All Stories

  1. Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation

    Article • mBio, September 2018, ASM Journals

    Dr David E Heinrichs

  2. The role of two branched-chain amino acid transporters inStaphylococcus aureusgrowth, membrane fatty acid composition and virulence

    Article • Molecular Microbiology, September 2016, Wiley

    Dr David E Heinrichs

  3. Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation

    Article • PLoS Genetics, August 2016, PLOS

    Dr David E Heinrichs

  4. Iron Acquisition Strategies of Bacterial Pathogens

    Article • Microbiology Spectrum, April 2016, ASM Journals

    Dr David E Heinrichs

  5. Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus

    Article • Pathogens, November 2015, MDPI AG

    Dr David E Heinrichs

  6. A Heme-responsive Regulator Controls Synthesis of Staphyloferrin B in Staphylococcus aureus

    Article • Journal of Biological Chemistry, November 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs

  7. Intracellular replication ofStaphylococcus aureusin mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination

    Article • Cellular Microbiology, October 2015, Wiley

    Dr David E Heinrichs

  8. Recent developments in understanding the iron acquisition strategies of gram positive pathogens

    Article • FEMS Microbiology Reviews, April 2015, Oxford University Press (OUP)

    Dr David E Heinrichs

  9. Inducible Expression of a Resistance-Nodulation-Division-Type Efflux Pump in Staphylococcus aureus Provides Resistance to Linoleic and Arachidonic Acids

    Article • Journal of Bacteriology, March 2015, ASM Journals

    Dr Martin J McGavin, Dr David E Heinrichs

  10. Involvement of major facilitator superfamily proteins SfaA and SbnD in staphyloferrin secretion inStaphylococcus aureus

    Article • FEBS Letters, February 2015, Wiley

    Dr David E Heinrichs

  11. Role of BrnQ1 and BrnQ2 in Branched-Chain Amino Acid Transport and Virulence in Staphylococcus aureus

    Article • Infection and Immunity, December 2014, ASM Journals

    Dr David E Heinrichs, Julie Kaiser

  12. Deferoxamine mesylate enhances virulence of community-associated methicillin resistant Staphylococcus aureus

    Article • Microbes and Infection, November 2014, Elsevier

    Dr David E Heinrichs

  13. SbnG, a Citrate Synthase in Staphylococcus aureus

    Article • Journal of Biological Chemistry, October 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs, Michael Murphy

  14. Role of Lipase from Community-Associated Methicillin-Resistant Staphylococcus aureus Strain USA300 in Hydrolyzing Triglycerides into Growth-Inhibitory Free Fatty Acids

    Article • Journal of Bacteriology, September 2014, ASM Journals

    Dr David E Heinrichs, Dr Martin J McGavin

  15. Identification of a Positively Charged Platform in Staphylococcus aureus HtsA That Is Essential for Ferric Staphyloferrin A Transport

    Article • Biochemistry, July 2014, American Chemical Society (ACS)

    Dr David E Heinrichs

  16. Staphylococcus, Streptococcus, and Bacillus

    Article • April 2014, ASM Journals

    Dr David E Heinrichs

  17. TCA cycle activity in Staphylococcus aureus is essential for iron‐regulated synthesis of staphyloferrin A, but not staphyloferrin B: the benefit of a second citrate synthase

    Article • Molecular Microbiology, April 2014, Wiley

    Dr David E Heinrichs

  18. Crystal and Solution Structure Analysis of FhuD2 from Staphylococcus aureus in Multiple Unliganded Conformations and Bound to Ferrioxamine-B

    Article • Biochemistry, March 2014, American Chemical Society (ACS)

    Dr David E Heinrichs

  19. Synthesis of L-2,3-Diaminopropionic Acid, a Siderophore and Antibiotic Precursor

    Article • Chemistry & Biology, March 2014, Elsevier

    Dr David E Heinrichs, Michael Murphy

  20. Growth promotion of the opportunistic human pathogen, Staphylococcus lugdunensis , by heme, hemoglobin, and coculture with Staphylococcus aureus

    Article • MicrobiologyOpen, February 2014, Wiley

    Dr David E Heinrichs

  21. Demonstration of the functional role of conserved Glu-Arg residues in the Staphylococcus aureus ferrichrome transporter

    Article • BioMetals, December 2013, Springer Science + Business Media

    Dr David E Heinrichs

  22. IsdB-dependent Hemoglobin Binding Is Required for Acquisition of Heme by Staphylococcus aureus

    Article • The Journal of Infectious Diseases, December 2013, Oxford University Press (OUP)

    Dr David E Heinrichs

  23. Structure of unliganded FhuD2 from Staphylococcus Aureus

    Article • June 2013, Protein Data Bank, Rutgers University

    Dr David E Heinrichs

  24. Structure of unliganded and reductively methylated FhuD2 from staphylococcus aureus

    Article • June 2013, Protein Data Bank, Rutgers University

    Dr David E Heinrichs

  25. Structure of FhuD2 from Staphylococcus Aureus with Bound Ferrioxamine B

    Article • June 2013, Protein Data Bank, Rutgers University

    Dr David E Heinrichs

  26. Discovery of an Iron-Regulated Citrate Synthase in Staphylococcus aureus

    Article • Chemistry & Biology, December 2012, Elsevier

    Dr David E Heinrichs, Michael Murphy

  27. Multiprotein Heme Shuttle Pathway in Staphylococcus aureus: Iron-Regulated Surface Determinant Cog-Wheel Kinetics

    Article • Journal of the American Chemical Society, October 2012, American Chemical Society (ACS)

    Martin Stillman, Dr David E Heinrichs

  28. Induction of the Staphylococcal Proteolytic Cascade by Antimicrobial Fatty Acids in Community Acquired Methicillin Resistant Staphylococcus aureus

    Article • PLoS ONE, September 2012, PLOS

    Dr David E Heinrichs, Dr Martin J McGavin

  29. The Staphylococci and staphylococcal pathogenesis

    Article • January 2012

    Dr David E Heinrichs

  30. The iron-regulated staphylococcal lipoproteins

    Article • Frontiers in Cellular and Infection Microbiology, January 2012, Frontiers

    Dr David E Heinrichs

  31. The Staphylococci and Staphylococcal Pathogenesis

    Article • Frontiers in Cellular and Infection Microbiology, January 2012, Frontiers

    Dr David E Heinrichs, Dr Martin J McGavin

  32. Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus

    Article • BMC Microbiology, September 2011, Springer Science + Business Media

    Dr David E Heinrichs

  33. A Modulatory Interleukin-10 Response to Staphylococcal Peptidoglycan Prevents Th1/Th17 Adaptive Immunity to Staphylococcus aureus

    Article • The Journal of Infectious Diseases, June 2011, Oxford University Press (OUP)

    Dr David E Heinrichs

  34. Staphylococcus aureus Transporters Hts, Sir, and Sst Capture Iron Liberated from Human Transferrin by Staphyloferrin A, Staphyloferrin B, and Catecholamine Stress Hormones, Respectively, and Contribute to Virulence

    Article • Infection and Immunity, March 2011, ASM Journals

    Dr David E Heinrichs

  35. Specificity of Staphyloferrin B Recognition by the SirA Receptor from Staphylococcus aureus

    Article • Journal of Biological Chemistry, September 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs, Michael Murphy

  36. Staphylococcus aureus Nonribosomal Peptide Secondary Metabolites Regulate Virulence

    Article • Science, June 2010, American Association for the Advancement of Science

    Dr David E Heinrichs

  37. Siderophore-mediated iron acquisition in the staphylococci

    Article • Journal of Inorganic Biochemistry, March 2010, Elsevier

    Dr David E Heinrichs

  38. The Staphylococcus aureus Siderophore Receptor HtsA Undergoes Localized Conformational Changes to Enclose Staphyloferrin A in an Arginine-rich Binding Pocket

    Article • Journal of Biological Chemistry, February 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs, Michael Murphy

  39. Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus

    Article • Molecular Microbiology, October 2009, Wiley

    Dr David E Heinrichs

  40. Characterization of IsdH (NEAT domain 3) and IsdB (NEAT domain 2) in Staphylococcus aureus by magnetic circular dichroism spectroscopy and electrospray ionization mass spectrometry

    Article • Journal of Porphyrins and Phthalocyanines, October 2009, World Scientific Pub Co Pte Lt

    Martin Stillman, Dr David E Heinrichs

  41. Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome

    Article • Nature Reports Stem Cells, May 2009, Springer Science + Business Media

    Dr David E Heinrichs, Professor Joaquin (Quim) Madrenas

  42. Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus

    Article • Molecular Microbiology, May 2009, Wiley

    Dr David E Heinrichs, Michael Murphy

  43. The N-Acetylmannosamine Transferase Catalyzes the First Committed Step of Teichoic Acid Assembly in Bacillus subtilis and Staphylococcus aureus

    Article • Journal of Bacteriology, April 2009, ASM Journals

    Dr David E Heinrichs

  44. Iron acquisition by the haem-binding Isd proteins in Staphylococcus aureus : studies of the mechanism using magnetic circular dichroism

    Article • Biochemical Society Transactions, December 2008, Portland Press Ltd.

    Martin Stillman, Dr David E Heinrichs

  45. Demonstration of the Iron-regulated Surface Determinant (Isd) Heme Transfer Pathway in Staphylococcus aureus

    Article • Journal of Biological Chemistry, August 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs

  46. NK Cells Play a Critical Protective Role in Host Defense against Acute Extracellular Staphylococcus aureus Bacterial Infection in the Lung

    Article • The Journal of Immunology, April 2008, The American Association of Immunologists

    Dr David E Heinrichs

  47. Heme binding in the NEAT domains of IsdA and IsdC of Staphylococcus aureus

    Article • Journal of Inorganic Biochemistry, March 2008, Elsevier

    Martin Stillman, Dr David E Heinrichs

  48. Receptor-Interacting Protein-2 Deficiency Delays Macrophage Migration and Increases Intracellular Infection during Peritoneal Dialysis-Associated Peritonitis

    Article • American Journal of Nephrology, January 2008, Karger Publishers

    Dr David E Heinrichs

  49. Heme Binding Properties of Staphylococcus aureus IsdE

    Article • Biochemistry, October 2007, American Chemical Society (ACS)

    Martin Stillman, Dr David E Heinrichs, Dr John Mack

  50. Heme Coordination by Staphylococcus aureus IsdE

    Article • Journal of Biological Chemistry, July 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs, Michael Murphy

  51. Protoporphyrin IX and heme binding properties of Staphylococcus aureus IsdC

    Article • Journal of Porphyrins and Phthalocyanines, March 2007, World Scientific Pub Co Pte Lt

    Martin Stillman, Dr David E Heinrichs

  52. Crystal structure IsdA NEAT domain from Staphylococcus aureus with heme bound

    Article • December 2006, Protein Data Bank, Rutgers University

    Dr David E Heinrichs

  53. Crystal structure of the IsdA NEAT domain from Staphylococcus aureus

    Article • December 2006, Protein Data Bank, Rutgers University

    Dr David E Heinrichs

  54. Haem recognition by a Staphylococcus aureus NEAT domain

    Article • Molecular Microbiology, November 2006, Wiley

    Dr David E Heinrichs, Michael Murphy

  55. Characterization of the Heme Binding Properties of Staphylococcus aureus IsdA

    Article • Biochemistry, October 2006, American Chemical Society (ACS)

    Martin Stillman, Dr David E Heinrichs, Dr John Mack

  56. The yjeQ Gene Is Required for Virulence of Staphylococcus aureus

    Article • Infection and Immunity, August 2006, ASM Journals

    Dr David E Heinrichs

  57. Requirement of Staphylococcus aureus ATP-Binding Cassette-ATPase FhuC for Iron-Restricted Growth and Evidence that It Functions with More than One Iron Transporter

    Article • Journal of Bacteriology, March 2006, ASM Journals

    Dr David E Heinrichs

  58. Evidence for siderophore‐dependent iron acquisition in group B streptococcus

    Article • Molecular Microbiology, December 2005, Wiley

    Dr David E Heinrichs

  59. Involvement of SirABC in Iron-Siderophore Import in Staphylococcus aureus

    Article • Journal of Bacteriology, December 2004, ASM Journals

    Dr David E Heinrichs

  60. FhuD1, a Ferric Hydroxamate-binding Lipoprotein in Staphylococcus aureus: A CASE OF GENE DUPLICATION AND LATERAL TRANSFER

    Article • Journal of Biological Chemistry, October 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs

  61. In vivo heme scavenging by Staphylococcus aureus IsdC and IsdE proteins

    Article • Biochemical and Biophysical Research Communications, July 2004, Elsevier

    Martin Stillman, Dr David E Heinrichs, Dr John Mack

  62. Role of Siderophore Biosynthesis in Virulence of Staphylococcus aureus: Identification and Characterization of Genes Involved in Production of a Siderophore

    Article • Infection and Immunity, January 2004, ASM Journals

    Dr David E Heinrichs

  63. The Role of FhuD2 in Iron(III)-Hydroxamate Transport in Staphylococcus aureus: DEMONSTRATION THAT FhuD2 BINDS IRON(III)-HYDROXAMATES BUT WITH MINIMAL CONFORMATIONAL CHANGE AND IMPLICATION OF MUTATIONS ON TRANSPORT

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs

  64. Transferrin binding in Staphylococcus aureus: involvement of a cell wall‐anchored protein

    Article • Molecular Microbiology, March 2002, Wiley

    Dr David E Heinrichs

  65. Identification and Characterization of fhuD1 and fhuD2, Two Genes Involved in Iron-Hydroxamate Uptake in Staphylococcus aureus

    Article • Journal of Bacteriology, September 2001, ASM Journals

    Dr David E Heinrichs

  66. Identification and Characterization of a Membrane Permease Involved in Iron-Hydroxamate Transport inStaphylococcus aureus

    Article • Journal of Bacteriology, August 2000, ASM Journals

    Dr David E Heinrichs

  67. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica

    Article • Molecular Microbiology, October 1998, Wiley

    Dr David E Heinrichs

  68. Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine

    Article • Molecular Microbiology, November 1993, Wiley

    Dr David E Heinrichs

  69. Pyoverdine-mediated iron transport in Pseudomonas aeruginosa : involvement of a high-molecular-mass outer membrane protein

    Article • FEMS Microbiology Letters, February 1991, Oxford University Press (OUP)

    Dr David E Heinrichs