All Stories

  1. Self-oxidation and proximity crosslinking of G-quadruplex in G-quadruplex /hemin peroxidase system
  2. Construction of Agonistic Bivalent Double‐Stranded Aptamers Targeting c‐MET
  3. Construction of Agonistic Bivalent Double‐Stranded Aptamers Targeting c‐MET
  4. Detection and Verification of Intestinal and Placental Alkaline Phosphatase Heterodimer in Extracellular Fluid
  5. DNA aptamer targeting zinc transporters ZIP10 and ZIP6 on cancer cells
  6. Embedding Dual-Responsive Polymer@Enzyme in Zeolitic Imidazolate Frameworks with a Hollow Space for Improving Its Catalytic Performance
  7. A preliminary profile of RNA bound on the cell surface
  8. A Comparative Study on the DNA Interactions and Biological Activities of Benzophenanthridine and Protoberberine Alkaloids
  9. A Bispecific Chimeric Aptamer Design Platform Based on c‐MET Aptamer with a Replaceable Redundant Region
  10. A naphthalimide-based fluorescent platform for endoplasmic reticulum targeted imaging
  11. Heptamethine Cyanine-Based Molecule Release Triggered by Mitochondrial ROS
  12. DNA Aptamer Binding Octapeptide Repeat Region of Cellular Prion Protein
  13. Structural Optimization and Interaction Study of a DNA Aptamer to L1 Cell Adhesion Molecule
  14. Generation of an Aptamer Targeting Receptor-Type Tyrosine-Protein Phosphatase F
  15. Potential G‐quadruplexes within the Promoter Nuclease Hypersensitive Sites of the Heat‐Responsive Genes in Rice
  16. Characterization and Identification of Aptamers against CD49c for the Detection, Capture, and Release of Cancer Cells
  17. Aptamer-Based Cell Nucleus Imaging via Expansion Microscopy
  18. Transferrin receptor-mediated internalization and intracellular fate of conjugates of a DNA aptamer
  19. A photo-activated aptamer–drug conjugate for targeted drug delivery
  20. Cell-SELEX-based selection of ssDNA aptamers for specifically targeting BRAF V600E-mutated melanoma
  21. A DNA Aptameric Ligand of Human Transferrin Receptor Generated by Cell-SELEX
  22. A 4-aminonaphthalimide-based fluorescent traceable prodrug with excellent photoinduced cytotoxicity
  23. Detection of Circulating Tumor-Related Materials by Aptamer Capturing and Endogenous Enzyme-Signal Amplification
  24. Prion Protein Targeted by a Prostate Cancer Cell Binding Aptamer, a Potential Tumor Marker?
  25. Thiazole Orange Styryl Derivatives as Fluorescent Probes for G-Quadruplex DNA
  26. FnCas12a/crRNA assisted dumbbell-PCR detection of IsomiRs with terminal and inner sequence variants
  27. Ratiometric detection and imaging of hydrogen sulfide in mitochondria based on a cyanine/naphthalimide hybrid fluorescent probe
  28. Cell‐SELEX, an Effective Way to the Discovery of Biomarkers and Unexpected Molecular Events
  29. Speeding up in Vitro Discovery of Structure-Switching Aptamers via Magnetic Cross-Linking Precipitation
  30. Dual-Monitoring Glycosylation and Local pH in Live Cells by Metabolic Oligosaccharide Engineering with a Ratiometric Fluorescent Tag
  31. A Nucleus-Targeting DNA Aptamer for Dead Cell Indication
  32. The Mechanism of the Selective Antiproliferation Effect of Guanine-Based Biomolecules and Its Compensation
  33. Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers
  34. In vitro selection of DNA aptamers recognizing drug-resistant ovarian cancer by cell-SELEX
  35. A Mitochondria-Targeted Ratiometric Fluorescent pH Probe
  36. Imaging of Neurite Network with an Anti-L1CAM Aptamer Generated by Neurite-SELEX
  37. Simultaneous Monitoring of Mitochondrial Temperature and ATP Fluctuation Using Fluorescent Probes in Living Cells
  38. Thiazole Orange-Modified Carbon Dots for Ratiometric Fluorescence Detection of G-Quadruplex and Double-Stranded DNA
  39. Oxidative degradation of polyamines by serum supplement causes cytotoxicity on cultured cells
  40. Flow Cytometric Bead Sandwich Assay Based on a Split Aptamer
  41. Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH in Vivo
  42. Triplex-quadruplex structural scaffold: a new binding structure of aptamer
  43. Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo
  44. Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo
  45. Detection of G-Quadruplex Structures Formed by G-Rich Sequences from Rice Genome and Transcriptome Using Combined Probes
  46. Development of squaraine based G-quadruplex ligands using click chemistry
  47. Microbead-Based Platform for Multiplex Detection of DNA and Protein
  48. Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound
  49. Ratiometric Fluorescent Biosensing of Hydrogen Peroxide and Hydroxyl Radical in Living Cells with Lysozyme–Silver Nanoclusters: Lysozyme as Stabilizing Ligand and Fluorescence Signal Unit
  50. A Protease-Activated Ratiometric Fluorescent Probe for pH-Mapping of Malignant Tumor
  51. A Cyanine Dye to Probe Mitophagy: Simultaneous Detection of Mitochondria and Autolysosomes in Live Cells
  52. Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes
  53. A Bis(methylpiperazinylstyryl)phenanthroline as a Fluorescent Ligand for G-Quadruplexes
  54. Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer
  55. Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer
  56. Activity Enhancement of G-Quadruplex/Hemin DNAzyme by Flanking d(CCC)
  57. Generating Cell Targeting Aptamers for Nanotheranostics Using Cell-SELEX
  58. DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives
  59. Facile Phase Transfer and Surface Biofunctionalization of Hydrophobic Nanoparticles Using Janus DNA Tetrahedron Nanostructures
  60. Facile Discovery of Cell-Surface Protein Targets of Cancer Cell Aptamers
  61. Protease-Activated Ratiometric Fluorescent Probe for pH Mapping of Malignant Tumors
  62. Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells
  63. Visible-light-induced cleavage of 4-α-amino acid substituted naphthalimides and its application in DNA photocleavage
  64. Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides
  65. Cell-SELEX: Aptamer Selection Against Whole Cells
  66. Ratiometric fluorescent silver nanoclusters for the determination of mercury and copper ions
  67. Interaction of bisbenzimidazole-substituted carbazole derivatives with G-quadruplexes and living cells
  68. Cell-SELEX-based selection of aptamers that recognize distinct targets on metastatic colorectal cancer cells
  69. Dicyanomethylene-Functionalized Squaraine as a Highly Selective Probe for Parallel G-Quadruplexes
  70. DNA Aptamer Evolved by Cell-SELEX for Recognition of Prostate Cancer
  71. Carbon Dots Based Dual-Emission Silica Nanoparticles as a Ratiometric Nanosensor for Cu 2+
  72. Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans -Platinum Anticancer Complex
  73. Fluorescence Light-Up Probe for Parallel G-Quadruplexes
  74. Activity enhancement of G-quadruplex/hemin DNAzyme by spermine
  75. Exact tailoring of an ATP controlled streptavidin binding aptamer
  76. Effects of side chains on DNA binding, cell permeability, nuclear localization and cytotoxicity of 4-aminonaphthalimides
  77. A label-free electrochemical biosensor based on a DNA aptamer against codeine
  78. One-step real time RT-PCR for detection of microRNAs
  79. General Cell-Binding Activity of Intramolecular G-Quadruplexes with Parallel Structure
  80. G-quadruplex DNA aptamers for zeatin recognizing
  81. A turn-on fluorescent sensor for zinc and cadmium ions based on perylene tetracarboxylic diimide
  82. Rational design of Hg2+controlled streptavidin-binding aptamer
  83. A guanidine derivative of naphthalimide with excited-state deprotonation coupled intramolecular charge transfer properties and its application
  84. A pH sensitive ratiometric fluorophore and its application for monitoring the intracellular and extracellular pHs simultaneously
  85. Specific interactions between adenosine and streptavidin/avidin
  86. Functional-Group Specific Aptamers Indirectly Recognizing Compounds with Alkyl Amino Group
  87. Selective isolation of G-quadruplexes by affinity chromatography
  88. PEG-urokinase nanogels with enhanced stability and controllable bioactivity
  89. Thermal responsive fluorescent block copolymer for intracellular temperature sensing
  90. Characterization of G-Quadruplex/Hemin Peroxidase: Substrate Specificity and Inactivation Kinetics
  91. G-quadruplex DNA aptamers generated for systemin
  92. Characterization and application of a DNA aptamer binding to l-tryptophan
  93. Mercury(ii)-mediated formation of imide-Hg-imide complexes
  94. Silencing of PTK7 in Colon Cancer Cells: Caspase-10-Dependent Apoptosis via Mitochondrial Pathway
  95. Development of DNA aptamers using Cell-SELEX
  96. Cancer Cell Proteomics using Molecular Aptamers
  97. Conservative secondary structure motif of streptavidin-binding aptamers generated by different laboratories
  98. Bifunctional combined aptamer for simultaneous separation and detection of thrombin
  99. Visual Detection of Hg2+ with High Selectivity Using Thymine Modified Gold Nanoparticles
  100. Specific DNA G-quadruplexes bind to ethanolamines
  101. General Peroxidase Activity of G-Quadruplex−Hemin Complexes and Its Application in Ligand Screening
  102. Highly Selective Phthalocyanine−Thymine Conjugate Sensor for Hg 2+ Based on Target Induced Aggregation
  103. Specific mercury(II) adsorption by thymine-based sorbent
  104. Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells
  105. A label-free fluorescence sensor for probing the interaction of oligonucleotides with target molecules
  106. Molecular recognition of acute myeloid leukemia using aptamers
  107. Recognition of subtype non-small cell lung cancer by DNA aptamers selected from living cells
  108. Fluorescent Aptamer Sensors
  109. Molecular Recognition of Small-Cell Lung Cancer Cells Using Aptamers
  110. Cell-Specific Aptamer Probes for Membrane Protein Elucidation in Cancer Cells
  111. Cell-Specific Internalization Study of an Aptamer from Whole Cell Selection
  112. Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells
  113. Design, synthesis and screening of antisense peptide based combinatorial peptide libraries towards an aromatic region of SARS-CoV
  114. Aptamer Directly Evolved from Live Cells Recognizes Membrane Bound Immunoglobin Heavy Mu Chain in Burkitt's Lymphoma Cells
  115. Selection of Aptamers for Molecular Recognition and Characterization of Cancer Cells
  116. Aptamers Evolved from Cultured Cancer Cells Reveal Molecular Differences of Cancer Cells in Patient Samples
  117. Optimization and Modifications of Aptamers Selected from Live Cancer Cell Lines
  118. Aptamer-Conjugated Nanoparticles for the Collection and Detection of Multiple Cancer Cells
  119. Uniform-sized molecularly imprinted polymer for metsulfuron-methyl by one-step swelling and polymerization method
  120. Aptamers evolved from live cells as effective molecular probes for cancer study
  121. Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phase
  122. Aptamer-Conjugated Nanoparticles for Selective Collection and Detection of Cancer Cells
  123. QCM–FIA with PGMA coating for dynamic interaction study of heparin and antithrombin III
  124. A novel matrix for high performance affinity chromatography and its application in the purification of antithrombin III
  125. Cancer Cell Proteomics Using Molecular Aptamers
  126. Preparation and evaluation of uniform-sized molecularly imprinted polymer beads used for the separation of sulfamethazine
  127. Screening of inhibitors for influenza A virus using high-performance affinity chromatography and combinatorial peptide libraries
  128. Acetylcholine release in the hippocampus during the operant conditioned reflex and the footshock stimulus in rats
  129. Quartz crystal biosensor for real-time kinetic analysis of interaction between human TNF-α and monoclonal antibodies
  130. Real time kinetic analysis of the interaction between immunoglobulin G and histidine using quartz crystal microbalance biosensor in solution
  131. Quartz crystal biosensor for real-time monitoring of molecular recognition between protein and small molecular medicinal agents
  132. Novel sulfamethazine ligand used for one-step purification of immunoglobulin G from human plasma
  133. Analysis of glucose and lactate in hippocampal dialysates of rats during the operant conditioned reflex using microdialysis
  134. Hyperoxia caused by microdialysis perfusion decreased striatal monoamines: involvement of oxidative stress
  135. Improved method for the routine determination of acetylcholine and choline in brain microdialysate using a horseradish peroxidase column as the immobilized enzyme reactor
  136. Simple PbII fluorescent probe based on PbII-catalyzed hydrolysis of phosphodiester
  137. A new type of capillary column for open-tubular electrochromatography
  138. Analysis of glucose and lactate in dialysate from hypothalamus of rats after exhausting swimming using microdialysis
  139. Derivatization and Fluorescence Detection of Amino Acids and Peptides with 9-Fluorenylmethyl Chloroformate on the Surface of a Solid Adsorbent
  140. New method for high-performance liquid chromatographic separation and fluorescence detection of ginsenosides
  141. Three novel high performance affinity chromatographic media for the separation of antithrombin III from human plasma