All Stories

  1. Molecular basis of tRNA substrate recognition and modification by the atypical SPOUT methyltransferase Trm10
  2. Design, Synthesis, and Evaluation of Novel Inhibitors of Aminoglycoside‐Resistance 16S Ribosomal RNA Methyltransferases
  3. KNexPHENIX: A PHENIX-Based Workflow for Improving Cryo-EM and Crystallographic Structural Models
  4. Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI
  5. Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification
  6. Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase
  7. Distant ribose 2′-O-methylation of 23S rRNA helix 69 pre-orders the capreomycin drug binding pocket at the ribosome subunit interface
  8. Regulation, structure, and activity of the Pseudomonas aeruginosa MexXY efflux system
  9. Abstract 2653 Defining the allosteric activation network in human OAS1
  10. Determination of Pseudomonas aeruginosa MexXY-OprM substrate profile in a major efflux knockout system reveals distinct antibiotic substrate classes
  11. Distant Ribose 2’-O-Methylation of 23S rRNA Helix 69 Pre-Orders the Capreomycin Drug Binding Pocket at the Ribosome Subunit Interface
  12. Evading resistance at the double
  13. Determination ofPseudomonas aeruginosaMexXY-OprM substrate profile in a major efflux knockout system reveals distinct antibiotic substrate classes
  14. Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance
  15. Differential roles of putative arginine fingers of AAA + ATPases Rvb1 and Rvb2
  16. Ensuring a sustained workforce to combat antibiotic resistance in the 21st century: the critical need for training the next-gen of scientists at the pre-doctoral level
  17. AI is a viable alternative to high throughput screening: a 318-target study
  18. tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10
  19. Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition
  20. 30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC
  21. Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS
  22. Di-berberine conjugates as chemical probes ofPseudomonas aeruginosaMexXY-OprM efflux function and inhibition
  23. 30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC
  24. tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10
  25. Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation
  26. Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases
  27. Tuberactinomycin antibiotics: Biosynthesis, anti-mycobacterial action, and mechanisms of resistance
  28. Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent integrated stress response in C9orf72 FTD/ALS
  29. 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA
  30. Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs
  31. 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA
  32. Targeted Redesign of Suramin Analogs for Novel Antimicrobial Lead Development
  33. Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency
  34. Targeted redesign of suramin analogs for novel antimicrobial lead development
  35. Antibiotic Substrate Selectivity of Pseudomonas aeruginosa MexY and MexB Efflux Systems Is Determined by a Goldilocks Affinity
  36. Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs
  37. Aminoglycoside conformation and ring substituents dictate evasion from bacterial resistance mechanisms
  38. Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain
  39. Substrate recognition by the Pseudomonas aeruginosa EF-Tu–modifying methyltransferase EftM
  40. Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition
  41. Substrate recognition by the Pseudomonas aeruginosa EF-Tu methyltransferase EftM
  42. Dysregulation of M segment gene expression contributes to influenza A virus host restriction
  43. Editorial: Bacterial Mechanisms of Antibiotic Resistance: A Structural Perspective
  44. Critical residues in the aminoglycoside-resistance 16S rRNA (m7G1405) methyltransferase RmtC play distinct roles in 30S substrate recognition
  45. RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetase
  46. Trimethylation of Elongation Factor-Tu by the Dual Thermoregulated Methyltransferase EftM Does Not Impact Its Canonical Function in Translation
  47. A human cellular noncoding RNA activates the antiviral protein 2’–5’-oligoadenylate synthetase 1
  48. Substrate Recognition and Modification by a Pathogen-Associated Aminoglycoside Resistance 16S rRNA Methyltransferase
  49. Human non-coding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR
  50. Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast
  51. A Novel Motif for S-adenosyl-L-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis
  52. Use of a Grant Writing Class in Training PhD Students
  53. Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase
  54. Adenovirus VA RNA: An essential pro-viral non-coding RNA
  55. Functional dichotomy in the 16S rRNA (m 1 A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization
  56. Heterologous Expression and Functional Characterization of the Exogenously Acquired Aminoglycoside Resistance Methyltransferases RmtD, RmtD2, and RmtG
  57. Functional roles inS‐adenosyl‐l‐methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase
  58. The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs
  59. The Pathogen-Derived Aminoglycoside Resistance 16S rRNA Methyltransferase NpmA Possesses Dual m1A1408/m1G1408 Specificity
  60. Assessment of the introduction of an adolescent transition urology clinic using a validated questionnaire
  61. 30S Subunit-Dependent Activation of the Sorangium cellulosum So ce56 Aminoglycoside Resistance-Conferring 16S rRNA Methyltransferase Kmr
  62. A novel RNA molecular signature for activation of 2′-5′ oligoadenylate synthetase-1
  63. Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate
  64. Binding Induced RNA Conformational Changes Control Substrate Recognition and Catalysis by the Thiostrepton Resistance Methyltransferase (Tsr)
  65. Expansion of the aminoglycoside-resistance 16S rRNA (m1A1408) methyltransferase family: Expression and functional characterization of four hypothetical enzymes of diverse bacterial origin
  66. Dissection of the Adenoviral VA RNAI Central Domain Structure Reveals Minimum Requirements for RNA-mediated Inhibition of PKR
  67. Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA
  68. Plasmid Template Design and In Vitro Transcription of Short RNAs Within a “Structure Cassette” for Structure Probing Experiments
  69. General Protocols for Preparation of Plasmid DNA Template, RNA In Vitro Transcription, and RNA Purification by Denaturing PAGE
  70. Cis-Acting Ribozymes for the Production of RNA In Vitro Transcripts with Defined 5′ and 3′ Ends
  71. Identification of new inhibitors of protein kinase R guided by statistical modeling
  72. Reduced Sweetness of a Monellin (MNEI) Mutant Results from Increased Protein Flexibility and Disruption of a Distant Poly-(L-Proline) II Helix
  73. Expression, purification and crystallization of adenosine 1408 aminoglycoside-resistance rRNA methyltransferases for structural studies
  74. Magnesium-Dependent Interaction of PKR with Adenovirus VAI
  75. Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria
  76. Regulation of PKR By Viral RNAS
  77. Heterologous Escherichia coli Expression, Purification and Characterization of the GrmA Aminoglycoside-Resistance Methyltransferase
  78. The PKR-binding domain of adenovirus VA RNAI exists as a mixture of two functionally non-equivalent structures
  79. Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics
  80. Structure of the Thiostrepton Resistance Methyltransferase{middle dot}S-Adenosyl-L-methionine Complex and Its Interaction with Ribosomal RNA
  81. Aminoglycoside resistance genes sgm and kgmB protect bacterial but not yeast small ribosomal subunits in vitro despite high conservation of the rRNA A-site
  82. Raman and Raman optical activity (ROA) analysis of RNA structural motifs
  83. Critical Residues for Cofactor Binding and Catalytic Activity in the Aminoglycoside Resistance Methyltransferase Sgm
  84. Systematic Deletion of the Adenovirus-associated RNAI Terminal Stem Reveals a Surprisingly Active RNA Inhibitor of Double-stranded RNA-activated Protein Kinase
  85. Analysis of adenovirus VA RNAI structure and stability using compensatory base pair modifications
  86. Recombinant RNA expression
  87. 902 INTRAVESICAL BOTULINUM TOXIN TYPE A IN INTERSTITIAL CYSTITIS
  88. Monellin (MNEI) at 1.15 Å resolution
  89. Raman and Raman optical activity (ROA) analysis of RNA structural motifs in Domain I of the EMCV IRES
  90. Optimization of a Ribosomal Structural Domain by Natural Selection †
  91. Expression and Purification of Functional Ligand-Binding Domains of T1R3 Taste Receptors
  92. Distinct Contributions of T1R2 and T1R3 Taste Receptor Subunits to the Detection of Sweet Stimuli
  93. A prospective study to evaluate the safety, tolerability, efficacy and durability of response of intravesical injection of botulinum toxin type A into detrusor muscle in patients with refractory idiopathic detrusor overactivity
  94. Coevolution of Protein and RNA Structures within a Highly Conserved Ribosomal Domain
  95. NMR studies of the structure and Mg2+ binding properties of a conserved RNA motif of EMCV picornavirus IRES element
  96. Virtual bronchoscopy and 3D spiral CT reconstructions in the management of kyphosis induced tracheal compression
  97. Conserved Nucleotides within the J Domain of the Encephalomyocarditis Virus Internal Ribosome Entry Site Are Required for Activity and for Interaction with eIF4G
  98. Expression of active RNA-activated protein kinase (PKR) in bacteria
  99. General plasmids for producing RNA in vitro transcripts with homogeneous ends
  100. The solution structure of a DNAmiddle dotRNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications
  101. A Compact RNA Tertiary Structure Contains a Buried Backbone–K+ Complex
  102. The crystal structure of the RNA/DNA hybrid r(GAAGAGAAGC){middle dot}d(GCTTCTCTTC) shows significant differences to that found in solution
  103. A Functional Ribosomal RNA Tertiary Structure Involves a Base Triple Interaction
  104. The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids
  105. RNA structure
  106. Solution Structures of DNA·RNA Hybrids with Purine-Rich and Pyrimidine-Rich Strands:  Comparison with the Homologous DNA and RNA Duplexes,
  107. Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes
  108. Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2
  109. The dependence of DNase I activity on the conformation of oligodeoxynucleotides
  110. Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR
  111. Comparison of the Thermodynamic Stabilities and Solution Conformations of DNA·RNA Hybrids Containing Purine-Rich and Pyrimidine-Rich Strands with DNA and RNA Duplexes