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  1. Application of physiologically‐based pharmacokinetic modeling to inform dosing decisions for geriatric patients

    Article • CPT Pharmacometrics & Systems Pharmacology, September 2024, Wiley

    Dr Eric Chun Yong Chan

  2. Ex vivo metabolism kinetics of primary to secondary bile acids via a physiologically relevant human faecal microbiota model

    Article • Chemico-Biological Interactions, July 2024, Elsevier

    Dr Eric Chun Yong Chan

  3. Physiologically‐based pharmacokinetic modelling guided dose evaluations of nirmatrelvir/ritonavir in renal impairment for the management of COVID‐19

    Article • British Journal of Clinical Pharmacology, April 2024, Wiley

    Dr Eric Chun Yong Chan

  4. Probe Substrate Dependencies in CYP3A4 Allosteric Inhibition: A Novel Molecular Mechanism Involving F–F′ Loop Perturbations

    Article • Journal of Chemical Information and Modeling, March 2024, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  5. Predictors associated with bleeding and thromboembolic complications in patients taking rivaroxaban-- a Singapore study

    Article • January 2024, Authorea, Inc.

    Dr Eric Chun Yong Chan

  6. Ciprofol is primarily glucuronidated by UGT1A9 and predicted not to cause drug-drug interactions with typical substrates of CYP1A2, CYP2B6, and CYP2C19

    Article • Chemico-Biological Interactions, November 2023, Elsevier

    Dr Eric Chun Yong Chan

  7. Investigating the relevance of CYP2J2 inhibition for drugs known to cause intermediate to high risk torsades de pointes

    Article • European Journal of Pharmaceutical Sciences, August 2023, Elsevier

    Dr Eric Chun Yong Chan

  8. Risk assessment of cultured meat

    Article • Trends in Food Science & Technology, August 2023, Elsevier

    Dr Eric Chun Yong Chan

  9. Unraveling Complexities in the Absorption and Disposition Kinetics of Abiraterone via Iterative PBPK Model Development and Refinement

    Article • Clinical Pharmacokinetics, July 2023, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  10. Role of Cytochrome P450 2C8 in Drug–Drug Interaction between Amiodarone and Nirmatrelvir/Ritonavir Via Physiologically‐Based Pharmacokinetic Modeling

    Article • Clinical Pharmacology & Therapeutics, March 2023, Wiley

    Dr Eric Chun Yong Chan

  11. Development and verification of a physiologically‐based pharmacokinetic model of dronedarone and its active metabolite N‐desbutyldronedarone: application to prospective simulation of complex drug‐drug interaction with rivaroxaban.

    Article • British Journal of Clinical Pharmacology, January 2023, Wiley

    Dr Eric Chun Yong Chan

  12. Lactobacillus paracasei IMC 502 ameliorate type 2 diabetes by mediating gut microbiota‐SCFAs ‐hormone/inflammation pathway in mice

    Article • Journal of the Science of Food and Agriculture, October 2022, Wiley

    Dr Eric Chun Yong Chan

  13. Identification of Optimal Urinary Biomarkers of Synthetic Cannabinoids BZO-HEXOXIZID, BZO-POXIZID, 5F-BZO-POXIZID, and BZO-CHMOXIZID for Illicit Abuse Monitoring

    Article • Clinical Chemistry, September 2022, Oxford University Press (OUP)

    Dr Eric Chun Yong Chan

  14. Inhibition of cytochrome P450 2J2-mediated metabolism of rivaroxaban and arachidonic acid by ibrutinib and osimertinib

    Article • Drug Metabolism and Disposition, July 2022, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  15. Physiologically Based Pharmacokinetic Modelling‐Guided Dose Management of Oral Anticoagulants when Initiating Paxlovid for COVID ‐19 Treatment

    Article • Clinical Pharmacology & Therapeutics, June 2022, Wiley

    Dr Eric Chun Yong Chan

  16. Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban

    Article • Journal of Pharmacology and Experimental Therapeutics, May 2022, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  17. Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore

    Article • Cardiovascular Drugs and Therapy, May 2022, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  18. Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A

    Article • Drug Metabolism and Disposition, May 2022, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  19. Quantification of the irreversible fibroblast growth factor receptor inhibitor futibatinib by UPLC-MS/MS: Application to the metabolic stability assay in human liver microsomes for the estimation of its in vitro hepatic intrinsic clearance

    Article • Journal of Pharmaceutical and Biomedical Analysis, May 2022, Elsevier

    Dr Eric Chun Yong Chan

  20. Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells

    Article • Toxicology Research, March 2022, Oxford University Press (OUP)

    Dr Eric Chun Yong Chan

  21. Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

    Article • Acta Pharmaceutica Sinica B, March 2022, Elsevier

    Dr Eric Chun Yong Chan

  22. Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminate in Mechanism-Based Inactivation of Cytochrome P450 3A

    Article • Drug Metabolism and Disposition, February 2022, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  23. Antidiabetic effects of multi-species probiotic and its fermented milk in mice via restoring gut microbiota and intestinal barrier

    Article • Food Bioscience, February 2022, Elsevier

    Dr Eric Chun Yong Chan

  24. Febuxostat and its Major Acyl Glucuronide Metabolite are Potent Inhibitors of Organic Anion Transporter 3: Implications for Drug‐Drug Interactions with Rivaroxaban

    Article • Biopharmaceutics & Drug Disposition, January 2022, Wiley

    Dr Eric Chun Yong Chan

  25. Transesterification of Indazole-3-Carboxamide Synthetic Cannabinoids: Identification of Metabolite Biomarker for Diagnosing Co-Abuse of 5F-MDMB-PINACA and Alcohol

    Article • Journal of Analytical Toxicology, December 2021, Oxford University Press (OUP)

    Dr Eric Chun Yong Chan

  26. Inhibition of cytochrome P450 enzymes and uridine 5′-diphospho-glucuronosyltransferases by vicagrel in human liver microsomes: A prediction of potential drug-drug interactions

    Article • Chemico-Biological Interactions, December 2021, Elsevier

    Dr Eric Chun Yong Chan

  27. Application of a PBPK Model of Rivaroxaban to Prospective Simulations of Drug‐Drug‐Disease Interactions with Protein Kinase Inhibitors in CA‐VTE

    Article • British Journal of Clinical Pharmacology, November 2021, Wiley

    Dr Eric Chun Yong Chan

  28. Model-Based Risk Prediction of Rivaroxaban with Amiodarone for Moderate Renal Impaired Elderly Population

    Article • Cardiovascular Drugs and Therapy, October 2021, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  29. Atypical kinetics of cytochrome P450 2J2: Epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors

    Article • European Journal of Pharmaceutical Sciences, September 2021, Elsevier

    Dr Eric Chun Yong Chan

  30. Urinary Metabolite Biomarkers for the Detection of Synthetic Cannabinoid ADB-BUTINACA Abuse

    Article • Clinical Chemistry, August 2021, Oxford University Press (OUP)

    Dr Eric Chun Yong Chan

  31. Preliminary discovery of novel markers for human cell line activation test (h-CLAT)

    Article • Toxicology in Vitro, August 2021, Elsevier

    Dr Eric Chun Yong Chan

  32. Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4

    Article • Drug Metabolism and Disposition, July 2021, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  33. Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5

    Article • Molecular Pharmacology, July 2021, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  34. Mechanism-Based Inactivation of Cytochrome P450 3A4 and 3A5 by the Fibroblast Growth Factor Receptor Inhibitor Erdafitinib

    Article • Chemical Research in Toxicology, June 2021, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  35. Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents

    Article • Drug Metabolism and Pharmacokinetics, June 2021, Elsevier

    Dr Eric Chun Yong Chan

  36. Fructose intolerance is not associated with malabsorption in patients with functional gastrointestinal disorders

    Article • Neurogastroenterology & Motility, April 2021, Wiley

    Dr Eric Chun Yong Chan

  37. Mechanism-based Inactivation of Cytochrome P450 3A4 by Benzbromarone

    Article • Molecular Pharmacology, January 2021, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  38. An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, January 2021, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  39. Diagnosing intake and rationalizing toxicities associated with 5F-MDMB-PINACA and 4F-MDMB-BINACA abuse

    Article • Archives of Toxicology, November 2020, Springer Science + Business Media

    Dr Eric Chun Yong Chan, Christophe Stove

  40. A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema

    Article • Gut Microbes, October 2020, Taylor & Francis

    Dr Eric Chun Yong Chan

  41. Tryptophan–kynurenine ratio as a biomarker of bladder cancer

    Article • BJU International, September 2020, Wiley

    Dr Eric Chun Yong Chan

  42. Combination Bacillus Calmette-Guérin and indoleamine 2,3-dioxygenase 1 inhibitor therapy of murine orthotopic bladder cancer

    Article • BJU International, August 2020, Wiley

    Dr Eric Chun Yong Chan

  43. Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2020, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  44. Increased Protein S-Glutathionylation in Leber’s Hereditary Optic Neuropathy (LHON)

    Article • International Journal of Molecular Sciences, April 2020, MDPI AG

    Dr Eric Chun Yong Chan

  45. How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone

    Article • Cardiovascular Toxicology, January 2020, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  46. Predicting human tissue exposures to xenobiotics using a bottom-up physiologically-based biokinetic model

    Article • ALTEX, January 2020, ALTEX Edition

    Dr Eric Chun Yong Chan

  47. Atypical Michaelis-Menten kinetics in cytochrome P450 enzymes: A focus on substrate inhibition

    Article • Biochemical Pharmacology, November 2019, Elsevier

    Dr Eric Chun Yong Chan

  48. Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban

    Article • Drug Metabolism and Disposition, September 2019, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  49. Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing

    Article • ALTEX, January 2019, ALTEX Edition

    Dr Eric Chun Yong Chan

  50. Faculty cooperation in teaching academic literacy using popular science texts: A case study

    Article • Teaching & Learning Inquiry The ISSOTL Journal, September 2018, International Society for the Scholarship of Teaching and Learning

    Dr Eric Chun Yong Chan

  51. Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study

    Article • Nutrients, July 2018, MDPI AG

    Dr Eric Chun Yong Chan

  52. Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity

    Article • Molecular & Cellular Proteomics, July 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Eric Chun Yong Chan

  53. Rivaroxaban With and Without Amiodarone in Renal Impairment

    Article • Journal of the American College of Cardiology, March 2018, Elsevier

    Dr Eric Chun Yong Chan

  54. Recent advances in the applications of metabolomics in eye research

    Article • Analytica Chimica Acta, February 2018, Elsevier

    Dr Eric Chun Yong Chan

  55. Dronedarone-Induced Cardiac Mitochondrial Dysfunction & Its Mitigation by Epoxyeicosatrienoic Acids

    Article • Toxicological Sciences, January 2018, Oxford University Press (OUP)

    Dr Eric Chun Yong Chan

  56. Polyphenol-rich curry made with mixed spices and vegetables benefits glucose homeostasis in Chinese males (Polyspice Study): a dose–response randomized controlled crossover trial

    Article • Zeitschrift für Ernährungswissenschaft, December 2017, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  57. Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine

    Article • Cancer Chemotherapy and Pharmacology, December 2017, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  58. Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids

    Article • Biochemical Pharmacology, December 2017, Elsevier

    Dr Eric Chun Yong Chan

  59. The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat

    Article • Hepatology, November 2017, Wiley

    Dr Eric Chun Yong Chan

  60. In Silico and in Vitro Interactions between Short Chain Fatty Acids and Human Histone Deacetylases

    Article • Biochemistry, August 2017, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  61. Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy

    Article • Biochemical Pharmacology, July 2017, Elsevier

    Dr Eric Chun Yong Chan

  62. A novel LCMSMS method for quantitative measurement of short-chain fatty acids in human stool derivatized with 12 C- and 13 C-labelled aniline

    Article • Journal of Pharmaceutical and Biomedical Analysis, May 2017, Elsevier

    Dr Eric Chun Yong Chan

  63. Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids

    Article • Chemosphere, April 2017, Elsevier

    Dr Eric Chun Yong Chan

  64. Application of Static Modeling ­­in the Prediction of In Vivo Drug–Drug Interactions between Rivaroxaban and Antiarrhythmic Agents Based on In Vitro Inhibition Studies

    Article • Drug Metabolism and Disposition, January 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  65. Proteo-metabolomics in elucidating mechanisms of acetaminophen toxicity

    Article • Drug Metabolism and Pharmacokinetics, January 2017, Elsevier

    Dr Eric Chun Yong Chan

  66. Targeted LC/MS-based quantitative profiling of 15 gut microbiome-derived short chain fatty acids in infant and adult stool

    Article • Drug Metabolism and Pharmacokinetics, January 2017, Elsevier

    Dr Eric Chun Yong Chan

  67. Dronedarone inhibits CYP2J3 activity in H9c2 cardiomyocytes without mitochondrial toxicity

    Article • Drug Metabolism and Pharmacokinetics, January 2017, Elsevier

    Dr Eric Chun Yong Chan

  68. Synergistic disruption of ERα/HER2 crosstalk by endoxifen and lapatinib in breast cancer cells

    Article • Cancer Chemotherapy and Pharmacology, December 2016, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  69. Evaluating Polymyxin B-Based Combinations against Carbapenem-Resistant Escherichia coli in Time-Kill Studies and in a Hollow-Fiber Infection Model

    Article • Antimicrobial Agents and Chemotherapy, October 2016, ASM Journals

    Dr Eric Chun Yong Chan

  70. In VitroActivity of Polymyxin B in Combination with Various Antibiotics against Extensively Drug-Resistant Enterobacter cloacae with Decreased Susceptibility to Polymyxin B

    Article • Antimicrobial Agents and Chemotherapy, June 2016, ASM Journals

    Dr Li Yang Hsu, Dr Eric Chun Yong Chan

  71. Phase I Metabolic Stability and Electrophilic Reactivity of 2-Phenylaminophenylacetic Acid Derived Compounds

    Article • Chemical Research in Toxicology, June 2016, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  72. Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites

    Article • Biochemical Pharmacology, May 2016, Elsevier

    Dr Eric Chun Yong Chan

  73. Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish

    Article • PLoS ONE, March 2016, PLOS

    Dr Eric Chun Yong Chan

  74. Metabolic Markers for Diabetic Retinopathy

    Article • Diabetes, January 2016, American Diabetes Association

    Dr Eric Chun Yong Chan

  75. The Isotope-Coded Affinity Tag Method for Quantitative Protein Profile Comparison and Relative Quantitation of Cysteine Redox Modifications

    Article • November 2015, Wiley

    Dr Eric Chun Yong Chan

  76. Metabonomic diagnosis of bladder cancer: what are the advantages and considerations?

    Article • Bioanalysis, November 2015, Future Science

    Dr Eric Chun Yong Chan

  77. Gastrointestinal Symptoms and Altered Intestinal Permeability Induced by Combat Training Are Associated with Distinct Metabotypic Changes

    Article • Journal of Proteome Research, October 2015, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  78. Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N-Desbutyl Dronedarone

    Article • Molecular Pharmacology, October 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  79. Understanding the cholesterol metabolism-perturbing effects of docosahexaenoic acid by gas chromatography–mass spectrometry targeted metabonomic profiling

    Article • Zeitschrift für Ernährungswissenschaft, October 2015, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  80. Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A

    Article • Biochemical Pharmacology, October 2015, Elsevier

    Dr Eric Chun Yong Chan

  81. Global Metabonomic and Proteomic Analysis of Human Conjunctival Epithelial Cells (IOBA-NHC) in Response to Hyperosmotic Stress

    Article • Journal of Proteome Research, August 2015, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  82. Prevalence of KRAS, BRAF, PI3K and EGFR mutations among Asian patients with metastatic colorectal cancer

    Article • Oncology Letters, August 2015, Spandidos Publications

    Dr Eric Chun Yong Chan

  83. Investigation of Host–Gut Microbiota Modulation of Therapeutic Outcome

    Article • Drug Metabolism and Disposition, May 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  84. In VitroPharmacodynamics of Various Antibiotics in Combination against Extensively Drug-Resistant Klebsiella pneumoniae

    Article • Antimicrobial Agents and Chemotherapy, February 2015, ASM Journals

    Dr Li Yang Hsu, Dr Eric Chun Yong Chan

  85. Metabolic Profiling of CHO-AβPP695 Cells Revealed Mitochondrial Dysfunction Prior to Amyloid-β Pathology and Potential Therapeutic Effects of Both PPARγ and PPARα Agonisms for Alzheimer's Disease

    Article • Journal of Alzheimer’s Disease, January 2015, IOS Press

    Dr Eric Chun Yong Chan

  86. Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinib

    Article • Drug Metabolism Reviews, January 2015, Taylor & Francis

    Dr Eric Chun Yong Chan

  87. Metabonomic Profiling of Bladder Cancer

    Article • Journal of Proteome Research, November 2014, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  88. Global fecal microRNA profiling in the identification of biomarkers for colorectal cancer screening among Asians

    Article • Oncology Reports, May 2014, Spandidos Publications

    Dr Eric Chun Yong Chan

  89. Metabotyping of Docosahexaenoic Acid - Treated Alzheimer’s Disease Cell Model

    Article • PLoS ONE, February 2014, PLOS

    Dr Eric Chun Yong Chan

  90. Development of an UPLC–MS/MS method for assaying the enzymatic activity of propionyl coenzyme-A carboxylase

    Article • Bioanalysis, February 2014, Future Science

    Dr Eric Chun Yong Chan

  91. Non-invasive fecal metabonomic detection of colorectal cancer

    Article • Cancer Biology & Therapy, January 2014, Taylor & Francis

    Dr Eric Chun Yong Chan

  92. Applications of monolithic materials for sample preparation

    Article • Journal of Pharmaceutical and Biomedical Analysis, January 2014, Elsevier

    Dr Eric Chun Yong Chan

  93. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

    Article • Nature Genetics, December 2013, Springer Science + Business Media

    Dr Frederic A Bard, Dr Eric Chun Yong Chan

  94. Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabonomic profiling of lyophilized human feces

    Article • Journal of Chromatography B, October 2013, Elsevier

    Dr Eric Chun Yong Chan

  95. Urinary Metabotyping of Bladder Cancer Using Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry

    Article • Journal of Proteome Research, August 2013, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  96. Metabolically Functional Hepatocyte-Like Cells from Human Umbilical Cord Lining Epithelial Cells

    Article • Assay and Drug Development Technologies, March 2013, Mary Ann Liebert Inc

    Dr Eric Chun Yong Chan

  97. An automated Pearson's correlation change classification (APC3) approach for GC/MS metabonomic data using total ion chromatograms (TICs)

    Article • The Analyst, January 2013, Royal Society of Chemistry

    Dr Eric Chun Yong Chan

  98. Gas Chromatography/Mass Spectrometry-Based Metabonomics

    Article • January 2013, Elsevier

    Dr Eric Chun Yong Chan

  99. Investigating the role of nucleoside transporters in the resistance of colorectal cancer to 5-fluorouracil therapy

    Article • Cancer Chemotherapy and Pharmacology, December 2012, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  100. Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties

    Article • European Journal of Pharmacology, December 2012, Elsevier

    Dr Eric Chun Yong Chan

  101. Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated drug clearance of rifampicin

    Article • Analytical and Bioanalytical Chemistry, November 2012, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  102. Metabonomic Profiling of TASTPM Transgenic Alzheimer’s Disease Mouse Model

    Article • Journal of Proteome Research, October 2012, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  103. An Investigation of the Bioactivation Potential and Metabolism Profile of Zebrafish versus Human

    Article • SLAS DISCOVERY, August 2012, SAGE Publications

    Dr Eric Chun Yong Chan

  104. LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells

    Article • Biotechnology and Bioengineering, July 2012, Wiley

    Dr Eric Chun Yong Chan

  105. Thomas O. Metz (Ed.): Metabolic profiling. Methods and protocols

    Article • Analytical and Bioanalytical Chemistry, May 2012, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  106. Interaction of Lapatinib with Cytochrome P450 3A5

    Article • Drug Metabolism and Disposition, April 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  107. ChemInform Abstract: Trend Analysis of Metabonomics and Systematic Review of Metabonomics-derived Cancer Marker Metabolites

    Article • ChemInform, March 2012, Wiley

    Dr Eric Chun Yong Chan

  108. Metabotyping of human colorectal cancer using two-dimensional gas chromatography mass spectrometry

    Article • Analytical and Bioanalytical Chemistry, February 2012, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  109. Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence

    Article • Breast Cancer Research and Treatment, February 2012, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  110. Metabonomics

    Article • January 2012, Elsevier

    Dr Eric Chun Yong Chan

  111. Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation

    Article • Toxicology Letters, October 2011, Elsevier

    Dr Eric Chun Yong Chan

  112. Global urinary metabolic profiling procedures using gas chromatography–mass spectrometry

    Article • Nature Protocols, September 2011, Nature

    Dr Eric Chun Yong Chan

  113. Efficiency of a miniaturized silica monolithic cartridge in reducing matrix ions as demonstrated in the simultaneous extraction of morphine and codeine from urine samples for quantification with liquid chromatography-tandem mass spectrometry (LC-MS/MS)

    Article • Journal of Mass Spectrometry, September 2011, Wiley

    Dr Eric Chun Yong Chan

  114. Characterization of The Human Tear Metabolome by LC–MS/MS

    Article • Journal of Proteome Research, August 2011, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  115. Use of Urine Volatile Organic Compounds To Discriminate Tuberculosis Patients from Healthy Subjects

    Article • Analytical Chemistry, June 2011, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  116. Metabolic Profiling of 3-Nitropropionic Acid Early-Stage Huntington’s Disease Rat Model Using Gas Chromatography Time-of-Flight Mass Spectrometry

    Article • Journal of Proteome Research, April 2011, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  117. Extraction of ketamine from urine using a miniature silica monolithic cartridge followed by quantification with liquid chromatography tandem mass spectrometry (LC-MS/MS)

    Article • Journal of Separation Science, March 2011, Wiley

    Dr Eric Chun Yong Chan

  118. Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib

    Article • Drug Metabolism and Disposition, March 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  119. Zebrafish for drug toxicity screening: bridging thein vitrocell-based models andin vivomammalian models

    Article • Expert Opinion on Drug Metabolism & Toxicology, February 2011, Informa Healthcare

    Dr Eric Chun Yong Chan

  120. Ultra-pressure liquid chromatography/tandem mass spectrometry targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer

    Article • Rapid Communications in Mass Spectrometry, February 2011, Wiley

    Dr Eric Chun Yong Chan

  121. Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells

    Article • Chinese Medicine, January 2011, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  122. Comparative evaluation of software for retention time alignment of gas chromatography/time-of-flight mass spectrometry-based metabonomic data

    Article • Journal of Chromatography A, December 2010, Elsevier

    Dr Eric Chun Yong Chan

  123. Trend analysis of metabonomics and systematic review of metabonomics-derived cancer marker metabolites

    Article • Metabolomics, November 2010, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  124. Metabolic footprinting of tumorigenic and nontumorigenic uroepithelial cells using two-dimensional gas chromatography time-of-flight mass spectrometry

    Article • Analytical and Bioanalytical Chemistry, August 2010, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  125. Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib

    Article • Molecular Pharmacology, July 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Eric Chun Yong Chan

  126. On-line chromatographic screening of matrix metalloproteinase inhibitors using immobilized MMP-9 enzyme reactor

    Article • Journal of Chromatography B, July 2010, Elsevier

    Dr Eric Chun Yong Chan

  127. Application of silica-based monolith as solid phase extraction cartridge for extracting polar compounds from urine

    Article • Talanta, July 2010, Elsevier

    Dr Eric Chun Yong Chan

  128. Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes

    Article • Toxicology Letters, June 2010, Elsevier

    Dr Eric Chun Yong Chan

  129. Ultra-high performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginseng

    Article • Journal of Pharmaceutical and Biomedical Analysis, May 2010, Elsevier

    Dr Eric Chun Yong Chan

  130. Noninvasive Urinary Metabonomic Diagnosis of Human Bladder Cancer

    Article • Journal of Proteome Research, April 2010, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  131. Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity

    Article • Toxicology Letters, February 2010, Elsevier

    Dr Eric Chun Yong Chan

  132. A sensitive LC/MS/MS bioanalysis assay of orally administered lipoic acid in rat blood and brain tissue

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2010, Elsevier

    Dr Eric Chun Yong Chan

  133. Fluorescence-Based Liver Microsomal Assay for Screening of Pharmaceutical Reactive Metabolites Using a Glutathione Conjugated 96-Well Plate

    Article • Bioconjugate Chemistry, January 2010, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  134. Metabolic Profiling of Rat Brain and Cognitive Behavioral Tasks: Potential Complementary Strategies in Preclinical Cognition Enhancement Research

    Article • Journal of Proteome Research, November 2009, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  135. Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

    Article • Toxicology and Applied Pharmacology, July 2009, Elsevier

    Dr Eric Chun Yong Chan

  136. Development and validation of a gas chromatography/mass spectrometry method for the metabolic profiling of human colon tissue

    Article • Rapid Communications in Mass Spectrometry, February 2009, Wiley

    Dr Eric Chun Yong Chan

  137. Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, January 2009, Wiley

    Dr Eric Chun Yong Chan

  138. Distribution study of orally administered lipoic acid in rat brain tissues

    Article • Brain Research, January 2009, Elsevier

    Dr Eric Chun Yong Chan

  139. Metabolic Profiling of Human Colorectal Cancer Using High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR) Spectroscopy and Gas Chromatography Mass Spectrometry (GC/MS)

    Article • Journal of Proteome Research, December 2008, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  140. Development and validation of a gas chromatography/mass spectrometry metabonomic platform for the global profiling of urinary metabolites

    Article • Rapid Communications in Mass Spectrometry, October 2008, Wiley

    Dr Eric Chun Yong Chan

  141. Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and1H NMR spectroscopy

    Article • Rapid Communications in Mass Spectrometry, August 2008, Wiley

    Dr Eric Chun Yong Chan

  142. Oxidative Bioactivation and Toxicity of Leflunomide in Immortalized Human Hepatocytes and Kinetics of the Non-Enzymatic to Its Major etabolitie, A77 1726

    Article • Drug Metabolism Letters, August 2008, Bentham Science Publishers

    Dr Eric Chun Yong Chan

  143. Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine

    Article • Toxicology Letters, August 2008, Elsevier

    Dr Eric Chun Yong Chan

  144. Gas chromatography/mass spectrometry in metabolic profiling of biological fluids

    Article • Journal of Chromatography B, August 2008, Elsevier

    Dr Eric Chun Yong Chan

  145. Investigation of the Drug–Drug Interaction Between α-Lipoic Acid and Valproate via Mitochondrial β-oxidation

    Article • Pharmaceutical Research, July 2008, Springer Science + Business Media

    Dr Eric Chun Yong Chan

  146. Bonding interfaces in wafer-level metal/adhesive bonded 3D integration

    Article • May 2008, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Eric Chun Yong Chan

  147. Evaluation of BEH C18, BEH HILIC, and HSS T3 (C18) Column Chemistries for the UPLC-MS-MS Analysis of Glutathione, Glutathione Disulfide, and Ophthalmic Acid in Mouse Liver and Human Plasma

    Article • Journal of Chromatographic Science, March 2008, Oxford University Press (OUP)

    Dr Eric Chun Yong Chan

  148. Enhancing pharmaceutical analysis laboratory classes via the measurement of minerals in Berocca® effervescent tablets

    Article • Pharmacy Education, January 2008, Taylor & Francis

    Dr Eric Chun Yong Chan

  149. In Vitro Metabolism of Leflunomide by Mouse and Human Liver Microsomes

    Article • Drug Metabolism Letters, December 2007, Bentham Science Publishers

    Dr Eric Chun Yong Chan

  150. Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultra-performance liquid chromatography/tandem mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, January 2007, Wiley

    Dr Eric Chun Yong Chan

  151. Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamedPanax notoginseng

    Article • Rapid Communications in Mass Spectrometry, January 2007, Wiley

    Dr Eric Chun Yong Chan

  152. Detection of aristolochic acid I, tetrandrine and fangchinoline in medicinal plants by high performance liquid chromatography and liquid chromatography/mass spectrometry

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2006, Elsevier

    Dr Eric Chun Yong Chan

  153. Modeling Caco-2 permeability of drugs using immobilized artificial membrane chromatography and physicochemical descriptors

    Article • Journal of Chromatography A, April 2005, Elsevier

    Dr Eric Chun Yong Chan

  154. Hydrophilic interaction liquid chromatography with tandem mass spectrometry for the determination of underivatized dencichine (β-N-oxalyl-L-α,β-diaminopropionic acid) inPanax medicinal plant species

    Article • Rapid Communications in Mass Spectrometry, January 2005, Wiley

    Dr Eric Chun Yong Chan

  155. Application of Visual Basic in High-Throughput Mass Spectrometry-Directed Purification of Combinatorial Libraries

    Article • Journal of Combinatorial Chemistry, October 2003, American Chemical Society (ACS)

    Dr Eric Chun Yong Chan

  156. Preparation and characterization of immunogens for antibody production against metanephrine and normetanephrine

    Article • Journal of Immunological Methods, August 2002, Elsevier

    Dr Eric Chun Yong Chan

  157. An automated LC method for the small-scale purification of organic molecules derived from combinatorial libraries

    Article • Journal of Pharmaceutical and Biomedical Analysis, June 2002, Elsevier

    Dr Eric Chun Yong Chan

  158. Evaluation of degradation of urinary catecholamines and metanephrines and deconjugation of their sulfoconjugates using stability-indicating reversed-phase ion-pair HPLC with electrochemical detection

    Article • Journal of Pharmaceutical and Biomedical Analysis, April 2000, Elsevier

    Dr Eric Chun Yong Chan

  159. High-performance liquid chromatographic assay for catecholamines and metanephrines using fluorimetric detection with pre-column 9-fluorenylmethyloxycarbonyl chloride derivatization

    Article • Journal of Chromatography B Biomedical Sciences and Applications, January 2000, Elsevier

    Dr Eric Chun Yong Chan

  160. High-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometric method for the analysis of catecholamines and metanephrines in human urine

    Article • Rapid Communications in Mass Spectrometry, January 2000, Wiley

    Dr Eric Chun Yong Chan

  161. The value of analytical assays that are stability-indicating

    Article • Clinica Chimica Acta, October 1999, Elsevier

    Dr Eric Chun Yong Chan

  162. Enantiomeric separation of tramadol hydrochloride and its metabolites by cyclodextrin-mediated capillary zone electrophoresis

    Article • Journal of Chromatography B Biomedical Sciences and Applications, April 1998, Elsevier

    Dr Eric Chun Yong Chan