All Stories

  1. LRRK2 Phosphorylation: Behind the Scenes

    Article • The Neuroscientist, January 2018, SAGE Publications

    Evy Lobbestael

  2. Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

    Article • Molecular Neurodegeneration, January 2018, Springer Science + Business Media

    Evy Lobbestael

  3. PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2

    Article • Frontiers in Molecular Neuroscience, December 2017, Frontiers

    Evy Lobbestael

  4. PARKINSON’S DISEASE-ASSOCIATED MUTATIONS IN LRRK2 CAUSE CENTROSOMAL DEFECTS VIA RAB8A PHOSPHORYLATION

    Article • Alzheimer s & Dementia, July 2017, Elsevier

    Evy Lobbestael

  5. Preface

    Article • January 2017, Elsevier

    Evy Lobbestael

  6. Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation

    Article • Scientific Reports, September 2016, Nature

    Evy Lobbestael

  7. Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate

    Article • The FASEB Journal, July 2015, Federation of American Societies For Experimental Biology (FASEB)

    Professor Veerle Baekelandt, Evy Lobbestael

  8. Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

    Article • Journal of Neurochemistry, July 2014, Wiley

    Evy Lobbestael, Elisa Belluzzi

  9. In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2

    Article • Frontiers in Molecular Neuroscience, June 2014, Frontiers

    Evy Lobbestael

  10. Long-Term Overexpression of Human Wild-Type and T240R Mutant Parkin in Rat Substantia Nigra Induces Progressive Dopaminergic Neurodegeneration

    Article • Journal of Neuropathology & Experimental Neurology, February 2014, Oxford University Press (OUP)

    Evy Lobbestael

  11. Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

    Article • Biochemical Journal, November 2013, Portland Press Ltd.

    Evy Lobbestael

  12. MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein

    Article • Human Molecular Genetics, November 2012, Oxford University Press (OUP)

    Evy Lobbestael

  13. Phosphorylation of LRRK2: from kinase to substrate

    Article • Biochemical Society Transactions, October 2012, Portland Press Ltd.

    Evy Lobbestael

  14. Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers

    Article • PLoS ONE, August 2012, PLOS

    Evy Lobbestael, Elisa Belluzzi

  15. Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, March 2012, Elsevier

    Evy Lobbestael

  16. Kinases as Targets for Parkinson's Disease: From Genetics to Therapy

    Article • CNS & Neurological Disorders - Drug Targets, September 2011, Bentham Science Publishers

    Evy Lobbestael

  17. LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding

    Article • PLoS ONE, August 2011, PLOS

    Evy Lobbestael

  18. Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

    Article • Journal of Neurochemistry, December 2010, Wiley

    Evy Lobbestael

  19. Immunohistochemical detection of transgene expression in the brain using small epitope tags

    Article • BMC Biotechnology, January 2010, Springer Science + Business Media

    Evy Lobbestael