation of branch retinal artery occlusion in SD-OCT

    Article • March 2016, SPIE

    Haoyu Chen

  43. An automated framework for 3D serous pigment epithelium detachment segmentation in SD-OCT images

    Article • Scientific Reports, February 2016, Nature

    Professor Dehui Xiang, Haoyu Chen

  44. Optical Intensities of Different Compartments of Subretinal Fluid in Acute Vogt-Koyanagi-Harada Disease

    Article • PLoS ONE, February 2016, PLOS

    Haoyu Chen

  45. Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical Coherence Tomography

    Article • PLoS ONE, February 2016, PLOS

    Professor Dehui Xiang, Haoyu Chen

  46. Association of Genetic Variants with Polypoidal Choroidal Vasculopathy

    Article • Ophthalmology, September 2015, Elsevier

    Haoyu Chen

  47. Prediction of spontaneous closure of traumatic macular hole with spectral domain optical coherence tomography

    Article • Scientific Reports, July 2015, Nature

    Haoyu Chen

  48. Comparison of Retinal Thickness Measurements between the Topcon Algorithm and a Graph-Based Algorithm in Normal and Glaucoma Eyes

    Article • PLoS ONE, June 2015, PLOS

    Professor Dehui Xiang, Haoyu Chen

  49. Automated segmentation of intraretinal cystoid macular edema for retinal 3D OCT images with macular hole

    Article • April 2015, Institute of Electrical & Electronics Engineers (IEEE)

    Haoyu Chen

  50. Association of PEDF polymorphisms with age-related macular degeneration and polypoidal choroidal vasculopathy: a systematic review and meta-analysis

    Article • Scientific Reports, March 2015, Nature

    Haoyu Chen

  51. Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians

    Article • Nature Communications, March 2015, Nature

    Haoyu Chen

  52. Automated segmentation of serous pigment epithelium detachment in SD-OCT images

    Article • March 2015, SPIE

    Professor Dehui Xiang, Haoyu Chen

  53. Automatic choroid cells segmentation and counting based on approximate convexity and concavity of chain code in fluorescence microscopic image

    Article • March 2015, SPIE

    Haoyu Chen

  54. Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography for central retinal artery occlusion

    Article • Scientific Reports, March 2015, Nature

    Professor Dehui Xiang, Haoyu Chen

  55. Automated 3-D Retinal Layer Segmentation of Macular Optical Coherence Tomography Images With Serous Pigment Epithelial Detachments

    Article • IEEE Transactions on Medical Imaging, February 2015, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Dehui Xiang, Haoyu Chen

  56. New loci and coding variants confer risk for age-related macular degeneration in East Asians

    Article • Nature Communications, January 2015, Nature

    Haoyu Chen

  57. Antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation

    Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

    Haoyu Chen, Prof. Tsz Kin Ng

  58. Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: A Systematic Review and Meta-analysis

    Article • Scientific Reports, November 2014, Nature

    Haoyu Chen

  59. Rapid and cost-effective molecular diagnosis using exome sequencing of one proband with autosomal dominant congenital cataract

    Article • Eye, October 2014, Nature

    Haoyu Chen

  60. Comparison of retinal thickness measurements of normal eyes between topcon algorithm and a graph based algorithm

    Article • September 2014, The University of Iowa

    Haoyu Chen

  61. Serological Association of Chlamydia pneumoniae Infection with Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

    Article • PLoS ONE, July 2014, PLOS

    Haoyu Chen

  62. Comparison of the optical coherence tomographic characters between acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy

    Article • BMC Ophthalmology, June 2014, Springer Science + Business Media

    Haoyu Chen

  63. A framework for retinal layer intensity analysis for retinal artery occlusion patient based on 3D OCT

    Article • March 2014, SPIE

    Haoyu Chen

  64. Support vector machine based IS/OS disruption detection from SD-OCT images

    Article • March 2014, SPIE

    Professor Dehui Xiang, Haoyu Chen

  65. Multimodal retinal imaging in a Chinese kindred with familial amyloid polyneuropathy secondary to transthyretin Ile107Met mutation

    Article • Eye, January 2014, Nature

    Haoyu Chen

  66. Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography

    Article • Investigative Ophthalmology & Visual Science, October 2013, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  67. Publication Times, Impact Factors, and Advance Online Publication in Ophthalmology Journals

    Article • Ophthalmology, August 2013, Elsevier

    Haoyu Chen

  68. PREDICTION OF VISUAL PROGNOSIS WITH SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IN OUTER RETINAL ATROPHY SECONDARY TO CLOSED GLOBE TRAUMA

    Article • Retina, June 2013, Wolters Kluwer Health

    Haoyu Chen

  69. A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population

    Article • Human Molecular Genetics, February 2013, Oxford University Press (OUP)

    Haoyu Chen

  70. Comparison of Pterygium Recurrence Rates After Limbal Conjunctival Autograft Transplantation and Other Techniques

    Article • Cornea, December 2012, Wolters Kluwer Health

    Haoyu Chen

  71. Survey of systematic reviews and meta-analyses published in ophthalmology

    Article • British Journal of Ophthalmology, March 2012, BMJ

    Haoyu Chen

  72. Interactive Effects ofATOH7andRFTN1in Association with Adult-Onset Primary Open-Angle Glaucoma

    Article • Investigative Ophthalmology & Visual Science, February 2012, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen

  73. MIDTERM RESULTS OF LOW-DOSE INTRAVITREAL TRIAMCINOLONE AS ADJUNCTIVE TREATMENT FOR PROLIFERATIVE VITREORETINOPATHY

    Article • Retina, June 2011, Wolters Kluwer Health

    Haoyu Chen

  74. Interactive Expressions of HtrA1 and VEGF in Human Vitreous Humors and Fetal RPE Cells

    Article • Investigative Ophthalmology & Visual Science, May 2011, Association for Research in Vision and Ophthalmology (ARVO)

    Haoyu Chen, Prof. Tsz Kin Ng

  75. Imaging inadvertent Desçemet's membrane break secondary to cataract surgery

    Article • Clinical and Experimental Optometry, September 2010, Wiley

    Haoyu Chen

  76. Genetic and Functional Dissection of HTRA1 and LOC387715 in Age-Related Macular Degeneration

    Article • PLoS Genetics, February 2010, PLOS

    Professor Ruifu Yang, Haoyu Chen

  77. Slit-Robo Signaling in Ocular Angiogenesis

    Article • December 2009, Springer Science + Business Media

    Haoyu Chen

  78. Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

    Article • Nature, October 2009, Nature

    Haoyu Chen

  79. Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados

    Article • Proceedings of the National Academy of Sciences, October 2009, Proceedings of the National Academy of Sciences

    Haoyu Chen

  80. Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice

    Article • Journal of Clinical Investigation, May 2009, American Society for Clinical Investigation

    Haoyu Chen

  81. Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration

    Article • New England Journal of Medicine, October 2008, New England Journal of Medicine (NEJM/MMS)

    Haoyu Chen

  82. Genetic susceptibility of diabetic retinopathy

    Article • Current Diabetes Reports, August 2008, Springer Science + Business Media

    Haoyu Chen

  83. Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice

    Article • Journal of Clinical Investigation, July 2008, American Society for Clinical Investigation

    Haoyu Chen, Professor David M Hunt

  84. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications

    Article • Proceedings of the National Academy of Sciences, May 2008, Proceedings of the National Academy of Sciences

    Dr Rola N Hamam, Haoyu Chen

  85. Corrigendum: Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

    Article • Nature Medicine, May 2008, Nature

    Haoyu Chen

  86. Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

    Article • Nature Medicine, March 2008, Nature

    Haoyu Chen

  87. Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort

    Article • Cell Cycle, February 2008, Taylor & Francis

    Haoyu Chen

  88. Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration

    Article • Vision Research, February 2008, Elsevier

    Haoyu Chen

  89. Familial aggregation of age-related macular degeneration in the Utah population

    Article • Vision Research, February 2008, Elsevier

    Haoyu Chen

  90. Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration

    Article • Vision Research, February 2008, Elsevier

    Haoyu Chen

  91. 10q26 Is Associated with Increased Risk of Age-Related Macular Degeneration in the Utah Population

    Article • January 2008, Springer Science + Business Media

    Haoyu Chen

  92. HTRA1 Variant Confers Similar Risks to Geographic Atrophy and Neovascular Age-related Macular Degeneration

    Article • Cell Cycle, May 2007, Taylor & Francis

    Haoyu Chen

  93. Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice

    Article • Vision Research, March 2007, Elsevier

    Haoyu Chen

  94. Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival

    Article • International Journal of Biological Sciences, January 2007, Ivyspring International Publisher

    Haoyu Chen

  95. A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration

    Article • Science, November 2006, American Association for the Advancement of Science

    Haoyu Chen