All Stories

  1. Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

    Article • Diabetes, August 2020, American Diabetes Association

    Lue Ping Zhao, George K Papadopoulos

  2. Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children

    Article • Diabetes, April 2020, American Diabetes Association

    Lue Ping Zhao, George K Papadopoulos

  3. A modified flow cytometry method for objective estimation of human CD4 + regulatory T cells (CD4 + Tregs) in peripheral blood, via CD4/CD25/CD45RO/FoxP3 labeling

    Article • Cytometry Part B Clinical Cytometry, September 2019, Wiley

    George K Papadopoulos

  4. Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer–mediated autoimmune diabetes

    Article • Science Advances, August 2019, American Association for the Advancement of Science

    George K Papadopoulos

  5. Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4 and 5 Include Potentially “Causal Residues” Responsible for the Risk of Childhood Type 1 Diabetes

    Article • Diabetes, May 2019, American Diabetes Association

    Lue Ping Zhao, George K Papadopoulos

  6. Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes

    Article • Diabetes, January 2019, American Diabetes Association

    George K Papadopoulos

  7. DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes

    Article • The Journal of Immunology, November 2018, The American Association of Immunologists

    George K Papadopoulos

  8. RGDtrip: A Database for the Investigation of Proteins Containing the RGD Tripeptide

    Article • Current Bioinformatics, September 2018, Bentham Science Publishers

    Elias Eliopoulos, Dr. Giannis E. Tzimas, George K Papadopoulos, Yiannis Hatzis, Trias Thireou, Konstantinos Poulas

  9. Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis

    Article • Annals of the Rheumatic Diseases, August 2017, BMJ

    George K Papadopoulos

  10. The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules

    Article • November 2016, Springer Science + Business Media

    George K Papadopoulos

  11. Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis

    Article • Nature Communications, May 2015, Springer Science + Business Media

    George K Papadopoulos

  12. Type 1 diabetes as an autoimmune disease: the evidence

    Article • Diabetologia, April 2014, Springer Science + Business Media

    George K Papadopoulos

  13. Differential Binding of Pyruvate Dehydrogenase Complex-E2 Epitopes by DRB1*08:01 and DRB1*11:01 Is Predicted by Their Structural Motifs and Correlates with Disease Risk

    Article • The Journal of Immunology, March 2013, The American Association of Immunologists

    George K Papadopoulos

  14. Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study

    Article • Diabetes, July 2012, American Diabetes Association

    George K Papadopoulos

  15. Regulation of catalytic behaviour of hydrolases through interactions with functionalized carbon-based nanomaterials

    Article • Journal of Nanoparticle Research, April 2012, Springer Science + Business Media

    Prof. Uwe T Bornscheuer, George K Papadopoulos

  16. DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9

    Article • Molecular Immunology, February 2012, Elsevier

    George K Papadopoulos

  17. Type 1 Diabetes-associated HLA-DQ8 Transdimer Accommodates a Unique Peptide Repertoire

    Article • Journal of Biological Chemistry, December 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    George K Papadopoulos

  18. Gluten-Specific T Cells Cross-React between HLA-DQ8 and the HLA-DQ2α/DQ8β Transdimer

    Article • The Journal of Immunology, October 2011, The American Association of Immunologists

    George K Papadopoulos

  19. Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized mice

    Article • Arthritis & Rheumatism, May 2011, Wiley

    George K Papadopoulos

  20. Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes

    Article • Genes & Immunity, May 2011, Springer Science + Business Media

    George K Papadopoulos

  21. HLA-DR1001 presents “altered-self” peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets

    Article • Arthritis & Rheumatism, June 2010, Wiley

    George K Papadopoulos

  22. Corrigendum

    Article • Current Pharmaceutical Design, December 2009, Bentham Science Publishers

    George K Papadopoulos

  23. Use of MHC II Structural Features in the Design of Vaccines for Organ-Specific Autoimmune Diseases

    Article • Current Pharmaceutical Design, October 2009, Bentham Science Publishers

    George K Papadopoulos

  24. Lipases in water-in-ionic liquid microemulsions: Structural and activity studies

    Article • Journal of Molecular Catalysis B Enzymatic, September 2009, Elsevier

    George K Papadopoulos

  25. The Binding of Antigenic Peptides to HLA-DR Is Influenced by Interactions between Pocket 6 and Pocket 9

    Article • The Journal of Immunology, July 2009, The American Association of Immunologists

    George K Papadopoulos

  26. Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule

    Article • Immunogenetics, June 2008, Springer Science + Business Media

    George K Papadopoulos

  27. Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling

    Article • Molecular Immunology, May 2008, Elsevier

    George K Papadopoulos

  28. Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands

    Article • European Journal of Immunology, January 2008, Wiley

    George K Papadopoulos

  29. The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function

    Article • Immunogenetics, May 2007, Springer Science + Business Media

    George K Papadopoulos

  30. T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1

    Article • Immunogenetics, February 2005, Springer Science + Business Media

    George K Papadopoulos

  31. Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

    Article • Journal of Clinical Investigation, May 2003, American Society for Clinical Investigation

    George K Papadopoulos

  32. SPECIFIC MONOCLONAL ANTIBODIES AGAINST THE SURFACE OF RAT ISLET β CELLS

    Article • Cell Biology International, September 2002, Wiley

    George K Papadopoulos

  33. Peptide analysis, stability studies, and structural modeling explain contradictory peptide motifs and unique properties of the NOD mouse MHC class II molecule H2-Ag7

    Article • European Journal of Immunology, August 2002, Wiley

    George K Papadopoulos

  34. Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: Keys to the fate of islet ?-cells

    Article • American Journal of Medical Genetics, May 2002, Wiley

    George K Papadopoulos

  35. Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2Kdthat stimulates CD8 T cells in insulin-dependent diabetes mellitus

    Article • Proceedings of the National Academy of Sciences, April 2002, Proceedings of the National Academy of Sciences

    George K Papadopoulos

  36. Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones

    Article • Human Immunology, March 2002, Elsevier

    George K Papadopoulos

  37. Modulation of T cell response to hGAD65 peptide epitopes

    Article • Tissue Antigens, February 2002, Wiley

    George K Papadopoulos

  38. Structural analysis of two HLA-DR-presented autoantigenic epitopes: crucial role of peripheral but not central peptide residues for T-cell receptor recognition

    Article • Molecular Immunology, October 2000, Elsevier

    George K Papadopoulos

  39. Modelling of the MHC II allele I-A g7 of NOD mouse: pH-dependent changes in specificity at pockets 9 and 6 explain several of the unique properties of this molecule

    Article • Diabetologia, May 2000, Springer Science + Business Media

    George K Papadopoulos

  40. Role of Cytokines in the Pathogenesis of Anemia of Chronic Disease in Rheumatoid Arthritis

    Article • Clinical Immunology, August 1999, Elsevier

    George K Papadopoulos

  41. The Destructive Action of IL-1α and IL-1β in IDDM is a Multistage Process: Evidence and Confirmation by Apoptotic Studies, Induction of Intermediates and Electron Microscopy

    Article • Mediators of Inflammation, January 1999, Hindawi Publishing Corporation

    George K Papadopoulos

  42. RGD sequences in several receptor proteins: novel cell adhesion function of receptors?

    Article • International Journal of Biological Macromolecules, February 1998, Elsevier

    George K Papadopoulos

  43. Unique peptide binding characteristics of the disease-associated DQ(α1 * 0501, β1 * 0201) vs the non-disease-associated DQ(α1 * 0201, β1 * 0202) molecule

    Article • Immunogenetics, October 1997, Springer Science + Business Media

    George K Papadopoulos

  44. Novel Structural Features of the Human Histocompatibility Molecules HLA-DQ as Revealed by Modeling Based on the Published Structure of the Related Molecule HLA-DR

    Article • Journal of Structural Biology, September 1996, Elsevier

    George K Papadopoulos

  45. Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM

    Article • Diabetologia, October 1995, Springer Science + Business Media

    George K Papadopoulos

  46. IL-6-mediated MHC class II induction on RIN-5AH insulinoma cells by IFN-γ occurs via the G-protein pathway

    Article • Mediators of Inflammation, January 1995, Hindawi Publishing Corporation

    George K Papadopoulos

  47. Response to commentary by Pujol-Borrell and Botazzo

    Article • Immunology Today, May 1989, Elsevier

    George K Papadopoulos

  48. Soluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseases

    Article • Clinical Immunology and Immunopathology, March 1989, Elsevier

    George K Papadopoulos

  49. Mechanism of Action of Prothynosin α in the Human Autologous Mixed Lymphocyte Response

    Article • Immunopharmacology and Immunotoxicology, January 1988, Taylor & Francis

    George K Papadopoulos

  50. Orientations of the retinyl and the heme chromophores in the brown membrane of Halobacterium halobium

    Article • Journal of Molecular Biology, October 1981, Elsevier

    George K Papadopoulos

  51. Comparative studies on the fine structure of purple membrane fromHalobacterium cutirubrum andHalobacterium halobium

    Article • The Journal of Membrane Biology, November 1978, Springer Science + Business Media

    George K Papadopoulos

  52. Determination of the retinal/protein molar ratios for the purple membranes of Halobacterium halobium and Halobacterium cutirubrum

    Article • Biochemical and Biophysical Research Communications, March 1978, Elsevier

    George K Papadopoulos