All Stories

  1. Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus

    Article • BioFactors, December 2017, Wiley

    Professor Ernesto Fedele

  2. The Amyloid Cascade Hypothesis in Alzheimer’s Disease: It’s Time to Change Our Mind

    Article • Current Neuropharmacology, July 2017, Bentham Science Publishers

    Professor Ernesto Fedele, Roberta Ricciarelli

  3. Amyloid β: Walking on the dark side of the moon

    Article • Mechanisms of Ageing and Development, December 2015, Elsevier

    Professor Ernesto Fedele

  4. PDE4D and memory

    Article • British Journal of Pharmacology, September 2015, Wiley

    Professor Ernesto Fedele

  5. Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors

    Article • Bioorganic & Medicinal Chemistry, July 2015, Elsevier

    Professor Ernesto Fedele

  6. Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis

    Article • Neurobiology of Disease, February 2015, Elsevier

    Professor Ernesto Fedele

  7. PDE4D inhibitors: A potential strategy for the treatment of memory impairment?

    Article • Neuropharmacology, October 2014, Elsevier

    Professor Ernesto Fedele

  8. Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O -(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors

    Article • Journal of Medicinal Chemistry, August 2014, American Chemical Society (ACS)

    Professor Ernesto Fedele

  9. A PHYSIOLOGICAL ROLE FOR AMYLOID BETA IN CYCLIC AMP-STIMULATED LONG TERM POTENTIATION

    Article • Alzheimer s & Dementia, July 2014, Elsevier

    Professor Ernesto Fedele

  10. LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

    Article • Frontiers in Molecular Neuroscience, May 2014, Frontiers

    Professor Ernesto Fedele, Elisa Belluzzi

  11. A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta

    Article • Annals of Neurology, April 2014, Wiley

    Professor Ernesto Fedele

  12. Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor

    Article • Neurochemistry International, March 2013, Elsevier

    Professor Ernesto Fedele

  13. Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-β precursor protein metabolism

    Article • IUBMB Life, January 2013, Wiley

    Professor Ernesto Fedele

  14. Letter to the Editor

    Article • Journal of Neuroscience Methods, January 2013, Elsevier

    Professor Ernesto Fedele

  15. Presynaptic Nicotinic α7 and Non-α7 Receptors Stimulate Endogenous GABA Release from Rat Hippocampal Synaptosomes through Two Mechanisms of Action

    Article • PLoS ONE, February 2011, PLOS

    Professor Ernesto Fedele

  16. Reduced GABA Content in the Motor Thalamus during Effective Deep Brain Stimulation of the Subthalamic Nucleus

    Article • Frontiers in Systems Neuroscience, January 2011, Frontiers

    Professor Ernesto Fedele

  17. Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitis

    Article • Journal of Neurochemistry, August 2010, Wiley

    Professor Ernesto Fedele

  18. The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico-subthalamic nucleus-globus pallidus pathway

    Article • The Journal of Physiology, September 2009, Wiley

    Professor Ernesto Fedele

  19. l-Aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes

    Article • Journal of Neurochemistry, August 2009, Wiley

    Professor Ernesto Fedele

  20. Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease

    Article • Parkinsonism & Related Disorders, June 2009, Elsevier

    Professor Ernesto Fedele, Dr Atticus H Hainsworth

  21. In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats

    Article • Journal of Neuroscience Research, November 2008, Wiley

    Professor Ernesto Fedele

  22. Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by ‘pathologically’ elevated extraterminal K+concentrations

    Article • Journal of Neurochemistry, November 2007, Wiley

    Professor Ernesto Fedele

  23. Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease

    Article • European Journal of Neuroscience, June 2006, Wiley

    Professor Ernesto Fedele

  24. Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-d-aspartate receptors in rat hippocampus

    Article • Journal of Neurochemistry, April 2005, Wiley

    Professor Ernesto Fedele

  25. Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients

    Article • Annals of Neurology, January 2005, Wiley

    Professor Ernesto Fedele, Dr Atticus H Hainsworth

  26. The NOS/sGC pathway in the rat central nervous system: a microdialysis overview

    Article • Neurochemistry International, November 2004, Elsevier

    Professor Ernesto Fedele

  27. Glutamate-mediated overexpression of CD38 in astrocytes cultured with neurones

    Article • Journal of Neurochemistry, April 2004, Wiley

    Professor Ernesto Fedele

  28. Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP

    Article • Biochemical Pharmacology, April 2004, Elsevier

    Professor Ernesto Fedele

  29. GABAA, but not NMDA, receptors modulate in vivo NO-mediated cGMP synthesis in the rat cerebral cortex

    Article • Neuropharmacology, March 2004, Elsevier

    Professor Ernesto Fedele

  30. Benzodiazepine-Sensitive GABAA Receptors Limit the Activity of the NMDA/NO/Cyclic GMP Pathway

    Article • Journal of Neurochemistry, January 2002, Wiley

    Professor Ernesto Fedele

  31. Dbs in Parkinsonian Subthalamic Nucleus: Electrophysiological and Biochemical Changes

    Article • January 2002, Springer Science + Business Media

    Professor Ernesto Fedele

  32. Helicobacter pylori‐induced reduction of acute levodopa absorption in parkinson's disease patients

    Article • Annals of Neurology, October 2001, Wiley

    Professor Ernesto Fedele

  33. Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes

    Article • Journal of Neurochemistry, August 2001, Wiley

    Professor Ernesto Fedele

  34. Microdialysis in Parkinsonian Patient Basal Ganglia: Acute Apomorphine-Induced Clinical and Electrophysiological Effects Not Paralleled by Changes in the Release of Neuroactive Amino Acids

    Article • Experimental Neurology, February 2001, Elsevier

    Professor Ernesto Fedele

  35. Native human neocortex release-regulating dopamine D2 type autoreceptors are dopamine D2 subtype

    Article • European Journal of Neuroscience, July 1999, Wiley

    Professor Ernesto Fedele

  36. In vivo studies of the cerebral glutamate receptor/NO/cGMP pathway

    Article • Progress in Neurobiology, June 1999, Elsevier

    Professor Ernesto Fedele

  37. Intracerebral administration of l-kynurenine decreases N-methyl-d-aspartate receptor-mediated production of cGMP in the cerebellum and hippocampus of unanaesthetized rats subjected to transcerebral microdialysis

    Article • Neuroscience Letters, May 1999, Elsevier

    Professor Ernesto Fedele

  38. Nicotine administration stimulates the in vivo N-methyl-D -aspartate receptor/nitric oxide/cyclic GMP pathway in rat hippocampus through glutamate release

    Article • British Journal of Pharmacology, November 1998, Wiley

    Professor Ernesto Fedele

  39. Activation of brain nitric oxide synthase in depolarized human temporal cortex slices: differential role of voltage-sensitive calcium channels

    Article • British Journal of Pharmacology, November 1997, Wiley

    Professor Ernesto Fedele

  40. In vivo microdialysis study of GABAA and GABaB receptors modulating the glutamate receptor/NO/ cyclic GMP pathway in the rat hippocampus

    Article • Neuropharmacology, October 1997, Elsevier

    Professor Ernesto Fedele

  41. The glutamate receptor/no/cyclic gmp pathway in the hippocampus of freely moving rats: Modulation by cyclothiazide, interaction with gaba and the behavioural consequences

    Article • Neuropharmacology, October 1997, Elsevier

    Professor Ernesto Fedele

  42. D-serine modulates the NMDA receptor/nitric oxide/cGMP pathway in the rat cerebellum during in vivo microdialysis

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, December 1996, Springer Science + Business Media

    Professor Ernesto Fedele

  43. Ectocellular in vitro and in vivo metabolism of cADP-ribose in cerebellum

    Article • Biochemical Journal, December 1996, Portland Press Ltd.

    Professor Ernesto Fedele

  44. In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway

    Article • British Journal of Pharmacology, October 1996, Wiley

    Professor Ernesto Fedele

  45. Desensitization of AMPA receptors and AMPA-NMDA receptor interaction: an in vivo cyclic GMP microdialysis study in rat cerebellum

    Article • British Journal of Pharmacology, March 1996, Wiley

    Professor Ernesto Fedele

  46. MRI postoperative monitoring in patients surgically treated for aortic dissection

    Article • Magnetic Resonance Imaging, January 1996, Elsevier

    Professor Ernesto Fedele

  47. Heterocarrier-mediated reciprocal modulation of glutamate and glycine release in rat cerebral cortex and spinal cord synaptosomes

    Article • European Journal of Pharmacology, January 1994, Elsevier

    Professor Ernesto Fedele

  48. Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum

    Article • European Journal of Pharmacology, November 1993, Elsevier

    Professor Ernesto Fedele

  49. Autoradiographical evaluation of [3H]glycine uptake in rat forebrain: Cellular localization in the hippocampus

    Article • Neuroscience Letters, October 1993, Elsevier

    Professor Ernesto Fedele

  50. Release-regulating dopamine autoreceptors in human cerebral cortex

    Article • British Journal of Pharmacology, September 1993, Wiley

    Professor Ernesto Fedele

  51. Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine

    Article • European Journal of Pharmacology, January 1993, Elsevier

    Professor Ernesto Fedele

  52. Dopamine release and dopaminergic inhibition of acetylcholine release in rat striatal slices after nigro-striatal hemitransection and parenteral ganglioside administration

    Article • European Journal of Pharmacology, March 1992, Elsevier

    Professor Ernesto Fedele

  53. [3H]Glycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization

    Article • Brain Research, February 1992, Elsevier

    Professor Ernesto Fedele

  54. Cholinergic modulation of [3H]dopamine release from dendrosomes of rat substantia nigra

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, September 1991, Springer Science + Business Media

    Professor Ernesto Fedele

  55. Glycine enhances [3H]noradrenaline release from slices of rat hippocampus

    Article • Neuroscience Letters, August 1990, Elsevier

    Professor Ernesto Fedele

  56. Glycine stimulates [3H]noradrenaline release by activating a strychnine-sensitive receptor present in rat hippocampus

    Article • European Journal of Pharmacology, August 1990, Elsevier

    Professor Ernesto Fedele

  57. Acetylcholine release from rat hippocampal slices is modulated by 5-hydroxytryptamine

    Article • European Journal of Pharmacology, June 1989, Elsevier

    Professor Ernesto Fedele

  58. Presynaptic Mechanisms Underlying the ?-Aminobutyric Acid-Evoked Receptor-Independent Release of [3H]Norepinephrine in Rat Hippocampus

    Article • Journal of Neurochemistry, June 1989, Wiley

    Professor Ernesto Fedele

  59. Functional damage of dopamine nerve terminals following intrastriatal kainic acid injection

    Article • Brain Research, February 1989, Elsevier

    Professor Ernesto Fedele

  60. Biochemical Markers of DBS-Induced Transition from “Off” to “On” State in Parkinsonian Patients

    Article • Springer Science + Business Media

    Professor Ernesto Fedele