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  1. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer’s disease in rodents
  2. The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents
  3. Creativity in large pharmaceutical research organizations: unleash the hungry drug hunter
  4. The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia
  5. Neuropeptide Receptor Ligands for the Treatment of Schizophrenia: Focus on Neurotensin and Tachykinins
  6. Long-lasting memory abnormalities following exposure to the mouse defense test battery: An animal model of PTSD
  7. Pharmacology, Biochemistry and Behavior: The 2015 Transition
  8. The CRF1 receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: Comparison with paroxetine and d-cycloserine
  9. Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents
  10. Tachykinins
  11. Optogenetics to study the circuits of fear- and depression-like behaviors: A critical analysis
  12. Mood and Anxiety Disorders
  13. Mice Deficient in Cryptochrome 1 (Cry1−/−) Exhibit Resistance to Obesity Induced by a High-Fat Diet
  14. Tachykinins
  15. Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep–wake disorders
  16. Phencyclidine decreases tickling-induced 50-kHz ultrasound vocalizations in juvenile rats
  17. 50 years of hurdles and hope in anxiolytic drug discovery
  18. Further evidence for the sleep-promoting effects of 5-HT2A receptor antagonists and demonstration of synergistic effects with the hypnotic, zolpidem in rats
  19. Deep brain stimulation in treatment-resistant depression in mice: Comparison with the CRF1 antagonist, SSR125543
  20. The Vasopressin V 1b Receptor Antagonist SSR149415 in the Treatment of Major Depressive and Generalized Anxiety Disorders
  21. SAR110894, a potent histamine H3-receptor antagonist, displays procognitive effects in rodents
  22. Awakening properties of newly discovered highly selective H3 receptor antagonists in rats
  23. Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
  24. Is there still a future for neurokinin 3 receptor antagonists as potential drugs for the treatment of psychiatric diseases?
  25. The neurokinin NK2 antagonist, saredutant, ameliorates stress-induced conditions without impairing cognition
  26. The corticotropin-releasing factor 1 receptor antagonist, SSR125543, and the vasopressin 1b receptor antagonist, SSR149415, prevent stress-induced cognitive impairment in mice
  27. Risk assessment as an evolved threat detection and analysis process
  28. The Mouse Defense Test Battery: A Model Measuring Different Facets of Anxiety-Related Behaviors
  29. SSR181507, a dopamine D2 receptor and 5-HT1A receptor ligand: Evidence for mixed anxiolytic- and antidepressant-like activities
  30. AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in rodents
  31. Effects of intra-hippocampal injections of the NK2 receptor antagonist saredutant on the elevated plus maze, and the mouse defense test battery
  32. Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression
  33. Implication of β3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress
  34. The Glycine Transporter-1 Inhibitor SSR103800 Displays a Selective and Specific Antipsychotic-like Profile in Normal and Transgenic Mice
  35. Pro-Cognitive and Antipsychotic Efficacy of the α7 Nicotinic Partial Agonist SSR180711 in Pharmacological and Neurodevelopmental Latent Inhibition Models of Schizophrenia
  36. Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat
  37. Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal
  38. Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal
  39. Confirmation of antidepressant potential of the selective β3 adrenoceptor agonist amibegron in an animal model of depression
  40. Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models
  41. Chapter 4.6 Genetic factors underlying anxiety-behavior: A meta-analysis of rodent studies involving targeted mutations of neurotransmission genes
  42. Stimulation of the β3-Adrenoceptor as a Novel Treatment Strategy for Anxiety and Depressive Disorders
  43. SSR180711, a Novel Selective α7 Nicotinic Receptor Partial Agonist: (1) Binding and Functional Profile
  44. SSR180711, a Novel Selective α7 Nicotinic Receptor Partial Agonist: (II) Efficacy in Experimental Models Predictive of Activity Against Cognitive Symptoms of Schizophrenia
  45. An Overview of SSR149415, a Selective Nonpeptide Vasopressin V1b Receptor Antagonist for the Treatment of Stress-Related Disorders
  46. Editorial [Hot Topic: Neuropeptide Systems as Novel Targets for Psychiatric Disorders (Guest Editor: Guy Griebel) ]
  47. Antidepressant-Like Effects of the Corticotropin-Releasing Factor 1 Receptor Antagonist, SSR125543, and the Vasopressin 1b Receptor Antagonist, SSR149415, in a DRL-72 s Schedule in the Rat
  48. Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat
  49. Neurochemical, Electrophysiological and Pharmacological Profiles of the Selective Inhibitor of the Glycine Transporter-1 SSR504734, a Potential New Type of Antipsychotic
  50. Disruption of the Prepulse Inhibition of the Startle Reflex in Vasopressin V1b Receptor Knockout Mice: Reversal by Antipsychotic Drugs
  51. Non-Peptide Vasopressin V1b Receptor Antagonists as Potential Drugs for the Treatment of Stress-Related Disorders
  52. ENZYMATIC RESOLUTION AND BASE PAIRING PROPERTIES OFD- ANDL-CYCLOHEXENYL NUCLEIC ACIDS (CeNA)
  53. Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents
  54. Defensive Responses to Predator Threat in the Rat and Mouse
  55. Chapter 4.2 Nonpeptide vasopressin V1b receptor antagonists
  56. Evidence that the Lateral Septum is Involved in the Antidepressant-Like Effects of the Vasopressin V1b Receptor Antagonist, SSR149415
  57. Nicotine-Associated Cues Maintain Nicotine-Seeking Behavior in Rats Several Weeks after Nicotine Withdrawal: Reversal by the Cannabinoid (CB1) Receptor Antagonist, Rimonabant (SR141716)
  58. Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression
  59. Response to Roesler et al.: Neuropeptides and stress-related disorders – multiple targets and converging concepts
  60. Effects of the CRF1 antagonist SSR125543A on aggressive behaviors in hamsters
  61. Impaired memory following predatory stress in mice is improved by fluoxetine
  62. Conditioning and residual emotionality effects of predator stimuli: some reflections on stress and emotion
  63. Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders
  64. The Vasopressin V1b Receptor as a Therapeutic Target in Stress-related Disorders
  65. Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice
  66. SL651498, a GABAA Receptor Agonist with Subtype-Selective Efficacy, as a Potential Treatment for Generalized Anxiety Disorder and Muscle Spasms
  67. The Mouse Defense Test Battery: pharmacological and behavioral assays for anxiety and panic
  68. Functional and Pharmacological Characterization of the First Specific Agonist and Antagonist for the V1b Receptor in Mammals
  69. Characterization of the profile of neurokinin-2 and neurotensin receptor antagonists in the mouse defense test battery
  70. Effects of SR48968, a selective non-peptide NK 2 receptor antagonist on emotional processes in rodents
  71. Measuring normal and pathological anxiety-like behaviour in mice: a review
  72. Behavioral and neurochemical changes following predatory stress in mice
  73. The effects of compounds varying in selectivity as 5-HT1A receptor antagonists in three rat models of anxiety
  74. Subtype-selective benzodiazepine receptor ligands
  75. Discriminative Stimulus Effects of Drugs Acting at GABAA Receptors
  76. Behavioral Effects of Acute and Chronic Fluoxetine in Wistar–Kyoto Rats
  77. Pharmacological studies on synthetic flavonoids: comparison with diazepam
  78. Orphanin FQ, a novel neuropeptide with anti-stress-like activity
  79. Is There a Future for Neuropeptide Receptor Ligands in the Treatment of Anxiety Disorders?
  80. Differences in Anxiolytic-Like Profile of Two Novel Nonbenzodiazepine BZ (ϖ) Receptor Agonists on Defensive Behaviors of Mice
  81. Study of the modulatory activity of bz (ω) receptor ligands on defensive behaviors in mice: Evaluation of the importance of intrinsic efficacy and receptor subtype selectivity
  82. Behavioral effects of phenelzine in an experimental model for screening anxiolytic and anti-panic drugs: correlation with changes in monoamine–oxidase activity and monoamine levels
  83. Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries
  84. Risk Assessment Behaviour: Evaluation of Utility in the Study of 5-HT-Related Drugs in the Rat Elevated Plus-Maze Test
  85. An Ethopharmacological Analysis of Selective Activation of 5-HT1A Receptors: The Mouse 5-HT1A Syndrome
  86. Genetic differences in the mouse defense test battery
  87. Genetic differences in the mouse defense test battery
  88. Evidence that the Behaviors in the Mouse Defense Test Battery Relate to Different Emotional States: A Factor Analytic Study
  89. Preclinical profile of the mixed 5-HT1A/5-HT2A receptor antagonist S 21357
  90. Predator-elicited plight responses in Swiss-Webster Mice: An experimental model of panic attacks
  91. 5-HT1A agonists modulate mouse antipredator defensive behavior differently from the 5-HT2A antagonist pirenperone
  92. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research
  93. Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents
  94. Some critical determinants of the behaviour of rats in the elevated plus-maze
  95. Prolactin similar to ectopic pituitary isograft restores responsiveness in Snell dwarf mice
  96. Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice
  97. m-Chlorophenylpiperazine enhances neophobic and anxious behaviour in mice
  98. Behavioral effects of rolipram and structurally related compounds in mice: Behavioral sedation of cAMP phosphodiesterase inhibitors
  99. Comparison of the behavioural effects of an adenosine A1/A2-receptor antagonist, CGS 15943A, and an A1-selective antagonist, DPCPX
  100. Behavioural effects of selective A2 adenosine receptor antagonists, CGS 21197 and CGS 22706, in mice
  101. Serenics fluprazine (DU 27716) and eltoprazine (DU 28853) enhance neophobic and emotional behaviour in mice
  102. Anxiolytic and sedative effects of 5-HT1A ligands, 8-OH-DPAT and MDL 73005EF, in mice
  103. Amino Acid Transmitter Systems
  104. Anxiety disorders
  105. Anxiety disorders
  106. Faculty of 1000 evaluation for Noninvasive optical inhibition with a red-shifted microbial rhodopsin.
  107. Faculty of 1000 evaluation for Global optogenetic activation of inhibitory interneurons during epileptiform activity.
  108. Faculty of 1000 evaluation for Astrocyte-derived ATP modulates depressive-like behaviors.
  109. Faculty of 1000 evaluation for Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.
  110. Faculty of 1000 evaluation for Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.
  111. Faculty of 1000 evaluation for Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice.
  112. Faculty of 1000 evaluation for Neutral antagonism at the cannabinoid 1 receptor: a safer treatment for obesity.
  113. Faculty of 1000 evaluation for Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss.
  114. Faculty of 1000 evaluation for Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
  115. Faculty of 1000 evaluation for Diverging neural pathways assemble a behavioural state from separable features in anxiety.
  116. Faculty of 1000 evaluation for The Corticotropin Releasing Hormone-1 (CRH1) Receptor Antagonist Pexacerfont in Alcohol Dependence: A Randomized Controlled Experimental Medicine Study.
  117. The Mouse Defense Test Battery: An experimental model of different emotional states.
  118. Faculty of 1000 evaluation for A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects.