All Stories

  1. Origin and Impact of Nitric Oxide in Pseudomonas aeruginosa Biofilms

    Article • Journal of Bacteriology, August 2015, ASM Journals

    Professor Francesca Cutruzzola

  2. Structural Basis of Functional Diversification of the HD-GYP Domain Revealed by the Pseudomonas aeruginosa PA4781 Protein, Which Displays an Unselective Bimetallic Binding Site

    Article • Journal of Bacteriology, February 2015, ASM Journals

    Professor Francesca Cutruzzola

  3. How pyridoxal 5′-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

    Article • FEBS Journal, February 2015, Wiley

    Professor Francesca Cutruzzola

  4. Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase

    Article • ChemMedChem, February 2015, Wiley

    Professor Francesca Cutruzzola

  5. Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), isoform 3, transcript variant 5, 483 aa, at 2.6 ang. resolution

    Article • January 2015, Protein Data Bank, Rutgers University

    Professor Francesca Cutruzzola

  6. SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

    Article • Cell Death and Disease, November 2014, Springer Science + Business Media

    Professor Francesca Cutruzzola

  7. Nitrosylation of c heme in cd1-nitrite reductase is enhanced during catalysis

    Article • Biochemical and Biophysical Research Communications, August 2014, Elsevier

    Professor Francesca Cutruzzola

  8. Distal–proximal crosstalk in the heme binding pocket of the NO sensor DNR

    Article • BioMetals, July 2014, Springer Science + Business Media

    Professor Francesca Cutruzzola

  9. Serine and glycine metabolism in cancer

    Article • Trends in Biochemical Sciences, April 2014, Elsevier

    Professor Francesca Cutruzzola

  10. The phytotoxin fusicoccin differently regulates 14-3-3 proteins association to mode III targets

    Article • IUBMB Life, January 2014, Wiley

    Professor Francesca Cutruzzola

  11. Crystal structure of the GGDEF domain of PA1120 (YfiN or TpbB) from Pseudomonas aeruginosa at 2.7 Ang.

    Article • December 2013, Protein Data Bank, Rutgers University

    Professor Francesca Cutruzzola

  12. p73 keeps metabolic control in balance

    Article • Cell Cycle, November 2013, Taylor & Francis

    Professor Francesca Cutruzzola

  13. Investigating the Allosteric Regulation of YfiN from Pseudomonas aeruginosa: Clues from the Structure of the Catalytic Domain

    Article • PLoS ONE, November 2013, PLOS

    Professor Francesca Cutruzzola

  14. C-di-GMP Hydrolysis by Pseudomonas aeruginosa HD-GYP Phosphodiesterases: Analysis of the Reaction Mechanism and Novel Roles for pGpG

    Article • PLoS ONE, September 2013, PLOS

    Professor Francesca Cutruzzola

  15. The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability

    Article • Applied Microbiology and Biotechnology, April 2013, Springer Science + Business Media

    Professor Francesca Cutruzzola, Elio Rossi

  16. Solvent Accessibility in the Distal Heme Pocket of the Nitrosyl d 1 -Heme Complex of Pseudomonas stutzeri cd 1 Nitrite Reductase

    Article • Biochemistry, November 2012, American Chemical Society (ACS)

    Professor Francesca Cutruzzola

  17. Interactions outside the Boundaries of the Canonical Binding Groove of a PDZ Domain Influence Ligand Binding

    Article • Biochemistry, November 2012, American Chemical Society (ACS)

    Professor Francesca Cutruzzola

  18. Unusual Heme Binding Properties of the Dissimilative Nitrate Respiration Regulator, a Bacterial Nitric Oxide Sensor

    Article • Antioxidants & Redox Signaling, November 2012, Mary Ann Liebert Inc

    Professor Francesca Cutruzzola

  19. Nitrite and Nitrite Reductases: From Molecular Mechanisms to Significance in Human Health and Disease

    Article • Antioxidants & Redox Signaling, August 2012, Mary Ann Liebert Inc

    Professor Francesca Cutruzzola

  20. Nitric oxide synthesis by bacterial cytochrome cd1 nitrite reductases

    Article • Nitric Oxide, July 2012, Elsevier

    Professor Francesca Cutruzzola

  21. Cytochromec551

    Article • December 2011, Wiley

    Professor Francesca Cutruzzola

  22. In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed

    Article • European Journal of Medicinal Chemistry, May 2011, Elsevier

    Professor Francesca Cutruzzola

  23. Observation of fast release of NO from ferrous d 1 haem allows formulation of a unified reaction mechanism for cytochrome cd 1 nitrite reductases

    Article • Biochemical Journal, April 2011, Portland Press Ltd.

    Professor Francesca Cutruzzola

  24. The catalytic mechanism of Pseudomonas aeruginosa cd 1 nitrite reductase

    Article • Biochemical Society Transactions, February 2011, Portland Press Ltd.

    Professor Francesca Cutruzzola

  25. The Pseudomonas aeruginosa DNR transcription factor: light and shade of nitric oxide-sensing mechanisms

    Article • Biochemical Society Transactions, February 2011, Portland Press Ltd.

    Professor Francesca Cutruzzola

  26. XAS study of the active site of a bacterial heme-sensor

    Article • Journal of Physics Conference Series, November 2009, Institute of Physics Publishing

    Professor Francesca Cutruzzola

  27. A dramatic conformational rearrangement is necessary for the activation of DNR fromPseudomonas aeruginosa. Crystal structure of wild-type DNR

    Article • Proteins Structure Function and Bioinformatics, October 2009, Wiley

    Professor Francesca Cutruzzola

  28. Nitrite reduction: a ubiquitous function from a pre-aerobic past

    Article • BioEssays, August 2009, Wiley

    Professor Francesca Cutruzzola

  29. The transcription factor DNR from Pseudomonas aeruginosa specifically requires nitric oxide and haem for the activation of a target promoter in Escherichia coli

    Article • Microbiology, May 2009, Society for General Microbiology

    Professor Francesca Cutruzzola

  30. Intramolecular Electron Transfer in Pseudomonas aeruginosa cd1 Nitrite Reductase: Thermodynamics and Kinetics

    Article • Biophysical Journal, April 2009, Elsevier

    Professor Francesca Cutruzzola

  31. New insights into the activity of Pseudomonas aeruginosa cd 1 nitrite reductase

    Article • Biochemical Society Transactions, December 2008, Portland Press Ltd.

    Professor Francesca Cutruzzola

  32. NO sensing in Pseudomonas aeruginosa: Structure of the Transcriptional Regulator DNR

    Article • Journal of Molecular Biology, May 2008, Elsevier

    Professor Francesca Cutruzzola

  33. Ancient hemes for ancient catalysts

    Article • Plant Signaling & Behavior, February 2008, Taylor & Francis

    Professor Francesca Cutruzzola

  34. Tyrosine as a redox-active center in electron transfer to ferryl heme in globins

    Article • Free Radical Biology and Medicine, February 2008, Elsevier

    Professor Francesca Cutruzzola

  35. Nitrite controls the release of nitric oxide in Pseudomonas aeruginosa cd1 nitrite reductase

    Article • Biochemical and Biophysical Research Communications, November 2007, Elsevier

    Professor Francesca Cutruzzola

  36. Fast Dissociation of Nitric Oxide from Ferrous Pseudomonas aeruginosa cd1 Nitrite Reductase: A NOVEL OUTLOOK ON THE CATALYTIC MECHANISM

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Francesca Cutruzzola

  37. Nitrite Reductases in Denitrification

    Article • January 2007, Elsevier

    Professor Francesca Cutruzzola

  38. Histidine and not tyrosine is required for the Peroxide-induced formation of haem to protein cross-linked myoglobin

    Article • IUBMB Life, January 2007, Wiley

    Professor Francesca Cutruzzola

  39. Critical role of His369 in the reactivity of Pseudomonas aeruginosa cytochrome cd1nitrite reductase with oxygen

    Article • FEBS Journal, October 2006, Wiley

    Professor Francesca Cutruzzola

  40. N-oxide sensing and denitrification: the DNR transcription factors: Figure 1

    Article • Biochemical Society Transactions, February 2006, Portland Press Ltd.

    Professor Francesca Cutruzzola

  41. 1H-NMR Study of the Effect of Temperature through Reversible Unfolding on the Heme Pocket Molecular Structure and Magnetic Properties of Aplysia limacina Cyano-Metmyoglobin

    Article • Biophysical Journal, December 2005, Elsevier

    Professor Francesca Cutruzzola

  42. An Obligatory Intermediate in the Folding Pathway of Cytochrome c 552 from Hydrogenobacter thermophilus

    Article • Journal of Biological Chemistry, May 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Francesca Cutruzzola

  43. N-oxide sensing in Pseudomonas aeruginosa : expression and preliminary characterization of DNR, an FNR–CRP type transcriptional regulator

    Article • Biochemical Society Transactions, February 2005, Portland Press Ltd.

    Professor Francesca Cutruzzola

  44. NO Production by Pseudomonas aeruginosa cd1 Nitrite Reductase

    Article • IUBMB Life, January 2004, Wiley

    Professor Francesca Cutruzzola

  45. Folding of Aplysia limacina Apomyoglobin Involves an Intermediate in Common with Other Evolutionarily Distant Globins †

    Article • Biochemistry, January 2004, American Chemical Society (ACS)

    Professor Francesca Cutruzzola

  46. Parallel Pathways in Cytochrome c551 Folding

    Article • Journal of Molecular Biology, July 2003, Elsevier

    Professor Francesca Cutruzzola

  47. Electrochemical study of the intermolecular electron transfer to Pseudomonas aeruginosa cytochrome cd1 nitrite reductase

    Article • Electrochimica Acta, April 2003, Elsevier

    Professor Francesca Cutruzzola

  48. Construction and characterization of a chimeric myoglobin

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, February 2003, Elsevier

    Professor Francesca Cutruzzola

  49. Expression of a fully functional cd1 nitrite reductase from Pseudomonas aeruginosa in Pseudomonas stutzeri

    Article • Protein Expression and Purification, January 2003, Elsevier

    Professor Francesca Cutruzzola

  50. Cytochrome c551 as a model system for protein folding

    Article • Biophysical Chemistry, December 2002, Elsevier

    Professor Francesca Cutruzzola

  51. Comparative Study of Tyrosine Radicals in Hemoglobin and Myoglobins Treated with Hydrogen Peroxide

    Article • Biophysical Journal, November 2002, Elsevier

    Professor Francesca Cutruzzola

  52. Cyanide Binding to cd1 Nitrite Reductase from Pseudomonas aeruginosa: Role of the Active-Site His369 in Ligand Stabilization

    Article • Biochemical and Biophysical Research Communications, February 2002, Elsevier

    Professor Francesca Cutruzzola, Didier Nurizzo

  53. Pseudomonas aeruginosa cytochrome C551: probing the role of the hydrophobic patch in electron transfer

    Article • Journal of Inorganic Biochemistry, February 2002, Elsevier

    Professor Francesca Cutruzzola

  54. Domain Swing Upon His to Ala Mutation in Nitrite Reductase of Pseudomonas aeruginosa

    Article • Journal of Molecular Biology, September 2001, Elsevier

    Professor Francesca Cutruzzola

  55. Binding of NO and CO to the d 1 Heme of cd 1 Nitrite Reductase from Pseudomonas aeruginosa †

    Article • Biochemistry, September 2001, American Chemical Society (ACS)

    Professor Francesca Cutruzzola

  56. Snapshots of protein folding. A study on the multiple transition state pathway of cytochrome c551 from Pseudomonas aeruginosa

    Article • Journal of Molecular Biology, June 2001, Elsevier

    Professor Francesca Cutruzzola

  57. Kinetics of CO binding and CO photodissociation in Pseudomonas stutzeri cd1 nitrite reductase: probing the role of extended N-termini in fast structural relaxation upon CO photodissociation

    Article • Biochemical Journal, April 2001, Portland Press Ltd.

    Professor Andrea Bellelli, Professor Francesca Cutruzzola

  58. Studies on Pseudomonas aeruginosa cd1 nitrite reductase: The association and dissociation reactions of the d1‐heme

    Article • Israel Journal of Chemistry, June 2000, Wiley

    Professor Andrea Bellelli, Professor Francesca Cutruzzola

  59. A new folding intermediate of apomyoglobin from Aplysia limacina: stepwise formation of a molten globule11Edited by P. E. Wright

    Article • Journal of Molecular Biology, April 2000, Elsevier

    Professor Francesca Cutruzzola

  60. Engineering His(E7) Affects the Control of Heme Reactivity in Aplysia limacina Myoglobin

    Article • Biochemical and Biophysical Research Communications, March 2000, Elsevier

    Professor Francesca Cutruzzola

  61. Does picosecond protein dynamics have survival value?

    Article • Trends in Biochemical Sciences, July 1999, Elsevier

    Professor Francesca Cutruzzola

  62. Folding mechanism of Pseudomonas aeruginosa cytochrome c 551 : role of electrostatic interactions on the hydrophobic collapse and transition state properties 1 1Edited by P. E. Wright

    Article • Journal of Molecular Biology, June 1999, Elsevier

    Professor Francesca Cutruzzola

  63. Internal Electron Transfer and Structural Dynamics of cd1 Nitrite Reductase Revealed by Laser CO Photodissociation

    Article • Biochemistry, May 1999, American Chemical Society (ACS)

    Professor Andrea Bellelli, Professor Francesca Cutruzzola

  64. Bacterial nitric oxide synthesis

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, May 1999, Elsevier

    Professor Francesca Cutruzzola

  65. Conformational Changes Occurring upon Reduction and NO Binding in Nitrite Reductase fromPseudomonas aeruginosa†,‡

    Article • Biochemistry, October 1998, American Chemical Society (ACS)

    Professor Francesca Cutruzzola, Didier Nurizzo

  66. Equilibrium unfolding of a small bacterial cytochrome, cytochrome c 551 from Pseudomonas aeruginosa

    Article • FEBS Letters, April 1998, Wiley

    Professor Francesca Cutruzzola

  67. Unfolding of apomyoglobin from Aplysia limacina : the effect of salt and ph on the cooperativity of folding 1 1Edited by P. E. Wright

    Article • Journal of Molecular Biology, January 1998, Elsevier

    Professor Francesca Cutruzzola

  68. N-terminal arm exchange is observed in the 2.15 Å crystal structure of oxidized nitrite reductase from Pseudomonas aeruginosa

    Article • Structure, September 1997, Elsevier

    Professor Francesca Cutruzzola, Didier Nurizzo

  69. Mutagenesis of nitrite reductase from Pseudomonas aeruginosa: tyrosine‐10 in the c heme domain is not involved in catalysis1

    Article • FEBS Letters, July 1997, Wiley

    Professor Andrea Bellelli, Professor Francesca Cutruzzola

  70. Electron-Transfer Properties of Pseudomonas Aeruginosa [Lys44, Glu64]azurin

    Article • European Journal of Biochemistry, July 1997, Wiley

    Professor Francesca Cutruzzola

  71. Isolation and characterization of the d1 domain of Pseudomonas aeruginosa nitrite reductase

    Article • Journal of Inorganic Biochemistry, May 1996, Elsevier

    Professor Francesca Cutruzzola

  72. Interactions among residues CD3, E7, E10, and E11 in myoglobins: Attempts to simulate the ligand-binding properties of Aplysia myoglobin

    Article • Biochemistry, July 1995, American Chemical Society (ACS)

    Professor Francesca Cutruzzola

  73. Haemoglobin Engineering: For fun and money

    Article • Current Biology, May 1995, Elsevier

    Professor Francesca Cutruzzola

  74. Formate binding to ferric wild type and mutant myoglobins thermodynamic and X-ray crystallographic study

    Article • FEBS Letters, January 1995, Wiley

    Professor Francesca Cutruzzola, Professor Martino Bolognesi

  75. Engineering Ascaris hemoglobin oxygen affinity in sperm whale myoglobin: role of tyrosine B10

    Article • FEBS Letters, September 1994, Wiley

    Professor Francesca Cutruzzola

  76. Selective oxidation of methionyl residues in the human recombinant secretory leukocyte proteinase inhibitor. Effect on the inhibitor binding properties

    Article • Journal of Molecular Recognition, March 1994, Wiley

    Professor Francesca Cutruzzola, Professor Martino Bolognesi

  77. Pseudomonas aeruginosa nitrite reductase (or cytochrome oxidase): An overview

    Article • Biochimie, January 1994, Elsevier

    Professor Francesca Cutruzzola

  78. Structural and functional characterization of sperm whale myoglobin mutants: Role of arginine (E10) in ligand stabilization

    Article • Biochemistry, June 1993, American Chemical Society (ACS)

    Professor Francesca Cutruzzola

  79. The nitrite reductase gene of Pseudomonas aeruginosa: Effect of growth conditions on the expression and construction of a mutant by gene disruption

    Article • FEMS Microbiology Letters, May 1993, Oxford University Press (OUP)

    Professor Francesca Cutruzzola

  80. Crystal structure of a distal site double mutant of sperm whale myoglobin at 1.6 Å resolution

    Article • FEBS Letters, March 1993, Wiley

    Professor Francesca Cutruzzola, Professor Martino Bolognesi

  81. Selective oxidation of Met-192 in bovine α-chymotrypsin. Effect on catalytic and inhibitor binding properties

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, February 1993, Elsevier

    Professor Francesca Cutruzzola, Professor Martino Bolognesi

  82. Control and recognition of anionic ligands in myoglobin

    Article • FEBS Letters, May 1991, Wiley

    Professor Francesca Cutruzzola, Professor Martino Bolognesi

  83. Analysis of the mechanisms controlling the expression of the L1 ribosomal protein gene in Xenopus laevis

    Article • Molecular Biology Reports, January 1987, Springer Science + Business Media

    Professor Francesca Cutruzzola

  84. Complementarity of conserved sequence elements present in 28S ribosomal RNA and in ribosomal protein genes of Xenopus laevis and Xenopus tropicalis

    Article • Gene, January 1986, Elsevier

    Professor Francesca Cutruzzola