All Stories

  1. Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes

    Article • Nucleic Acids Research, December 2017, Oxford University Press (OUP)

    Professor Emmanuel Skordalakes

  2. ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

    Article • Nature Structural & Molecular Biology, April 2017, Nature

    Professor Emmanuel Skordalakes

  3. Structure of the human POT1-TPP1 telomeric complex

    Article • April 2017, Protein Data Bank, Rutgers University

    Professor Emmanuel Skordalakes

  4. Structural and functional analysis of the human POT1-TPP1 telomeric complex

    Article • Nature Communications, April 2017, Nature

    Professor Emmanuel Skordalakes

  5. STRUCTURE OF THE HUMAN TELOMERASE THUMB DOMAIN

    Article • February 2017, Protein Data Bank, Rutgers University

    Professor Emmanuel Skordalakes

  6. Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes

    Article • Journal of Biological Chemistry, February 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Emmanuel Skordalakes

  7. Structure and function of the telomeric CST complex

    Article • Computational and Structural Biotechnology Journal, January 2016, Elsevier

    Professor Emmanuel Skordalakes

  8. Crystallographic Studies of Telomerase

    Article • January 2016, Elsevier

    Professor Emmanuel Skordalakes

  9. SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase

    Article • Cell Reports, November 2015, Elsevier

    Dr. Katherine M Aird, Professor Emmanuel Skordalakes

  10. Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532

    Article • Structure, October 2015, Elsevier

    Professor Emmanuel Skordalakes

  11. The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases

    Article • Journal of Molecular Biology, September 2015, Elsevier

    Professor Emmanuel Skordalakes

  12. Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes

    Article • Molecular Cell, September 2015, Elsevier

    Professor Emmanuel Skordalakes

  13. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

    Article • Science Signaling, June 2015, American Association for the Advancement of Science

    Professor Emmanuel Skordalakes

  14. LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

    Article • Cancer Research, March 2014, American Association for Cancer Research (AACR)

    Professor Emmanuel Skordalakes

  15. A Motif in the Vertebrate Telomerase N-Terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and Processivity

    Article • Structure, October 2013, Elsevier

    Professor Emmanuel Skordalakes

  16. Structure of the Human Telomeric Stn1-Ten1 Capping Complex

    Article • PLoS ONE, June 2013, PLOS

    Professor Emmanuel Skordalakes

  17. Single Cell Analysis of RNA-mediated Histone H3.3 Recruitment to a Cytomegalovirus Promoter-regulated Transcription Site

    Article • Journal of Biological Chemistry, May 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Emmanuel Skordalakes

  18. Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance

    Article • Structure, January 2013, Elsevier

    Professor Emmanuel Skordalakes

  19. Structure function of telomerase and human disease

    Article • May 2012, Wiley

    Professor Emmanuel Skordalakes

  20. In vitro Reconstitution of the Active T. castaneum Telomerase

    Article • Journal of Visualized Experiments, July 2011, MyJove Corporation

    Professor Emmanuel Skordalakes

  21. Telomerase structure function

    Article • Current Opinion in Structural Biology, February 2011, Elsevier

    Professor Emmanuel Skordalakes

  22. Neural and Synaptic Defects in slytherin, a Zebrafish Model for Human Congenital Disorders of Glycosylation

    Article • PLoS ONE, October 2010, PLOS

    Professor Emmanuel Skordalakes

  23. Insights into Cdc13 dependent telomere length regulation

    Article • Aging, October 2010, Impact Journals, LLC

    Professor Emmanuel Skordalakes

  24. Cdc13 N-Terminal Dimerization, DNA Binding, and Telomere Length Regulation

    Article • Molecular and Cellular Biology, September 2010, ASM Journals

    Professor Emmanuel Skordalakes

  25. Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA

    Article • Nature Structural & Molecular Biology, March 2010, Nature

    Professor Emmanuel Skordalakes

  26. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation

    Article • Human Molecular Genetics, December 2009, Oxford University Press (OUP)

    Professor Emmanuel Skordalakes

  27. Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Professor Emmanuel Skordalakes

  28. Telomerase structure paves the way for new cancer therapies

    Article • Future Oncology, March 2009, Future Medicine

    Professor Emmanuel Skordalakes

  29. Telomerase and the benefits of healthy living

    Article • The Lancet Oncology, November 2008, Elsevier

    Professor Emmanuel Skordalakes

  30. Structure of the Tribolium castaneum telomerase catalytic subunit TERT

    Article • Nature, August 2008, Nature

    Professor Emmanuel Skordalakes

  31. Structure of the catalytic subunit of telomerase, TERT

    Article • August 2008, Protein Data Bank, Rutgers University

    Professor Emmanuel Skordalakes

  32. Structure of the catalytic subunit of telomerase, TERT

    Article • August 2008, Protein Data Bank, Rutgers University

    Professor Emmanuel Skordalakes

  33. Function and Structure of a Prokaryotic Formylglycine-generating Enzyme

    Article • Journal of Biological Chemistry, April 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Emmanuel Skordalakes

  34. The high resolution structure of the RNA-binding domain of telomerase

    Article • November 2007, Protein Data Bank, Rutgers University

    Professor Emmanuel Skordalakes

  35. Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding

    Article • Structure, November 2007, Elsevier

    Professor Emmanuel Skordalakes

  36. Comparison of Proteolytic Susceptibility in Phosphoglycerate Kinases from Yeast and E. coli: Modulation of Conformational Ensembles Without Altering Structure or Stability

    Article • Journal of Molecular Biology, May 2007, Elsevier

    Professor Emmanuel Skordalakes

  37. Structural Insights into RNA-Dependent Ring Closure and ATPase Activation by the Rho Termination Factor

    Article • Cell, November 2006, Elsevier

    Professor Emmanuel Skordalakes

  38. Structural Mechanism of Inhibition of the Rho Transcription Termination Factor by the Antibiotic Bicyclomycin

    Article • Structure, January 2005, Elsevier

    Professor Emmanuel Skordalakes

  39. Structure and Function of the Conserved Core of Histone Deposition Protein Asf1

    Article • Current Biology, December 2003, Elsevier

    Professor Emmanuel Skordalakes, Paul D. Kaufman

  40. Structure of the Rho Transcription Terminator

    Article • Cell, July 2003, Elsevier

    Professor Emmanuel Skordalakes

  41. A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion

    Article • Proceedings of the National Academy of Sciences, December 2002, Proceedings of the National Academy of Sciences

    Professor Emmanuel Skordalakes

  42. Inhibition of human α-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate 1 1Edited by R. Huber

    Article • Journal of Molecular Biology, August 2001, Elsevier

    Professor Emmanuel Skordalakes

  43. Bifunctional Peptide Boronate Inhibitors of Thrombin:  Crystallographic Analysis of Inhibition Enhanced by Linkage to an Exosite 1 Binding Peptide

    Article • Biochemistry, October 1998, American Chemical Society (ACS)

    Professor Emmanuel Skordalakes

  44. Crystallographic Structures of Human α-Thrombin Complexed to Peptide Boronic Acids Lacking a Positive Charge at P1. Evidence of Novel Interactions

    Article • Journal of the American Chemical Society, October 1997, American Chemical Society (ACS)

    Professor Emmanuel Skordalakes

  45. Design of a novel class of bifunctional thrombin inhibitors, synthesised by the first application of peptide boronates in solid phase chemistry

    Article • Tetrahedron Letters, May 1997, Elsevier

    Professor Emmanuel Skordalakes

  46. The facile synthesis of O,O-Dialkyl α-halobenzylphosphonates from O,O-Dialkyl α-hydroxybenzylphosphonates

    Article • Tetrahedron, July 1996, Elsevier

    Professor Emmanuel Skordalakes

  47. Substrate Related O,O-Dialkyldipeptidylaminophosphonates, a New Type of Thrombin Inhibitor

    Article • Phosphorus Sulfur and Silicon and the Related Elements, February 1996, Taylor & Francis

    Professor Emmanuel Skordalakes

  48. Characterization of a Class of Peptide Boronates with Neutral P1 Side Chains as Highly Selective Inhibitors of Thrombin

    Article • Journal of Medicinal Chemistry, April 1995, American Chemical Society (ACS)

    Professor Emmanuel Skordalakes

  49. Rhodium(I)-catalysed hydroboration of 1-halo-1-alkenes

    Article • Tetrahedron Letters, April 1994, Elsevier

    Professor Emmanuel Skordalakes