All Stories

  1. Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant

    Article • Advanced Drug Delivery Reviews, October 2013, Elsevier

    Professor Hans P Merkle

  2. Impact of IGF-I release kinetics on bone healing: A preliminary study in sheep

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2013, Elsevier

    Professor Hans P Merkle

  3. Biocompatibility and osteoconduction of macroporous silk fibroin implants in cortical defects in sheep

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2013, Elsevier

    Professor Hans P Merkle

  4. Remodeling of tissue-engineered bone structures in vivo

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2013, Elsevier

    Professor Hans P Merkle

  5. Electrospun matrices for localized drug delivery: Current technologies and selected biomedical applications

    Article • European Journal of Pharmaceutics and Biopharmaceutics, May 2012, Elsevier

    Professor Hans P Merkle

  6. Surface assembly of poly(I:C) on PEGylated microspheres to shield from adverse interactions with fibroblasts

    Article • Journal of Controlled Release, April 2012, Elsevier

    Professor Hans P Merkle

  7. Tuning the immune response of dendritic cells to surface-assembled poly(I:C) on microspheres through synergistic interactions between phagocytic and TLR3 signaling

    Article • Biomaterials, April 2011, Elsevier

    Professor Hans P Merkle

  8. Silk fibroin as a vehicle for drug delivery applications

    Article • Journal of Controlled Release, March 2011, Elsevier

    Professor Hans P Merkle

  9. The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration

    Article • Biomaterials, February 2010, Elsevier

    Professor Hans P Merkle

  10. Design and validation of a novel bioreactor principle to combine online micro-computed tomography monitoring and mechanical loading in bone tissue engineering

    Article • Review of Scientific Instruments, January 2010, American Institute of Physics

    Professor Hans P Merkle

  11. Silk fibroin/hyaluronan scaffolds for human mesenchymal stem cell culture in tissue engineering

    Article • Biomaterials, October 2009, Elsevier

    Professor Hans P Merkle

  12. Biopolymer-Based Growth Factor Delivery for Tissue Repair: From Natural Concepts to Engineered Systems

    Article • Tissue Engineering Part B Reviews, September 2009, Mary Ann Liebert Inc

    Professor Hans P Merkle

  13. Concomitant delivery of a CTL-restricted peptide antigen and CpG ODN by PLGA microparticles induces cellular immune response

    Article • Journal of Drug Targeting, July 2009, Taylor & Francis

    Professor Hans P Merkle

  14. Optimization strategies for electrospun silk fibroin tissue engineering scaffolds

    Article • Biomaterials, June 2009, Elsevier

    Professor Hans P Merkle

  15. Microporous silk fibroin scaffolds embedding PLGA microparticles for controlled growth factor delivery in tissue engineering

    Article • Biomaterials, May 2009, Elsevier

    Professor Hans P Merkle

  16. PEGylation as a tool for the biomedical engineering of surface modified microparticles

    Article • Journal of Pharmaceutical Sciences, November 2008, Elsevier

    Professor Hans P Merkle

  17. Silk fibroin spheres as a platform for controlled drug delivery

    Article • Journal of Controlled Release, November 2008, Elsevier

    Professor Hans P Merkle

  18. Mannose-Based Molecular Patterns on Stealth Microspheres for Receptor-Specific Targeting of Human Antigen-Presenting Cells

    Article • Langmuir, October 2008, American Chemical Society (ACS)

    Professor Hans P Merkle

  19. CONTROL OF TISSUE-ENGINEERED BONE-LIKE STRUCTURES ON SILK FIBROIN SCAFFOLDS

    Article • Journal of Biomechanics, July 2008, Elsevier

    Professor Hans P Merkle

  20. Controlled nerve growth factor release from multi-ply alginate/chitosan-based nerve conduits

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2008, Elsevier

    Professor Hans P Merkle

  21. Metabolic Cleavage and Translocation Efficiency of Selected Cell Penetrating Peptides: A Comparative Study with Epithelial Cell Cultures

    Article • The AAPS Journal, June 2008, American Association of Pharmaceutical Scientists (AAPS)

    Professor Hans P Merkle

  22. Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells

    Article • Journal of Controlled Release, April 2008, Elsevier

    Professor Hans P Merkle

  23. Cotton wool-like nanocomposite biomaterials prepared by electrospinning:In vitrobioactivity and osteogenic differentiation of human mesenchymal stem cells

    Article • Journal of Biomedical Materials Research Part B Applied Biomaterials, February 2008, Wiley

    Dr Robert N Grass, Professor Hans P Merkle

  24. The effect of hyaluronic acid on silk fibroin conformation

    Article • Biomaterials, February 2008, Elsevier

    Professor Hans P Merkle

  25. Dendronised block copolymers as potential vectors for gene transfection

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Professor Hans P Merkle

  26. On The Biomedical Promise of Cell Penetrating Peptides: Limits Versus Prospects

    Article • Journal of Pharmaceutical Sciences, January 2008, Elsevier

    Professor Hans P Merkle

  27. Stable Stealth Function for Hollow Polyelectrolyte Microcapsules through a Poly(ethylene glycol) Grafted Polyelectrolyte Adlayer

    Article • Biomacromolecules, January 2008, American Chemical Society (ACS)

    Professor Hans P Merkle

  28. Silk coatings on PLGA and alginate microspheres for protein delivery

    Article • Biomaterials, October 2007, Elsevier

    Prof. Guillermo Raul Castro, Professor Hans P Merkle

  29. A Protective Allergy Vaccine Based on CpG- and Protamine-Containing PLGA Microparticles

    Article • Pharmaceutical Research, July 2007, Springer Science + Business Media

    Professor Hans P Merkle

  30. Non-Invasive Time-Lapsed Monitoring and Quantification of Engineered Bone-Like Tissue

    Article • Annals of Biomedical Engineering, June 2007, Springer Science + Business Media

    Professor Hans P Merkle

  31. Nerve conduits and growth factor delivery in peripheral nerve repair

    Article • Journal of the Peripheral Nervous System, June 2007, Wiley

    Professor Hans P Merkle

  32. A Protective Allergy Vaccine Based on CpG- and Protamine-Containing PLGA Microparticles

    Article • Pharmaceutical Research, May 2007, Springer Science + Business Media

    Professor Hans P Merkle

  33. Differentiation Restricted Endocytosis of Cell Penetrating Peptides in MDCK Cells Corresponds with Activities of Rho-GTPases

    Article • Pharmaceutical Research, March 2007, Springer Science + Business Media

    Professor Hans P Merkle

  34. The preservation of phenotype and functionality of dendritic cells upon phagocytosis of polyelectrolyte-coated PLGA microparticles

    Article • Biomaterials, February 2007, Elsevier

    Professor Hans P Merkle

  35. Control of in vitro tissue-engineered bone-like structures using human mesenchymal stem cells and porous silk scaffolds

    Article • Biomaterials, February 2007, Elsevier

    Professor Hans P Merkle

  36. Reviewing Biophysical and Cell Biological Methodologies in Cell-Penetrating Peptide (CPP) Research

    Article • Critical Reviews in Therapeutic Drug Carrier Systems, January 2007, Begell House

    Professor Hans P Merkle

  37. Erratum: Reviewing Biophysical and Cell Biological Methodologies in Cell-Penetrating Peptite (CPP) Research (Volume 24, Issue 3)

    Article • Critical Reviews in Therapeutic Drug Carrier Systems, January 2007, Begell House

    Professor Hans P Merkle

  38. Hydrogel nerve conduits produced from alginate/chitosan complexes

    Article • Journal of Biomedical Materials Research Part A, October 2006, Wiley

    Professor Hans P Merkle

  39. Cartilage-like Tissue Engineering Using Silk Scaffolds and Mesenchymal Stem Cells

    Article • Tissue Engineering, October 2006, Mary Ann Liebert Inc

    Professor Hans P Merkle

  40. Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: Comparison of adenovirus mediated gene transfer and protein delivery of BMP-2

    Article • Biomaterials, October 2006, Elsevier

    Professor Hans P Merkle

  41. Cartilage-like Tissue Engineering Using Silk Scaffolds and Mesenchymal Stem Cells

    Article • Tissue Engineering, September 2006, Mary Ann Liebert Inc

    Professor Hans P Merkle

  42. Encapsulation of proteins and peptides into biodegradable poly(d,l-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells

    Article • Vaccine, March 2006, Elsevier

    Professor Hans P Merkle

  43. One-step preparation of polyelectrolyte-coated PLGA microparticles and their functionalization with model ligands

    Article • Journal of Controlled Release, March 2006, Elsevier

    Professor Hans P Merkle

  44. The Cell Penetrating Peptides pVEC and W2-pVEC Induce Transformation of Gel Phase Domains in Phospholipid Bilayers without Affecting Their Integrity †

    Article • Biochemistry, March 2006, American Chemical Society (ACS)

    Professor Hans P Merkle

  45. Effects of structural modification on gene transfection and self-assembling properties of amphiphilic dendrimers

    Article • Organic & Biomolecular Chemistry, January 2006, Royal Society of Chemistry

    Professor Hans P Merkle

  46. Continuous contact- and contamination-free ultrasonic emulsification—a useful tool for pharmaceutical development and production

    Article • Ultrasonics Sonochemistry, January 2006, Elsevier

    Professor Hans P Merkle

  47. Phagocytosis of poly(L-lysine)-graft-poly(ethylene glycol) coated microspheres by antigen presenting cells: Impact of grafting ratio and poly(ethylene glycol) chain length on cellular recognition

    Article • Biointerphases, January 2006, American Vacuum Society

    Professor Hans P Merkle

  48. Membrane Surface-Associated Helices Promote Lipid Interactions and Cellular Uptake of Human Calcitonin-Derived Cell Penetrating Peptides

    Article • Biophysical Journal, December 2005, Elsevier

    Professor Hans P Merkle

  49. Bilayer interaction and localization of cell penetrating peptides with model membranes: A comparative study of a human calcitonin (hCT)-derived peptide with pVEC and pAntp(43–58)

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 2005, Elsevier

    Professor Hans P Merkle

  50. Insulin-like Growth Factor I—Releasing Alginate-Tricalciumphosphate Composites for Bone Regeneration

    Article • Pharmaceutical Research, June 2005, Springer Science + Business Media

    Professor Hans P Merkle

  51. Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology

    Article • Journal of Controlled Release, February 2005, Elsevier

    Professor Hans P Merkle, Dr Ahmed F Zobaa

  52. Transport Of Surface-Modified Nanoparticles Through Cell Monolayers

    Article • ChemBioChem, January 2005, Wiley

    Professor Hans P Merkle

  53. Decoding the Entry of Two Novel Cell-Penetrating Peptides in HeLa Cells:  Lipid Raft-Mediated Endocytosis and Endosomal Escape

    Article • Biochemistry, December 2004, American Chemical Society (ACS)

    Professor Hans P Merkle

  54. Transfection of a mouse dendritic cell line by plasmid DNA-loaded PLGA microparticles in vitro

    Article • European Journal of Pharmaceutics and Biopharmaceutics, November 2004, Elsevier

    Professor Hans P Merkle

  55. Concepts and Prototypes for Formulation and Delivery of Biopharmaceuticals and in Tissue Engineering

    Article • CHIMIA International Journal for Chemistry, October 2004, Swiss Chemical Society

    Professor Hans P Merkle

  56. Modulation of allergic responses in mice by using biodegradable poly(lactide-co-glycolide) microspheres

    Article • Journal of Allergy and Clinical Immunology, October 2004, Elsevier

    Professor Hans P Merkle

  57. Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: human calcitonin (hCT)-derived peptides, Tat(47–57) and penetratin(43–58)

    Article • Biochemical Journal, September 2004, Portland Press Ltd.

    Professor Hans P Merkle

  58. Localized delivery of growth factors for bone repair

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2004, Elsevier

    Professor Hans P Merkle

  59. Chances and pitfalls of cell penetrating peptides for cellular drug delivery

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2004, Elsevier

    Professor Hans P Merkle

  60. Composition and Surface Charge of DNA-Loaded Microparticles Determine Maturation and Cytokine Secretion in Human Dendritic Cells

    Article • Pharmaceutical Research, July 2004, Springer Science + Business Media

    Professor Hans P Merkle

  61. Cellular Uptake But Low Permeation of Human Calcitonin-Derived Cell Penetrating Peptides and Tat(47-57) Through Well-Differentiated Epithelial Models

    Article • Pharmaceutical Research, July 2004, Springer Science + Business Media

    Professor Hans P Merkle

  62. Phenotype and functional analysis of human monocyte-derived dendritic cells loaded with biodegradable poly(lactide-co-glycolide) microspheres for immunotherapy

    Article • Journal of Immunological Methods, April 2004, Elsevier

    Professor Hans P Merkle

  63. Ultrasonic atomisation into reduced pressure atmosphere—envisaging aseptic spray-drying for microencapsulation

    Article • Journal of Controlled Release, March 2004, Elsevier

    Professor Hans P Merkle

  64. Immobilisation of GM-CSF onto particulate vaccine carrier systems

    Article • International Journal of Pharmaceutics, January 2004, Elsevier

    Professor Hans P Merkle

  65. Cellular Internalization of Human Calcitonin Derived Peptides in MDCK Monolayers: A Comparative Study with Tat(47-57) and Penetratin(43-58)

    Article • Pharmaceutical Research, January 2004, Springer Science + Business Media

    Professor Hans P Merkle

  66. Localized insulin-like growth factor I delivery to enhance new bone formation

    Article • Bone, October 2003, Elsevier

    Professor Hans P Merkle, Regula Bettschart

  67. Evaluation of pH-dependent membrane-disruptive properties of poly(acrylic acid) derived polymers

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2003, Elsevier

    Professor Hans P Merkle

  68. An experimental divalent vaccine based on biodegradable microspheres induces protective immunity against tetanus and diphtheria

    Article • Journal of Pharmaceutical Sciences, May 2003, Elsevier

    Professor Hans P Merkle

  69. Amphiphilic Dendrimers: Novel Self-Assembling Vectors for Efficient Gene Delivery

    Article • Angewandte Chemie International Edition, April 2003, Wiley

    Professor Hans P Merkle

  70. Improved Stimulation of Human Dendritic Cells by Receptor Engagement with Surface-modified Microparticles

    Article • Journal of Drug Targeting, January 2003, Taylor & Francis

    Professor Hans P Merkle

  71. Evaluation of cationic solid lipid microparticles as synthetic carriers for the targeted delivery of macromolecules to phagocytic antigen-presenting cells

    Article • Biomaterials, December 2002, Elsevier

    Professor Hans P Merkle

  72. In vitro methodologies to study nasal delivery using excised mucosa

    Article • August 2002, Taylor & Francis

    Professor Hans P Merkle

  73. A crystal clear solution for insulin delivery

    Article • Nature Biotechnology, August 2002, Springer Science + Business Media

    Professor Hans P Merkle

  74. Phagocytosis of synthetic particulate vaccine delivery systems to program dendritic cells

    Article • Expert Review of Vaccines, August 2002, Taylor & Francis

    Professor Hans P Merkle

  75. Cellular Internalization of Enhanced Green Fluorescent Protein Ligated to a Human Calcitonin-Based Carrier Peptide

    Article • ChemBioChem, July 2002, Wiley

    Professor Hans P Merkle

  76. In vitro phagocytosis and monocyte-macrophage activation with poly(lactide) and poly(lactide-co-glycolide) microspheres

    Article • European Journal of Pharmaceutical Sciences, March 2002, Elsevier

    Professor Carlos Gamazo, Professor Hans P Merkle, Professor Juan M. Irache

  77. Compromised integrity of excised porcine intestinal epithelium obtained from the abattoir affects the outcome of in vitro particle uptake studies

    Article • European Journal of Pharmaceutical Sciences, February 2002, Elsevier

    Professor Hans P Merkle

  78. In Vitro Assessment of Intestinal IGF‐I Stability

    Article • Journal of Pharmaceutical Sciences, January 2002, Elsevier

    Professor Hans P Merkle

  79. Microparticle-mediated Transfection of Non-phagocytic Cells In Vitro

    Article • Journal of Drug Targeting, January 2002, Taylor & Francis

    Professor Hans P Merkle

  80. Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages?

    Article • Journal of Controlled Release, September 2001, Elsevier

    Professor Hans P Merkle

  81. Hydrophilic poly(dl-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells

    Article • Journal of Controlled Release, September 2001, Elsevier

    Professor Hans P Merkle

  82. Release kinetics and immunogenicity of parvovirus microencapsulated in PLA/PLGA microspheres

    Article • International Journal of Pharmaceutics, June 2001, Elsevier

    Professor Hans P Merkle

  83. Stabilizing insulin-like growth factor-I in poly(d,l-lactide-co-glycolide) microspheres

    Article • Journal of Controlled Release, January 2001, Elsevier

    Professor Hans P Merkle

  84. Technological considerations related to the up-scaling of protein microencapsulation by spray-drying

    Article • European Journal of Pharmaceutics and Biopharmaceutics, November 2000, Elsevier

    Professor Hans P Merkle

  85. Control of gentamicin release from a calcium phosphate cement by admixed poly(acrylic acid)

    Article • Journal of Pharmaceutical Sciences, October 2000, Elsevier

    Professor Hans P Merkle

  86. Control of Gentamicin Release From a Calcium Phosphate Cement by Admixed Poly(acrylic acid)

    Article • Journal of Pharmaceutical Sciences, October 2000, Elsevier

    Professor Hans P Merkle

  87. Formulation of sustained release aqueous Zn–hirudin suspensions

    Article • European Journal of Pharmaceutical Sciences, July 2000, Elsevier

    Professor Hans P Merkle

  88. Modeling of Diffusion and Concurrent Metabolism in Cutaneous Tissue

    Article • Journal of Theoretical Biology, June 2000, Elsevier

    Professor Hans P Merkle

  89. In vitro and in vivo evaluation of a somatostatin analogue released from PLGA microspheres

    Article • Journal of Controlled Release, June 2000, Elsevier

    Professor Hans P Merkle, Professor Maria J Blanco-Prieto

  90. Validation of Excised Bovine Nasal Mucosa as In Vitro Model to Study Drug Transport and Metabolic Pathways in Nasal Epithelium‡‡Data adopted from yet unpublished parts of the Ph.D. theses of Günter Ditzinger, Steffen Lang, and M. Christiane Schmidt

    Article • Journal of Pharmaceutical Sciences, March 2000, Elsevier

    Professor Hans P Merkle

  91. Immunogenicity of single-dose diphtheria vaccines based on PLA/PLGA microspheres in guinea pigs

    Article • Vaccine, September 1999, Elsevier

    Professor Hans P Merkle

  92. Microencapsulation of DNA using poly(dl-lactide-co-glycolide): stability issues and release characteristics

    Article • Journal of Controlled Release, September 1999, Elsevier

    Professor Hans P Merkle

  93. Function and immunolocalization of overexpressed human intestinal H+/peptide cotransporter in adenovirus-transduced Caco-2 cells

    Article • AAPS PharmSci, September 1999, American Association of Pharmaceutical Scientists (AAPS)

    Professor Hans P Merkle

  94. Sustained release of heparin from polymeric particles for inhibition of human vascular smooth muscle cell proliferation

    Article • Journal of Controlled Release, August 1999, Elsevier

    Professor Hans P Merkle

  95. The venus flytrap of periplasmic binding proteins: An ancient protein module present in multiple drug receptors

    Article • AAPS PharmSci, June 1999, American Association of Pharmaceutical Scientists (AAPS)

    Professor Hans P Merkle

  96. Diphtheria and tetanus toxoid microencapsulation into conventional and end-group alkylated PLA/PLGAs

    Article • European Journal of Pharmaceutics and Biopharmaceutics, May 1999, Elsevier

    Professor Hans P Merkle

  97. MHC class I- and class II-restricted processing and presentation of microencapsulated antigens

    Article • Vaccine, March 1999, Elsevier

    Professor Hans P Merkle

  98. Translocation of Human Calcitonin in Respiratory Nasal Epithelium Is Associated with Self-Assembly in Lipid Membrane

    Article • Biochemistry, November 1998, American Chemical Society (ACS)

    Professor Hans P Merkle

  99. Physico-chemical and antigenic properties of tetanus and diphtheria toxoids and steps towards improved stability

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 1998, Elsevier

    Professor Hans P Merkle

  100. Mechanistic and Quantitative Prediction of Aminopeptidase Activity in Stripped Human Skin Based on the HaCaT Cell Sheet Model

    Article • Journal of Investigative Dermatology Symposium Proceedings, August 1998, Elsevier

    Professor Hans P Merkle

  101. P-Glycoprotein (P-gp) Mediated Efflux in Caco-2 Cell Monolayers: The Influence of Culturing Conditions and Drug Exposure on P-gp Expression Levels

    Article • Journal of Pharmaceutical Sciences, June 1998, Elsevier

    Professor Hans P Merkle

  102. Sustained release of injectable zinc-recombinant hirudin suspensions: development and validation of in vitro release model

    Article • European Journal of Pharmaceutics and Biopharmaceutics, May 1998, Elsevier

    Professor Hans P Merkle

  103. Drug Microencapsulation by PLA/PLGA Coacervation in the Light of Thermodynamics. 1. Overview and Theoretical Considerations

    Article • Journal of Pharmaceutical Sciences, March 1998, Elsevier

    Professor Hans P Merkle

  104. Drug Microencapsulation by PLA/PLGA Coacervation in the Light of Thermodynamics. 2. Parameters Determining Microsphere Formation

    Article • Journal of Pharmaceutical Sciences, March 1998, Elsevier

    Professor Hans P Merkle

  105. Permeation and Pathways of Human Calcitonin (hCT) Across Excised Bovine Nasal Mucosa

    Article • Peptides, January 1998, Elsevier

    Professor Hans P Merkle

  106. In vitro cell models to study nasal mucosal permeability and metabolism

    Article • Advanced Drug Delivery Reviews, January 1998, Elsevier

    Professor Hans P Merkle

  107. Structure-Permeation Relations of Met-enkephalin Peptide Analogues on Absorption and Secretion Mechanisms in Caco-2 Monolayers

    Article • Journal of Pharmaceutical Sciences, July 1997, Elsevier

    Professor Hans P Merkle

  108. Intestinal absorption of the quaternary trospium chloride: permeability-lowering factors and bioavailabilities for oral dosage forms

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 1997, Elsevier

    Professor Hans P Merkle

  109. Gentamicin-Loaded Hydraulic Calcium Phosphate Bone Cement as Antibiotic Delivery System

    Article • Journal of Pharmaceutical Sciences, May 1997, Elsevier

    Professor Hans P Merkle

  110. Epidermal Aminopeptidase Activity and Metabolism as Observed in an Organized HaCaT Cell Sheet Model

    Article • Journal of Pharmaceutical Sciences, March 1997, Elsevier

    Professor Hans P Merkle

  111. Physico-chemical parameters governing protein microencapsulation into biodegradable polyesters by coacervation

    Article • International Journal of Pharmaceutics, February 1997, Elsevier

    Professor Hans P Merkle

  112. Localization of Aminopeptidase Activity in Freshly Excised Human Skin: Direct Visualization by Confocal Laser Scanning Microscopy

    Article • Journal of Investigative Dermatology, January 1997, Elsevier

    Professor Hans P Merkle

  113. Transport and Metabolic Pathway of Thymocartin (TP4) in Excised Bovine Nasal Mucosa

    Article • Journal of Pharmacy and Pharmacology, November 1996, Wiley

    Professor Hans P Merkle

  114. Tetanus toxoid and synthetic malaria antigen containing poly(lactide)/poly(lactide-co-glycolide) microspheres: importance of polymer degradation and antigen release for immune response

    Article • Journal of Controlled Release, August 1996, Elsevier

    Professor Hans P Merkle

  115. Physical Model Relating Diffusional Transport and Concurrent Metabolism of Peptides in Metabolically Active Cell Sheets

    Article • Journal of Pharmaceutical Sciences, November 1995, Elsevier

    Professor Hans P Merkle

  116. Membrane modulated dissolution of oral drug delivery systems

    Article • Pharmaceutica Acta Helvetiae, July 1995, Elsevier

    Professor Hans P Merkle

  117. Architecture and Polymorphism of Fibrillar Supramolecular Assemblies Produced by in Vitro Aggregation of Human Calcitonin

    Article • Journal of Structural Biology, July 1995, Elsevier

    Professor Hans P Merkle

  118. Dermal metabolism of topically applied drugs: Pathways and models reconsidered

    Article • Pharmaceutica Acta Helvetiae, April 1995, Elsevier

    Professor Hans P Merkle

  119. Interfacial Adsorption and Aggregation Associated Changes in Secondary Structure of Human Calcitonin Monitored by ATR-FTIR Spectroscopy

    Article • Biochemistry, October 1994, American Chemical Society (ACS)

    Professor Hans P Merkle

  120. New aspects of pharmaceutical dosage forms for controlled drug delivery of peptides and proteins

    Article • European Journal of Pharmaceutical Sciences, September 1994, Elsevier

    Professor Hans P Merkle

  121. Metabolism and Transport of the Pentapeptide Metkephamid by Brush-border Membrane Vesicles of Rat Intestine

    Article • Journal of Pharmacy and Pharmacology, January 1994, Wiley

    Professor Hans P Merkle

  122. Intraoral Peptide Absorption

    Article • January 1993, Springer Science + Business Media

    Professor Hans P Merkle

  123. Fluorescence study of human calcitonin fibrillation kinetics using the hydrophobic probe Nile red

    Article • January 1993, Springer Science + Business Media

    Professor Hans P Merkle

  124. Buccal delivery for peptide drugs

    Article • Journal of Controlled Release, July 1992, Elsevier

    Professor Hans P Merkle

  125. Formulation of Silicone Matrix Systems for Long Term Constant Release of Peptides

    Article • Drug Development and Industrial Pharmacy, January 1991, Taylor & Francis

    Professor Hans P Merkle

  126. Intrinsic diffusion coefficients of drugs in pressure-sensitive adhesive polymer masses

    Article • International Journal of Pharmaceutics, October 1990, Elsevier

    Professor Hans P Merkle

  127. Evaluation of laminated muco-adhesive patches for buccal drug delivery

    Article • International Journal of Pharmaceutics, February 1989, Elsevier

    Professor Hans P Merkle

  128. Drug Delivery of Peptides: The Buccal Route

    Article • January 1986, Springer Science + Business Media

    Professor Hans P Merkle

  129. Modeling and Numerical Computation of Drug Transport in Laminates: Model Case Evaluation of Transdermal Delivery System

    Article • Journal of Pharmaceutical Sciences, January 1986, Elsevier

    Professor Hans P Merkle

  130. Release kinetics of polymeric laminates for transdermal delivery: Experimental evaluation and physical modelling

    Article • Journal of Controlled Release, November 1985, Elsevier

    Professor Hans P Merkle

  131. Design of oral drug delivery systems – Past, present and future

    Article • Drug Development and Industrial Pharmacy, January 1983, Taylor & Francis

    Professor Hans P Merkle

  132. Quantitative, mechanistic and physiologically realistic approach to the biopharmaceutical design of oral drug delivery systems

    Article • Drug Development and Industrial Pharmacy, January 1983, Taylor & Francis

    Professor Hans P Merkle