All Stories

  1. Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms

    Article • Journal of Comparative Physiology A, March 2020, Springer Science + Business Media

    Gary Lewin

  2. The Sensory Coding of Warm Perception

    Article • Neuron, March 2020, Elsevier

    Gary Lewin

  3. Rapid molecular evolution of pain insensitivity in multiple African rodents

    Article • Science, May 2019, American Association for the Advancement of Science

    Dr Heike Lutermann, Gary Lewin

  4. Publisher Correction: Lipidome determinants of maximal lifespan in mammals

    Article • Scientific Reports, May 2019, Springer Science + Business Media

    Gary Lewin

  5. The sensory coding of warm perception

    Article • December 2018, Cold Spring Harbor Laboratory Press

    Gary Lewin

  6. The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

    Article • Science Translational Medicine, October 2018, American Association for the Advancement of Science

    Gary Lewin

  7. Specialized mechanoreceptor systems in rodent glabrous skin

    Article • The Journal of Physiology, September 2018, Wiley

    Dr Maria K Oosthuizen, Gary Lewin

  8. Specialized mechanoreceptor systems in rodent glabrous skin

    Article • June 2018, Cold Spring Harbor Laboratory Press

    Gary Lewin, Dr Maria K Oosthuizen

  9. Voltage gating of mechanosensitive PIEZO channels

    Article • Nature Communications, March 2018, Springer Science + Business Media

    Gary Lewin

  10. Mechanoelectrical transduction in chondrocytes

    Article • Clinical and Experimental Pharmacology and Physiology, February 2018, Wiley

    Gary Lewin

  11. The Absence of Sensory Axon Bifurcation Affects Nociception and Termination Fields of Afferents in the Spinal Cord

    Article • Frontiers in Molecular Neuroscience, February 2018, Frontiers

    Gary Lewin

  12. Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability

    Article • Neuron, February 2018, Elsevier

    Gary Lewin

  13. Voltage-gating of mechanosensitive PIEZO channels

    Article • June 2017, Cold Spring Harbor Laboratory Press

    Gary Lewin

  14. Congenital deafness is associated with specific somatosensory deficits in adolescents

    Article • Scientific Reports, June 2017, Springer Science + Business Media

    Gary Lewin

  15. Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

    Article • Science, April 2017, American Association for the Advancement of Science

    Dr Heike Lutermann, Gary Lewin

  16. Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System

    Article • Frontiers in Molecular Neuroscience, March 2017, Frontiers

    Gary Lewin

  17. Lipidome determinants of maximal lifespan in mammals

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Gary Lewin

  18. Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

    Article • eLife, January 2017, eLife

    Gary Lewin

  19. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

    Article • Nature Neuroscience, December 2016, Springer Science + Business Media

    Gary Lewin

  20. Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain

    Article • Scientific Reports, November 2016, Springer Science + Business Media

    Gary Lewin

  21. Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat

    Article • Cell Reports, October 2016, Elsevier

    Gary Lewin

  22. Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects

    Article • Journal of Visualized Experiments, September 2016, MyJove Corporation

    Gary Lewin

  23. A Molecular Signature of Myalgia in Myotonic Dystrophy 2

    Article • EBioMedicine, May 2016, Elsevier

    Gary Lewin

  24. A Probabilistic Model for Estimating the Depth and Threshold Temperature of C-fiber Nociceptors

    Article • Scientific Reports, December 2015, Nature

    Michael Schmuker, Gary Lewin

  25. ASICs and mammalian mechanoreceptor function

    Article • Neuropharmacology, July 2015, Elsevier

    Gary Lewin

  26. Photoswitchable fatty acids enable optical control of TRPV1

    Article • Nature Communications, May 2015, Springer Science + Business Media

    Gary Lewin

  27. GABA Blocks Pathological but Not Acute TRPV1 Pain Signals

    Article • Cell, February 2015, Elsevier

    Gary Lewin

  28. PIEZO2 is required for mechanotransduction in human stem cell–derived touch receptors

    Article • Nature Neuroscience, December 2014, Springer Science + Business Media

    Gary Lewin

  29. Piezo2 is the major transducer of mechanical forces for touch sensation in mice

    Article • Nature, December 2014, Springer Science + Business Media

    Gary Lewin

  30. A somatosensory circuit for cooling perception in mice

    Article • Nature Neuroscience, September 2014, Springer Science + Business Media

    Gary Lewin

  31. Sensory mechanotransduction at membrane-matrix interfaces

    Article • Pflügers Archiv - European Journal of Physiology, July 2014, Springer Science + Business Media

    Gary Lewin

  32. Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans

    Article • Pain, July 2014, Wolters Kluwer Health

    Gary Lewin

  33. Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

    Article • Nature Communications, March 2014, Springer Science + Business Media

    Gary Lewin

  34. Pro‐neurotrophins, sortilin, and nociception

    Article • European Journal of Neuroscience, February 2014, Wiley

    Gary Lewin

  35. Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination

    Article • Genes & Development, February 2014, Cold Spring Harbor Laboratory Press

    Gary Lewin

  36. Water-Induced Finger Wrinkles Do Not Affect Touch Acuity or Dexterity in Handling Wet Objects

    Article • PLoS ONE, January 2014, PLOS

    Gary Lewin

  37. Subunit‐specific inhibition of acid sensing ion channels by stomatin‐like protein 1

    Article • The Journal of Physiology, January 2014, Wiley

    Gary Lewin

  38. Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy

    Article • January 2014, Springer Science + Business Media

    Gary Lewin

  39. Natural Selection and Pain Meet at a Sodium Channel

    Article • Science, October 2013, American Association for the Advancement of Science

    Gary Lewin

  40. Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity

    Article • The Journal of Physiology, October 2013, Wiley

    Gary Lewin

  41. Hairy Sensation

    Article • Physiology, May 2013, American Physiological Society

    Gary Lewin

  42. A stomatin dimer modulates the activity of acid-sensing ion channels

    Article • The EMBO Journal, July 2012, Wiley

    Gary Lewin

  43. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

    Article • Nature Reports Stem Cells, July 2012, Springer Science + Business Media

    Gary Lewin

  44. Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons

    Article • Open Biology, June 2012, Royal Society Publishing

    Gary Lewin

  45. Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: Comparative analysis using six species of bathyergidae

    Article • The Journal of Comparative Neurology, June 2012, Wiley

    Gary Lewin

  46. A Genetic Basis for Mechanosensory Traits in Humans

    Article • PLoS Biology, May 2012, PLOS

    Gary Lewin

  47. Stomatin-domain proteins

    Article • European Journal of Cell Biology, April 2012, Elsevier

    Gary Lewin

  48. Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity

    Article • PLoS Biology, March 2012, PLOS

    Gary Lewin

  49. The Transcription Factor c-Maf Controls Touch Receptor Development and Function

    Article • Science, February 2012, American Association for the Advancement of Science

    Dr Katja Reuter, Gary Lewin

  50. Gαq/11 signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization

    Article • Pain, January 2012, Wolters Kluwer Health

    Gary Lewin

  51. The Molecular Basis of Acid Insensitivity in the African Naked Mole-Rat

    Article • Science, December 2011, American Association for the Advancement of Science

    Gary Lewin

  52. KCNQ4 K+ channels tune mechanoreceptors for normal touch sensation in mouse and man

    Article • Nature Neuroscience, November 2011, Springer Science + Business Media

    Gary Lewin

  53. Erratum: Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

    Article • Nature Neuroscience, August 2011, Springer Science + Business Media

    Gary Lewin

  54. Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons

    Article • Nature Neuroscience, July 2011, Springer Science + Business Media

    Gary Lewin

  55. The Cav3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors

    Article • The Journal of Physiology, April 2011, Wiley

    Gary Lewin

  56. Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice

    Article • Journal of Clinical Investigation, April 2011, American Society for Clinical Investigation

    Gary Lewin

  57. The Molecular and Cellular Identity of Peripheral Osmoreceptors

    Article • Neuron, January 2011, Elsevier

    Gary Lewin

  58. Functional Neurokinin and NMDA Receptor Activity in an Animal Naturally Lacking Substance P: The Naked Mole-Rat

    Article • PLoS ONE, December 2010, PLOS

    Gary Lewin

  59. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

    Article • Nature Neuroscience, November 2010, Springer Science + Business Media

    Gary Lewin

  60. Ultraviolet-B-induced mechanical hyperalgesia: A role for peripheral sensitisation

    Article • Pain, July 2010, Wolters Kluwer Health

    Gary Lewin

  61. RAPID REPORT: Anin vivotethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors

    Article • The Journal of Physiology, May 2010, Wiley

    Gary Lewin

  62. Evidence for a protein tether involved in somatic touch

    Article • The EMBO Journal, January 2010, Wiley

    Gary Lewin

  63. Absence of Histamine-Induced Itch in the African Naked Mole-Rat and “Rescue” by Substance P

    Article • Molecular Pain, January 2010, SAGE Publications

    Gary Lewin

  64. Nociceptors: a phylogenetic view

    Article • Journal of Comparative Physiology A, October 2009, Springer Science + Business Media

    Gary Lewin

  65. Peripheral sensitisation of nociceptors via G-proteindependent potentiation of mechanotransduction currents

    Article • The Journal of Physiology, July 2009, Wiley

    Gary Lewin

  66. Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development

    Article • The EMBO Journal, March 2009, Wiley

    Gary Lewin

  67. Speed and Temperature Dependences of Mechanotransduction in Afferent Fibers Recorded From the Mouse Saphenous Nerve

    Article • Journal of Neurophysiology, November 2008, American Physiological Society

    Gary Lewin

  68. Stretching it for pain

    Article • Pain, June 2008, Wolters Kluwer Health

    Gary Lewin

  69. Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber)

    Article • PLoS Biology, January 2008, PLOS

    Gary Lewin

  70. Nociceptive Tuning by Stem Cell Factor/c-Kit Signaling

    Article • Neuron, December 2007, Elsevier

    Gary Lewin

  71. Stomatin and Sensory Neuron Mechanotransduction

    Article • Journal of Neurophysiology, December 2007, American Physiological Society

    Gary Lewin

  72. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

    Article • Nature Neuroscience, October 2007, Springer Science + Business Media

    Gary Lewin

  73. A stomatin-domain protein essential for touch sensation in the mouse

    Article • Nature, December 2006, Nature

    Prof Halina Machelska, Gary Lewin

  74. Mechanosensitive currents in the neurites of cultured mouse sensory neurones

    Article • The Journal of Physiology, December 2006, Wiley

    Gary Lewin

  75. A role for T-type Ca2+ channels in mechanosensation

    Article • Cell Calcium, August 2006, Elsevier

    Gary Lewin

  76. The high threshold mechanotransducer: A status report

    Article • Pain, January 2006, Wolters Kluwer Health

    Gary Lewin

  77. Chapter 13 Finding Sensory Neuron Mechanotransduction Components

    Article • January 2006, Elsevier

    Gary Lewin

  78. A plethora of painful molecules [Curr. Opin. Neuro. 14 (2004) 443]

    Article • Current Opinion in Neurobiology, February 2005, Elsevier

    Gary Lewin

  79. The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability

    Article • Neuroscience, January 2005, Elsevier

    Gary Lewin

  80. The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function

    Article • Gastroenterology, December 2004, Elsevier

    Gary Lewin

  81. The AMPA Receptor Subunits GluR-A and GluR-B Reciprocally Modulate Spinal Synaptic Plasticity and Inflammatory Pain

    Article • Neuron, November 2004, Elsevier

    Gary Lewin

  82. Role of T-Type Calcium Current in Identified D-Hair Mechanoreceptor Neurons Studied In Vitro

    Article • Journal of Neuroscience, September 2004, Society for Neuroscience

    Gary Lewin

  83. A plethora of painful molecules

    Article • Current Opinion in Neurobiology, August 2004, Elsevier

    Gary Lewin

  84. Mechanosensation and pain

    Article • Journal of Neurobiology, January 2004, Wiley

    Gary Lewin

  85. A T-type calcium channel required for normal function of a mammalian mechanoreceptor

    Article • Nature Neuroscience, June 2003, Springer Science + Business Media

    Gary Lewin

  86. Identification of Caveolae-like Structures on the Surface of Intact Cells Using Scanning Force Microscopy

    Article • The Journal of Membrane Biology, June 2003, Springer Science + Business Media

    Gary Lewin

  87. cGMP-mediated signaling via cGKIα is required for the guidance and connectivity of sensory axons

    Article • The Journal of Cell Biology, November 2002, Rockefeller University Press

    Gary Lewin

  88. GFRα2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons

    Article • The Journal of Physiology, November 2002, Wiley

    Gary Lewin

  89. Neurotrophin-4

    Article • Current Biology, August 2002, Elsevier

    Gary Lewin

  90. The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice

    Article • Neuron, July 2002, Elsevier

    Gary Lewin

  91. Erratum: corrigendum: The mammalian sodium channel BNC1 is required for normal touch sensation

    Article • Nature, July 2002, Springer Science + Business Media

    Gary Lewin

  92. The Homeodomain Factor Lbx1 Distinguishes Two Major Programs of Neuronal Differentiation in the Dorsal Spinal Cord

    Article • Neuron, May 2002, Elsevier

    Gary Lewin

  93. Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons

    Article • Genes & Development, March 2002, Cold Spring Harbor Laboratory Press

    Dr. Bernd Fritzsch, Gary Lewin

  94. The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice

    Article • Neuron, December 2001, Elsevier

    Gary Lewin

  95. BDNF but not NT-4 is required for normal flexion reflex plasticity and function

    Article • Proceedings of the National Academy of Sciences, July 2001, Proceedings of the National Academy of Sciences

    Gary Lewin

  96. Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin

    Article • The Journal of Physiology, July 2001, Wiley

    Gary Lewin

  97. Neurotrophins, nociceptors and pain

    Article • Current Opinion in Anaesthesiology, October 2000, Wolters Kluwer Health

    Gary Lewin

  98. The mammalian sodium channel BNC1 is required for normal touch sensation

    Article • Nature, October 2000, Springer Science + Business Media

    Gary Lewin

  99. Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors

    Article • Proceedings of the National Academy of Sciences, June 2000, Proceedings of the National Academy of Sciences

    Gary Lewin

  100. Cellular Sources of Enhanced Brain-Derived Neurotrophic Factor Production in a Mouse Model of Allergic Inflammation Notice to Professional Recruitment and Announcement Advertisers

    Article • American Journal of Respiratory Cell and Molecular Biology, October 1999, American Thoracic Society

    Gary Lewin

  101. Stomatin, a MEC-2 Like Protein, Is Expressed by Mammalian Sensory Neurons

    Article • Molecular and Cellular Neuroscience, June 1999, Elsevier

    Gary Lewin

  102. Stability and plasticity of primary afferent projections following nerve regeneration and central degeneration

    Article • European Journal of Neuroscience, February 1999, Wiley

    Gary Lewin

  103. Neurotrophins: A Link between Airway Inflammation and Airway Smooth Muscle Contractility in Asthma?

    Article • International Archives of Allergy and Immunology, January 1999, Karger Publishers

    Gary Lewin

  104. BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin

    Article • European Journal of Neuroscience, October 1998, Wiley

    Gary Lewin

  105. Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses

    Article • Neuron, August 1998, Elsevier

    Professor Alun M Davies, Gary Lewin

  106. Neurotrophin-3 Involvement in the Regulation of Hair Follicle Morphogenesis

    Article • Journal of Investigative Dermatology, August 1998, Elsevier

    Gary Lewin

  107. A role for BDNF in mechanosensation

    Article • Nature Neuroscience, May 1998, Springer Science + Business Media

    Gary Lewin

  108. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

    Article • Nature, October 1997, Springer Science + Business Media

    Gary Lewin

  109. Neurotrophins Live or Let Die: Does p75NTR Decide?

    Article • Neuron, February 1997, Elsevier

    Gary Lewin

  110. Maintenance of Modality-specific Connections in the Spinal Cord after Neonatal Nerve Growth Factor Deprivation

    Article • European Journal of Neuroscience, August 1996, Wiley

    Gary Lewin

  111. Physiology of the Neurotrophins

    Article • Annual Review of Neuroscience, March 1996, Annual Reviews

    Gary Lewin

  112. Specific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation

    Article • Neuron, February 1996, Elsevier

    Gary Lewin

  113. Neurotrophic factors and pain

    Article • Seminars in Neuroscience, August 1995, Elsevier

    Gary Lewin

  114. Peripheral and Central Mechanisms of NGF-induced Hyperalgesia

    Article • European Journal of Neuroscience, December 1994, Wiley

    Gary Lewin

  115. NMDA receptors and activity-dependent tuning of the receptive fields of spinal cord neurons

    Article • Nature, June 1994, Springer Science + Business Media

    Gary Lewin

  116. An ultrastructural size principle

    Article • Neuroscience, February 1994, Elsevier

    Gary Lewin

  117. Altered expression of nerve growth factor in the skin of transgenic mice leads to changes in response to mechanical stimuli

    Article • Neuroscience, October 1993, Elsevier

    Gary Lewin

  118. Nerve growth factor and nociception

    Article • Trends in Neurosciences, September 1993, Elsevier

    Gary Lewin

  119. Central hyperexcitability triggered by noxious inputs

    Article • Current Opinion in Neurobiology, August 1993, Elsevier

    Gary Lewin

  120. Muscle Afferents Innervating Skin Form Somatotopically Appropriate Connections in the Adult Rat Dorsal Horn

    Article • European Journal of Neuroscience, August 1993, Wiley

    Gary Lewin

  121. Regulation of myelinated nociceptor function by nerve growth factor in neonatal and adult rats

    Article • Brain Research Bulletin, January 1993, Elsevier

    Gary Lewin

  122. Neonatal Anti-NGF Treatment Reduces the Aδ- and C-Fibre Evoked Vasodilator Responses in Rat Skin: Evidence That Nociceptor Afferents Mediate Antidromic Vasodilatation

    Article • European Journal of Neuroscience, December 1992, Wiley

    Gary Lewin

  123. Regulation of Afferent Connectivity in the Adult Spinal Cord by Nerve Growth Factor

    Article • European Journal of Neuroscience, August 1992, Wiley

    Gary Lewin

  124. Removing constraints on neural sprouting

    Article • Current Biology, May 1992, Elsevier

    Gary Lewin

  125. Dorsal Horn Plasticity Following Re-routeing of Peripheral Nerves: Evidence for Tissue-Specific Neurotrophic Influences from the Periphery

    Article • European Journal of Neuroscience, November 1991, Wiley

    Gary Lewin

  126. Requirement for nerve growth factor in the development of myelinated nociceptors in vivo

    Article • Nature, April 1991, Springer Science + Business Media

    Gary Lewin

  127. The consequences of long-term topical capsaicin application in the rat

    Article • Pain, March 1991, Wolters Kluwer Health

    Gary Lewin

  128. Increase of blood flow in skin and spinal cord following activation of small diameter primary afferents

    Article • Brain Research, February 1990, Elsevier

    Gary Lewin

  129. Quantitative analysis of peptide levels and neurogenic extravasation following regeneration of afferents to appropriate and inappropriate targets

    Article • Neuroscience, January 1989, Elsevier

    Gary Lewin