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  1. Neutral ceramidase-active site inhibitor chemotypes and binding modes

    Article • Bioorganic Chemistry, October 2023, Elsevier

    Dr Essa M. Saied

  2. Unveiling the antitumor potential of novel N-(substituted-phenyl)-8-methoxycoumarin-3-carboxamides as dual inhibitors of VEGFR2 kinase and cytochrome P450 for targeted treatment of hepatocellular carcinoma

    Article • Frontiers in Chemistry, August 2023, Frontiers

    Dr Essa M. Saied

  3. Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro, in silico, and in-vivo study

    Article • Drug Delivery, August 2023, Taylor & Francis

    Dr Essa M. Saied

  4. Exploring the antibacterial potential of plant extracts and essential oils against Bacillus thermophilus in beet sugar for enhanced sucrose retention: a comparative assessment and implications

    Article • Frontiers in Microbiology, July 2023, Frontiers

    Dr Essa M. Saied

  5. Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens

    Article • Antibiotics, January 2023, MDPI AG

    Samar Sami Alkafaas, Dr Essa M. Saied

  6. Metabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis

    Article • International Journal of Molecular Sciences, December 2022, MDPI AG

    Dr Essa M. Saied

  7. Antidiabetic Potential of Novel 1,3,5-Trisubstituted-2-Thioxoimidazloidin-4-One Analogues: Insights into α-Glucosidase, α-Amylase, and Antioxidant Activities

    Article • Pharmaceuticals, December 2022, MDPI AG

    Dr Essa M. Saied

  8. Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments

    Article • Molecules, September 2022, MDPI AG

    Dr Essa M. Saied

  9. Novel 1,3-Thiazole Analogues with Potent Activity against Breast Cancer: A Design, Synthesis, In Vitro, and In Silico Study

    Article • Molecules, July 2022, MDPI AG

    Dr Essa M. Saied

  10. Novel Exopolysaccharide from Marine Bacillus subtilis with Broad Potential Biological Activities: Insights into Antioxidant, Anti-Inflammatory, Cytotoxicity, and Anti-Alzheimer Activity

    Article • Metabolites, July 2022, MDPI AG

    Dr Essa M. Saied

  11. Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study

    Article • Pharmaceuticals, July 2022, MDPI AG

    Dr Essa M. Saied

  12. Acetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated with Atorvastatin Intake by Targeting Cerebral miRNA155 and NLRP3: In Vivo, and In Silico Study

    Article • Pharmaceutics, February 2022, MDPI AG

    Dr Essa M. Saied

  13. Trust Your Gut: The Human Gut Microbiome in Health and Disease

    Article • January 2022, Springer Science + Business Media

    Dr Essa M. Saied

  14. Vitamin D3 Prevents the Deleterious Effects of Testicular Torsion on Testis by Targeting miRNA-145 and ADAM17: In Silico and In Vivo Study

    Article • Pharmaceuticals, November 2021, MDPI AG

    Dr Essa M. Saied

  15. A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19

    Article • Pharmaceutics, October 2021, MDPI AG

    Dr Essa M. Saied

  16. Novel N-bridged pyrazole-1-carbothioamides with potential antiproliferative activity: design, synthesis, in vitro and in silico studies

    Article • Future Medicinal Chemistry, October 2021, Future Science

    Dr. Nadia Ali Ahmed Elkanzi, Dr Essa M. Saied

  17. The long chain base unsaturation has a stronger impact on 1-deoxy(methyl)-sphingolipids biophysical properties than the structure of its C1 functional group

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 2021, Elsevier

    Dr Essa M. Saied

  18. Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx

    Article • International Journal of Molecular Sciences, July 2021, MDPI AG

    Dr Essa M. Saied

  19. The Catalytic Activity of Biosynthesized Magnesium Oxide Nanoparticles (MgO-NPs) for Inhibiting the Growth of Pathogenic Microbes, Tanning Effluent Treatment, and Chromium Ion Removal

    Article • Catalysts, July 2021, MDPI AG

    Dr Essa M. Saied

  20. Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

    Article • Marine Drugs, April 2021, MDPI AG

    Dr Essa M. Saied

  21. New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

    Article • Molecules, April 2021, MDPI AG

    Dr Essa M. Saied

  22. Acrylamide-induced peripheral neuropathy: manifestations, mechanisms, and potential treatment modalities

    Article • Environmental Science and Pollution Research, January 2021, Springer Science + Business Media

    Dr Essa M. Saied

  23. Novel Papaverine Metal Complexes with Potential Anticancer Activities

    Article • Molecules, November 2020, MDPI AG

    Dr Essa M. Saied

  24. Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT)

    Article • Chemistry - A European Journal, November 2020, Wiley

    Dr. Fabian Schumacher, Dr Essa M. Saied

  25. Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening

    Article • SLAS DISCOVERY, July 2020, SAGE Publications

    Dr Essa M. Saied

  26. Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases

    Article • Proceedings of the National Academy of Sciences, June 2020, Proceedings of the National Academy of Sciences

    museer lone, Dr Essa M. Saied

  27. Innentitelbild: Unterscheidung von isomeren Sphingolipiden mittels kryogener Infrarotspektroskopie (Angew. Chem. 32/2020)

    Article • Angewandte Chemie, June 2020, Wiley

    Dr Essa M. Saied

  28. Inside Cover: Resolving Sphingolipid Isomers Using Cryogenic Infrared Spectroscopy (Angew. Chem. Int. Ed. 32/2020)

    Article • Angewandte Chemie International Edition, June 2020, Wiley

    Dr Essa M. Saied

  29. Resolving Sphingolipid Isomers Using Cryogenic Infrared Spectroscopy

    Article • Angewandte Chemie International Edition, May 2020, Wiley

    Dr Essa M. Saied

  30. Unterscheidung von isomeren Sphingolipiden mittels kryogener Infrarotspektroskopie

    Article • Angewandte Chemie, May 2020, Wiley

    Dr Essa M. Saied

  31. Canonical and 1-Deoxy(methyl) Sphingoid Bases: Tackling the Effect of the Lipid Structure on Membrane Biophysical Properties

    Article • Langmuir, May 2020, American Chemical Society (ACS)

    Dr Essa M. Saied

  32. Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy

    Article • Nature Communications, December 2018, Springer Science + Business Media

    Dr Essa M. Saied

  33. Developmental toxicity of carbon nanoparticles during embryogenesis in chicken

    Article • Environmental Science and Pollution Research, November 2018, Springer Science + Business Media

    Dr mohamed E. Abd El-Hack, Dr Essa M. Saied

  34. FRET probes for measuring sphingolipid metabolizing enzyme activity

    Article • Chemistry and Physics of Lipids, November 2018, Elsevier

    Dr Essa M. Saied

  35. Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway

    Article • Journal of Lipid Research, August 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Essa M. Saied

  36. Synthesis and characterization of some atypical sphingoid bases

    Article • Bioorganic & Medicinal Chemistry, August 2018, Elsevier

    Dr Essa M. Saied

  37. Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New Insights into the Gas Phase Structures of Ionized Lipids

    Article • Analytical Chemistry, April 2018, American Chemical Society (ACS)

    Dr Essa M. Saied

  38. The Activity of the Neutral Sphingomyelinase Is Important in T Cell Recruitment and Directional Migration

    Article • Frontiers in Immunology, August 2017, Frontiers

    Dr Essa M. Saied

  39. The cellular ceramide transport protein CERT promotes Chlamydia psittaci infection and controls bacterial sphingolipid uptake

    Article • Cellular Microbiology, June 2017, Wiley

    Dr Essa M. Saied

  40. Structural insights into adiponectin receptors suggest ceramidase activity

    Article • Nature, March 2017, Nature

    Dr Essa M. Saied

  41. Elemental labelling and mass spectrometry for the specific detection of sulfenic acid groups in model peptides: a proof of concept

    Article • Analytical and Bioanalytical Chemistry, January 2017, Springer Science + Business Media

    Dr Essa M. Saied

  42. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway

    Article • Journal of Lipid Research, November 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Essa M. Saied

  43. Elucidating the chemical structure of native 1-deoxysphingosine

    Article • Journal of Lipid Research, May 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Essa M. Saied

  44. Inhibitors of Ceramidases

    Article • Chemistry and Physics of Lipids, May 2016, Elsevier

    Dr Essa M. Saied

  45. A series of ceramide analogs modified at the 1-position with potent activity against the intracellular growth of Chlamydia trachomatis

    Article • Future Medicinal Chemistry, October 2015, Future Science

    Dr Essa M. Saied

  46. Erratum to: Spectroscopic and Thermal Studies of Mn(II), Fe(III), Cr(III) and Zn(II) Complexes Derived from the Ligand Resulted by the Reaction Between 4-Acetyl Pyridine and Thiosemicarbazide

    Article • Journal of Inorganic and Organometallic Polymers and Materials, August 2014, Springer Science + Business Media

    Dr Essa M. Saied

  47. Improved Plaque Assay Identifies a Novel Anti-Chlamydia Ceramide Derivative with Altered Intracellular Localization

    Article • Antimicrobial Agents and Chemotherapy, July 2014, ASM Journals

    Dr Essa M. Saied

  48. Facile Synthesis of the CERT Inhibitor HPA-12 and Some Novel Derivatives

    Article • Chemistry - An Asian Journal, June 2014, Wiley

    Dr Essa M. Saied

  49. Small Molecule Inhibitors of Ceramidases

    Article • Cellular Physiology and Biochemistry, January 2014, Karger Publishers

    Dr Essa M. Saied

  50. Spectroscopic and Thermal Studies of Mn(II), Fe(III), Cr(III) and Zn(II) Complexes Derived from the Ligand Resulted by the Reaction Between 4-Acetyl Pyridine and Thiosemicarbazide

    Article • Journal of Inorganic and Organometallic Polymers and Materials, August 2009, Springer Science + Business Media

    Dr Essa M. Saied