All Stories

  1. Functional sites involved in modulation of the GABAA receptor channel by the intravenous anesthetics propofol, etomidate and pentobarbital

    Article • Neuropharmacology, June 2016, Elsevier

    Professor Erwin Sigel

  2. Novel positive allosteric modulators of GABAA receptors with anesthetic activity

    Article • Scientific Reports, May 2016, Nature

    Professor Erwin Sigel

  3. A new chromanone derivative isolated from Hypericum lissophloeus (Hypericaceae) potentiates GABAA receptor currents in a subunit specific fashion

    Article • Bioorganic & Medicinal Chemistry, February 2016, Elsevier

    Professor Erwin Sigel

  4. A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes

    Article • The FASEB Journal, August 2015, Federation of American Societies For Experimental Biology (FASEB)

    Professor Peter Bütikofer, Professor Erwin Sigel

  5. Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site

    Article • Neuropharmacology, August 2015, Elsevier

    Professor Erwin Sigel

  6. Trypanosoma brucei Bloodstream Forms Depend upon Uptake ofmyo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth

    Article • Eukaryotic Cell, April 2015, ASM Journals

    Professor Peter Bütikofer, Professor Erwin Sigel

  7. Modulatory Effects ofEschscholzia californicaAlkaloids on Recombinant GABAAReceptors

    Article • Biochemistry Research International, January 2015, Hindawi Publishing Corporation

    Professor Erwin Sigel

  8. Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABAA receptors

    Article • Bioorganic & Medicinal Chemistry, December 2014, Elsevier

    Professor Erwin Sigel

  9. Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids

    Article • Biochemical Journal, October 2014, Portland Press Ltd.

    Professor Peter Bütikofer, Professor Erwin Sigel

  10. Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2014, Elsevier

    Professor Erwin Sigel

  11. A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels

    Article • PLoS ONE, September 2014, PLOS

    Professor Erwin Sigel

  12. Accelerated Discovery of Novel Benzodiazepine Ligands by Experiment-Guided Virtual Screening

    Article • ACS Chemical Biology, August 2014, American Chemical Society (ACS)

    Professor Erwin Sigel

  13. Relative Positioning of Classical Benzodiazepines to the γ 2 -Subunit of GABA A Receptors

    Article • ACS Chemical Biology, August 2014, American Chemical Society (ACS)

    Professor Erwin Sigel

  14. Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β 2 subunit of GABA A receptors?

    Article • PeerJ, September 2013, PeerJ

    Professor Erwin Sigel

  15. acr-23 Encodes a Monepantel-Sensitive Channel in Caenorhabditis elegans

    Article • PLoS Pathogens, August 2013, PLOS

    Professor Erwin Sigel

  16. Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms

    Article • Molecular and Biochemical Parasitology, July 2013, Elsevier

    Professor Peter Bütikofer, Professor Erwin Sigel

  17. Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β2subunit of GABAAreceptors

    Article • Journal of Neurochemistry, May 2013, Wiley

    Professor Erwin Sigel

  18. Azo-Propofols: Photochromic Potentiators of GABAAReceptors

    Article • Angewandte Chemie, September 2012, Wiley

    Professor Erwin Sigel

  19. Azo-Propofols: Photochromic Potentiators of GABAAReceptors

    Article • Angewandte Chemie International Edition, September 2012, Wiley

    Professor Erwin Sigel

  20. Influence of GABAA Receptor α Subunit Isoforms on the Benzodiazepine Binding Site

    Article • PLoS ONE, July 2012, PLOS

    Professor Erwin Sigel

  21. A Closer Look at the High Affinity Benzodiazepine Binding Site on GABAA Receptors

    Article • Current Topics in Medicinal Chemistry, January 2011, Bentham Science Publishers

    Professor Erwin Sigel

  22. A residue close to α1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained

    Article • Journal of Neurochemistry, November 2010, Wiley

    Professor Erwin Sigel

  23. ChemInform Abstract: Use of Bicuculline, a GABA Antagonist, as a Template for the Development of a New Class of Ligands Showing Positive Allosteric Modulation of the GABAA Receptor.

    Article • ChemInform, May 2010, Wiley

    Professor Erwin Sigel

  24. Highly Potent Modulation of GABAA Receptors by Valerenic Acid Derivatives

    Article • ChemMedChem, March 2010, Wiley

    Professor Erwin Sigel

  25. Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABAAreceptors

    Article • Journal of Neurochemistry, December 2009, Wiley

    Professor Erwin Sigel

  26. Structure of α6β3δ GABAAreceptors and their lack of ethanol sensitivity

    Article • Journal of Neurochemistry, December 2009, Wiley

    Professor Erwin Sigel

  27. Use of concatamers to study GABA A receptor architecture and function: application to δ-subunit-containing receptors and possible pitfalls

    Article • Biochemical Society Transactions, December 2009, Portland Press Ltd.

    Professor Erwin Sigel

  28. Covalent modification of GABAAreceptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs

    Article • Journal of Neurochemistry, September 2008, Wiley

    Professor Erwin Sigel

  29. Novel chloride channel mutations leading to mild myotonia among Chinese

    Article • Neuromuscular Disorders, August 2008, Elsevier

    Professor Erwin Sigel

  30. Anticipating antiport in P-type ATPases

    Article • Trends in Biochemical Sciences, April 2008, Elsevier

    Professor Erwin Sigel

  31. The promiscuous role of the epsilon subunit in GABAA receptor biogenesis

    Article • Molecular and Cellular Neuroscience, March 2008, Elsevier

    Professor Erwin Sigel

  32. Replacement of histidine in position 105 in the α5subunit by cysteine stimulates zolpidem sensitivity of α5β2γ2GABAAreceptors

    Article • Journal of Neurochemistry, October 2007, Wiley

    Professor Erwin Sigel

  33. Two neighboring residues of loop A of the α1subunit point towards the benzodiazepine binding site of GABAAreceptors

    Article • FEBS Letters, September 2007, Wiley

    Professor Erwin Sigel

  34. A GABAAreceptor of defined subunit composition and positioning: Concatenation of five subunits

    Article • FEBS Letters, February 2006, Wiley

    Professor Erwin Sigel

  35. Consequence of the presence of two different beta subunit isoforms in a GABAA receptor

    Article • Journal of Neurochemistry, December 2005, Wiley

    Professor Erwin Sigel

  36. Influence of the point mutation alpha-1-H101R on the assembly of gamma-aminobutyric acid type A receptors

    Article • Neuroreport, November 2005, Wolters Kluwer Health

    Professor Erwin Sigel

  37. The Benzodiazepine Recognition Site on GABAA Receptors

    Article • Medicinal Chemistry Reviews - Online, June 2005, Bentham Science Publishers

    Professor Erwin Sigel

  38. TheXenopus oocyte: System for the study of functional expression and modulation of proteins

    Article • Molecular Nutrition & Food Research, March 2005, Wiley

    Professor Erwin Sigel

  39. Conformational changes at benzodiazepine binding sites of GABAA receptors detected with a novel technique

    Article • Journal of Neurochemistry, February 2005, Wiley

    Professor Erwin Sigel

  40. The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects

    Article • British Journal of Pharmacology, July 2004, Wiley

    Professor Erwin Sigel

  41. Ligand-Operated Membrane Channels: GABA

    Article • January 2004, Elsevier

    Professor Erwin Sigel

  42. Exon 17 skipping inCLCN1 leads to recessive myotonia congenita

    Article • Muscle & Nerve, January 2004, Wiley

    Professor Erwin Sigel

  43. Naturally occurring 2′-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands

    Article • Biochemical Pharmacology, December 2003, Elsevier

    Professor Erwin Sigel

  44. On high- and low-affinity agonist sites in GABAA receptors

    Article • Journal of Neurochemistry, September 2003, Wiley

    Professor Erwin Sigel

  45. Proteins Associated with α1-Subunit-Containing GABAA Receptors from Bovine Brain

    Article • Journal of Neurochemistry, November 2002, Wiley

    Professor Erwin Sigel

  46. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi

    Article • Biochemical Pharmacology, November 2002, Elsevier

    Professor Erwin Sigel

  47. Mapping of the Benzodiazepine Recognition Site on GABA-A Receptors

    Article • Current Topics in Medicinal Chemistry, August 2002, Bentham Science Publishers

    Professor Erwin Sigel

  48. Functional characterization of the new human GABAA receptor mutation β3(R192H)

    Article • Human Genetics, July 2002, Springer Science + Business Media

    Professor Erwin Sigel

  49. Role of the Conserved Lysine Residue in the Middle of the Predicted Extracellular Loop Between M2 and M3 in the GABAA Receptor

    Article • Journal of Neurochemistry, June 2002, Wiley

    Professor Erwin Sigel

  50. N-Substituted 4-Amino-3,3-dipropyl-2(3 H )-furanones: New Positive Allosteric Modulators of the GABA A Receptor Sharing Electrophysiological Properties with the Anticonvulsant Loreclezole

    Article • Journal of Medicinal Chemistry, June 2002, American Chemical Society (ACS)

    Professor Erwin Sigel

  51. Electrophysiological Evidence for the Coexistence of α1 and α6 Subunits in a Single Functional GABAA Receptor

    Article • Journal of Neurochemistry, January 2002, Wiley

    Professor Erwin Sigel

  52. Microinjection intoXenopusOocytes

    Article • April 2001, Wiley

    Professor Erwin Sigel

  53. Loreclezole as a simple functional marker for homomeric ρ type GABAC receptors

    Article • European Journal of Pharmacology, November 2000, Elsevier

    Professor Erwin Sigel

  54. 5-[1‘-(2‘- N -Arylsulfonyl-1‘,2‘,3‘,4‘-tetrahydroisoquinolyl)]-4,5-dihydro-2(3 H )-furanones: Positive Allosteric Modulators of the GABA A Receptor with a New Mode of Action

    Article • Journal of Medicinal Chemistry, November 2000, American Chemical Society (ACS)

    Professor Erwin Sigel

  55. Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABAA receptor

    Article • Bioorganic & Medicinal Chemistry Letters, November 2000, Elsevier

    Professor Erwin Sigel

  56. A novel positive allosteric modulator of the GABAA receptor: the action of (+)-ROD188

    Article • British Journal of Pharmacology, October 2000, Wiley

    Professor Erwin Sigel

  57. Dual mode of stimulation by the β-carboline ZK 91085 of recombinant GABAA receptor currents: molecular determinants affecting its action

    Article • British Journal of Pharmacology, July 1999, Wiley

    Professor Erwin Sigel

  58. EDPC: a novel high affinity ligand for the benzodiazepine site on rat GABAA receptors

    Article • Neuroscience Letters, July 1999, Elsevier

    Professor Erwin Sigel

  59. Amino acid residue 200 on the α1 subunit of GABAA receptors affects the interaction with selected benzodiazepine binding site ligands

    Article • European Journal of Pharmacology, August 1998, Elsevier

    Professor Erwin Sigel

  60. The antiepileptic drug AWD 131–138 stimulates different recombinant isoforms of the GABAA receptor through the benzodiazepine binding site

    Article • Neuroscience Letters, April 1998, Elsevier

    Professor Erwin Sigel

  61. The benzodiazepine binding site of GABAA receptors

    Article • Trends in Pharmacological Sciences, July 1997, Elsevier

    Professor Erwin Sigel

  62. GABAA-receptor subtypes

    Article • Trends in Neurosciences, January 1996, Elsevier

    Professor Erwin Sigel

  63. Cellular prion protein and GABAA receptors: no physical association?

    Article • Neuroreport, December 1995, Wolters Kluwer Health

    Professor Erwin Sigel

  64. Cellular prion protein and GABAA receptors

    Article • Neuroreport, December 1995, Wolters Kluwer Health

    Professor Erwin Sigel

  65. Minireview: Functional Modulation of Ligand-Gated GABAAand NMDA Receptor Channels by Phosphorylation

    Article • Journal of Receptors and Signal Transduction, January 1995, Taylor & Francis

    Professor Erwin Sigel

  66. Recombinant GABAA receptor function and ethanol

    Article • FEBS Letters, June 1993, Wiley

    Professor Erwin Sigel

  67. Activation of protein kinase C results in down-modulation of different recombinant GABAA -channels

    Article • FEBS Letters, October 1991, Wiley

    Professor Erwin Sigel

  68. Ionic channels: modulation by G proteins and by phosphorylation

    Article • Current Opinion in Neurobiology, June 1991, Elsevier

    Professor Erwin Sigel

  69. Demonstration of a voltage dependent calcium current in follicles of the cockroachNauphoeta cinerea

    Article • Invertebrate Reproduction & Development, December 1990, Taylor & Francis

    Professor Erwin Sigel

  70. The effect of subunit composition of rat brain GABAA receptors on channel function

    Article • Neuron, November 1990, Elsevier

    Professor Erwin Sigel

  71. Use ofXenopus oocytes for the functional expression of plasma membrane proteins

    Article • The Journal of Membrane Biology, September 1990, Springer Science + Business Media

    Professor Erwin Sigel

  72. The rat β1 -subunit of the GABAA receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA

    Article • FEBS Letters, November 1989, Wiley

    Professor Erwin Sigel

  73. Nonequilibrium Thermodynamics and Cellular Bioenergetics

    Article • January 1988, Springer Science + Business Media

    Professor Erwin Sigel

  74. Preparation and utilization of an ion-specific calcium minielectrode

    Article • January 1987, Elsevier

    Professor Erwin Sigel

  75. Structure and Properties of the Brain GABA/Benzodiazepine Receptor Complex

    Article • January 1984, Springer Science + Business Media

    Professor Erwin Sigel

  76. The Purified Gaba/Benzodiazepine/Barbiturate Receptor Complex: Four Types of Ligand-Binding Sites, and the Interactions between them, are Preserved in a Single Isolated Protein Complex

    Article • Journal of Receptor Research, January 1984, Taylor & Francis

    Professor Erwin Sigel

  77. Isolation of a GABA receptor from bovine brain using a benzodiazepine affinity column

    Article • FEBS Letters, October 1982, Wiley

    Professor Erwin Sigel

  78. Inhibition of the purified and reconstituted calcium pump of erythrocytes by μM levels of dids and nap-taurine

    Article • FEBS Letters, February 1982, Wiley

    Professor Erwin Sigel

  79. Quantitative Analysis of the Proton and Charge Stoichiometry of Cytochrome c Oxidase from Beef Heart Reconstituted into Phospholipid Vesicles

    Article • European Journal of Biochemistry, October 1980, Wiley

    Professor Erwin Sigel

  80. A simple system for the measurement of ion activities with solvent polymeric membrane electrodes

    Article • Analytical Biochemistry, September 1979, Elsevier

    Professor Erwin Sigel

  81. Proton Translocation Catalyzed by Mitochondrial Cytochrome Oxidase

    Article • January 1979, Springer Science + Business Media

    Professor Erwin Sigel

  82. The Proton Pump of Cytochrome c Oxidase and Its Stoichiometry

    Article • European Journal of Biochemistry, August 1978, Wiley

    Professor Erwin Sigel

  83. A Kinetic Study of the Energy-Linked Influx of Ca2+ into Heart Mitochondria

    Article • European Journal of Biochemistry, October 1976, Wiley

    Professor Erwin Sigel

  84. THE REGULATION OF INTRACELLULAR CALCIUM

    Article • Clinical Endocrinology, February 1976, Wiley

    Professor Erwin Sigel