All Stories

  1. Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids

    Article • Toxicology Letters, February 2020, Elsevier

    Dr Juan Francisco Leon

  2. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

    Article • Journal of Medicinal Chemistry, December 2019, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  3. Total Phenolic and Flavonoid Content and Biological Activities of Extracts and Isolated Compounds of Cytisus villosus Pourr.

    Article • Biomolecules, November 2019, MDPI AG

    Dr Juan Francisco Leon

  4. Perspective on the Therapeutics of Anti-Snake Venom

    Article • Molecules, September 2019, MDPI AG

    Dr Juan Francisco Leon

  5. The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats

    Article • Psychopharmacology, May 2019, Springer Science + Business Media

    Dr Juan Francisco Leon

  6. Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra‐performance liquid chromatography−tandem mass spectrometry

    Article • Drug Testing and Analysis, May 2019, Wiley

    Dr Juan Francisco Leon

  7. Motives for using Kratom (Mitragyna speciosa Korth.) among regular users in Malaysia

    Article • Journal of Ethnopharmacology, April 2019, Elsevier

    Dr Juan Francisco Leon

  8. Computationally aided stereochemical assignment of undescribed bisabolenes from Calea urticifolia

    Article • Phytochemistry, January 2019, Elsevier

    Dr Juan Francisco Leon

  9. Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)

    Article • Xenobiotica, December 2018, Taylor & Francis

    Dr Juan Francisco Leon, Shyam Kamble

  10. Centaurea microcarpa Coss. & Dur. (Asteraceae) extracts: New cyanogenic glucoside and other constituents

    Article • Natural Product Research, November 2018, Taylor & Francis

    thamere cheriet, Dr Juan Francisco Leon, Djamel SARRI

  11. Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats

    Article • Planta Medica, November 2018, Thieme Publishing Group

    Dr Juan Francisco Leon

  12. Humulene derivatives from Saharian Asteriscus graveolens

    Article • Tetrahedron Letters, July 2018, Elsevier

    Dr Juan Francisco Leon

  13. Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine

    Article • Addiction Biology, June 2018, Wiley

    Dr Juan Francisco Leon

  14. Secondary metabolites from two Hispaniola Ageratina species and their cytotoxic activity

    Article • Medicinal Chemistry Research, May 2018, Springer Science + Business Media

    Dr Juan Francisco Leon

  15. 3′-Hydroxy-3,4′-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK

    Article • Chemico-Biological Interactions, May 2018, Elsevier

    Dr Juan Francisco Leon

  16. Isolation, Antioxidant and Antimicrobial Activities of Ecdysteroids from Serratula cichoracea

    Article • Current Bioactive Compounds, April 2018, Bentham Science Publishers

    habiba larguet, Dr Juan Francisco Leon

  17. Secondary metabolites from the aerial parts of Cytisus villosus Pourr.

    Article • Phytochemistry Letters, April 2018, Elsevier

    Dr Juan Francisco Leon

  18. Evaluation of triazole and isoxazole derivatives as potential anti-infective agents

    Article • Medicinal Chemistry Research, February 2018, Springer Science + Business Media

    Dr Juan Francisco Leon

  19. Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants

    Article • Phytomedicine, February 2018, Elsevier

    Dr Juan Francisco Leon

  20. 3′-Hydroxy-3,4′-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells

    Article • Bioorganic & Medicinal Chemistry, November 2017, Elsevier

    Dr Juan Francisco Leon

  21. Molecular Modeling Evaluation of the Enantiomers of a Novel Adenylyl Cyclase 2 Inhibitor

    Article • Journal of Chemical Information and Modeling, January 2017, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  22. Interactions of Desmethoxyyangonin, a Secondary Metabolite fromRenealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B

    Article • Evidence-based Complementary and Alternative Medicine, January 2017, Hindawi Publishing Corporation

    Dr Juan Francisco Leon, Babu Tekwani

  23. Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B

    Article • Journal of Natural Products, October 2016, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  24. Components and antioxidant, anti-inflammatory, anti-ulcer and antinociceptive activities of the endemic species Stachys mialhesi de Noé

    Article • Arabian Journal of Chemistry, September 2016, Elsevier

    Dr Juan Francisco Leon

  25. Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance

    Article • Journal of Natural Products, May 2016, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  26. Secondary Metabolites, Evaluation of the DPPH Free-Radical Scavenging Effect by Electron Spin Resonance and Antibacterial Activity of the Endemic Species Stachys circinata

    Article • Chemistry of Natural Compounds, April 2016, Springer Science + Business Media

    Dr Juan Francisco Leon

  27. Secondary Metabolites and Antioxidant Activity of Limonium duriusculum (de Girard) Kuntze Extracts

    Article • Asian Journal of Chemistry, January 2016, Asian Journal of Chemistry

    Dr Juan Francisco Leon

  28. In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower

    Article • Journal of Ethnopharmacology, November 2015, Elsevier

    Dr Juan Francisco Leon

  29. Secondary Metabolites from Linaria tingitana

    Article • Chemistry of Natural Compounds, November 2015, Springer Science + Business Media

    Dr Juan Francisco Leon

  30. Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors

    Article • Journal of Natural Products, June 2015, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  31. Antinociceptive activity of extracts and secondary metabolites from wild growing and micropropagated plants of Renealmia alpinia

    Article • Journal of Ethnopharmacology, May 2015, Elsevier

    Dr Juan Francisco Leon

  32. Phenolic compounds, antioxidant activity and ultrastructural study from Protea hybrid ‘Susara’

    Article • Industrial Crops and Products, April 2014, Elsevier

    Dr Juan Francisco Leon

  33. Flavanones from Miconia prasina

    Article • Phytochemistry Letters, February 2014, Elsevier

    Dr Juan Francisco Leon

  34. Secondary Metabolites from Eupenicillium parvum and Their in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors

    Article • Planta Medica, November 2013, Thieme Publishing Group

    Dr Juan Francisco Leon

  35. Fatty Acids with in Vitro Binding Affinity for Human Opioid Receptors from the Fungus Emericella nidulans

    Article • Journal of Agricultural and Food Chemistry, October 2013, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  36. Correction to Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors

    Article • Journal of Natural Products, October 2013, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  37. A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands

    Article • Phytochemistry, August 2013, Elsevier

    Dr Juan Francisco Leon

  38. New strategy toward the diverted synthesis of oxidized abietane diterpenes via oxidation of 6,7-dehydroferruginol methyl ether with dimethyldioxirane

    Article • Tetrahedron Letters, August 2013, Elsevier

    Dr Juan Francisco Leon, Dr. José M. Padrón

  39. Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors

    Article • Journal of Natural Products, May 2013, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  40. A New Flavonoid C-Glycoside from Solanum elaeagnifolium with Hepatoprotective and Curative Activities against Paracetamol- Induced Liver Injury in Mice

    Article • Zeitschrift für Naturforschung C, February 2013, De Gruyter

    Dr Juan Francisco Leon

  41. Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells

    Article • Biochemical and Biophysical Research Communications, November 2012, Elsevier

    Dr Juan Francisco Leon

  42. Secondary Metabolites from Two Species of Tolpis and Their Biological Activities

    Article • Molecules, November 2012, MDPI AG

    Dr Juan Francisco Leon

  43. Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling

    Article • European Journal of Medicinal Chemistry, September 2012, Elsevier

    Dr Juan Francisco Leon

  44. Cytotoxic sesquiterpene lactones and other constituents of Centaurea omphalotricha

    Article • Journal of the Brazilian Chemical Society, May 2012, FapUNIFESP (SciELO)

    Dr Juan Francisco Leon

  45. A new flavonoid and other constituents fromCentaurea nicaeensisAll. var.wallianaM.

    Article • Natural Product Research, February 2012, Taylor & Francis

    Dr Juan Francisco Leon

  46. Phytochemical study of Halimium halimifolium

    Article • Chemistry of Natural Compounds, January 2012, Springer Science + Business Media

    Dr Juan Francisco Leon

  47. Antifungal Metabolites from the Roots of Diospyros virginiana by Overpressure Layer Chromatography

    Article • Chemistry & Biodiversity, December 2011, Wiley

    Dr Juan Francisco Leon

  48. Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens

    Article • Medicinal Chemistry Research, November 2011, Springer Science + Business Media

    Dr Juan Francisco Leon

  49. Secondary Metabolites from Two Species of Pulicaria and Their Cytotoxic Activity

    Article • Chemistry & Biodiversity, November 2011, Wiley

    Dr Juan Francisco Leon

  50. Benzyl Derivatives within VitroBinding Affinity for Human Opioid and Cannabinoid Receptors from the FungusEurotium repens

    Article • Journal of Natural Products, July 2011, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  51. Flavonoid aglycones and sterol from Chrysanthemum fontanesii

    Article • Chemistry of Natural Compounds, March 2011, Springer Science + Business Media

    Dr Juan Francisco Leon

  52. Flavonoid aglycones from Centaurea maroccana

    Article • Chemistry of Natural Compounds, March 2011, Springer Science + Business Media

    Dr Juan Francisco Leon

  53. Chemotaxonomy of Gonospermum and related genera

    Article • Phytochemistry, April 2010, Elsevier

    Dr Juan Francisco Leon

  54. Four flavonoids from the aerial part of Ononis angustissima species

    Article • Chemistry of Natural Compounds, November 2009, Springer Science + Business Media

    Dr Juan Francisco Leon

  55. A flavonoid with cytotoxic activity and other constituents from Centaurea africana

    Article • Phytochemistry Letters, August 2009, Elsevier

    Dr Juan Francisco Leon

  56. Sesquiterpene Lactones fromGonospermum gomeraeandG. fruticosumand Their Cytotoxic Activities

    Article • Journal of Natural Products, December 2008, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  57. Mycophenolic Derivatives fromEupenicilliumparvum

    Article • Journal of Natural Products, December 2008, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  58. Induction of G2-M phase arrest and apoptosis by α-methylene-γ-butyrolactones in human leukemia cells

    Article • Cancer Letters, September 2008, Elsevier

    Dr Juan Francisco Leon

  59. A new guaianolide and other constituents from Achillea ligustica

    Article • Biochemical Systematics and Ecology, May 2008, Elsevier

    Dr Juan Francisco Leon

  60. Synthesis of novel spirostanic saponins and their cytotoxic activity

    Article • Bioorganic & Medicinal Chemistry, February 2008, Elsevier

    Dr Juan Francisco Leon

  61. The Presence of Capsule in Cryptococcus neoformans Influences the Gene Expression Profile in Dendritic Cells during Interaction with the Fungus

    Article • Infection and Immunity, February 2008, ASM Journals

    Dr Juan Francisco Leon

  62. A New Ceramide fromSuillus luteus and Its Cytotoxic Activity against Human Melanoma Cells

    Article • Chemistry & Biodiversity, January 2008, Wiley

    Dr Juan Francisco Leon

  63. Sesquiterpene lactones and other constituents from Matricaria chamomilla L.

    Article • Biochemical Systematics and Ecology, August 2007, Elsevier

    Dr Juan Francisco Leon

  64. Revisiting the Reaction Between Diaminomaleonitrile and Aromatic Aldehydes: a Green Chemistry Approach

    Article • Molecules, November 2006, MDPI AG

    Dr Juan Francisco Leon

  65. Synthesis and antiproliferative activity of novel sugiol β-amino alcohol analogs

    Article • European Journal of Medicinal Chemistry, November 2006, Elsevier

    Dr Juan Francisco Leon, Dr. José M. Padrón

  66. Isolation, Structure Elucidation, Total Synthesis, and Evaluation of New Natural and Synthetic Ceramides on Human SK-MEL-1 Melanoma Cells

    Article • Journal of Medicinal Chemistry, September 2006, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  67. A Homo-Isoflavonoid and a Cytotoxic Saponin fromDracaena draco

    Article • Chemistry & Biodiversity, January 2006, Wiley

    Dr Juan Francisco Leon

  68. A new guaianolide and other sesquiterpene lactones from Centaurea acaulis L. (Asteraceae)

    Article • Biochemical Systematics and Ecology, October 2005, Elsevier

    Dr Juan Francisco Leon

  69. Sesquiterpenoids fromPulicariacanariensisand Their Cytotoxic Activities#

    Article • Journal of Natural Products, April 2005, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  70. Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity

    Article • Phytochemistry, March 2005, Elsevier

    Dr Juan Francisco Leon

  71. Lanostanoid Triterpenes fromLaetiporussulphureusand Apoptosis Induction on HL-60 Human Myeloid Leukemia Cells

    Article • Journal of Natural Products, December 2004, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  72. Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

    Article • Bioorganic & Medicinal Chemistry, August 2004, Elsevier

    Dr Juan Francisco Leon

  73. Isolation fromEucalyptusoccidentalisand Identification of a New Kaempferol Derivative that Induces Apoptosis in Human Myeloid Leukemia Cells

    Article • Journal of Natural Products, April 2004, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  74. Flavans of dragon’s blood from Dracaena draco and Dracaena tamaranae

    Article • Biochemical Systematics and Ecology, February 2004, Elsevier

    Dr Juan Francisco Leon

  75. Novel Cytostatic Lanostanoid Triterpenes fromGanoderma australe

    Article • Helvetica Chimica Acta, September 2003, Wiley

    Dr Juan Francisco Leon

  76. Sesquiterpenoid Derivatives fromGonospermumelegansand Their Cytotoxic Activity for HL-60 Human Promyelocytic Cells#

    Article • Journal of Natural Products, July 2003, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  77. Synthesis and Antiproliferative Activity of a New Compound Containing an α-Methylene-γ-Lactone Group

    Article • Journal of Medicinal Chemistry, June 2002, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  78. New Lanostanoids from the FungusGanodermaconcinna

    Article • Journal of Natural Products, March 2002, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  79. A facile chemoselective deacetylation in the presence of benzoyl and p-bromobenzoyl groups using p-toluenesulfonic acid

    Article • Tetrahedron Letters, April 2001, Elsevier

    Dr Juan Francisco Leon

  80. Phenolic Compounds of Dragon's Blood fromDracaenadraco

    Article • Journal of Natural Products, September 2000, American Chemical Society (ACS)

    Dr Juan Francisco Leon

  81. Synthesis of 2t-Substituted-1r,3c-BIS(2′-Hydroxy-5-Substituted-Benzyl)-Imidazolidines by Reaction of 1,3-BIS(2′-Hydroxy-5′-Substituted-Benzyl)-Imidazolidines with Aromatic Aldehydes

    Article • Synthetic Communications, June 2000, Taylor & Francis

    Dr Juan Francisco Leon

  82. Lanostanoid Triterpenes fromGanodermalucidum

    Article • Journal of Natural Products, December 1999, American Chemical Society (ACS)

    Dr Juan Francisco Leon