All Stories

  1. Effects of repeated weight cycling on non‐alcoholic steatohepatitis in diet‐induced obese mice

    Article • The FASEB Journal, April 2024, Wiley

    Dr Hans M Princen

  2. A systems toxicology approach for identification of disruptions in cholesterol homeostasis after aggregated exposure to mixtures of perfluorinated compounds in humans

    Article • Toxicological Sciences, January 2024, Oxford University Press (OUP)

    Dr Hans M Princen

  3. Intensive cholesterol-lowering treatment reduces synovial inflammation during early collagenase-induced osteoarthritis, but not pathology at end-stage disease in female dyslipidemic E3L.CETP mice

    Article • Osteoarthritis and Cartilage, July 2023, Elsevier

    Dr Hans M Princen

  4. Proof-of-concept study for liver-directed miQURE technology in a dyslipidemic mouse model

    Article • Molecular Therapy — Nucleic Acids, June 2023, Elsevier

    Dr Hans M Princen

  5. Semaglutide Has Beneficial Effects on Non-Alcoholic Steatohepatitis in Ldlr-/-.Leiden Mice

    Article • International Journal of Molecular Sciences, May 2023, MDPI AG

    Dr Hans M Princen

  6. Atorvastatin Attenuates Diet-Induced Non-Alcoholic Steatohepatitis in APOE*3-Leiden Mice by Reducing Hepatic Inflammation

    Article • International Journal of Molecular Sciences, April 2023, MDPI AG

    Dr Hans M Princen

  7. IL-1β inhibition combined with cholesterol-lowering therapies decreases synovial lining thickness and spontaneous cartilage degeneration in a humanized dyslipidemia mouse model

    Article • Osteoarthritis and Cartilage, March 2023, Elsevier

    Dr Hans M Princen

  8. A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo

    Article • Journal of Lipid Research, November 2022, Elsevier

    Dr Hans M Princen

  9. The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis

    Article • British Journal of Pharmacology, July 2022, Wiley

    Dr Hans M Princen

  10. Novel high-intensive cholesterol-lowering therapies do not ameliorate knee OA development in humanized dyslipidemic mice

    Article • Osteoarthritis and Cartilage, September 2021, Elsevier

    Dr Hans M Princen

  11. Chronic Oral Administration of Mineral Oil Compared With Corn Oil: Effects on Gut Permeability and Plasma Inflammatory and Lipid Biomarkers

    Article • Frontiers in Pharmacology, August 2021, Frontiers

    Dr Hans M Princen

  12. Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs

    Article • European Journal of Pharmaceutical Sciences, June 2021, Elsevier

    Dr Hans M Princen

  13. Common Variants Associated With OSMR Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans

    Article • Frontiers in Cardiovascular Medicine, April 2021, Frontiers

    Dr Hans M Princen

  14. Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?

    Article • Critical Reviews in Toxicology, April 2021, Taylor & Francis

    Dr Hans M Princen

  15. Beneficial effects of elafibranor on NASH in E3L.CETP mice and differences between mice and men

    Article • Scientific Reports, March 2021, Springer Science + Business Media

    Dr Hans M Princen

  16. No effects of PCSK9-inhibitor treatment on spatial learning, locomotor activity, and novel object recognition in mice

    Article • Behavioural Brain Research, January 2021, Elsevier

    Dr Hans M Princen

  17. Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering

    Article • Basic Research in Cardiology, December 2020, Springer Science + Business Media

    Dr Hans M Princen

  18. In Vivo Magnetic Resonance Imaging‐Based Detection of Heterogeneous Endothelial Response in Thoracic and Abdominal Aorta to Short‐Term High‐Fat Diet Ascribed to Differences in Perivascular Adipose Tissue in Mice

    Article • Journal of the American Heart Association, November 2020, Wolters Kluwer Health

    Dr Hans M Princen

  19. Effects of Inhibition or Deletion of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) on Intracerebral Hemorrhage Volumes in Mice

    Article • Stroke, November 2020, Wolters Kluwer Health

    Dr Hans M Princen

  20. Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative

    Article • Liver International, October 2020, Wiley

    Dr Hans M Princen

  21. Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice

    Article • Hepatology Communications, December 2019, Wiley

    Dr Hans M Princen

  22. Triple therapy to treat atherosclerosis

    Article • Journal of Lipid Research, December 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Hans M Princen

  23. Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans

    Article • PLoS ONE, August 2019, PLOS

    Dr Hans M Princen

  24. The Structurally Engineered Fatty Acid Icosabutate Improves Lipid Metabolism And Reduces Severity Of Atherogenesis In Mice

    Article • Atherosclerosis, August 2019, Elsevier

    Dr Hans M Princen

  25. Triple Treatment With Alirocumab And Evinacumab On Top Of Atorvastatin Regresses Lesion Size And Improves Plaque Phenotype In Apoe*3leiden.Cetp Mice

    Article • Atherosclerosis, August 2019, Elsevier

    Dr Hans M Princen

  26. Anti-PCSK9 antibodies inhibit pro-atherogenic mechanisms in APOE*3Leiden.CETP mice

    Article • Scientific Reports, July 2019, Springer Science + Business Media

    Dr Hans M Princen

  27. FRI0528 HIGH INTENSIVE THERAPEUTIC LOWERING OF SYSTEMIC CHOLESTEROL DOES NOT AMELIORATE OA DEVELOPMENT IN KNEE JOINTS OF HUMANIZED DYSLIPIDEMIC MICE

    Article • June 2019, BMJ

    Dr Hans M Princen

  28. Common variants associated with OSMR expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humans

    Article • March 2019, Cold Spring Harbor Laboratory Press

    Dr Hans M Princen

  29. The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

    Article • Journal of Diabetes Research, February 2019, Hindawi Publishing Corporation

    Dr Hans M Princen

  30. Dose Effects of Ammonium Perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP Mice

    Article • Toxicological Sciences, January 2019, Oxford University Press (OUP)

    Dr Hans M Princen

  31. Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice

    Article • PLoS ONE, October 2018, PLOS

    Dr Hans M Princen

  32. The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model

    Article • Frontiers in Cardiovascular Medicine, June 2018, Frontiers

    Dr Hans M Princen

  33. Elafibranor Reverses Nonalcoholic Steatohepatitis and Blocks Progression of Fibrosis in APOE*3.Leiden.CETP Mice

    Article • Atherosclerosis Supplements, June 2018, Elsevier

    Dr Hans M Princen

  34. Inflammatory Cytokine Oncostatin M Induces Endothelial Activation in vitro and in APOE*3Leiden.CETP Mice

    Article • Atherosclerosis Supplements, June 2018, Elsevier

    Dr Hans M Princen

  35. Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings

    Article • Amino Acids, May 2018, Springer Science + Business Media

    Dr Hans M Princen

  36. Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought

    Article • Osteoarthritis and Cartilage, January 2018, Elsevier

    Dr Hans M Princen

  37. Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis

    Article • Atherosclerosis, December 2017, Elsevier

    Dr Hans M Princen

  38. Cardiovascular safety of BCR-ABL1 tyrosine kinase inhibitors: imatinib and ponatinib decrease plasma cholesterol and atherosclerosis in APOE3*Leiden.CETP Mice

    Article • Atherosclerosis, August 2017, Elsevier

    Dr Hans M Princen

  39. Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, July 2017, New England Journal of Medicine (NEJM/MMS)

    Dr Hans M Princen

  40. The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice

    Article • European Heart Journal, June 2017, Oxford University Press (OUP)

    Günther Staffler, Dr Hans M Princen

  41. Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase

    Article • Atherosclerosis, January 2017, Elsevier

    Dr Hans M Princen

  42. Affitope-based anti-PCSK9 (proprotein convertase subtilisin/kexin type 9) vaccine (AT04A) reduces atherosclerosis in APOE*3Leiden.CETP mice

    Article • Atherosclerosis, September 2016, Elsevier

    Dr Hans M Princen

  43. The APOE*3Leiden.GK +/- mouse as novel translational model for dyslipidemia, type 2 diabetes and macrovascular complications

    Article • Atherosclerosis, September 2016, Elsevier

    Dr Hans M Princen

  44. Comment on “Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice” by Rebholz S.L. et al. Toxicol. Rep. 2016 (3) 46–54

    Article • Toxicology Reports, January 2016, Elsevier

    Dr Hans M Princen

  45. Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes

    Article • British Journal of Pharmacology, October 2015, Wiley

    Dr Hans M Princen

  46. Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9

    Article • Journal of Lipid Research, September 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Hans M Princen

  47. Treatment of cardiovascular disease: contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raising

    Article • European Journal of Pharmacology, September 2015, Elsevier

    Dr Hans M Princen

  48. No effects of atorvastatin (10mg/d or 80mg/d) on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study

    Article • Pharmacological Research, April 2015, Elsevier

    Dr Hans M Princen

  49. PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE

    Article • Journal of Lipid Research, September 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Hans M Princen

  50. Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin

    Article • European Heart Journal, August 2014, European Society of Cardiology

    Dr Hans M Princen

  51. Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin

    Article • Journal of Lipid Research, August 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Hans M Princen

  52. Alirocumab, monoclonal antibody to PCSK9, dose-dependently decreases atherosclerosis, improves plaque stability and shows additive effects with atorvastatin in apoe*3leiden.cetp mice

    Article • Atherosclerosis, August 2014, Elsevier

    Dr Hans M Princen

  53. APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome

    Article • Diabetes Obesity and Metabolism, January 2014, Wiley

    Dr Hans M Princen

  54. Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice

    Article • Diabetes, November 2013, American Diabetes Association

    Dr Hans M Princen

  55. Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice

    Article • The Journal of Nutritional Biochemistry, August 2013, Elsevier

    Dr Hans M Princen

  56. Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol

    Article • PLoS ONE, June 2013, PLOS

    Dr Hans M Princen

  57. Both Transient and Continuous Corticosterone Excess Inhibit Atherosclerotic Plaque Formation in APOE*3-Leiden.CETP Mice

    Article • PLoS ONE, May 2013, PLOS

    Dr Hans M Princen

  58. Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice--a translational model for atherosclerosis

    Article • Annals of the Rheumatic Diseases, April 2013, BMJ

    Dr Hans M Princen

  59. Osteoarthritis development is induced by increased dietary cholesterol in APOE*3Leiden.CETP mice, a translational model for atherosclerosis, and can be inhibited by atorvastatin

    Article • Osteoarthritis and Cartilage, April 2013, Elsevier

    Dr Hans M Princen

  60. Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion

    Article • Journal of Lipid Research, February 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Hans M Princen

  61. Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice

    Article • Biochemical Pharmacology, September 2012, Elsevier

    Dr Hans M Princen

  62. P40—Perfluorohexanesulfonate and perfluorooctanesulfonate decrease plasma cholesterol and triglycerides in APOE*3LEIDEN.CETP mice by reducing VLDL production and increasing VLDL and HDL clearance

    Article • Reproductive Toxicology, July 2012, Elsevier

    Dr Hans M Princen

  63. P52—Distribution of perfluorooctanesulfonate and perfluorooctanoate into human plasma lipoprotein fractions over a wide range of concentrations

    Article • Reproductive Toxicology, July 2012, Elsevier

    Dr Hans M Princen

  64. Distribution of perfluorooctanesulfonate and perfluorooctanoate into human plasma lipoprotein fractions

    Article • Toxicology Letters, May 2012, Elsevier

    Dr Hans M Princen

  65. PO32 La réduction des VLDL-triglycerides plasmatiques par la metformine est due à une augmentation spécifique de leur clairance par le tissu adipeux brun chez la souris APOE*3-Leiden. CETP

    Article • Diabetes & Metabolism, March 2012, Elsevier

    Dr Hans M Princen

  66. Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin

    Article • Journal of Hypertension, January 2012, Wolters Kluwer Health

    Dr Hans M Princen

  67. PS16 - 80. VLDL-lowering effects of metformin in APOE*3-Leiden.CETP mice, a transgenic model for human-like lipoprotein metabolism

    Article • Nederlands Tijdschrift voor Diabetologie, November 2011, Springer Science + Business Media

    Dr Hans M Princen

  68. Perfluoroalkyl Sulfonates Cause Alkyl Chain Length-Dependent Hepatic Steatosis and Hypolipidemia Mainly by Impairing Lipoprotein Production in APOE*3-Leiden CETP Mice

    Article • Toxicological Sciences, June 2011, Oxford University Press (OUP)

    Dr Hans M Princen

  69. 172 NIACIN, ATORVASTATIN AND FENOFIBRATE DECREASE PLASMA CETP BY REDUCTION OF THE HEPATIC MACROPHAGE CONTENT IN APOE*3-LEIDEN.CETP MICE

    Article • Atherosclerosis Supplements, June 2011, Elsevier

    Dr Hans M Princen

  70. 181 ADDITIVE EFFECTS OF NIACIN ON TOP OF SIMVASTATIN TREATMENT IN REDUCING ATHEROSCLEROSIS IN APOE*3LEIDEN.CETP MICE

    Article • Atherosclerosis Supplements, June 2011, Elsevier

    Dr Hans M Princen

  71. 244 APOE*3LEIDEN.CETP TRANSGENIC MICE AS MODEL FOR THE METABOLIC SYNDROME

    Article • Atherosclerosis Supplements, June 2011, Elsevier

    Dr Hans M Princen

  72. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels

    Article • British Journal of Pharmacology, March 2011, Wiley

    Dr Hans M Princen

  73. P181 - Effets hypocholestérolémiants de la metformine chez la souris APOE*3-Leiden. CETP, un modèle transgénique au profil lipoprotéique humanisé

    Article • Diabetes & Metabolism, March 2011, Elsevier

    Dr Hans M Princen

  74. P28 RESVERATROL PROTECTS AGAINST ATHEROSCLEROSIS DEVELOPMENT IN APOE*3-LEIDEN.CETP MICE

    Article • Atherosclerosis Supplements, June 2010, Elsevier

    Dr Hans M Princen

  75. P70 THE EFFECT OF ALISKIREN ON ATHEROSCLEROSIS DEVELOPMENT IN APOE*3LEIDEN.CETP TRANSGENIC MICE WITH AND WITHOUT TREATMENT WITH ATORVASTATIN

    Article • Atherosclerosis Supplements, June 2010, Elsevier

    Dr Hans M Princen

  76. P328 APOE*3LEIDEN.CETP TRANSGENIC MICE AS MODEL FOR THE METABOLIC SYNDROME

    Article • Atherosclerosis Supplements, June 2010, Elsevier

    Dr Hans M Princen

  77. Fenofibrate Increases Very Low Density Lipoprotein Triglyceride Production Despite Reducing Plasma Triglyceride Levels in APOE*3-Leiden.CETP Mice

    Article • Journal of Biological Chemistry, May 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Hans M Princen

  78. Plasma pre β-HDL formation is decreased by atorvastatin treatment in type 2 diabetes mellitus: Role of phospholipid transfer protein

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, August 2009, Elsevier

    Dr Hans M Princen

  79. CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice

    Article • Journal of Lipid Research, June 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Hans M Princen

  80. Abstract: P982 PREGNANE X RECEPTOR AGONISM DECREASES PLASMA HDL LEVELS IN APOE*3-LEIDEN.CETP MICE

    Article • Atherosclerosis Supplements, June 2009, Elsevier

    Dr Hans M Princen

  81. Abstract: P984 PPAR Δ AGONIST GW501516 STRONGLY PREVENTS DEVELOPMENT OF ATHEROSCLEROSIS IN APOE*3LEIDEN MICE

    Article • Atherosclerosis Supplements, June 2009, Elsevier

    Dr Hans M Princen

  82. Abstract: P980 PERFLUOROHEXANESULFONATE AND PERFLUOROOCTANESULFONATE DECREASE PLASMA CHOLESTEROL AND TRIGLYCERIDES IN APOE*3LEIDEN.CETP MICE BY REDUCING VLDL PRODUCTION AND INCREASING VLDL AND HDL CLEARANCE

    Article • Atherosclerosis Supplements, June 2009, Elsevier

    Dr Hans M Princen

  83. Abstract: P479 RESVERATROL PROTECTS AGAINST ATHEROSCLEROSIS DEVELOPMENT IN APOE*3-LEIDEN.CETP MICE

    Article • Atherosclerosis Supplements, June 2009, Elsevier

    Dr Hans M Princen

  84. Abstract: P482 NOVEL LXR AGONIST AZ876 REDUCES ATHEROSCLEROSIS WITHOUT INCREASING TRIGLYCERIDES IN PLASMA AND LIVER

    Article • Atherosclerosis Supplements, June 2009, Elsevier

    Dr Hans M Princen

  85. Abstract: P201 APOE*3LEIDEN.CETP TRANSGENIC MICE AS MODEL FOR THE METABOLIC SYNDROME

    Article • Atherosclerosis Supplements, June 2009, Elsevier

    Dr Hans M Princen

  86. Abstract: P202 APOE*3LEIDEN-HCETP MICE AS MODEL TO UNRAVEL MECHANISMS UNDERLYING LIPID METABOLISM DISTURBANCES INDUCED BY HIV1 PROTEASE INHIBITORS

    Article • Atherosclerosis Supplements, June 2009, Elsevier

    Dr Hans M Princen

  87. Abstract: 533 BEXAROTENE INDUCES DYSLIPIDEMIA BY INCREASED VLDL PRODUCTION AND CETP-MEDIATED REDUCTION OF HDL

    Article • Atherosclerosis Supplements, June 2009, Elsevier

    Dr Hans M Princen

  88. Bexarotene Induces Dyslipidemia by Increased Very Low-Density Lipoprotein Production and Cholesteryl Ester Transfer Protein-Mediated Reduction of High-Density Lipoprotein

    Article • Endocrinology, May 2009, Endocrine Society

    Dr Hans M Princen

  89. The dual PPARα/γ agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice

    Article • British Journal of Pharmacology, March 2009, Wiley

    Dr Hans M Princen

  90. PXR agonism decreases plasma HDL levels in ApoE⁎3-Leiden.CETP mice

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, March 2009, Elsevier

    Dr Hans M Princen

  91. Preferential campesterol incorporation into various tissues in apolipoprotein E*3-Leiden mice consuming plant sterols or stanols

    Article • Metabolism, September 2008, Elsevier

    Dr Hans M Princen

  92. Negative effects of rofecoxib treatment on cardiac function after ischemia-reperfusion injury in APOE*3Leiden mice are prevented by combined treatment with thromboxane prostanoid-receptor antagonist S18886 (terutroban)*

    Article • Critical Care Medicine, September 2008, Wolters Kluwer Health

    Dr Hans M Princen

  93. Niacin Increases HDL by Reducing Hepatic Expression and Plasma Levels of Cholesteryl Ester Transfer Protein in APOE*3Leiden.CETP Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2008, Wolters Kluwer Health

    Dr Hans M Princen

  94. Torcetrapib Does Not Reduce Atherosclerosis Beyond Atorvastatin and Induces More Proinflammatory Lesions Than Atorvastatin

    Article • Circulation, May 2008, Wolters Kluwer Health

    Dr Hans M Princen

  95. DUAL PPAR-ALPHA/GAMMA AGONIST TESAGLITAZAR BLOCKS PROGRESSION OF PRE-EXISTING ATHEROSCLEROSIS IN APOE*3LEIDEN.CETP TRANSGENIC MICE

    Article • Atherosclerosis Supplements, May 2008, Elsevier

    Dr Hans M Princen

  96. The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus

    Article • European Journal of Internal Medicine, March 2008, Elsevier

    Dr Hans M Princen

  97. Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

    Article • Atherosclerosis, March 2008, Elsevier

    Dr Hans M Princen

  98. Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice

    Article • Journal of Hypertension, December 2007, Wolters Kluwer Health

    Dr Hans M Princen

  99. The Cholesterol-Raising Factor from Coffee Beans, Cafestol, as an Agonist Ligand for the Farnesoid and Pregnane X Receptors

    Article • Molecular Endocrinology, July 2007, Endocrine Society

    Dr Hans M Princen

  100. YI-792 NIACIN DECREASES PLASMA CHOLESTEROL AND TRIGLYCERIDES AND INCREASES HDL IN APOE*3LEIDEN. CETP TRANSGENIC MICE. REDUCED CETP LEVELS AND HEPATIC LIPASE ACTIVITY

    Article • Atherosclerosis Supplements, June 2007, Elsevier

    Dr Hans M Princen

  101. PO4-98 PERFLUOROHEXANESULFONATE AND PERFLUOROOCTANESULFONATE DECREASE PLASMA CHOLESTEROL AND TRIGLYCERIDES IN APOE*3LEIDEN TRANSGENIC MICE. INDICATION FOR A PPARα AGONIST MECHANISM

    Article • Atherosclerosis Supplements, June 2007, Elsevier

    Dr Hans M Princen

  102. PO10-274 RATIO OF PLASMA OXIDIZED LOW-DENSITY LIPOPROTEIN AND ANNEXIN A5 POSITIVELY RELATES TO SEVERITY OF CARDIOVASCULAR DISEASE

    Article • Atherosclerosis Supplements, June 2007, Elsevier

    Dr Hans M Princen

  103. Mouse Models for Atherosclerosis and Pharmaceutical Modifiers

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2007, Wolters Kluwer Health

    Dr Hans M Princen

  104. Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression

    Article • Journal of Lipid Research, May 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Hans M Princen

  105. Plasma annexin A5 level relates inversely to the severity of coronary stenosis

    Article • Biochemical and Biophysical Research Communications, May 2007, Elsevier

    Dr Hans M Princen

  106. Cholesterol 7 -Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Increases Hepatic ABCA1 mRNA Expression and HDL-Cholesterol

    Article • Arteriosclerosis Thrombosis and Vascular Biology, December 2006, Wolters Kluwer Health

    Dr Hans M Princen

  107. Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects

    Article • American Journal of Clinical Nutrition, December 2006, Oxford University Press (OUP)

    Dr Hans M Princen

  108. ID: 135 Products of limited elastase/cathepsin G degradation of fibrinogen as new biomarker in cardiovascular disease.

    Article • Journal of Thrombosis and Haemostasis, October 2006, Wiley

    Dr Hans M Princen

  109. Fenofibrate Reduces Atherogenesis in ApoE*3Leiden Mice: Evidence for Multiple Antiatherogenic Effects Besides Lowering Plasma Cholesterol

    Article • Arteriosclerosis Thrombosis and Vascular Biology, October 2006, Wolters Kluwer Health

    Dr Hans M Princen

  110. Fenofibrate reduces the development of atherosclerosis in ApoE⁎3-Leiden transgenic mice: Evidence for anti-atherogenic effects beyond cholesterol-lowering

    Article • Vascular Pharmacology, September 2006, Elsevier

    Dr Hans M Princen

  111. CETP expression decreases HDL and severely aggravates atherosclerosis in ApoE*⁎3-Leiden mice

    Article • Vascular Pharmacology, September 2006, Elsevier

    Dr Hans M Princen

  112. Fish Oil Increases Bile Acid Synthesis in Male Patients with Hypertriglyceridemia

    Article • Journal of Nutrition, April 2006, Oxford University Press (OUP)

    Dr Hans M Princen

  113. Anti-Atherosclerotic Effect of Amlodipine, Alone and in Combination With Atorvastatin, in APOE*3-Leiden/hCRP Transgenic Mice

    Article • Journal of Cardiovascular Pharmacology, January 2006, Wolters Kluwer Health

    Dr Hans M Princen

  114. Th-W61:2 Leptin deficiency in APOE*3Leiden transgenic mice. A new mouse model with combined insulin resistance and atherosclerosis

    Article • Atherosclerosis Supplements, January 2006, Elsevier

    Dr Hans M Princen

  115. Th-P16:263 Torcetrapib inhibits cholesteryl ester transfer protein and increases HDL in CTEP.ApoE*3-Leiden transgenic mice

    Article • Atherosclerosis Supplements, January 2006, Elsevier

    Dr Hans M Princen

  116. We-P11:215 The thromboxane receptor antagonist S 18886 (Terutroban) favored atherosclerosis regression in APOE*3 Leiden transgenic mice

    Article • Atherosclerosis Supplements, January 2006, Elsevier

    Dr Hans M Princen

  117. Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7α-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events

    Article • Clinical Science, June 2005, Portland Press Ltd.

    Dr Hans M Princen

  118. No Effect of C-Reactive Protein on Early Atherosclerosis Development in Apolipoprotein E*3-Leiden/Human C-Reactive Protein Transgenic Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2005, Wolters Kluwer Health

    Dr Hans M Princen

  119. Coffee Oil Consumption Increases Plasma Levels of 7α-Hydroxy-4-cholesten-3-one in Humans

    Article • Journal of Nutrition, April 2005, Oxford University Press (OUP)

    Dr Hans M Princen

  120. W12-P-082 Subjects presenting with clinical suspect symptoms for CAD but having normal angiogram and lipid profile exhibit elevated plasma oxidized LDL

    Article • Atherosclerosis Supplements, April 2005, Elsevier

    Dr Hans M Princen

  121. Modification of Low-Density Lipoprotein by Methylglyoxal Alters its Physico-Chemical and Biological Properties

    Article • January 2005, Elsevier

    Dr Hans M Princen

  122. Rosuvastatin Reduces Plasma Lipids by Inhibiting VLDL Production and Enhancing Hepatobiliary Lipid Excretion in ApoE*3-Leiden Mice

    Article • Journal of Cardiovascular Pharmacology, January 2005, Wolters Kluwer Health

    Dr Hans M Princen

  123. Absence of an atheroprotective effect of the garlic powder printanor in APOE*3-Leiden transgenic mice

    Article • Atherosclerosis, December 2004, Elsevier

    Dr Hans M Princen

  124. Effect of Low Dose Atorvastatin Versus Diet-Induced Cholesterol Lowering on Atherosclerotic Lesion Progression and Inflammation in Apolipoprotein E*3-Leiden Transgenic Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, October 2004, Wolters Kluwer Health

    Dr Hans M Princen

  125. α-Tocopherol levels in plasma in new-onset, insulin-dependent diabetes mellitus

    Article • European Journal of Internal Medicine, October 2004, Elsevier

    Dr Hans M Princen

  126. Serum carotenoids and vitamins in relation to markers of endothelial

    Article • European Journal of Epidemiology, October 2004, Springer Science + Business Media

    Dr Hans M Princen

  127. CYP7A1 A-278C Polymorphism Affects the Response of Plasma Lipids after Dietary Cholesterol or Cafestol Interventions in Humans

    Article • Journal of Nutrition, September 2004, Oxford University Press (OUP)

    Dr Hans M Princen

  128. Modulating effect of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene on serum lipid levels in normolipidaemic and hypertriglyceridaemic individuals

    Article • European Journal of Human Genetics, July 2004, Nature

    Dr Hans M Princen

  129. Evidence for anti-inflammatory activity of statins and PPAR  activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro

    Article • Blood, June 2004, American Society of Hematology

    Dr Hans M Princen

  130. Well-Characterized Garlic-Derived Materials Are Not Hypolipidemic in APOE*3-Leiden Transgenic Mice

    Article • Journal of Nutrition, June 2004, Oxford University Press (OUP)

    Dr Hans M Princen

  131. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol

    Article • Blood, May 2004, American Society of Hematology

    Dr Hans M Princen

  132. W01.43 Evidence for anti-inflammatory activity of statins and fibrates from studies in human C-reactive protein transgenic mice and in cultured human hepatocytes

    Article • Atherosclerosis Supplements, April 2004, Elsevier

    Dr Hans M Princen

  133. Cholesterol 7 -Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Impairs Very-Low-Density Lipoprotein Production

    Article • Arteriosclerosis Thrombosis and Vascular Biology, February 2004, Wolters Kluwer Health

    Dr Hans M Princen

  134. Rosuvastatin Reduces Atherosclerosis Development Beyond and Independent of Its Plasma Cholesterol-Lowering Effect in APOE*3-Leiden Transgenic Mice: Evidence for Antiinflammatory Effects of Rosuvastatin

    Article • Circulation, September 2003, Wolters Kluwer Health

    Dr Hans M Princen

  135. Soluble intercellular adhesion molecule 1 and flow-mediated dilatation are related to the estimated risk of coronary heart disease independently from each other

    Article • Atherosclerosis, September 2003, Elsevier

    Dr Hans M Princen

  136. Genetic Analysis of Indicators of Cholesterol Synthesis and Absorption: Lathosterol and Phytosterols in Dutch Twins and Their Parents

    Article • Twin Research, August 2003, Cambridge University Press

    Professor Dorret I Boomsma, Dr Hans M Princen

  137. Genetic Analysis of Indicators of Cholesterol Synthesis and Absorption: Lathosterol and Phytosterols in Dutch Twins and Their Parents

    Article • Twin Research, August 2003, Cambridge University Press

    Professor Dorret I Boomsma, Dr Hans M Princen

  138. Decrease of hemostatic cardiovascular risk factors by aggressive vs. conventional atorvastatin treatment in patients with Type 2 diabetes mellitus

    Article • Journal of Thrombosis and Haemostasis, August 2003, Wiley

    Dr Hans M Princen

  139. Differential Effects of Amlodipine and Atorvastatin Treatment and Their Combination on Atherosclerosis in ApoE*3-Leiden Transgenic Mice

    Article • Journal of Cardiovascular Pharmacology, July 2003, Wolters Kluwer Health

    Dr Hans M Princen

  140. Safety of long-term consumption of plant sterol esters-enriched spread

    Article • European Journal of Clinical Nutrition, May 2003, Nature

    Dr Hans M Princen

  141. Increased Fecal Bile Acid Excretion in Transgenic Mice With Elevated Expression of Human Phospholipid Transfer Protein

    Article • Arteriosclerosis Thrombosis and Vascular Biology, March 2003, Wolters Kluwer Health

    Dr Hans M Princen

  142. Vitamin E inhibits lipid peroxidation-induced adhesion molecule expression in endothelial cells and decreases soluble cell adhesion molecules in healthy subjects

    Article • Cardiovascular Research, February 2003, European Society of Cardiology

    Dr Hans M Princen

  143. Strong decrease of high sensitivity C-reactive protein with high-dose atorvastatin in patients with type 2 diabetes mellitus

    Article • Atherosclerosis, January 2003, Elsevier

    Dr Hans M Princen

  144. Effects of amlodipine, atorvastatin and combination of both on advanced atherosclerotic plaque in APOE*3-Leiden transgenic mice

    Article • Journal of Molecular and Cellular Cardiology, January 2003, Elsevier

    Dr Hans M Princen

  145. 4P-1178 Direct in vivo down-regulation of IL-1-induced C-reactive protein (CRP) expression by statins and fibrates in human CRP transgenic mice

    Article • Atherosclerosis Supplements, January 2003, Elsevier

    Dr Hans M Princen

  146. 2P-0562 Rosuvastatin reduces atherosclerosis development beyond and independently of its plasma cholesterol-lowering effect in APOE∗3-Leiden transgenic mice. Evidence for anti-inflammatory effects of rosuvastatin

    Article • Atherosclerosis Supplements, January 2003, Elsevier

    Dr Hans M Princen

  147. 2P-0569 The novel bile acid reabsorption inhibitor B1-1 lowers plasma cholesterol levels by reduction of VLDL-cholesterol production in apoE∗3-Leiden mice

    Article • Atherosclerosis Supplements, January 2003, Elsevier

    Dr Hans M Princen

  148. 2P-0570 The PPAR-α-agonist fenofibrate reduces development of atherosclerosis beyond and independently of its plasma cholesterol-lowering effect in APOE∗3-Leiden transgenic mice

    Article • Atherosclerosis Supplements, January 2003, Elsevier

    Dr Hans M Princen

  149. 3P-0737 Bile acid metabolism in hypertriglyceridemic patients. Effects of body mass index and triglyceride-lowering therapy by bezafibrate and fish-oil

    Article • Atherosclerosis Supplements, January 2003, Elsevier

    Dr Hans M Princen

  150. 3P-0740 Low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol

    Article • Atherosclerosis Supplements, January 2003, Elsevier

    Dr Hans M Princen

  151. Raman spectroscopic investigation of atorvastatin, amlodipine, and both on atherosclerotic plaque development in APOE*3 Leiden transgenic mice

    Article • Atherosclerosis, September 2002, Elsevier

    Dr Hans M Princen

  152. Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation

    Article • Blood, August 2002, American Society of Hematology

    Dr Hans M Princen

  153. HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice

    Article • Biochemical Pharmacology, May 2002, Elsevier

    Dr Hans M Princen

  154. Design of a Targeted Peptide Nucleic Acid Prodrug To Inhibit Hepatic Human Microsomal Triglyceride Transfer Protein Expression in Hepatocytes †

    Article • Bioconjugate Chemistry, March 2002, American Chemical Society (ACS)

    Dr Hans M Princen

  155. Increased lipogenesis and resistance of lipoproteins to oxidative modification in two patients with glycogen storage disease type 1a

    Article • The Journal of Pediatrics, February 2002, Elsevier

    Dr Hans M Princen

  156. Fibrates Suppress Bile Acid Synthesis via Peroxisome Proliferator-Activated Receptor- -Mediated Downregulation of Cholesterol 7 -Hydroxylase and Sterol 27-Hydroxylase Expression

    Article • Arteriosclerosis Thrombosis and Vascular Biology, November 2001, Wolters Kluwer Health

    Dr Hans M Princen

  157. Raman Spectroscopic Evaluation of the Effects of Diet and Lipid-Lowering Therapy on Atherosclerotic Plaque Development in Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, October 2001, Wolters Kluwer Health

    Dr Hans M Princen

  158. Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in apoE3-Leiden transgenic mice

    Article • Atherosclerosis, August 2001, Elsevier

    Dr Hans M Princen

  159. The Effect of Aggressive Versus Standard Lipid Lowering by Atorvastatin on Diabetic Dyslipidemia: The DALI Study: a double-blind, randomized, placebo-controlled trial in patients with type 2 diabetes and diabetic dyslipidemia

    Article • Diabetes Care, August 2001, American Diabetes Association

    Dr Hans M Princen

  160. Dietary Plant Stanol Esters Reduce VLDL Cholesterol Secretion and Bile Saturation in Apolipoprotein E*3-Leiden Transgenic Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, June 2001, Wolters Kluwer Health

    Dr Hans M Princen

  161. Concurrently increased cholesterol synthesis and decreased cholesterol absorption in hypertriglyceridemia. Effects of bezafibrate therapy

    Article • Atherosclerosis Supplements, May 2001, Elsevier

    Dr Hans M Princen

  162. Increased fecal bile acid excretion in transgenic mice overexpressing human plasma phospholipid transfer protein

    Article • Atherosclerosis Supplements, May 2001, Elsevier

    Dr Hans M Princen

  163. Association of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene with hyperlipidemic disorders

    Article • Atherosclerosis Supplements, May 2001, Elsevier

    Dr Hans M Princen

  164. Dose dependent effects of atorvastatin on C-reactive protein in type 2 diabetes mellitus

    Article • Atherosclerosis Supplements, May 2001, Elsevier

    Dr Hans M Princen

  165. Quantitative evaluation of the effects of amlodipine and atorvastatin on atherosclerotic plaque formation in mice by raman spectroscopy

    Article • Atherosclerosis Supplements, May 2001, Elsevier

    Dr Hans M Princen

  166. Long term dietary vitamin E reduces atherosclerotic lesion size and increases plaque stability in heterozygous LDL-receptor deficient mice

    Article • Atherosclerosis Supplements, May 2001, Elsevier

    Dr Hans M Princen

  167. Acyl-CoA:Cholesterol Acyltransferase Inhibitor Avasimibe Reduces Atherosclerosis in Addition to Its Cholesterol-Lowering Effect in ApoE*3-Leiden Mice

    Article • Circulation, April 2001, Wolters Kluwer Health

    Dr Hans M Princen

  168. Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice

    Article • Journal of Hepatology, February 2001, Elsevier

    Dr Hans M Princen

  169. Normal Oxidative Stress and Enhanced Lipoprotein Resistance to In Vitro Oxidation in Hypertriglyceridemia : Effects of Bezafibrate Therapy

    Article • Arteriosclerosis Thrombosis and Vascular Biology, November 2000, Wolters Kluwer Health

    Dr Hans M Princen

  170. Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals

    Article • European Journal of Clinical Nutrition, October 2000, Nature

    Dr Hans M Princen

  171. Consumption of French-press coffee raises cholesteryl ester transfer protein activity levels before LDL cholesterol in normolipidaemic subjects

    Article • Journal of Internal Medicine, September 2000, Wiley

    Dr Hans M Princen

  172. Accelerated Atherosclerosis by Placement of a Perivascular Cuff and a Cholesterol-Rich Diet in ApoE*3Leiden Transgenic Mice

    Article • Circulation Research, August 2000, Wolters Kluwer Health

    Dr Hans M Princen, Victor van Hinsbergh, Professor Paul HA Quax

  173. New HMG-CoA reductase inhibitor ZD4522 lowers plasma lipids and VLDL production in APOE*3Leiden transgenic mice

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Hans M Princen

  174. Effects of amlodipine and atorvastatin on the development of atherosclerosis in ApoE*3-Leiden transgenic mice

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Hans M Princen

  175. Long term vitamin E feeding attenuates aortic atherosclerosis independent of plasma lipid levels in heterozygous LDL-receptor deficient mice

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Hans M Princen

  176. Dietary vegetable-, wood- or vegetable/wood-derived stanol esters reduce atherosclerotic lesion size and severity in APOE*3-Leiden transgenic mice

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Hans M Princen

  177. The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations

    Article • Twin Research, June 2000, Cambridge University Press

    Dr Hans M Princen

  178. Cafestol Increases Serum Cholesterol Levels in Apolipoprotein E*3-Leiden Transgenic Mice by Suppression of Bile Acid Synthesis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, June 2000, Wolters Kluwer Health

    Dr Hans M Princen

  179. Glycogen storage disease type 1a patients with severe hyperlipidemia are protected from premature onset of atherosclerosis by resistance of lipoproteins to oxidative modification

    Article • European Journal of Gastroenterology & Hepatology, December 1999, Wolters Kluwer Health

    Dr Hans M Princen

  180. Fibrates suppress bile acid synthesis via PPAR-mediated down-regulation of cholesterol 7-hydroxylase gene expression

    Article • European Journal of Gastroenterology & Hepatology, December 1999, Wolters Kluwer Health

    Dr Hans M Princen

  181. Cafestol, the cholesterol-raising factor in boiled coffee, increases serum cholesterol levels in apolipoprotein E3-Leiden transgenic mice by suppression of bile acid synthesis

    Article • European Journal of Gastroenterology & Hepatology, December 1999, Wolters Kluwer Health

    Dr Hans M Princen

  182. Acyl-coenzyme A: Cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7?-hydroxylase in cultured rat hepatocytes andin vivo in the rat

    Article • Hepatology, August 1999, Wiley

    Dr Hans M Princen

  183. Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7α-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes

    Article • Biochemical Journal, July 1999, Portland Press Ltd.

    Dr Hans M Princen

  184. Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7α-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes

    Article • Biochemical Journal, July 1999, Portland Press Ltd.

    Dr Hans M Princen

  185. Inhibition of apolipoprotein(a) synthesis in cynomolgus monkey hepatocytes by retinoids via involvement of the retinoic acid receptor

    Article • Biochemical Pharmacology, July 1999, Elsevier

    Dr Hans M Princen

  186. No short-term effect of oral isotretinoin (13-cis retinoic acid) on lipoprotein(a) and HDL subclasses LP-A-I and LP-A-I:A-II in healthy volunteers

    Article • Journal of Internal Medicine, July 1999, Wiley

    Dr Hans M Princen

  187. Fibrates suppress bile acid synthesis via PPARα-mediated down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene expression

    Article • Atherosclerosis, May 1999, Elsevier

    Dr Hans M Princen

  188. βVLDL and IDL but not HDL increase bile acid synthesis by upregulation of cholesterol 7α-hydroxylase gene expression in cultured rat hepatocytes

    Article • Atherosclerosis, May 1999, Elsevier

    Dr Hans M Princen

  189. The coffee diterpene cafestol decreases bile acid synthesis by down-regulation of cholesterol 7α-hydroxylase in apolipoprotein E3-Leiden mice

    Article • Atherosclerosis, May 1999, Elsevier

    Dr Hans M Princen

  190. Effect of dietary stanolesters on hepatic lipid metabolism in APOE*3-Leiden transgenic mice

    Article • Atherosclerosis, May 1999, Elsevier

    Dr Hans M Princen

  191. REGULATION OF BILE ACID BIOSYNTHESIS

    Article • Gastroenterology Clinics of North America, March 1999, Elsevier

    Dr Hans M Princen

  192. Insulin suppresses apolipoprotein(a) synthesis by primary cultures of cynomolgus monkey hepatocytes (Short Communication)

    Article • Diabetologia, January 1999, Springer Science + Business Media

    Dr Hans M Princen

  193. Plasma coenzyme Q10concentrations are not decreased in male patients with coronary atherosclerosis

    Article • Free Radical Research, January 1999, Taylor & Francis

    Dr Hans M Princen

  194. Oxidation of LDL and extent of peripheral atherosclerosis

    Article • Free Radical Research, January 1999, Taylor & Francis

    Dr Hans M Princen

  195. Relationship between Visceral Fat and PAI-1 in Overweight Men and Women before and after Weight Loss

    Article • Thrombosis and Haemostasis, January 1999, Thieme Publishing Group

    Dr Hans M Princen

  196. Effects of fenofibrate on hyperlipidemia and postprandial triglyceride metabolism in human apolipoprotein C1 transgenic mice

    Article • Atherosclerosis, December 1998, Elsevier

    Dr Hans M Princen

  197. Role of the peroxisome proliferator-activated receptor-α in the down regulation of fibrinogen gene expression in rodents

    Article • European Journal of Gastroenterology & Hepatology, December 1998, Wolters Kluwer Health

    Dr Hans M Princen

  198. Effect of methylglyoxal on the physico-chemical and biological properties of low-density lipoprotein

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, November 1998, Elsevier

    Dr Hans M Princen

  199. Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice?

    Article • Atherosclerosis, September 1998, Elsevier

    Dr Hans M Princen

  200. Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids.

    Article • Journal of Clinical Investigation, August 1998, American Society for Clinical Investigation

    Dr Hans M Princen

  201. Effect of fish-oil-enriched margarine on plasma lipids, low-density-lipoprotein particle composition, size, and susceptibility to oxidation

    Article • American Journal of Clinical Nutrition, August 1998, Elsevier

    Dr Hans M Princen

  202. Working group on epidemiology & prevention of the european society of cardiology

    Article • Irish Journal of Medical Science (1971 -), July 1998, Springer Science + Business Media

    Dr Hans M Princen

  203. Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice☆☆☆

    Article • Gastroenterology, May 1998, Elsevier

    Dr Hans M Princen

  204. No Effect of Consumption of Green and Black Tea on Plasma Lipid and Antioxidant Levels and on LDL Oxidation in Smokers

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 1998, Wolters Kluwer Health

    Dr Hans M Princen

  205. No Effect of Fibrates on Synthesis of Apolipoprotein(a) in Primary Cultures of Cynomolgus Monkey and Human Hepatocytes: Apolipoprotein A-I Synthesis Increased

    Article • Biochemical and Biophysical Research Communications, March 1998, Elsevier

    Dr Hans M Princen

  206. LDL Oxidation and Extent of Coronary Atherosclerosis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, February 1998, Wolters Kluwer Health

    Dr Hans M Princen

  207. Cafestol, the Cholesterol-Raising Factor in Boiled Coffee, Suppresses Bile Acid Synthesis by Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase in Rat Hepatocytes

    Article • Arteriosclerosis Thrombosis and Vascular Biology, November 1997, Wolters Kluwer Health

    Dr Hans M Princen

  208. Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: involvement of retinoic acid and retinoid X receptors

    Article • Journal of Lipid Research, November 1997, Elsevier

    Dr Hans M Princen

  209. 4.P.98 Effect of methylglyoxal on the physico-chemical and biological properties of low density lipoprotein

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Hans M Princen

  210. 1.P.349 LDL oxidation and risk of coronary atherosclerosis

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Hans M Princen

  211. 4.P.176 Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase in rat hepatocytes

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Hans M Princen

  212. 2.P.139 Effects of oral isotretinoin (13-cis retinoic acid) on lipoprotein(a) and HDL subclasses lpA-I and lpA-I: A-II in healthy volunteers

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Hans M Princen

  213. Lipoprotein oxidation, antioxidants and cardiovascular risk: epidemiologic evidence

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, October 1997, Elsevier

    Dr Hans M Princen

  214. Effect of 17 -Estradiol on Plasma Lipids and LDL Oxidation in Postmenopausal Women With Type II Diabetes Mellitus

    Article • Arteriosclerosis Thrombosis and Vascular Biology, February 1997, Wolters Kluwer Health

    Dr Hans M Princen

  215. Seasonal Variation in Low Density Lipoprotein Oxidation and Antioxidant Status

    Article • Free Radical Research, January 1997, Taylor & Francis

    Dr Hans M Princen

  216. Effects of Gemfibrozil and Ciprofibrate on Plasma Levels of Tissue-type Plasminogen Activator, Plasminogen Activator Inhibitor-1 and Fibrinogen in Hyperlipidaemic Patients

    Article • Thrombosis and Haemostasis, January 1997, Thieme Publishing Group

    Dr Hans M Princen

  217. Studies on the Mechanism of Fibrate-Inhibited Expression of Plasminogen Activator Inhibitor-1 in Cultured Hepatocytes From Cynomolgus Monkey

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 1997, Wolters Kluwer Health

    Dr Hans M Princen

  218. Studies on the Role of PPAR in the Fibrate-modulated Gene Expression of Apolipoprotein A-I, Plasminogen Activator Inhibitor 1, and Fibrinogen in Primary Hepatocyte Cultures from Cynomolgus Monkey

    Article • Annals of the New York Academy of Sciences, December 1996, Wiley

    Dr Hans M Princen

  219. Effects of Fish Oil on Oxidation Resistance of VLDL in Hypertriglyceridemic Patients

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 1996, Wolters Kluwer Health

    Dr Hans M Princen

  220. Altered lipid metabolism in apolipoprotein E-deficient mice does not affect cholesterol balance across the liver

    Article • Hepatology, July 1996, Wiley

    Dr Hans M Princen

  221. Altered lipid metabolism in apolipoprotein E-deficient mice does not affect cholesterol balance across the liver

    Article • Hepatology, July 1996, Wolters Kluwer Health

    Dr Hans M Princen

  222. Autoantibodies against MDA-LDL in subjects with severe and minor atherosclerosis and healthy population controls

    Article • Atherosclerosis, May 1996, Elsevier

    Dr Hans M Princen

  223. Effects of Simvastatin on Plasma Lipids and Apolipoproteins in Familial Hypercholesterolemic Swine

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 1996, Wolters Kluwer Health

    Dr Hans M Princen

  224. Enhanced susceptibility of low-density lipoproteins to oxidation in coronary bypass patients with progression of atherosclerosis

    Article • Clinica Chimica Acta, December 1995, Elsevier

    Dr Hans M Princen

  225. Induction of liver sterol 27-hydroxylase by bile acid sequestrants in rat

    Article • Atherosclerosis, June 1995, Elsevier

    Dr Hans M Princen

  226. Decreased plasma lathosterol levels in growth hormone deficient men during treatment with growth hormone

    Article • Atherosclerosis, June 1995, Elsevier

    Dr Hans M Princen

  227. Effects of fish oil on oxidation resistance of very low density lipoprotein in hypertriglyceride

    Article • Atherosclerosis, June 1995, Elsevier

    Dr Hans M Princen

  228. Stimulation of cholesterol 7α-hydroxylase by β-VLDL, but not by LDL, in cultured rat hepatocytes

    Article • Atherosclerosis, June 1995, Elsevier

    Dr Hans M Princen

  229. Supplementation with low doses of vitamin E protects low density lipoprotein from lipid peroxidation in men and women

    Article • Atherosclerosis, June 1995, Elsevier

    Dr Hans M Princen

  230. Structural Aspects of Bile Acids Involved in the Regulation of Cholesterol 7alpha-Hydroxylase and Sterol 27-Hydroxylase

    Article • FEBS Journal, March 1995, Wiley

    Dr Hans M Princen

  231. Structural Aspects of Bile Acids Involved in the Regulation of Cholesterol 7alpha-Hydroxylase and Sterol 27-Hydroxylase

    Article • FEBS Journal, March 1995, Wiley

    Dr Hans M Princen

  232. Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus.

    Article • Journal of Clinical Investigation, March 1995, American Society for Clinical Investigation

    Dr Hans M Princen

  233. Supplementation With Low Doses of Vitamin E Protects LDL From Lipid Peroxidation in Men and Women

    Article • Arteriosclerosis Thrombosis and Vascular Biology, March 1995, Wolters Kluwer Health

    Dr Hans M Princen, Victor van Hinsbergh

  234. Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene transcription

    Article • Hepatology, February 1995, Wiley

    Dr Hans M Princen

  235. Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 27-hydroxylase and sterol 7?-hydroxylase gene transcription*1, *2

    Article • Hepatology, February 1995, Elsevier

    Dr Hans M Princen

  236. Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes

    Article • Biochemical Journal, January 1995, Portland Press Ltd.

    Dr Hans M Princen

  237. No effect of β-carotene supplementation on plasma lipoproteins in healthy smokers

    Article • American Journal of Clinical Nutrition, November 1994, Elsevier

    Dr Hans M Princen

  238. Co-translational inhibition of apolipoprotein B-100 synthesis by cyclosporin A in the human hepatoma cell line HepG2

    Article • Atherosclerosis, September 1994, Elsevier

    Dr Hans M Princen

  239. Lack of effect of β-carotene supplementation on plasma lipoproteins in healthy smokers

    Article • Atherosclerosis, September 1994, Elsevier

    Dr Hans M Princen

  240. Enhanced susceptibility of LDL to oxidation in coronary bypass patients

    Article • Atherosclerosis, September 1994, Elsevier

    Dr Hans M Princen

  241. Dietary supplementation with vitamin E to protect LDL from lipid peroxidation

    Article • Atherosclerosis, September 1994, Elsevier

    Dr Hans M Princen

  242. Butyrate stimulates the secretion of apolipoprotein B-100-containing lipoproteins from HepG2 cells by inhibiting the intracellular degradation

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, August 1994, Elsevier

    Dr Hans M Princen

  243. Cotranslational inhibition of apoB-100 synthesis by cyclosporin A in the human hepatoma cell line HepG2.

    Article • Arteriosclerosis and Thrombosis A Journal of Vascular Biology, May 1994, Wolters Kluwer Health

    Dr Hans M Princen

  244. Transcriptional regulation of the gene encoding cholesterol 7α-hydroxylase in the rat

    Article • Gene, April 1994, Elsevier

    Dr Hans M Princen

  245. Antioxidants and Coronary Heart Disease

    Article • Annals of Medicine, January 1994, Taylor & Francis

    Dr Hans M Princen

  246. Direct suppression of the synthesis of plasminogen activator inhibitor 1 (PAI-1) by gemfibrozil in primary hepatocyte cultures and hep g2 cells

    Article • Fibrinolysis and Proteolysis, January 1994, Elsevier

    Dr Hans M Princen

  247. Effect of fish oil and vitamin E on the cardiovascular risk indicators fibrinogen, C-reactive protein and PAI activity in healthy young volunteers

    Article • Fibrinolysis and Proteolysis, January 1994, Elsevier

    Dr Hans M Princen

  248. Retinoids stimulate ApoA-I synthesis by induction of gene transcription in primary hepatocyte cultures from cynomolgus monkey (Macaca fascicularis)

    Article • Arteriosclerosis and Thrombosis A Journal of Vascular Biology, October 1993, Wolters Kluwer Health

    Dr Hans M Princen

  249. Transcriptional regulation of the gene encoding cholesterol 7α-hydroxylase in the rat

    Article • Gene, August 1993, Elsevier

    Dr Hans M Princen

  250. Selective inhibition of mitochondrial 27-hydroxylation of bile acid intermediates and 25-hydroxylation of vitamin D 3 by cyclosporin A

    Article • Biochemical Journal, July 1993, Portland Press Ltd.

    Dr Hans M Princen

  251. Differential feedback regulation of cholesterol 7 α -hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes

    Article • Biochemical Journal, March 1993, Portland Press Ltd.

    Dr Hans M Princen

  252. Lipoprotein(a): relation to other risk factors and genetic heritability. Results from a Dutch parent-twin study

    Article • Atherosclerosis, February 1993, Elsevier

    Dr Hans M Princen

  253. Butyrate stimulates the secretion of apolipoprotein A-I and apolipoprotein B-100 in Hep G2 cells by different mechanisms

    Article • Clinical Biochemistry, October 1992, Elsevier

    Dr Hans M Princen

  254. Susceptibility of low-density lipoproteins to oxidation in coronary bypass patients

    Article • The Lancet, October 1992, Elsevier

    Dr Hans M Princen

  255. Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 1992, Wolters Kluwer Health

    Dr Hans M Princen

  256. Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a)

    Article • Atherosclerosis, October 1991, Elsevier

    Dr Hans M Princen

  257. Butyrate stimulates the secretion of apolipoprotein (apo) A-I and apo B100 by the human hepatoma cell line Hep G2. Induction of apo A-I mRNA with no change of apo B100 mRNA

    Article • Biochemical Journal, September 1991, Portland Press Ltd.

    Dr Hans M Princen

  258. Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acid synthesis

    Article • Biochemical Journal, May 1991, Portland Press Ltd.

    Dr Hans M Princen

  259. Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis

    Article • Biochemical Journal, April 1991, Portland Press Ltd.

    Dr Hans M Princen

  260. Maintenance of bile acid synthesis and cholesterol 7α-hydroxylase activity in cultured rat hepatocytes

    Article • Biochemical Journal, November 1990, Portland Press Ltd.

    Dr Hans M Princen

  261. One-step solvolysis of 3-, 7- and 12-sulfated free and conjugated bile acids

    Article • Clinica Chimica Acta, November 1990, Elsevier

    Dr Hans M Princen

  262. Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7α-hydroxylase activity

    Article • Hepatology, November 1990, Wiley

    Dr Hans M Princen

  263. Cholesterol 7α-hydroxylase activity and bile acid synthesis in hepatocytes of unwearied and weaned pigs in monolayer culture

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, February 1990, Elsevier

    Dr Hans M Princen

  264. Differential effects of endotoxin and fibrinogen degradation products (FDPs) on liver synthesis of fibrinogen and albumin: Evidence for the involvement of a novel monokine in the stimulation of fibrinogen synthesis induced by FDPs

    Article • International Journal of Biochemistry, January 1990, Elsevier

    Dr Hans M Princen

  265. Inhibition and induction of bile acid synthesis by ketoconazole effects on bile formation in the rat

    Article • Lipids, September 1989, Springer Science + Business Media

    Dr Hans M Princen

  266. Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7α-hydroxylase

    Article • Biochemical Journal, August 1989, Portland Press Ltd.

    Dr Hans M Princen

  267. Comparison of taurocholate accumulation in cultured hepatocytes of pig, rat and man

    Article • Biochemical and Biophysical Research Communications, July 1989, Elsevier

    Dr Hans M Princen

  268. Regulation of plasminogen activator inhibitor 1 synthesis: Studies on the DNA and cellular level

    Article • Fibrinolysis and Proteolysis, January 1989, Elsevier

    Dr Hans M Princen

  269. Plasminogen Activator Inhibitor 1: Biosynthesis and mRNA Level Are Increased by Insulin in Cultured Human Hepatocytes

    Article • Thrombosis and Haemostasis, January 1989, Thieme Publishing Group

    Dr Hans M Princen

  270. Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo

    Article • Blood, November 1988, American Society of Hematology

    Dr Hans M Princen

  271. Feedback inhibition of bile acid synthesis in cultured pig hepatocytes

    Article • Biochemical and Biophysical Research Communications, September 1988, Elsevier

    Dr Hans M Princen

  272. Hydroxylation, conjugation and sulfation of bile acids in primary monolayer cultures of rat hepatocytes

    Article • Biochemical and Biophysical Research Communications, August 1988, Elsevier

    Dr Hans M Princen

  273. Bile acid synthesis by human hepatoma cell line Hep-G2 is stimulated by low density lipoprotein

    Article • Biochemical Society Transactions, August 1988, Portland Press Ltd.

    Dr Hans M Princen

  274. Assay of cholesterol 7α-hydroxylase activity in rat hepatocytes in primary monolayer culture

    Article • Analytical Biochemistry, May 1988, Elsevier

    Dr Hans M Princen

  275. 321 Secretion of protein-C and plasminogen by human hepatocytes: Influence of hormones

    Article • Fibrinolysis and Proteolysis, January 1988, Elsevier

    Dr Hans M Princen

  276. Cellular free cholesterol in Hep G2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activity

    Article • Biochemical Journal, November 1987, Portland Press Ltd.

    Dr Hans M Princen

  277. Regulation of cholesterol metabolism in the liver in vivo and in vitro

    Article • Biochemical Society Transactions, June 1987, Portland Press Ltd.

    Dr Hans M Princen

  278. Regulation of low density lipoprotein receptor activity in primary cultures of human hepatocytes by serum lipoproteins

    Article • Hepatology, November 1986, Wiley

    Dr Hans M Princen

  279. Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase.

    Article • Journal of Clinical Investigation, October 1986, American Society for Clinical Investigation

    Dr Hans M Princen

  280. Regulation of squalene synthetase activity in rat liver: Elevation by cholestyramine, but no diurnal variation

    Article • Biochemical and Biophysical Research Communications, July 1986, Elsevier

    Dr Hans M Princen

  281. Stimulation of the LDL receptor activity in the human hepatoma cell line Hep G2 by high-density serum fractions

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, February 1986, Elsevier

    Dr Hans M Princen

  282. Regulation of LDL Receptor Activity in Human Hepatocytes

    Article • January 1986, Springer Science + Business Media

    Dr Hans M Princen

  283. The influence of glucocorticoid on albumin synthesis and its messenger RNA in rat in vivo and in hepatocyte suspension culture

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, January 1985, Elsevier

    Dr Hans M Princen

  284. Fibrinogen Fragments X, Y, D and E Increase Levels of Plasma Fibrinogen and Liver mRNAs Coding for Fibrinogen Polypeptides in Rats

    Article • Thrombosis and Haemostasis, January 1985, Thieme Publishing Group

    Dr Hans M Princen

  285. Changes in the sequence content of albumin mRNA and in its translational activity in the rat liver with age

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, October 1984, Elsevier

    Dr Hans M Princen

  286. Fine structure of exoerythrocytic forms in cultured primary rat hepatocytes

    Article • Cell Biology International Reports, September 1984, Wiley

    Dr Jacques F Meis, Dr Hans M Princen

  287. The influence of glucocorticoid on the fibrinogen messenger RNA content of rat liver in vivo and in hepatocyte suspension culture

    Article • Biochemical Journal, June 1984, Portland Press Ltd.

    Dr Hans M Princen

  288. Restoration Effects of Glucose Refeeding on Reduced Synthesis of Albumin and Total Protein and on Disaggregated Polyribosomes in Liver of Starved Rats: Evidence of a Post-Transcriptional Control Mechanism

    Article • Annals of Nutrition and Metabolism, January 1983, Karger Publishers

    Dr Hans M Princen

  289. Distribution of mRNAs of fibrinogen polypeptides and albumin in free and membrane-bound polyribosomes and induction of α-fetoprotein mRNA synthesis during liver regeneration after partial hepatectomy

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, November 1982, Elsevier

    Dr Hans M Princen

  290. Sequence content of α-fetoprotein, albumin and fibrinogen polypeptide mRNAs in different organs, developing tissues and in liver during carcinogenesis in rats

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, November 1982, Elsevier

    Dr Hans M Princen

  291. Acute effects of ethanol intake on albumin and total protein synthesis in free and membrane-bound polyribosomes of rat liver

    Article • Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, September 1981, Elsevier

    Dr Hans M Princen

  292. Direct evidence of transcriptional control of fibrinogen and albumin synthesis in rat liver during the acute phase response

    Article • Biochemical and Biophysical Research Communications, September 1981, Elsevier

    Dr Hans M Princen

  293. Free cytoplasmic messenger ribonucleoprotein complexes from rabbit reticulocytes

    Article • Molecular Biology Reports, March 1979, Springer Science + Business Media

    Dr Hans M Princen

  294. Specific poly-A-binding protein of 76,000 molecular weight in polyribosomes is not present on poly A of free cytoplasmic mRNP

    Article • Nature, November 1977, Nature

    Dr Hans M Princen