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  1. 5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression

    Article • International Journal of Molecular Sciences, April 2023, MDPI AG

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  2. Agonistic properties of a series of psychotropic drugs at 5-HT1A receptors in rat and human brain membranes determined by [35S]GTPγS binding assay

    Article • Pharmacological Reports, January 2023, Springer Science + Business Media

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  3. GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant‐like effects involving BDNF actions

    Article • Journal of Cellular Physiology, January 2023, Wiley

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  4. The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson’s Disease

    Article • Molecular Neurobiology, July 2022, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  5. Dysfunctional Heteroreceptor Complexes as Novel Targets for the Treatment of Major Depressive and Anxiety Disorders

    Article • Cells, June 2022, MDPI AG

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  6. Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus with Consequent Augmented Spatial Memory

    Article • Biomedicines, June 2022, MDPI AG

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  7. Increased density and antagonistic allosteric interactions in A2AR-D2R heterocomplexes in extinction from cocaine use, lost in cue induced reinstatement of cocaine seeking

    Article • Pharmacology Biochemistry and Behavior, April 2022, Elsevier

    Dr. Dasiel Oscar Borroto Escuela

  8. Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats

    Article • Frontiers in Pharmacology, February 2022, Frontiers

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  9. Molecular Integration in Adenosine Heteroreceptor Complexes Through Allosteric and De-Phosphorylation (STEP) Mechanisms and its Role in Brain Disease

    Article • Frontiers in Pharmacology, January 2022, Frontiers

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  10. The integrative role of G protein-coupled receptor heterocomplexes in Parkinson’s disease

    Article • Neural Regeneration Research, January 2022, Medknow

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  11. Correction to: The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons

    Article • Pharmacological Reports, September 2021, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  12. The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons

    Article • Pharmacological Reports, August 2021, Springer Science + Business Media

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  13. Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia—Relevance for Mental Diseases

    Article • Cells, July 2021, MDPI AG

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  14. Adenosine and Kynurenic Acid Interactions: Possible Relevance for Schizophrenia Treatment?

    Article • Frontiers in Pharmacology, April 2021, Frontiers

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  15. The Balance of MU-Opioid, Dopamine D2 and Adenosine A2A Heteroreceptor Complexes in the Ventral Striatal-Pallidal GABA Antireward Neurons May Have a Significant Role in Morphine and Cocaine Use Disorders

    Article • Frontiers in Pharmacology, March 2021, Frontiers

    Christophe Stove, Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  16. The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  17. Molecular, biochemical and behavioural evidence for a novel oxytocin receptor and serotonin 2C receptor heterocomplex

    Article • Neuropharmacology, February 2021, Elsevier

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  18. Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus

    Article • Journal of Cellular Physiology, October 2020, Wiley

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  19. Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing

    Article • Mechanisms of Ageing and Development, September 2020, Elsevier

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  20. Conventional and Novel Pharmacological Approaches to Treat Dopamine-Related Disorders: Focus on Parkinson’s Disease and Schizophrenia

    Article • Neuroscience, July 2020, Elsevier

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  21. Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine

    Article • Cells, June 2020, MDPI AG

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  22. Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations

    Article • Neuropharmacology, June 2020, Elsevier

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  23. Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia

    Article • Cells, April 2020, MDPI AG

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  24. Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor–receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels

    Article • Pharmacological Reports, March 2020, Springer Science + Business Media

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  25. Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer

    Article • Oncogene, February 2020, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  26. A2AR Transmembrane 2 Peptide Administration Disrupts the A2AR-A2AR Homoreceptor but Not the A2AR-D2R Heteroreceptor Complex: Lack of Actions on Rodent Cocaine Self-Administration

    Article • International Journal of Molecular Sciences, December 2019, MDPI AG

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  27. OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes

    Article • Neurotoxicity Research, November 2019, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  28. Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling

    Article • Scientific Reports, November 2019, Springer Science + Business Media

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  29. Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids

    Article • Translational Psychiatry, October 2019, Springer Science + Business Media

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  30. Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS

    Article • Frontiers in Molecular Neuroscience, September 2019, Frontiers

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  31. Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy?

    Article • Frontiers in Endocrinology, August 2019, Frontiers

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  32. Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists

    Article • Glia, August 2019, Wiley

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  33. Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor

    Article • Biomolecules, August 2019, MDPI AG

    Christophe Stove, Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  34. Understanding receptor heteromerization and its allosteric integration of signals

    Article • Neuropharmacology, July 2019, Elsevier

    Dr. Dasiel Oscar Borroto Escuela

  35. On the G Protein-Coupled Receptor Neuromodulation of the Claustrum

    Article • Neurochemical Research, June 2019, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  36. Attenuation of Oxytocin and Serotonin 2A Receptor Signaling through Novel Heteroreceptor Formation

    Article • ACS Chemical Neuroscience, April 2019, American Chemical Society (ACS)

    Dr. Dasiel Oscar Borroto Escuela

  37. Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes

    Article • Molecular Neurobiology, April 2019, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  38. Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson’s disease and its treatment

    Article • Journal of Neural Transmission, January 2019, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  39. Co-immunoprecipitation (Co-IP) of G Protein-Coupled Receptor (GPCR)-Receptor Tyrosine Kinase (RTK) Complexes from the Dorsal Hippocampus of the Rat Brain

    Article • December 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  40. Coimmunoprecipitation (co-IP) Analysis for Protein-Protein Interactions in the Neurons of the Cerebral Ganglia of the Land Snails of the Genus Polymita During Aestivation

    Article • December 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  41. Isolation and Detection of G Protein-Coupled Receptor (GPCR) Heteroreceptor Complexes in Rat Brain Synaptosomal Preparation Using a Combined Brain Subcellular Fractionation/Co-immunoprecipitation (Co-IP) Procedures

    Article • December 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  42. A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction

    Article • Trends in Pharmacological Sciences, December 2018, Elsevier

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  43. Effects of intra-accumbal or intra-prefrontal cortex microinjections of adenosine 2A receptor ligands on responses to cocaine reward and seeking in rats

    Article • Psychopharmacology, November 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  44. Glutamate heteroreceptor complexes in the brain

    Article • Pharmacological Reports, October 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  45. Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer

    Article • Frontiers in Pharmacology, August 2018, Frontiers

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  46. Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors

    Article • Frontiers in Synaptic Neuroscience, July 2018, Frontiers

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  47. Dopamine receptor supersensitivity

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Richard Kostrzewa, Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  48. Receptor–Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

    Article • Molecules, June 2018, MDPI AG

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  49. A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats

    Article • Frontiers in Cellular Neuroscience, May 2018, Frontiers

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  50. Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation

    Article • Frontiers in Neuroscience, February 2018, Frontiers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  51. Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors

    Article • Oncotarget, February 2018, Impact Journals, LLC

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  52. Disruption of A2AR-D2R Heteroreceptor Complexes After A2AR Transmembrane 5 Peptide Administration Enhances Cocaine Self-Administration in Rats

    Article • Molecular Neurobiology, January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  53. Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats

    Article • Alcoholism Clinical and Experimental Research, January 2018, Wiley

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  54. Differential activation of arginine-vasopressin receptor subtypes in the amygdaloid modulation of anxiety in the rat by arginine-vasopressin

    Article • Psychopharmacology, January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  55. Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia

    Article • Brain Behavior and Immunity, January 2018, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  56. Adenosine Receptors as a Paradigm to Identify Dimer/Oligomers of G-Protein-Coupled Receptors and as Targets in Parkinson’s Disease and Schizophrenia

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  57. Analysis and Quantification of GPCR Allosteric Receptor–Receptor Interactions Using Radioligand Binding Assays: The A2AR-D2R Heteroreceptor Complex Example

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  58. Analysis and Quantification of GPCR Heteroreceptor Complexes and Their Allosteric Receptor–Receptor Interactions Using Radioligand Binding Autoradiography

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  59. Behavioral Methods to Study the Impact of Receptor–Receptor Interactions in Fear and Anxiety

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  60. Detection of Fibroblast Growth Factor Receptor 1 (FGFR1) Transactivation by Muscarinic Acetylcholine Receptors (mAChRs) in Primary Neuronal Hippocampal Cultures Through Use of Biochemical and Morphological Approaches

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  61. Detection, Analysis, and Quantification of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  62. Electrophysiological Approach to GPCR–RTK Interaction Study in Hippocampus of Adult Rats

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  63. In Vivo Microdialysis Technique Applications to Understand the Contribution of Receptor–Receptor Interactions to the Central Nervous System Signaling

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  64. Methods to Identify the Signature of Trimers Formed by Three G Protein-Coupled Receptors or by Two G Protein-Coupled and One Ionotropic Receptor with Special Emphasis in the Functional Role in the Central Nervous System

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  65. Searching the GPCR Heterodimer Network (GPCR-hetnet) Database for Information to Deduce the Receptor–Receptor Interface and Its Role in the Integration of Receptor Heterodimer Functions

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  66. Use of Superfused Synaptosomes to Understand the Role of Receptor–Receptor Interactions as Integrative Mechanisms in Nerve Terminals from Selected Brain Region

    Article • January 2018, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela

  67. Cocaine modulates allosteric D2-σ1 receptor-receptor interactions on dopamine and glutamate nerve terminals from rat striatum

    Article • Cellular Signalling, December 2017, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  68. Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression

    Article • Frontiers in Cellular Neuroscience, October 2017, Frontiers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  69. Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition

    Article • ACS Omega, August 2017, American Chemical Society (ACS)

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  70. The neuropeptides Galanin and Galanin(1–15) in depression-like behaviours

    Article • Neuropeptides, August 2017, Elsevier

    Dr. Dasiel Oscar Borroto Escuela

  71. Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression

    Article • Neuropharmacology, May 2017, Elsevier

    Dr. Dasiel Oscar Borroto Escuela

  72. Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder

    Article • Pharmacology Biochemistry and Behavior, April 2017, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  73. Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease

    Article • Frontiers in Cellular Neuroscience, February 2017, Frontiers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  74. IL1R2, CCR2, and CXCR4 May Form Heteroreceptor Complexes with NMDAR and D2R: Relevance for Schizophrenia

    Article • Frontiers in Psychiatry, February 2017, Frontiers

    Dr. Dasiel Oscar Borroto Escuela

  75. Diversity and bias through dopamine D2R heteroreceptor complexes

    Article • Current Opinion in Pharmacology, February 2017, Elsevier

    Dr. Dasiel Oscar Borroto Escuela

  76. Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, February 2017, Elsevier

    Dr. Dasiel Oscar Borroto Escuela

  77. Alterations in ventral and dorsal striatal allosteric A2AR-D2R receptor-receptor interactions after amphetamine challenge: Relevance for schizophrenia

    Article • Life Sciences, December 2016, Elsevier

    Dr. Dasiel Oscar Borroto Escuela

  78. Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, November 2016, Elsevier

    Dr. Dasiel Oscar Borroto Escuela

  79. Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins

    Article • Cellular Signalling, August 2016, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  80. Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission

    Article • Journal of Neurochemistry, June 2016, Wiley

    Luca Ferraro, Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  81. Dopamine D4receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction

    Article • Addiction Biology, May 2016, Wiley

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  82. Cocaine self-administration differentially affects allosteric A2A-D2 receptor-receptor interactions in the striatum. Relevance for cocaine use disorder

    Article • Pharmacology Biochemistry and Behavior, May 2016, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  83. Purinergic signaling in Parkinson's disease. Relevance for treatment

    Article • Neuropharmacology, May 2016, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  84. Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia

    Article • Therapeutic Advances in Psychopharmacology, March 2016, SAGE Publications

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  85. Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system

    Article • Brain Structure and Function, January 2016, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  86. Role of iso-receptors in receptor-receptor interactions with a focus on dopamine iso-receptor complexes

    Article • Reviews in the Neurosciences, January 2016, De Gruyter

    Dr. Diego Guidolin, Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  87. FGFR1–5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression

    Article • Trends in Neurosciences, January 2016, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  88. Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes

    Article • Neural Plasticity, January 2016, Hindawi Publishing Corporation

    Dr. Dasiel Oscar Borroto Escuela

  89. Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication

    Article • Neural Regeneration Research, January 2016, Medknow

    Dr. Dasiel Oscar Borroto Escuela

  90. In Situ Proximity Ligation Assay to Study and Understand the Distribution and Balance of GPCR Homo- and Heteroreceptor Complexes in the Brain

    Article • January 2016, Springer Science + Business Media

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  91. Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects

    Article • Brain Structure and Function, December 2015, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  92. Heteroreceptor Complexes and their Allosteric Receptor–Receptor Interactions as a Novel Biological Principle for Integration of Communication in the CNS: Targets for Drug Development

    Article • Neuropsychopharmacology, December 2015, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  93. The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, December 2015, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  94. Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5

    Article • Expert Opinion on Investigational Drugs, July 2015, Informa Healthcare

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  95. Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression

    Article • Biochemical and Biophysical Research Communications, July 2015, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  96. The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural–glial networks

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, May 2015, Royal Society Publishing

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  97. Volume Transmission in Central Dopamine and Noradrenaline Neurons and Its Astroglial Targets

    Article • Neurochemical Research, April 2015, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  98. A Role for Galanin N-Terminal Fragment (1–15) in Anxiety- and Depression-Related Behaviors in Rats

    Article • The International Journal of Neuropsychopharmacology, February 2015, Oxford University Press (OUP)

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  99. Evidence for the existence of FGFR1–5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system

    Article • Biochemical and Biophysical Research Communications, January 2015, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  100. Dopamine heteroreceptor complexes as therapeutic targets in Parkinson’s disease

    Article • Expert Opinion on Therapeutic Targets, December 2014, Informa Healthcare

    Professor Kjell Fuxe, Dr. Dasiel Oscar Borroto Escuela

  101. On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats

    Article • Psychopharmacology, November 2014, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  102. G-protein-coupled receptor type A heteromers as an emerging therapeutic target

    Article • Expert Opinion on Therapeutic Targets, November 2014, Informa Healthcare

    Dr. Diego Guidolin, Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  103. Potential of caveolae in the therapy of cardiovascular and neurological diseases

    Article • Frontiers in Physiology, September 2014, Frontiers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  104. Editorial (Thematic Issue: Understanding the Role of Heteroreceptor Complexes in the Central Nervous System)

    Article • Current Protein and Peptide Science, September 2014, Bentham Science Publishers

    Dr. Dasiel Oscar Borroto Escuela

  105. Role of Dimerization in Dopamine D4 Receptor Biogenesis

    Article • Current Protein and Peptide Science, September 2014, Bentham Science Publishers

    Dr. Dasiel Oscar Borroto Escuela

  106. “Neuro-Semeiotics” and “Free-Energy Minimization” Suggest a Unified Perspective for Integrative Brain Actions: Focus on Receptor Heteromers and Roamer Type of Volume Transmission

    Article • Current Protein and Peptide Science, September 2014, Bentham Science Publishers

    Dr. Dasiel Oscar Borroto Escuela

  107. Preferential activation by galanin 1–15 fragment of the GalR1 protomer of a GalR1–GalR2 heteroreceptor complex

    Article • Biochemical and Biophysical Research Communications, September 2014, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  108. G-Protein-Coupled Receptors Oligomerization: Emerging Signaling Units and New Opportunities for Drug Design

    Article • Current Protein and Peptide Science, August 2014, Bentham Science Publishers

    Dr. Dasiel Oscar Borroto Escuela

  109. Neurotensin NTS1-Dopamine D2 Receptor-Receptor Interactions in Putative Receptor Heteromers: Relevance for Parkinson’s Disease and Schizophrenia

    Article • Current Protein and Peptide Science, August 2014, Bentham Science Publishers

    Luca Ferraro, Dr. Dasiel Oscar Borroto Escuela

  110. Dopamine D1 and D2 receptor immunoreactivities in the arcuate-median eminence complex and their link to the tubero-infundibular dopamine neurons

    Article • European Journal of Histochemistry, July 2014, PAGEPress Publications

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  111. The impact of receptor–receptor interactions in heteroreceptor complexes on brain plasticity

    Article • Expert Review of Neurotherapeutics, June 2014, Taylor & Francis

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  112. Information handling by the brain: proposal of a new “paradigm” involving the roamer type of volume transmission and the tunneling nanotube type of wiring transmission

    Article • Journal of Neural Transmission, May 2014, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  113. Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the amygdala lead to increased anxiolytic actions

    Article • Brain Structure and Function, May 2014, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  114. The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

    Article • International Journal of Molecular Sciences, May 2014, MDPI AG

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  115. Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization

    Article • Frontiers in Endocrinology, May 2014, Frontiers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  116. Dopamine D4 Receptor Counteracts Morphine-Induced Changes in µ Opioid Receptor Signaling in the Striosomes of the Rat Caudate Putamen

    Article • International Journal of Molecular Sciences, January 2014, MDPI AG

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  117. Dopamine D2 heteroreceptor complexes and their receptor–receptor interactions in ventral striatum

    Article • January 2014, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  118. Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes

    Article • Biochemical and Biophysical Research Communications, January 2014, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  119. Understanding the balance and integration of volume and synaptic transmission. Relevance for psychiatry

    Article • Neurology Psychiatry and Brain Research, December 2013, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  120. Dynamic modulation of FGFR1–5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2

    Article • Biochemical and Biophysical Research Communications, November 2013, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  121. Moonlighting Proteins and Protein–Protein Interactions as Neurotherapeutic Targets in the G Protein-Coupled Receptor Field

    Article • Neuropsychopharmacology, September 2013, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  122. Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers

    Article • Biochemical and Biophysical Research Communications, May 2013, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  123. Volume transmission and its different forms in the central nervous system

    Article • Chinese Journal of Integrative Medicine, May 2013, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  124. A New Interpretative Paradigm for Conformational Protein Diseases

    Article • Current Protein and Peptide Science, April 2013, Bentham Science Publishers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  125. Bioluminescence Resonance Energy Transfer Methods to Study G Protein-Coupled Receptor–Receptor Tyrosine Kinase Heteroreceptor Complexes

    Article • January 2013, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  126. G Protein–Coupled Receptor Heterodimerization in the Brain

    Article • January 2013, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  127. On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System: Focus on Their Role in Pain Modulation

    Article • Evidence-based Complementary and Alternative Medicine, January 2013, Hindawi Publishing Corporation

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  128. G protein-coupled receptor oligomerization and brain integration: Focus on adenosinergic transmission

    Article • Brain Research, October 2012, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  129. On the role of volume transmission and receptor–receptor interactions in social behaviour: Focus on central catecholamine and oxytocin neurons

    Article • Brain Research, October 2012, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  130. Possible genetic and epigenetic links between human inner speech, schizophrenia and altruism

    Article • Brain Research, October 2012, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  131. Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R

    Article • Journal of Neurochemistry, September 2012, Wiley

    Dr Kenneth A. Jacobson, Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  132. Fluorescence resonance energy transfer-based technologies in the study of protein–protein interactions at the cell surface

    Article • Methods, August 2012, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  133. Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions

    Article • Molecular Psychiatry, July 2012, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  134. Integrin triplets of marine sponges in human D2 receptor heteromers

    Article • Journal of Receptors and Signal Transduction, June 2012, Taylor & Francis

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  135. Integrin Triplets of Marine Sponges in Human Brain Receptor Heteromers

    Article • Journal of Molecular Neuroscience, May 2012, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  136. Microvesicle and tunneling nanotube mediated intercellular transfer of g-protein coupled receptors in cell cultures

    Article • Experimental Cell Research, March 2012, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  137. Muscarinic Acetylcholine Receptor-Interacting Proteins (mAChRIPs): Targeting the Receptorsome

    Article • Current Drug Targets, January 2012, Bentham Science Publishers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  138. Extrasynaptic Neurotransmission in the Modulation of Brain Function. Focus on the Striatal Neuronal–Glial Networks

    Article • Frontiers in Physiology, January 2012, Frontiers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  139. Fibroblast Growth Factor Receptor 1– 5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity

    Article • Biological Psychiatry, January 2012, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  140. On the existence and function of galanin receptor heteromers in the central nervous system

    Article • Frontiers in Endocrinology, January 2012, Frontiers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  141. On the origin of the triplet puzzle of homologies in receptor heteromers: toll-like receptor triplets in different types of receptors

    Article • Journal of Neural Transmission, November 2011, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  142. On the Origin of the Triplet Puzzle of Homologies in Receptor Heteromers: Immunoglobulin Triplets in Different Types of Receptors

    Article • Journal of Molecular Neuroscience, September 2011, Springer Science + Business Media

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  143. Differential expression of muscarinic acetylcholine receptor subtypes in Jurkat cells and their signaling

    Article • Journal of Neuroimmunology, August 2011, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  144. Altered trafficking and unfolded protein response induction as a result of M3 muscarinic receptor impaired N-glycosylation

    Article • Glycobiology, July 2011, Oxford University Press (OUP)

    Dr. Dasiel Oscar Borroto Escuela

  145. Moonlighting characteristics of G protein-coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration

    Article • IUBMB Life, June 2011, Wiley

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  146. Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family

    Article • Biochemical and Biophysical Research Communications, June 2011, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  147. Adenosine receptor containing oligomers: Their role in the control of dopamine and glutamate neurotransmission in the brain

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, May 2011, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  148. Overproduction of human M3 muscarinic acetylcholine receptor: An approach toward structural studies

    Article • Biotechnology Progress, May 2011, Wiley

    Dr. Dasiel Oscar Borroto Escuela

  149. Dopamine D4 receptor oligomerization - contribution to receptor biogenesis

    Article • European Journal of Biochemistry, March 2011, Wiley

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  150. On the Existence of a Possible A2A–D2–β-Arrestin2 Complex: A2A Agonist Modulation of D2 Agonist-Induced β-Arrestin2 Recruitment

    Article • Journal of Molecular Biology, March 2011, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  151. Muscarinic receptor family interacting proteins: Role in receptor function

    Article • Journal of Neuroscience Methods, February 2011, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  152. Dissecting the Conserved NPxxY Motif of the M3 Muscarinic Acetylcholine Receptor: Critical Role of Asp-7.49 for Receptor Signaling and Multiprotein Complex Formation

    Article • Cellular Physiology and Biochemistry, January 2011, Karger Publishers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  153. Dopamine D2 and D4 receptor heteromerization and its allosteric receptor–receptor interactions

    Article • Biochemical and Biophysical Research Communications, January 2011, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  154. Characterization of the A2AR–D2R interface: Focus on the role of the C-terminal tail and the transmembrane helices

    Article • Biochemical and Biophysical Research Communications, November 2010, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  155. Dopamine D2 and 5-hydroxytryptamine 5-HT2A receptors assemble into functionally interacting heteromers

    Article • Biochemical and Biophysical Research Communications, October 2010, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  156. G protein-coupled receptor oligomerization for what?

    Article • Journal of Receptors and Signal Transduction, August 2010, Taylor & Francis

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  157. The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor–receptor interactions

    Article • Journal of Receptors and Signal Transduction, August 2010, Taylor & Francis

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe, Dr. Diego Guidolin

  158. The M5 muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, July 2010, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  159. Adenosine-Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders

    Article • CNS Neuroscience & Therapeutics, May 2010, Wiley

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  160. A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R

    Article • Biochemical and Biophysical Research Communications, March 2010, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  161. Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization

    Article • Biochemical and Biophysical Research Communications, March 2010, Elsevier

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  162. Impaired M3 Muscarinic Acetylcholine Receptor Signal Transduction Through Blockade of Binding of Multiple Proteins to its Third Intracellular Loop

    Article • Cellular Physiology and Biochemistry, January 2010, Karger Publishers

    Dr. Dasiel Oscar Borroto Escuela, Professor Kjell Fuxe

  163. Vectors and P64k gene targeting for tandem affinity purification in Neisseria meningitidis

    Article • Journal of Microbiological Methods, April 2006, Elsevier

    Dr. Dasiel Oscar Borroto Escuela